CN114767804B - Acupoint application for treating bronchial asthma and preparation method thereof - Google Patents

Acupoint application for treating bronchial asthma and preparation method thereof Download PDF

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CN114767804B
CN114767804B CN202210306330.8A CN202210306330A CN114767804B CN 114767804 B CN114767804 B CN 114767804B CN 202210306330 A CN202210306330 A CN 202210306330A CN 114767804 B CN114767804 B CN 114767804B
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layer
parts
bronchial asthma
ointment
acupoint application
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CN114767804A (en
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朱为康
陈旻
郭鹏
徐静
陆俊骏
滕文静
郑诗芸
司徒夏昊
薛亚
朱笛忻
徐悠畅
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SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Abstract

The invention discloses an acupoint application for treating bronchial asthma, which is characterized by comprising a stripping layer, a base cloth layer, an ointment layer and a back lining layer from inside to outside in sequence; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, and the ointment layer and the back lining layer are respectively and independently bonded by the adhesive layers; the ointment layer is prepared by Chinese herbal medicine extract powder, ginger juice, essential balm and skin penetrating agent according to the mass ratio of 5 (0.8-1.2) to 0.1-0.3) to 0.2; the Chinese herbal medicine extract powder comprises the following raw materials: the invention also discloses a preparation method of the acupoint application for treating bronchial asthma. The acupoint application for treating bronchial asthma disclosed by the invention has the advantages of good curative effect, no toxic or side effect, small irritation to skin, safety in use, high efficiency, simplicity and convenience, and suitability for industrial mass production.

Description

Acupoint application for treating bronchial asthma and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine patches, and particularly relates to an acupoint application for treating bronchial asthma and a preparation method thereof.
Background
Bronchial asthma is the most common chronic lung disease worldwide and has the characteristics of high morbidity and easy repeated attack of the disease. The disease is a chronic inflammatory disease of the airways, which is involved by a plurality of cells and cell components, is mainly characterized by airway hyperresponsiveness and repeatedly shows symptoms of shortness of breath, chest distress, wheezing or cough and the like. The severity and duration of the attack vary greatly among individuals, mild patients only feel chest tightness for several minutes, severe patients have extreme dyspnea for several weeks or more, and the patients have inconvenience in normal life, work and study.
At present, the treatment of bronchial asthma mainly relies on oral drugs; however, no medicine or technology for preventing and radically treating bronchial asthma exists in modern medicine. The western medicine mainly controls and relieves the symptoms of bronchial asthma by antibiotics, hormones and other medicines, treats the symptoms and the root causes, and has slow effect. The oral drug has more side effects, and the drug is absorbed by intestines and stomach with large loss, so the drug has the defect of low drug effect; and poor compliance with elderly and pediatric patients. Under the situation, the technology for treating bronchial asthma by acupoint application has come into play, and the appearance of the technology arouses high importance in the industry.
The acupoint application is an external treatment method in which the traditional Chinese medicine or traditional Chinese medicine extract is mixed with proper matrix and/or transdermal absorption enhancer, and then the mixture is applied to the surface of the skin or corresponding acupoints to achieve the treatment effect. The acupoint application has the best curative effect in three-volt days, the acupoint application medicines are obtained by cutting multiple groups of 'cold asthma prescription', and the specific medicines are absorbed at the specific acupoints, so that the pharmacological effects of the medicines can be exerted, and the lung qi is nourished, and phlegm is removed to relieve cough and asthma. The curative effect of the traditional Chinese medicine composition is determined by the medical field, the traditional Chinese medicine composition can effectively prevent and treat bronchial asthma, and the life quality of patients can be well improved. However, the existing acupuncture point application for treating bronchial asthma causes inconvenience to patients due to the fact that the application time is more or less too long; the irritation is large, and discomfort symptoms such as burning sensation or pain of the skin can be often caused, so that the compliance of a patient is low, and the medication requirement of the patient can not be well met; has the defects of non-ideal effect, complex medication, slow curative effect and certain toxic and side effect.
