CN104147396A - Preparation method of traditional Chinese medicine tablet for treating neurogenic muscular dystrophy - Google Patents

Preparation method of traditional Chinese medicine tablet for treating neurogenic muscular dystrophy Download PDF

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CN104147396A
CN104147396A CN201410430026.XA CN201410430026A CN104147396A CN 104147396 A CN104147396 A CN 104147396A CN 201410430026 A CN201410430026 A CN 201410430026A CN 104147396 A CN104147396 A CN 104147396A
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radix
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pheretima
scorpio
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袁训辉
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袁训辉
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Abstract

The invention discloses a traditional Chinese medicine tablet for treating neurogenic muscular dystrophy and a preparation method thereof. The tablet is prepared from following main raw materials comprising, by weight, 40 parts of radix aconiti, 40 parts of gastrodin, 40 parts of cinnamon, 40 parts of clematis chinensis, 45 parts of astragalus, 45 parts of lily, 45 parts of polygala tenuifolia, 4 parts of earthworm and 4 parts of scorpions. The traditional Chinese medicine tablet has effects of dispelling wind and freeing collaterals, relaxing sinews and activating blood, reinforcing healthy qi and supporting body basis, boosting qi and nourishing blood, and activating blood, resolving stasis and relieving pain. Meanwhile, the traditional Chinese medicine tablet is significant in effect, is definite in effects, is 99% in effective rate, has an effect of treating both interior and exterior and has an effect of being not liable to relapse after cure.

