CN1579450A - She medicinal composition for treating bone fracture and relieving pain, and its cataplasm and preparation process thereof - Google Patents
She medicinal composition for treating bone fracture and relieving pain, and its cataplasm and preparation process thereof Download PDFInfo
- Publication number
- CN1579450A CN1579450A CN 03149638 CN03149638A CN1579450A CN 1579450 A CN1579450 A CN 1579450A CN 03149638 CN03149638 CN 03149638 CN 03149638 A CN03149638 A CN 03149638A CN 1579450 A CN1579450 A CN 1579450A
- Authority
- CN
- China
- Prior art keywords
- zhejiang
- jiangxi
- nationality
- guangdong
- distributed over
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a pain easing animal medicine compound for curing fracture and its babism agent and its manufacturing method. The compound include mountain crab, mountain pit crab, dog button, eupolyphage sinensis, carpet bugle, copper sheel gagger, jinshouchuan, rhubarb, mastic, myrrh, fragrant dahurian angelica root, keel, camphor, borneol, they can be produced into several kinds of preparations, especially the babism agent, the producing method for the babsim agent include: the producing of babsim base plaster and medicine extract process; the base plaster and the medicine extract are blended together and coated onto the supporting layer, the babism agent can be acquired through cutting. The babsim agent contains skin permeable advancer and cross linker, it upgrades the slow release performance, skin permeable performance and adhesive force of the medicine; and it has no stimulation to skin, the dose is accurate, the blood medicine density is table, the moisture ability is good.
Description
Technical field
The present invention relates to a kind of treatment fracture and analgesic composition, its cataplasma and preparation technology thereof, relate in particular to a kind of treatment fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition, its cataplasma and preparation technology thereof.
Background technology
Background of the present invention derives from the unique She's municipality one Zhejiang Province's Jingning She Autonomous County of China, the Chinese herbal medicine that the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong people locality has some unique curative effects, especially treatment fracture and analgesic the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong medicine, prescription is simple, application method is single, the normal crude drug that adopts is mashed with the wine external application, grind powder with vinegar, flour external application wrapping, or be processed into plaster, the ointment external application is cured the wound and is controlled crazy pain, fracture is brought inconvenience to the patient, and is big as the zest to skin, easily cause skin and general allergy, shortcoming such as be inconvenient to move does not make full use of the efficient resource of She locality, and the single shortcoming of application method can not fully reach the due curative effect of medicine.
Summary of the invention
The purpose of this invention is to provide a kind of treatment fracture and analgesic composition, its cataplasma and preparation technology thereof, relate in particular to a kind of treatment fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition, its cataplasma and preparation technology thereof, it is simple to have overcome treatment fracture and analgesic the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong medicine prescription, application method is single, can not make full use of the efficient resource of She locality and the shortcoming of the due curative effect of medicine.
The present invention is that the inventor takes up a job as a doctor year surplus in the of 30, sum up clinical experience, constantly excavate local folk secret, filter out the people of the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong carry out autonomy combating the disease for thousands of years, save oneself the accumulation under and effective prescription, organically combine with improved modern medicines preparation cataplasma preparation technique and to be prepared from, changed the application method of the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's medicine.
The objective of the invention is to be achieved through the following technical solutions:
A kind of treatment fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition are by the medicament that comprises that following parts by weight of component is made:
Mountain Semen Momordicae 5-25, mountain pit crab 5-25, Semen Strychni 1-20, Eupolyphaga Seu Steleophaga 1-10, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 2-10, copper sheet gagger 2-25, golden hands are worn 1-10, Radix Et Rhizoma Rhei 2-20, Olibanum (processed) 1-15, Myrrha (processed) 1-15, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 2-15, Os Draconis 1-15, Camphora 0.1-2, Borneolum Syntheticum 0.1-2, quick 0.1-3 is drawn in the benzene sea
Preferred weight part component is that mountain Semen Momordicae 12-17, mountain pit crab 12-17, Semen Strychni 3-7, Eupolyphaga Seu Steleophaga 3-7, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12, copper sheet gagger 8-12, golden hands are worn 3-7, Radix Et Rhizoma Rhei 8-12, Olibanum (processed) 3-7, Myrrha (processed) 3-7, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 6-10, Os Draconis 3-7, Camphora 0.8-1.0, Borneolum Syntheticum 0.8-1.0, quick 0.2-0.4 is drawn in the benzene sea
Most preferably parts by weight of component is that mountain Semen Momordicae 15, mountain pit crab 15, Semen Strychni 5, Eupolyphaga Seu Steleophaga 5, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10, copper sheet gagger 10, golden hands wear 5, Radix Et Rhizoma Rhei 10, Olibanum (processed) 5, Myrrha (processed) 5, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 8, Os Draconis 5, Camphora 0.8, Borneolum Syntheticum 0.8, benzene sea draw quick 0.4.