In order to solve the problems, the Chinese patent application 200610020039.5 discloses an acupoint application for preventing and treating bronchial asthma, which comprises the following raw materials of asarum, euphorbia kansui, corydalis tuber and white mustard seed in a weight ratio of 2. The acupoint application is prepared by concocting rhizoma Zingiberis recens juice with raw materials into paste, and placing the paste on patch. However, the acupoint application is inconvenient to use, has low production efficiency, is not suitable for large-scale production, and cannot well meet market requirements; the irritation is large, uncomfortable symptoms such as burning sensation or pain of the skin are often caused, the compliance of a patient is low, and the medication requirement of the patient cannot be well met.
Therefore, the acupoint application for treating bronchial asthma and the preparation method thereof, which have the advantages of good curative effect, no toxic or side effect, small skin irritation, safe use, high efficiency, simplicity and convenience, are suitable for industrial mass production, meet the market demand, and have wide market value and application prospect, are developed.
Disclosure of Invention
The invention mainly aims to provide the acupoint application for treating bronchial asthma and the preparation method thereof, wherein the acupoint application has the advantages of good curative effect, no toxic or side effect, small skin irritation, safe use, high efficiency, simplicity and convenience, and suitability for industrial mass production.
In order to achieve the purpose, the invention adopts the technical scheme that: an acupoint application for treating bronchial asthma is characterized by comprising a stripping layer, a base cloth layer, an ointment layer and a back lining layer from inside to outside in sequence; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, and the ointment layer and the back lining layer are respectively bonded by the adhesive layers independently; the ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and skin penetrating agent according to the mass ratio of 5 (0.8-1.2) to 0.1-0.3) to 0.2; the Chinese herbal medicine extract powder comprises the following raw materials: flos Chrysanthemi Indici, radix kansui, flos Helianthi, radix Angelicae Dahuricae, scutellariae radix, pericarpium Granati, semen plantaginis, flos Lonicerae, and pericarpium Citri Tangerinae.
Further, the skin penetrating agent is any one of laurocapram and borneol.
Further, the Chinese herbal medicine extract powder raw materials also comprise: radix Stemonae, bulbus Fritillariae Cirrhosae, radix Ophiopogonis, rhizoma anemarrhenae, bulbus Lilii, radix Glycyrrhizae, cortex Cinnamomi, and cortex Pruni.
Further, the Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 6-8 parts of wild chrysanthemum flower, 3-5 parts of euphorbia kansui, 7-10 parts of sunflower, 4-6 parts of angelica dahurica, 2-4 parts of scutellaria baicalensis, 1-3 parts of pomegranate rind, 2-5 parts of semen plantaginis, 4-6 parts of honeysuckle, 3-7 parts of dried orange peel, 1-3 parts of radix stemonae, 1-2 parts of bulbus fritillariae cirrhosae, 3-5 parts of radix ophiopogonis, 1-2 parts of rhizoma anemarrhenae, 2-4 parts of lily, 0.3-0.8 part of liquorice, 0.2-0.5 part of cinnamon and 1-2 parts of apricot rind.
Further, the preparation method of the Chinese herbal medicine extract powder comprises the following steps: drying, crushing and grinding wild chrysanthemum flower, euphorbia kansui, sunflower, angelica dahurica, scutellaria baicalensis, pomegranate rind, plantain seed, honeysuckle, dried orange peel, radix stemonae, bulbus fritilariae, radix ophiopogonis, rhizoma anemarrhenae, lily, liquorice, cinnamon and apricot rind into powder, then stirring and mixing uniformly to obtain a mixture, then placing the mixture into an extraction tank, adding a mixed extraction solvent, heating to 90-100 ℃, carrying out reflux extraction for 1-2 hours, then drying the concentrated solution under reduced pressure, grinding and sieving by a 100-300-mesh sieve to obtain Chinese herbal medicine extract powder.
Further, the mass ratio of the mixture to the mixed extraction solvent is 1 (6-8); the mixed extraction solvent is prepared by mixing ethanol and water according to the mass ratio of 1 (2-4).
Further, the adhesive layer is made of any one of polyacrylate pressure-sensitive adhesive, silicone pressure-sensitive adhesive and polyurethane pressure-sensitive adhesive; the polyacrylate pressure-sensitive adhesive is prepared from the following components in parts by weight: 3-6 parts of bis (1-vinyl imidazole-2-) ketone, 30-40 parts of methyl methacrylate, 10-20 parts of 2-acrylic acid-hexahydro-4, 7-methylene-1H-indenyl ester, 8-14 parts of vinyl tributyrinoxime silane, 4-8 parts of 2-methyl-2-acrylic acid-2, 6-tetramethyl-4-piperidyl ester, 1-2 parts of an initiator and 10-20 parts of a solvent; the initiator is at least one of azobisisobutyronitrile and azobisisoheptonitrile; the solvent is ethylene glycol ether.