Description

A kind of preparation method for the treatment of nerve amyotrophy Chinese medicinal tablet
The application is for dividing an application, and original bill application number is 201310416190.0, and the applying date is 2013.9.13, and denomination of invention is a kind of amyotrophic Chinese medicinal tablet of nerve and preparation method thereof for the treatment of.
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of amyotrophic Chinese medicinal tablet of nerve and preparation method thereof for the treatment of.
background technology
Amyotrophy refers to striped muscle malnutrition, and meat fiber attenuates even to disappear and waits the muscle volume causing to dwindle.The cause of disease mainly contains: neurogenic muscular atrophy, muscle-derived amyotrophy, muscular atrophy of disuse and other reasons amyotrophy.Muscle nutrition situation, except the pathological change of muscular tissue itself, more has substantial connection with nervous system.Diseases of spinal cord often causes muscular dystrophy and amyotrophy occurs.Amyotrophy patient is due to amyotrophy, myasthenia and long-term bed, easily Complicating Pneumonia In Patients, decubital ulcer etc., and there is bulbar paralysis symptom in Most patients in addition, forms greatly to patient's life and threaten.Amyotrophy patient is except sending for a doctor treatment, and oneself's medical treatment is very important.
Nerve amyotrophy is when neural impulse arrives, teleneuron discharges chemical mediator acetylcholine, and the temporary transient combination of receptor on the latter and soleplate, increases the permeability of this place's sarolemma to sodium, make extracellular sodium ion enter cell, thereby make the transmembrane potential depolarization of endplate regions; Reach after certain threshold value and cause around and produce action potential on sarolemma.Action potential is transmitted to sarcoplasmic reticulum, impels it to sarcoplasm, to discharge calcium ion; The latter can impel adenosine triphosphate to decompose, and emits energy and some protein molecular in myocyte is closely agreed with, and causes the contraction of myocyte's length.
Common former of neuropathic muscular atrophy is because useless use, malnutrition, ischemia and poisoning.Anterior angle pathological changes, nerve root, plexus nervorum, perineural amyotrophy
Pathological changes etc. all can cause the conductive impairment of neural excitation impulsion, thereby make the part muscle fiber use of give up, generation muscular atrophy of disuse.
After the infringement of any position of lower motor neuron, the acetylcholine that its tip position discharges reduces on the other hand, and sympathetic nerve Nutrition weakens and causes amyotrophy.Myogenicity amyotrophy is by the disease of muscle own, may also comprise some other factor, and the muscular dystrophy patient as shoulder belt or facio scapulo humeral type, turns out to be spinal muscular atrophy by morphological examination.
In existing patent application, also there is not the amyotrophic Chinese medicinal tablet for the treatment of nerve.
Summary of the invention
For above problem, the invention provides a kind of amyotrophic Chinese medicinal tablet of nerve for the treatment of, the amyotrophy that this Chinese medicinal tablet causes nerve amyotrophy and a variety of causes by the proof of clinical treatment for many years has good therapeutic effect, Chinese medicinal tablet of the present invention has dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons to promote blood circulation, the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, promoting blood circulation, removing blood stasis and relieving pain, has advantages of that effect is remarkable, drug effect is definite.
The present invention is achieved through the following technical solutions:
Treat the amyotrophic Chinese medicinal tablet of nerve, take off the primary raw material of stating weight proportion and be prepared from: Radix Aconiti 20-45 part, Rhizoma Gastrodiae 20-45 part, Cortex Cinnamomi 20-45 part, Radix Clematidis 20-45 part, Radix Astragali 30-50 part, Bulbus Lilii 30-50 part, Radix Polygalae 30-50 part, Pheretima 1-5 part, Scorpio 1-5 part.
Chinese medicinal tablet according to claim 1, preferred scheme is: its preferred version is to take off the primary raw material of stating weight proportion to be prepared from: Radix Aconiti 25-40 part, Rhizoma Gastrodiae 25-40 part, Cortex Cinnamomi 25-40 part, Radix Clematidis 25-40 part, Radix Astragali 35-45 part, Bulbus Lilii 35-45 part, Radix Polygalae 35-45 part, Pheretima 2-4 part, Scorpio 2-4 part.
Chinese medicinal tablet according to claim 1, the scheme being more preferably is: its preferred plan is to take off the primary raw material of stating weight proportion to be prepared from: 30 parts of Radix Aconitis, 30 parts, Rhizoma Gastrodiae, 30 parts of Cortex Cinnamomis, 30 parts of Radix Clematidis, 35 parts of the Radixs Astragali, 35 parts of Bulbus Liliies, 35 parts of Radix Polygalaes, 3 parts of Pheretimas, 3 parts of Scorpio.
The preparation method of above-mentioned Chinese medicinal tablet, step is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in heat pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry while heaving to surperficial brown color is micro-, take out sieve shakeout, spreading for cooling;
(2) Scorpio is decaptitated truncate and soak 20-40 minute completely with vinegar, taking-up is dried, vinegar Scorpio processed;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 120-140 mesh sieve;
(4) by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio processed, by temperature, be that preferably the cold water of 30 ℃ soaks 2 hours, water consumption is described Pheretima (parched) and vinegar Scorpio weight processed 2-5 times;
(5) step (4) gained mixed liquor is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume obtains concentrated solution;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried to 1-2 hour, obtain oven dry thing, is dry at 70-90 ℃ in temperature;
(7) step (6) gains are measured according to 0.3-0.7g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form.
The described preparation method that obtains, preferred scheme is: step (2) is soaked 25-35 minute (preferably soaking 30 minutes).
Described preparation method, preferred scheme is: step (3) is crossed 125-135 mesh sieve (preferred mistake 130 mesh sieves).
Described preparation method, preferred scheme is: step (4) water consumption be described fine powder weight 3-4 doubly (
Preferably 3.5 times).
Described preparation method, preferred scheme is: step (6) is dried 1.3-1.8 hour (preferably 1.5 hours).
Described preparation method, preferred scheme is: step (6) is dry at 75-85 ℃ (preferably dry at 80 ℃ of temperature) in temperature.
Described preparation method, preferred scheme is: the dosage form of step (7) tablet is 0.4-0.6g/ sheet (preferred dosage form is 0.5 g/ sheet).
Using method: for making the present invention reach optimum therapeuticing effect, after 1 hour after meal, take, 3 times on the one, each 2-3 gram.
This Chinese medicinal tablet is remarkable to nerve amyotrophy effect, has relaxing muscles and tendons to promote blood circulation, the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, the feature of promoting blood circulation, removing blood stasis and relieving pain.