Described medicament can especially be solution, unguentum, patch for the above dosage form of any pharmaceutics, cataplasma, particularly cataplasma.
A kind of preparation method for the treatment of fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition may further comprise the steps: get above-mentioned raw materials, be mixed in proportion, adopt ethanol extraction, decoct with water, filtering and concentrating is mixed extracting solution and decoction liquor, and the preparation method is made required dosage form routinely again; Perhaps grind powder, cross 200 orders, the preparation method is made required dosage form routinely again.
The cataplasma of the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong of the present invention drug composition, comprise supporting layer, hypothallus and backing layer, described hypothallus comprises following weight portion ratio component: the described drug composition principal agent 5-15 of the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong, medicinal substrate adjuvant 75-95 especially are the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's drug composition principal agent 10, medicinal substrate adjuvant 100.
Described supporting layer is selected from cellulose acetate, spun rayon cloth, medical adhesive-bonded fabric;
Described backing layer is selected from polypropylene thin film, polyethylene thin film, cellophane, mylar;
Described principal agent is a said components.
Described medicinal substrate adjuvant comprises following parts by weight of component: sticker 1.5-27, wetting agent 9-75, excipient 1-10, filler 3-15, transdermal enhancer 2.5-17 and water 25-55; Be preferably following parts by weight of component: sticker 1.5-8 or 21-27, wetting agent 9-19 or 41-75, excipient, 1-9, filler, 3-6, transdermal enhancer 6-17 and water 31;
Described sticker is selected from gelatin, sodium polyacrylate, polyvinyl alcohol, sodium carboxymethyl cellulose and sodium salt thereof, corn starch, the basic cellulose of first (second), sodium alginate, polyvinylpyrrolidone, cellulose derivative, is preferably sodium polyacrylate, polyvinyl alcohol, sodium carboxymethyl cellulose; Described wetting agent is selected from glycerol, sorbitol, castor oil, propylene glycol, Polyethylene Glycol, is preferably glycerol, sorbitol, castor oil; Described excipient is a gelatin; Described filler is Kaolin, micropowder silica gel, calcium carbonate, titanium dioxide, zinc oxide, is preferably Kaolin; Described transdermal enhancer is glutaraldehyde solution, azone, pyrrolones, polyalcohols, saturated or unsaturated fatty acid and esters thereof, sulfoxide class, amide-type, nonionic surfactant, is preferably azone.
Described medicinal substrate adjuvant is preferably following parts by weight of component: gelatin 1-10, sodium polyacrylate 0.5-9, sodium carboxymethyl cellulose 0.5-9, polyvinyl alcohol 0.5-5, Kaolin 3-15, glycerol 3-35, sorbitol 5-30, castor oil 1-10,25% glutaraldehyde solution, 2-12, azone 0.5-5 and water are an amount of, and most preferably parts by weight of component is: gelatin 5.5, sodium polyacrylate 5, polyvinyl alcohol 3, sodium carboxymethyl cellulose, Kaolin 10, glycerol 22, sorbitol 13, Oleum Ricini 1.5,25% glutaraldehyde 6, azone 1, water 31.
Cataplasma preparation method of the present invention may further comprise the steps: the preparation and the extract drugs preparation of crust cloth based substrate mastic;
The preparation of described crust cloth based substrate mastic comprises: the excipient gelatin is added water soak into expansion for 18 parts, in 55-65 ℃ of water-bath, after especially 55 ℃ of water-baths are dissolved, add Kaolin, sodium carboxymethyl cellulose, sorbitol, mix, stir, make the standby A liquid of composite gelatin liquid; Get polyvinyl alcohol, sodium polyacrylate, castor oil, glycerol and add water and soak into for 13 parts and expand, heat 60 ℃ of abundant stirring and dissolving, stir the adding azone, make the standby B liquid of glue; With A liquid stir add B liquid simultaneously after, add 25% glutaraldehyde solution, continue fully to stir into thick mastic, make crust cloth based substrate mastic.