Further, the stripping layer is any one of glassine silicone oil paper and common release paper; the base cloth layer is made of non-woven fabric; the backing layer is made of non-woven fabric.
Furthermore, a porous bamboo charcoal layer is arranged between the ointment layer and the back lining layer; the ointment layer, the porous bamboo charcoal layer and the back lining layer are mutually and independently bonded by the adhesive layer.
Another object of the present invention is to provide a method for preparing an acupoint application for treating bronchial asthma using the above method, comprising the steps of: mixing the Chinese herbal extract powder, rhizoma Zingiberis recens juice, essential balm, and skin penetrating agent uniformly to obtain ointment layer, coating adhesive on the surface of each layer, sequentially laminating the stripping layer, base cloth layer, ointment layer, and backing layer from inside to outside, standing, and making into acupoint application for treating bronchial asthma.
Compared with the prior art, the invention has the following beneficial effects:
1. the preparation method of the acupoint application for treating bronchial asthma, provided by the invention, only needs to laminate each layer, does not need complex procedures and special equipment, has high preparation efficiency, good preparation environment and low labor intensity, and is suitable for large-scale continuous production.
2. The invention provides an acupoint application for treating bronchial asthma, wherein a medicinal ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and a skin penetrating agent according to a mass ratio of 5 (0.8-1.2) to 0.1-0.3) to 0.2; the components are matched and interacted with each other, so that the prepared application can be well absorbed by a human body, the drug effect can be fully utilized, the skin irritation is small, the toxic and side effects are avoided, and the application is safer. Through the design of the adhesive formula, the adhesive has better adhesive property and performance stability.
3. The Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 6-8 parts of wild chrysanthemum flower, 3-5 parts of euphorbia kansui, 7-10 parts of sunflower, 4-6 parts of angelica dahurica, 2-4 parts of scutellaria baicalensis, 1-3 parts of pomegranate rind, 2-5 parts of semen plantaginis, 4-6 parts of honeysuckle, 3-7 parts of dried orange peel, 1-3 parts of radix stemonae, 1-2 parts of bulbus fritillariae cirrhosae, 3-5 parts of radix ophiopogonis, 1-2 parts of rhizoma anemarrhenae, 2-4 parts of lily, 0.3-0.8 part of liquorice, 0.2-0.5 part of cinnamon and 1-2 parts of apricot rind. Through reasonable selection of the variety and the proportion of the raw materials, the prepared product has the effects of relieving cough and reducing sputum, and freeing lung and relieving exterior syndrome, and the medicines are applied to acupuncture points to reach viscera from exterior to interior and along the channels so as to regulate qi and blood and yin, strengthen body resistance and eliminate pathogenic factors, embody the effect of treating internal diseases by external therapy, and achieve the purpose of treating both principal and secondary aspect of disease. The synergistic effect of the two can promote the synthesis of lung surfactant, protect lung function to improve pathological changes, and stimulate the proliferation of vascular endothelial cells to repair vascular intima.
4. According to the acupoint application for treating bronchial asthma, the porous bamboo charcoal layer is arranged between the ointment layer and the back lining layer, so that a skin moistening microenvironment can be created, the drug effect and drug absorption can be enhanced, and the skin injury caused by application can be avoided.
Detailed Description
The following will describe in more detail a point application for the treatment of bronchial asthma and a method for preparing the same according to the present invention, in which preferred embodiments of the present invention are shown, it being understood that those skilled in the art can modify the present invention described herein while still achieving the advantageous effects of the present invention, and therefore, the following description should be construed as being widely known to those skilled in the art and not as limiting the present invention.
An acupoint application for the treatment of bronchial asthma comprises a stripping layer, a base cloth layer, an ointment layer, a porous bamboo charcoal layer, and a back lining layer from inside to outside; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, the ointment layer and the porous bamboo charcoal layer, and the porous bamboo charcoal layer and the back lining layer are respectively and independently bonded by the adhesive layers; the ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and a skin penetrating agent according to the mass ratio of 5; the skin penetrating agent is laurocapram.
The Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 6 parts of wild chrysanthemum flower, 3 parts of euphorbia kansui, 7 parts of sunflower, 4 parts of angelica dahurica, 2 parts of scutellaria baicalensis, 1 part of pomegranate rind, 2 parts of semen plantaginis, 4 parts of honeysuckle, 3 parts of dried orange peel, 1 part of radix stemonae, 1 part of bulbus fritillariae cirrhosae, 3 parts of radix ophiopogonis, 1 part of rhizoma anemarrhenae, 2 parts of lily, 0.3 part of liquorice, 0.2 part of cinnamon and 1 part of apricot rind.
The preparation method of the Chinese herbal medicine extract powder comprises the following steps: drying, crushing and grinding wild chrysanthemum flower, euphorbia kansui, sunflower, angelica dahurica, scutellaria baicalensis, pomegranate rind, plantain seed, honeysuckle, dried orange peel, radix stemonae, bulbus fritilariae, radix ophiopogonis, rhizoma anemarrhenae, lily, liquorice, cinnamon and apricot rind into powder, then stirring and mixing uniformly to obtain a mixture, then placing the mixture into an extraction tank, adding a mixed extraction solvent, heating to 90 ℃, carrying out reflux extraction for 1 hour, then drying the concentrated solution under reduced pressure, grinding and sieving by a 100-mesh sieve to obtain Chinese herbal medicine extract powder; the mass ratio of the mixture to the mixed extraction solvent is 1; the mixed extraction solvent is prepared by mixing ethanol and water according to a mass ratio of 1.
The adhesive layer is made of polyacrylate pressure-sensitive adhesive; the stripping layer is glassine; the base cloth layer is made of non-woven fabric; the backing layer is made of non-woven fabric.
The polyacrylate pressure-sensitive adhesive is prepared from the following components in parts by weight: 5 parts of bis (1-vinyl imidazole-2-) ketone, 35 parts of methyl methacrylate, 15 parts of 2-acrylic acid-hexahydro-4, 7-methylene-1H-indenyl ester, 11 parts of vinyl tributoxy silane, 6 parts of 2-methyl-2-acrylic acid-2, 6-tetramethyl-4-piperidyl ester, 1.5 parts of an initiator and 15 parts of a solvent; the initiator is azobisisobutyronitrile; the solvent is ethylene glycol ether.
A preparation method of an acupoint application for treating bronchial asthma comprises the following steps: mixing the Chinese herbal extract powder, rhizoma Zingiberis recens juice, essential balm, and skin penetrating agent uniformly to obtain ointment layer, coating adhesive on the surface of each layer, sequentially laminating the stripping layer, base cloth layer, ointment layer, and backing layer from inside to outside, standing, and making into acupoint application for treating bronchial asthma.
Example 2
An acupoint application for the treatment of bronchial asthma comprises a stripping layer, a base cloth layer, an ointment layer, a porous bamboo charcoal layer, and a back lining layer from inside to outside; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, the ointment layer and the porous bamboo charcoal layer, and the porous bamboo charcoal layer and the back lining layer are respectively and independently bonded by the adhesive layers; the ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and a skin penetrating agent according to the mass ratio of 5; the skin penetrating agent is Borneolum Syntheticum.
The Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 6.5 parts of wild chrysanthemum flower, 3.5 parts of euphorbia kansui, 8 parts of sunflower, 4.5 parts of angelica dahurica, 2.5 parts of scutellaria baicalensis, 1.5 parts of pomegranate rind, 3 parts of semen plantaginis, 4.5 parts of honeysuckle, 4 parts of dried orange peel, 1.5 parts of radix stemonae, 1.2 parts of bulbus fritilariae, 3.5 parts of radix ophiopogonis, 1.2 parts of rhizoma anemarrhenae, 2.5 parts of lily, 0.4 part of liquorice, 0.3 part of cinnamon and 1.2 parts of apricot rind.