A kind of pharmacological effect for the treatment of amyotrophic each crude drug of Chinese medicinal tablet of nerve of the present invention is:
Radix Aconiti: pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type, have a pain.Be used for the treatment of the diseases such as anemofrigid-damp arthralgia, arthralgia.For oral administration after general process of preparing Chinese medicine.Radix Aconiti tincture external energy chafe, produces feeling of numbness then, therefore be used as the analgesics of some neuralgia and rheumatism outward.
Rhizoma Gastrodiae: sweet flat, return Liver Channel.Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
Cortex Cinnamomi: hide pungent, temperature.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.
Radix Clematidis: pungent, salty, temperature, poisonous.Return urinary bladder channel.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
The Radix Astragali: sweet, tepor.The Radix Astragali has the effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating, raw by consolidating superficial resistance holder skin ulcer.
Bulbus Lilii: mind tranquilizing and the heart calming: Bulbus Lilii enters heart channel, cold nature, the relieving restlessness that can clear away heart-fire, mind tranquilizing and the heart calming, for waste heat after calentura do not disappear, lost in a reverie, insomnia and dreamful sleep, feel depressed, the disease such as susceptible to sorrow and being about to weep.
Radix Polygalae: bitter, pungent, tepor.GUIXIN, kidney, lung meridian.The Fructus Alpiniae Oxyphyllae of calming the nerves, eliminates the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.
Scorpio: pungent, flat; Poisonous.Return Liver Channel.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Pheretima: calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia.External is coated with the diseases such as erysipelas, dermatitis rhus.
A kind of amyotrophic Chinese medicinal tablet of nerve for the treatment of of the present invention meets the traditional Chinese medical science about the theory of dermatitis.For above-mentioned, in a kind of defect for the treatment of in the amyotrophic Chinese medicinal tablet process of nerve, this product, summing up on the basis of forefathers' experience, is gone through clinical research for many years, adopts natural Chinese medicines unique formula and technique to refine and forms.This product includes abundant plant biological active component, can directly act on affected part.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1treat the amyotrophic Chinese medicinal tablet of nerve, by following weight parts, get the raw materials ready (getting 10g for every part): Radix Aconiti 20, Rhizoma Gastrodiae 20, Cortex Cinnamomi 20, Radix Clematidis 20, the Radix Astragali 30, Bulbus Lilii 30, Radix Polygalae 30, Pheretima 1, Scorpio 1.
Treat the amyotrophic Chinese medicinal tablet of nerve, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in heat pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry while heaving to surperficial brown color is micro-, take out sieve shakeout, spreading for cooling;
(2) Scorpio is decaptitated truncate and soak completely 20 minutes with vinegar, taking-up is dried, vinegar Scorpio processed;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 120 mesh sieves;
(4) by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio processed, by temperature, be that preferably the cold water of 30 ℃ soaks 2 hours, water consumption is described Pheretima (parched) and vinegar Scorpio weight processed 2 times;
(5) step (4) gained mixed liquor is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume obtains concentrated solution;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 1 hour, obtain oven dry thing, is dry at 70 ℃ in temperature;
(7) step (6) gains are measured according to 0.3g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form.
model case one: Zhao so-and-so, man, 23 years old, people from Harbin.In February, 2010, occur facial Hyperalgesia, bicker is sagging without reason, and neck is soft, the symptom that two lower limb are ached, and father and mother go to Chinese herbalist clinic to give out the application of returning of a little Western medicine, and after medication, symptom improves, afterwards just drug withdrawal.General one month, there is numb limbs and tense tendons, the disease such as weak, tired in Zhao again, and sensation walking difficulty comparatively, and the old sialorrhea of the corners of the mouth speaks that some is unintelligible, and appetite declines, and other is without abnormal.Zhao continue after drug administration not before treatment so desirable, not only do not control PD, there is the phenomenon of spasm and atrophy in muscle on the contrary, what go that examination in hospital just learns trouble is muscular dystrophy thereupon.The head of a family recognizes ill seriousness, by friend, introduces and buys Chinese medicinal tablet of the present invention, take after 1 course for the treatment of above-mentioned symptom be improved significantly, the mental status is better, continue to take 2 courses for the treatment of of Chinese medicinal tablet of the present invention, above-mentioned symptom disappears substantially, after drug withdrawal without recurrence.
embodiment 2treat the amyotrophic Chinese medicinal tablet of nerve, by following weight parts, get the raw materials ready (getting 10g for every part): Radix Aconiti 45, Rhizoma Gastrodiae 45, Cortex Cinnamomi 45, Radix Clematidis 45, the Radix Astragali 50, Bulbus Lilii 50, Radix Polygalae 50, Pheretima 5, Scorpio 5.
Treat the amyotrophic Chinese medicinal tablet of nerve, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in heat pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry while heaving to surperficial brown color is micro-, take out sieve shakeout, spreading for cooling;
(2) Scorpio is decaptitated truncate and soak completely 40 minutes with vinegar, taking-up is dried, vinegar Scorpio processed;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 140 mesh sieves;
(4) by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio processed, by temperature, be that preferably the cold water of 30 ℃ soaks 2 hours, water consumption is described Pheretima (parched) and vinegar Scorpio weight processed 5 times;
(5) step (4) gained mixed liquor is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume obtains concentrated solution;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 2 hours, obtain oven dry thing, is dry at 90 ℃ in temperature;
(7) step (6) gains are measured according to 0.7g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form.
embodiment 3:treat the amyotrophic Chinese medicinal tablet of nerve, by following weight parts, get the raw materials ready (getting 10g for every part): Radix Aconiti 25, Rhizoma Gastrodiae 25, Cortex Cinnamomi 25, Radix Clematidis 25, the Radix Astragali 35, Bulbus Lilii 35, Radix Polygalae 35, Pheretima 2, Scorpio 2.