The extract drugs preparation method: comprise all the other the described crude drug except that Camphora, Borneolum Syntheticum, benzene Hai Lamin are pulverized, available 65-95% ethanol conventional method extraction method, making relative density as four stream extraction methods is 1.20-1.30, as the fluid extract of relative density 1.15; Medicinal residues with extracting behind the composition add the duple decocting of medicinal residues amount again and boil twice, and collecting decoction filters, and it is that the thick paste of 1.20-1.30 is standby that filtrate is concentrated into relative density; The fluid extract of above-mentioned ethanol extraction and decocting thick paste are merged, camphorate after cooling, Borneolum Syntheticum, that benzene Hai Lamin mix homogeneously is made extractum is standby.
Described drug extract is added the catablasm base material mastic, mix, coat equably on the non-woven fabrics, coating weight can be 450g/m
2, covering above-mentioned backing layer thin film, specification section on demand promptly gets the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's cataplasma finished product.
Described extract drugs preparation method: can also be for described medicine is distinguished the porphyrize powder, sieve with 200 orders, the fine powder that sieves adds catablasm base material and mixes, mixed proportion substrate: the crude drug powder is 100: 10, coat supporting layer, wait to do the back and cover the backing layer thin film, specification section on demand promptly gets the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's medicine cataplasma finished product.
Described copper sheet gagger derives from the ethnic groups medicine of the peaceful She of Zhejiang scape municipality, do not go into pharmacopeia, according to " Zhejiang Province's cloud and, the peaceful medicinal plants register of scape " (institute for drug control, Yunhe County, Zhejiang Province chief editor, in April, 1985) textual criticism, described copper sheet gagger: title: Radix Maackiae tenuifoliae (pulse family) latin name: Maackiatenuifolia (Hemsi.) Hand.-Mazz.Place and She's name: the copper sheet gagger, the crow nib, white written, medicinal part: root.Nature,taste and action: poisonous, promoting blood circulation and detumescence, dispelling wind and removing obstruction in the collateral.Cure mainly and usage: normal dispelling the wind and dampness pathogens arthralgia pain, sciatica, traumatic injury, 5-10g for oral administration is decocted in water for oral dose, and suitable amount used externally is mashed deposited affected part.
Described golden hands is worn the ethnic groups medicine that derives from the peaceful She of Zhejiang scape municipality, do not go into pharmacopeia, according to " Zhejiang Province's cloud and, the peaceful medicinal plants register of scape " (institute for drug control, Yunhe County, Zhejiang Province chief editor, in April, 1985) textual criticism, described golden hands is worn title: Eomecon chionantha Hance (Papaveraceae), and latin name: Eomecon chionanthaHance, local and She's name: golden hands is worn, spire falls back, Zantedeschia aethiopica Spreng..Medicinal part: rhizome or herb.Nature,taste and action: hot, bitter, flat.Slightly poisonous.Effect with heat-clearing and toxic substances removing, promoting blood circulation and hemostasis.Cure mainly and usage: be usually used in treating traumatic injury, impairment caused by overstrain lumbago, eczema, furuncle, venom, innominate toxic swelling.5g for oral administration is decocted in water for oral dose, the bright root of external or herb is mashed in right amount or extracting juice is cleaned the affected part.
Described mountain Semen Momordicae, pharmacopeia name Radix Illicii Lanceolati, acrid in the mouth is warm in nature poisonous, has the effect of promoting the circulation of blood, blood stasis dispelling, synthetism.
Described mountain pit crab, pharmacopeia name Eriocheir sinensis class, the present invention selects the Eriocheir sinensis in growth Yushan Hill hole for use, so be mountain pit crab, salty in the mouth is cold in nature, has the effect of diffusing blood, broken knot, continuous muscle, synthetism.
Described Semen Strychni, flavor is cold very toxic, has the effect of removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.
Described Eupolyphaga Seu Steleophaga, salty in the mouth is cold in nature slightly poisonous, has the effect of removing blood stasis, reunion of fractured tendons and bones.
Described Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), bitter in the mouth is cold in nature, has the effect of heat reliving and toxin-eliminating, promoting blood circulation and hemostasis.
Described Radix Et Rhizoma Rhei, bitter in the mouth is cold in nature, the effect of blood circulation promoting and blood stasis dispelling, eliminating fire and detoxication.
Described Olibanum (processed), acrid in the mouth is warm in nature, has the effect of promoting blood circulation and stopping pain, detumescence Shujin.