The preparation method of the Chinese herbal medicine extract powder comprises the following steps: drying, crushing and grinding wild chrysanthemum flower, euphorbia kansui, sunflower, angelica dahurica, scutellaria baicalensis, pomegranate rind, plantain seed, honeysuckle, dried orange peel, radix stemonae, bulbus fritilariae, radix ophiopogonis, rhizoma anemarrhenae, lily, liquorice, cinnamon and apricot rind into powder, then stirring and mixing uniformly to obtain a mixture, then placing the mixture into an extraction tank, adding a mixed extraction solvent, heating to 93 ℃, carrying out reflux extraction for 1.2 hours, then carrying out reduced pressure drying on a concentrated solution, grinding and sieving by a 150-mesh sieve to obtain Chinese herbal medicine extract powder; the mass ratio of the mixture to the mixed extraction solvent is 1; the mixed extraction solvent is prepared by mixing ethanol and water according to the mass ratio of 1.
The adhesive layer is made of silicone pressure-sensitive adhesive; the stripping layer is common release paper; the base cloth layer is made of non-woven fabric; the backing layer is made of non-woven fabric.
A preparation method of an acupoint application for treating bronchial asthma comprises the following steps: mixing the Chinese herbal extract powder, rhizoma Zingiberis recens juice, essential balm, and skin penetrating agent uniformly to obtain ointment layer, coating adhesive on the surface of each layer, sequentially laminating the stripping layer, base cloth layer, ointment layer, and backing layer from inside to outside, standing, and making into acupoint application for treating bronchial asthma.
Example 3
An acupoint application for the treatment of bronchial asthma comprises a stripping layer, a base cloth layer, an ointment layer, a porous bamboo charcoal layer, and a back lining layer from inside to outside; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, the ointment layer and the porous bamboo charcoal layer, and the porous bamboo charcoal layer and the back lining layer are respectively and independently bonded by the adhesive layers; the ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and a skin penetrating agent according to the mass ratio of 5; the skin penetrating agent is laurocapram.
The Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 7 parts of wild chrysanthemum, 4 parts of euphorbia kansui, 8.5 parts of sunflower, 5 parts of angelica dahurica, 3 parts of scutellaria baicalensis, 2 parts of pomegranate rind, 3.5 parts of semen plantaginis, 5 parts of honeysuckle, 5 parts of dried orange peel, 2 parts of radix stemonae, 1.5 parts of bulbus fritilariae, 4 parts of radix ophiopogonis, 1.5 parts of rhizoma anemarrhenae, 3 parts of lily, 0.5 part of liquorice, 0.35 part of cinnamon and 1.5 parts of apricot rind.
The preparation method of the Chinese herbal medicine extract powder comprises the following steps: drying, crushing and grinding wild chrysanthemum flower, euphorbia kansui, sunflower, angelica dahurica, scutellaria baicalensis, pomegranate rind, plantain seed, honeysuckle, dried orange peel, radix stemonae, bulbus fritilariae, radix ophiopogonis, rhizoma anemarrhenae, lily, liquorice, cinnamon and apricot rind into powder, then stirring and mixing uniformly to obtain a mixture, then placing the mixture into an extraction tank, adding a mixed extraction solvent, heating to 95 ℃, carrying out reflux extraction for 1.5 hours, then carrying out reduced pressure drying on a concentrated solution, grinding and sieving by a 200-mesh sieve to obtain Chinese herbal medicine extract powder; the mass ratio of the mixture to the mixed extraction solvent is 1; the mixed extraction solvent is prepared by mixing ethanol and water according to a mass ratio of 1.
The adhesive layer is made of polyurethane pressure-sensitive adhesive; the stripping layer is glassine; the base cloth layer is made of non-woven fabric; the backing layer is made of non-woven fabric.
A preparation method of an acupoint application for treating bronchial asthma comprises the following steps: mixing the Chinese herbal extract powder, rhizoma Zingiberis recens juice, essential balm, and skin penetrating agent uniformly to obtain ointment layer, coating adhesive on the surface of each layer, sequentially laminating the stripping layer, base cloth layer, ointment layer, and backing layer from inside to outside, standing, and making into acupoint application for treating bronchial asthma.
Example 4
An acupoint application for the treatment of bronchial asthma comprises a stripping layer, a base cloth layer, an ointment layer, a porous bamboo charcoal layer, and a back lining layer from inside to outside; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, the ointment layer and the porous bamboo charcoal layer, and the porous bamboo charcoal layer and the back lining layer are respectively and independently bonded by the adhesive layers; the ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and a skin penetrating agent according to the mass ratio of 5; the skin penetrating agent is Borneolum Syntheticum.
The Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 7.5 parts of wild chrysanthemum, 4.5 parts of euphorbia kansui, 9.5 parts of sunflower, 5.5 parts of angelica dahurica, 3.5 parts of scutellaria baicalensis, 2.5 parts of pomegranate rind, 4 parts of semen plantaginis, 5.5 parts of honeysuckle, 6 parts of dried orange peel, 2.5 parts of radix stemonae, 1.8 parts of bulbus fritillariae cirrhosae, 4.5 parts of radix ophiopogonis, 1.8 parts of rhizoma anemarrhenae, 3.5 parts of lily, 0.7 part of liquorice, 0.45 part of cinnamon and 1.8 parts of apricot rind.
The preparation method of the Chinese herbal medicine extract powder comprises the following steps: drying, crushing and grinding wild chrysanthemum flower, euphorbia kansui, sunflower, angelica dahurica, scutellaria baicalensis, pomegranate rind, plantain seed, honeysuckle, dried orange peel, radix stemonae, bulbus fritilariae, radix ophiopogonis, rhizoma anemarrhenae, lily, liquorice, cinnamon and apricot rind into powder, then stirring and mixing uniformly to obtain a mixture, then placing the mixture into an extraction tank, adding a mixed extraction solvent, heating to 98 ℃, carrying out reflux extraction for 1.8 hours, then drying the concentrated solution under reduced pressure, grinding and sieving by a 250-mesh sieve to obtain Chinese herbal medicine extract powder; the mass ratio of the mixture to the mixed extraction solvent is 1; the mixed extraction solvent is prepared by mixing ethanol and water according to the mass ratio of 1.
The adhesive layer is made of polyacrylate pressure-sensitive adhesive; the stripping layer is glassine; the base cloth layer is made of non-woven fabric; the backing layer is made of non-woven fabric.
The polyacrylate pressure-sensitive adhesive is prepared from the following components in parts by weight: 6 parts of bis (1-vinyl imidazole-2-) ketone, 38 parts of methyl methacrylate, 18 parts of 2-acrylic acid-hexahydro-4, 7-methylene-1H-indenyl ester, 14 parts of vinyl tributyl ketoxime silane, 8 parts of 2, 6-tetramethyl-4-piperidyl 2-methyl-2-acrylate, 2 parts of an initiator and 18 parts of a solvent; the initiator is azobisisoheptonitrile; the solvent is ethylene glycol ether.
A preparation method of an acupoint application for treating bronchial asthma comprises the following steps: mixing the Chinese herbal extract powder, rhizoma Zingiberis recens juice, essential balm, and skin penetrating agent uniformly to obtain ointment layer, coating adhesive on the surface of each layer, sequentially laminating the stripping layer, base cloth layer, ointment layer, and backing layer from inside to outside, standing, and making into acupoint application for treating bronchial asthma.
Example 5
An acupoint application for the treatment of bronchial asthma comprises a stripping layer, a base cloth layer, an ointment layer, a porous bamboo charcoal layer, and a back lining layer from inside to outside; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, the ointment layer and the porous bamboo charcoal layer, and the porous bamboo charcoal layer and the back lining layer are respectively and independently bonded by the adhesive layers; the ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and a skin penetrating agent according to the mass ratio of 5.2; the skin penetrating agent is laurocapram.
The Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 8 parts of wild chrysanthemum flower, 5 parts of euphorbia kansui, 10 parts of sunflower, 6 parts of angelica dahurica, 4 parts of scutellaria baicalensis, 3 parts of pomegranate rind, 5 parts of semen plantaginis, 6 parts of honeysuckle, 7 parts of dried orange peel, 3 parts of radix stemonae, 2 parts of bulbus fritillariae cirrhosae, 5 parts of radix ophiopogonis, 2 parts of rhizoma anemarrhenae, 4 parts of lily, 0.8 part of liquorice, 0.5 part of cinnamon and 2 parts of apricot rind.