Treat the amyotrophic Chinese medicinal tablet of nerve, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in heat pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry while heaving to surperficial brown color is micro-, take out sieve shakeout, spreading for cooling;
(2) Scorpio is decaptitated truncate and soak completely 25 minutes with vinegar, taking-up is dried, vinegar Scorpio processed;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 125 mesh sieves;
(4) by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio processed, by temperature, be that preferably the cold water of 30 ℃ soaks 2 hours, water consumption is described Pheretima (parched) and vinegar Scorpio weight processed 3 times;
(5) step (4) gained mixed liquor is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume obtains concentrated solution;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 1.3 hours, obtain oven dry thing, is dry at 75 ℃ in temperature;
(7) step (6) gains are measured according to 0.4g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form.
model case two:journey, male, 23 years old, people from Changsha.Because " movable weak companion's amyotrophy more than 10 years " is admitted to hospital.Patient felt malaise without obvious cause in the time of 5 years old, and, without uncomfortable, since idiopathy, the weak symptom of patient does not increase the weight of gradually, before 7 years, occurred two lower limb muscles atrophys, climb building difficulty, both hands can be held thing, can not complete the fine movement such as write, stop school work, over nearly 3 years, patient can not take care of oneself.Since morbidity, patient once arrived the famous hospital therapy of domestic many families, finally be diagnosed as neurotic atrophy, at present without effective Therapeutic Method, after knowing Chinese medicinal tablet of the present invention, come to buy and treat, taking Chinese medicinal tablet of the present invention after 1 course for the treatment of, both hands can be taken thing, doing some simply moves, after taking two courses for the treatment of, patient's symptom is before improved substantially, and can be by crutch station for a moment, continue to take 2 courses for the treatment of of Chinese medicinal tablet of the present invention, not transference cure, and can take care of oneself, be in the best of spirit.
embodiment 4treat the amyotrophic Chinese medicinal tablet of nerve, by following weight parts, get the raw materials ready (getting 10g for every part): Radix Aconiti 40, Rhizoma Gastrodiae 40, Cortex Cinnamomi 40, Radix Clematidis 40, the Radix Astragali 45, Bulbus Lilii 45, Radix Polygalae 45, Pheretima 4, Scorpio 4.
Treat the amyotrophic Chinese medicinal tablet of nerve, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in heat pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry while heaving to surperficial brown color is micro-, take out sieve shakeout, spreading for cooling;
(2) Scorpio is decaptitated truncate and soak completely 35 minutes with vinegar, taking-up is dried, vinegar Scorpio processed;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 135 mesh sieves;
(4) by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio processed, by temperature, be that preferably the cold water of 30 ℃ soaks 2 hours, water consumption is described Pheretima (parched) and vinegar Scorpio weight processed 4 times;
(5) step (4) gained mixed liquor is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume obtains concentrated solution;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 1.8 hours, obtain oven dry thing, is dry at 85 ℃ in temperature;
(7) step (6) gains are measured according to 0.6g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form.
embodiment 5treat the amyotrophic Chinese medicinal tablet of nerve, by following weight parts, get the raw materials ready (getting 10g for every part): Radix Aconiti 30, Rhizoma Gastrodiae 30, Cortex Cinnamomi 30, Radix Clematidis 30, the Radix Astragali 35, Bulbus Lilii 35, Radix Polygalae 35, Pheretima 3, Scorpio 3.
Treat the amyotrophic Chinese medicinal tablet of nerve, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in heat pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry while heaving to surperficial brown color is micro-, take out sieve shakeout, spreading for cooling;
(2) Scorpio is decaptitated truncate and soak completely 30 minutes with vinegar, taking-up is dried, vinegar Scorpio processed;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 130 mesh sieves;
(4) by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio processed, by temperature, be that preferably the cold water of 30 ℃ soaks 2 hours, water consumption is described Pheretima (parched) and vinegar Scorpio weight processed 3.5 times;
(5) step (4) gained mixed liquor is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume obtains concentrated solution;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 1.5 hours, obtain oven dry thing, is dry at 80 ℃ in temperature;
(7) step (6) gains are measured according to 0.5g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form.
test examplethe clinical practice of the amyotrophic Chinese medicinal tablet of embodiment 5 gained treatments nerve: in June, 2008-2011 year December, screens 120 routine patients in 4 hospitals, women's 58 examples wherein, male's 62 examples, oldest 72 years old, minimal ages 18 years old, 60 years old mean age.Test 2 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, is divided at random two groups, experimental group and matched group, and experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other medicine.Using method is: (warm) taken three times a day, each 2-3 gram (depending on concrete condition, adjusting to some extent), 15 days courses for the treatment of, of the present inventionly coordinates and adhere to taking exercise every day 1 hour simultaneously taking.Curative effect situation criterion: cure: take 3 courses for the treatment of of this product, amyotrophy degree is obviously improved, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, amyotrophy degree is improved, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 18-72 year nerve amyotrophy patient treatment results
Experimental group Matched group
Number of cases 100 20
Male's number of cases 52 10
Women's number of cases 48 10
Age (year) 18-72 18-72
Clinical cure number of cases 72 5
Effective number of cases 27 11
Invalid number of cases 1 4
Total effective rate 99% 80%
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
The present invention selects Radix Aconiti, Rhizoma Gastrodiae, and Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii, Radix Polygalae, Pheretima and Scorpio etc. carries out compatibility, makes to produce synergism after these drug regimens, can more effectively treat nerve amyotrophy.Take 10 days, more than 53% feeling takes a turn for the better to some extent, and malaise symptoms improves; Take 20 days, more than 72% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 30 days, more than 97% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves, the recovery from illness of some patients were self-induction.In experimental group, take more than 30 days, effective percentage can reach 93%, and matched group is only 76%.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.