Described Myrrha (processed), bitter in the mouth is flat, has the effect of promoting blood circulation and stopping pain, detumescence and promoting granulation.
Described Radix Angelicae Dahuricae (Radix Heraclei Scabridi), acrid in the mouth is warm in nature, has the effect of wind-expelling pain-stopping, detumescence dehumidifying.
Described Os Draconis, sweet in the mouth is flat, has the effect of promoting tissue regeneration by astringents, tranquilizing mind.
Effect of the present invention: have and invigorate blood circulation, blood stasis dispelling, antiinflammatory, detumescence, dampness removing is dispeled the wind in analgesia, functions such as relaxing muscles and tendons and activating QI and blood in the collateral, all kinds of pain diseases, arthromyodynias such as back one-tenth is crazy, rheumatalgia, arthritis, hyperosteogeny, sciatica, lumbago, myalgia, neuralgia are hindered, hindered to quickly-healing, the many years ago that is used for the treatment of miscellaneous fracture always.
For proving described effect of the present invention, carried out following clinical trial:
Get 300 routine out-patients, men and women's ratio is 3: 2, and in age 24-67 year, according to its state of an illness invention medicine cataplasma that loses money in a business respectively, once a day, observing 7 days is a course of treatment, and curative effect is as follows:
Basic condition: 300 routine patients, wherein chi, fracture of radius 51 examples, fracture of tibia 29 examples, carpal joint pain 45 examples, lumbago 75 examples, hyperosteogeny of cervical vertebra 100 examples.
Criterion of therapeutical effect: A) transference cure, functional rehabilitation, the recidivist is not recovery from illness so far; B) after course of treatment, symptom has obviously to alleviate and is produce effects; C) after the treatment, transference cure, functional rehabilitation is effective but the recidivist is arranged; D) after the treatment, symptom is not improved, and movable function not recuperator is invalid.
Curative effect situation such as following table 1:
Table 1
| Disease | The example number | Effectively | ???％ | Produce effects | ??％ | Invalid | ???％ | Recovery from illness | ????％ | The course of treatment |
| Chi, fracture of radius | ???51 | ???51 | ???100 | ???51 | ???100 | ???/ | ???/ | ???51 | ???100 | ???5 |
| Fracture of tibia | ???29 | ???29 | ???100 | ???29 | ???100 | ???/ | ???/ | ???29 | ???100 | ???6 |
| Carpal joint pain | ???45 | ???45 | ???100 | ???45 | ???100 | ???/ | ???/ | ???34 | ???75 | ???3 |
| Lumbago | ???75 | ???75 | ???100 | ???75 | ???100 | ???/ | ???/ | ???56 | ???75 | ???3 |
| Hyperosteogeny of cervical vertebra | ???100 | ???100 | ???100 | ???100 | ???100 | ???/ | ???/ | ???70 | ???70 | ???8 |
| Add up to | ???300 | ???300 | ???100 | ???300 | ???100 | ???/ | ???/ | ???264 | ???80 | ???/ |
The present invention has the following advantages:
1, the present invention adopts the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's medicine and part Chinese herbal medicine commonly used and a spot of antihistamine Western medicine, is the exterior-applied formulation that carrier is made with the water-soluble high-molecular substance, has guaranteed the effective active of medical substance.
2, for reaching medicine better therapeutic of the present invention, adopt the cataplasma dosage form,, strengthened the slow-releasing of medicine greatly, transdermal characteristic and adhesion strength because this dosage form adds a certain amount of transdermal enhancer and cross-linking agent; The bioavailability height, dosage is accurate, and the unit drug loading is big, and blood drug level is stable, has moisture retention and percutaneous absorbability is good, and is non-stimulated and use easyly, takes off subsides freely, advantage such as can use repeatedly.
3, the product of this dosage form and each flavor medicine intermiscibility are good, theory according to the traditional Chinese medical science " inner disease outer treat ", effective prescription of many diseases is made this exterior-applied formulation, is present wide application, comparatively advanced a kind of external-use drug form, is the novel form of She's medicine external plaster.
The specific embodiment
Embodiment 1
Cataplasma
Matrix formulations (kilogram): gelatin 5.5, sodium polyacrylate 5, polyvinyl alcohol 3, sodium carboxymethyl cellulose 2, Kaolin 10, glycerol 22, sorbitol 13, Oleum Ricini 1.5,25% glutaraldehyde 6, azone 1, water 31.