The preparation method of the Chinese herbal medicine extract powder comprises the following steps: drying, crushing and grinding wild chrysanthemum flower, euphorbia kansui, sunflower, angelica dahurica, scutellaria baicalensis, pomegranate rind, plantain seed, honeysuckle, dried orange peel, radix stemonae, bulbus fritillariae cirrhosae, radix ophiopogonis, rhizoma anemarrhenae, lily, liquorice, cinnamon and apricot rind into powder, then stirring and mixing uniformly to obtain a mixture, then placing the mixture into an extraction tank, adding a mixed extraction solvent, heating to 100 ℃, carrying out reflux extraction for 2 hours, then drying a concentrated solution under reduced pressure, grinding and sieving by a 300-mesh sieve to obtain Chinese herbal medicine extract powder; the mass ratio of the mixture to the mixed extraction solvent is 1; the mixed extraction solvent is prepared by mixing ethanol and water according to a mass ratio of 1.
The adhesive layer is made of silicone pressure-sensitive adhesive; the stripping layer is glassine; the base cloth layer is made of non-woven fabric; the backing layer is made of non-woven fabric.
A preparation method of acupoint application for treating bronchial asthma is characterized by comprising the following steps: mixing the Chinese herbal extract powder, rhizoma Zingiberis recens juice, essential balm, and skin penetrating agent uniformly to obtain ointment layer, coating adhesive on the surface of each layer, sequentially laminating the stripping layer, base cloth layer, ointment layer, and backing layer from inside to outside, standing, and making into acupoint application for treating bronchial asthma.
Comparative example 1
This example provides an acupoint application for treating bronchial asthma, which is substantially the same in structure, formulation and preparation method as example 1, except that essential balm and radix angelicae dahuricae are not added.
Comparative example 2
This example provides an acupoint application for treating bronchial asthma, which is substantially the same in structure, formulation and preparation method as example 1, except that scutellaria baicalensis and cinnamon are not added.
Test 1: safety tests (multiple complete skin irritation test)
Shearing the rabbit back 24h before application, and selecting intact skin for local toxicity and irritation test. The acupuncture points obtained in each example are pasted on the sheared part, and whether the medicine-coated part has erythema, edema and the like is observed and recorded. The observation period of the experiment is 15 days. The experimental results show that the skin erythema and edema do not appear in each group, and the safety of the groups is better.
Test 2: clinical test of therapeutic effect
140 patients diagnosed with bronchial asthma were selected, randomized into 7 groups of 20 patients each, and the 7 patients had no significant difference in age and disease course (P > 0.05). The applications of examples 1 to 5 and comparative examples 1 to 2 were used correspondingly. The acupuncture points of the above groups are selected for application, and Feishu, zhongfu, gaohuang and Shenshu are alternately used, and applied in summer for treating winter diseases and in three-volt days; the application is started on the first day of lodging in summer every year, the application is changed for 1 time every 9 days, the application is increased once in leap months, the patient takes the sitting position, the chest and the back are fully exposed, the application with the same area size is applied to the selected acupuncture points, and the patient can take the application off by himself after 4-6 hours generally; the best one is flushing skin at the application site. Applied 3 times per year for 1 course of treatment.
Criteria for evaluating therapeutic effects
Remarkably: the severe asthma symptoms of sufferers such as chest distress, chest pain, dyspnea, etc. are completely relieved, and occasionally mild attacks are accompanied with mild symptoms, and the medicine is not needed.
The method has the following advantages: the symptoms of the patients are obviously relieved during asthma attack, and the attack frequency is also reduced.
And (4) invalidation: the asthma symptoms of the patients are not relieved after the medicine is taken.