Claims (8)

1. a treatment nerve amyotrophic Chinese medicinal tablet, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from: 40 parts of Radix Aconitis, 40 parts, Rhizoma Gastrodiae, 40 parts of Cortex Cinnamomis, 40 parts of Radix Clematidis, 45 parts of the Radixs Astragali, 45 parts of Bulbus Liliies, 45 parts of Radix Polygalaes, 4 parts of Pheretimas, 4 parts of Scorpio.
2. the preparation method of Chinese medicinal tablet according to claim 1, is characterized in that, step is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in heat pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry while heaving to surperficial brown color is micro-, take out sieve shakeout, spreading for cooling;
(2) Scorpio is decaptitated truncate and soak 20-40 minute completely with vinegar, taking-up is dried, vinegar Scorpio processed;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 120-140 mesh sieve;
(4) by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio processed, by temperature, be that preferably the cold water of 30 ℃ soaks 2 hours, water consumption is described Pheretima (parched) and vinegar Scorpio weight processed 2-5 times;
(5) step (4) gained mixed liquor is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume obtains concentrated solution;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried to 1-2 hour, obtain oven dry thing, is dry at 70-90 ℃ in temperature;
(7) step (6) gains are measured according to 0.3-0.7g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form.
3. preparation method according to claim 2, is characterized in that: step (2) is soaked 25-35 minute (preferably soaking 30 minutes).
4. preparation method according to claim 2, is characterized in that: step (3) is crossed 125-135 mesh sieve (preferred mistake 130 mesh sieves).
5. preparation method according to claim 2, is characterized in that: step (4) water consumption is 3-4 times (preferably 3.5 times) of described fine powder weight.
6. preparation method according to claim 2, is characterized in that: step (6) is dried 1.3-1.8 hour (preferably 1.5 hours).
7. preparation method according to claim 2, is characterized in that: step (6) is dry at 75-85 ℃ (preferably dry at 80 ℃ of temperature) in temperature.
8. preparation method according to claim 2, is characterized in that: the dosage form of step (7) tablet is 0.4-0.6g/ sheet (preferred dosage form is 0.5 g/ sheet).
CN201410430026.XA 2013-09-13 2013-09-13 Preparation method of traditional Chinese medicine tablet for treating neurogenic muscular dystrophy Pending CN104147396A (en)

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Publication number Priority date Publication date Assignee Title
CN1463721A (en) * 2002-06-15 2003-12-31 郭合政 Medicine for treating muscle atrophy
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105381408A (en) * 2015-12-15 2016-03-09 刘学来 Compound preparation for treating trigeminal neuralgia and preparation method thereof

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