TABLE 1
Figure BDA0003565349260000111
Figure BDA0003565349260000121
The data results show that the acupoint application for treating bronchial asthma disclosed by the embodiment of the invention has obvious curative effect, and the addition of the scutellaria baicalensis, the cinnamon, the essential balm and the radix angelicae is beneficial to improving the curative effect.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (8)

1. An acupoint application for treating bronchial asthma is characterized by comprising a stripping layer, a base cloth layer, an ointment layer and a back lining layer from inside to outside in sequence; the stripping layer and the base cloth layer, the base cloth layer and the ointment layer, and the ointment layer and the back lining layer are respectively bonded by the adhesive layers independently; the ointment layer is prepared from Chinese herbal medicine extract powder, ginger juice, essential balm and skin penetrating agent according to the mass ratio of 5 (0.8-1.2) to 0.1-0.3) to 0.2; the Chinese herbal medicine extract powder comprises the following raw materials: flos Chrysanthemi Indici, radix kansui, flos Helianthi, radix Angelicae Dahuricae, scutellariae radix, pericarpium Granati, semen plantaginis, flos Lonicerae, pericarpium Citri Tangerinae, radix Stemonae, bulbus Fritillariae Cirrhosae, radix Ophiopogonis, rhizoma anemarrhenae, bulbus Lilii, glycyrrhrizae radix, cortex Cinnamomi, and cortex Pruni; the Chinese herbal medicine extract powder is prepared from the following raw materials in parts by weight: 6-8 parts of wild chrysanthemum flower, 3-5 parts of euphorbia kansui, 7-10 parts of sunflower, 4-6 parts of angelica dahurica, 2-4 parts of scutellaria baicalensis, 1-3 parts of pomegranate rind, 2-5 parts of semen plantaginis, 4-6 parts of honeysuckle, 3-7 parts of dried orange peel, 1-3 parts of radix stemonae, 1-2 parts of bulbus fritilariae, 3-5 parts of radix ophiopogonis, 1-2 parts of rhizoma anemarrhenae, 2-4 parts of lily, 0.3-0.8 part of liquorice, 0.2-0.5 part of cinnamon and 1-2 parts of apricot rind.
2. The patch according to claim 1, wherein the skin penetrating agent is one of laurocapram and borneol.
3. The acupoint application for treating bronchial asthma as set forth in claim 1, wherein the preparation method of the Chinese herbal medicine extract powder comprises the steps of: drying, crushing and grinding wild chrysanthemum flower, euphorbia kansui, sunflower, angelica dahurica, scutellaria baicalensis, pomegranate rind, plantain seed, honeysuckle, dried orange peel, radix stemonae, bulbus fritilariae, radix ophiopogonis, rhizoma anemarrhenae, lily, liquorice, cinnamon and apricot rind into powder, then stirring and mixing uniformly to obtain a mixture, then placing the mixture into an extraction tank, adding a mixed extraction solvent, heating to 90-100 ℃, carrying out reflux extraction for 1-2 hours, then drying the concentrated solution under reduced pressure, grinding and sieving by a 100-300-mesh sieve to obtain Chinese herbal medicine extract powder; the mixed extraction solvent is prepared by mixing ethanol and water according to the mass ratio of 1 (2-4).
4. The acupoint application for treating bronchial asthma as claimed in claim 3, wherein the mass ratio of the mixed material to the mixed extraction solvent is 1 (6-8).
5. The acupoint application for treating bronchial asthma as set forth in claim 1, wherein the adhesive layer is made of any one of polyacrylate pressure-sensitive adhesive, silicone pressure-sensitive adhesive, and polyurethane pressure-sensitive adhesive; the polyacrylate pressure-sensitive adhesive is prepared from the following components in parts by weight: 3-6 parts of bis (1-vinyl imidazole-2-) ketone, 30-40 parts of methyl methacrylate, 10-20 parts of 2-acrylic acid-hexahydro-4, 7-methylene-1H-indenyl ester, 8-14 parts of vinyl tributyrinoxime silane, 4-8 parts of 2-methyl-2-acrylic acid-2, 6-tetramethyl-4-piperidyl ester, 1-2 parts of an initiator and 10-20 parts of a solvent; the initiator is at least one of azobisisobutyronitrile and azobisisoheptonitrile; the solvent is ethylene glycol ether.
6. The acupoint application for treating bronchial asthma according to claim 1, wherein the release layer is any one of glassine and common release paper; the base cloth layer is made of non-woven fabric; the backing layer is made of non-woven fabric.
7. The patch according to claim 1, wherein a porous bamboo charcoal layer is disposed between the ointment layer and the backing layer; the ointment layer, the porous bamboo charcoal layer and the back lining layer are mutually and independently bonded by the adhesive layer.
8. A method for preparing an acupoint application for treating bronchial asthma using the acupoint application according to any one of claims 1 to 7, comprising the steps of: mixing the Chinese herbal extract powder, rhizoma Zingiberis recens juice, essential balm, and skin penetrating agent uniformly to obtain ointment layer, coating adhesive on the surface of each layer, sequentially laminating the stripping layer, base cloth layer, ointment layer, and backing layer from inside to outside, standing, and making into acupoint application for treating bronchial asthma.
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