Substrate preparation technology:
Gelatin is added water soak into expansion for 18 kilograms, after 55 ℃ of water-baths dissolvings, adding Kaolin, sodium carboxymethyl cellulose, sorbitol fully mix, stir and make composite gelatin liquid A liquid.After polyvinyl alcohol, sodium polyacrylate, Oleum Ricini, glycerol added 13 kilograms of infiltrations of water, the 60 ℃ of abundant stirring and dissolving of heating added azone while stirring after the dissolving, make colloidal solution B liquid.A liquid is added B liquid while stirring, add 25% glutaraldehyde solution again, fully stir into thick mastic, promptly get catablasm base material.
Pharmaceutical formulation (kilogram): mountain Semen Momordicae 15, mountain pit crab 15, Semen Strychni 5, Eupolyphaga Seu Steleophaga 5, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10, copper sheet gagger 10, golden hands wear 5, Radix Et Rhizoma Rhei 10, Olibanum (processed) 5, Myrrha (processed) 5, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 8, Os Draconis 5, Camphora 0.8, Borneolum Syntheticum 0.8, benzene sea draw quick 0.4;
Pharmaceutical preparation: the described crude drug of except that Camphora, Borneolum Syntheticum, benzene Hai Lamin all the other are pulverized, and flowing extraction methods with 95% ethanol four, to make relative density be 1.15 fluid extract; Medicinal residues with extracting behind the composition add the duple decocting of medicinal residues amount again and boil twice, and collecting decoction filters, and it is that 1.25 thick paste is standby that filtrate is concentrated into relative density; The fluid extract of above-mentioned ethanol extraction and decocting thick paste are merged, camphorate after cooling, Borneolum Syntheticum, that benzene Hai Lamin mix homogeneously is made extractum is standby.
Described drug extract is added described catablasm base material mastic, mix, mixed proportion substrate: the crude drug powder is 100: 10, coats equably on the non-woven fabrics, and coating weight is 450g/m
2, cover above-mentioned polyethylene film, cut into 5 * 8cm specification size, promptly get the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's cataplasma finished product.Adopt Franz diffusion cell method and high effective liquid chromatography for measuring, it is 47.8% that this product accumulation of Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) element in three-dimensional rat skin 48 hours sees through percentage rate.
Embodiment 2
Cataplasma
Matrix formulations (kilogram): gelatin 1, sodium polyacrylate 0.5, sodium carboxymethyl cellulose 0.5, polyvinyl alcohol 0.5, Kaolin 3, glycerol 3, sorbitol 5, castor oil 1,25% glutaraldehyde solution 2, azone 0.5, water 26
Pharmaceutical formulation (kilogram): mountain Semen Momordicae 5, mountain pit crab 5, Semen Strychni 1, Eupolyphaga Seu Steleophaga 1, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 2, copper sheet gagger 2, golden hands wear 1, Radix Et Rhizoma Rhei 2, Olibanum (processed) 1, Myrrha (processed) 1, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 2, Os Draconis 1, Camphora 0.1, Borneolum Syntheticum 0.1, benzene sea draw quick 0.1
Substrate preparation technology and pharmaceutical preparation are with embodiment 1, be not both described drug extract is added described catablasm base material mastic, mix, mixed proportion is a substrate: the crude drug powder is 75: 15, this product adopts Franz diffusion cell method and high effective liquid chromatography for measuring, and it is 46.35% that this product accumulation of Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) element in three-dimensional rat skin 48 hours sees through percentage rate.
Embodiment 3
Cataplasma
Matrix formulations (kilogram): gelatin 10, sodium polyacrylate 9, sodium carboxymethyl cellulose 9, polyvinyl alcohol 5, Kaolin 15, glycerol 35, sorbitol 30, castor oil 10,25% glutaraldehyde solution 12, azone 5, water 55
Pharmaceutical formulation (kilogram): mountain Semen Momordicae 25, mountain pit crab 25, Semen Strychni 20, Eupolyphaga Seu Steleophaga 10, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 20, copper sheet gagger 25, golden hands wear 10, Radix Et Rhizoma Rhei 20, Olibanum (processed) 15, Myrrha (processed) 15, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 15, Os Draconis 15, Camphora 2, Borneolum Syntheticum 2, benzene sea draw quick 3
Substrate preparation technology is with embodiment 1,
Pharmaceutical preparation: with described drug component difference porphyrize powder, sieve with 200 orders, the fine powder that sieves adds catablasm base material and mixes, mixed proportion substrate: the crude drug powder is 95: 5, coat nonwoven layer, wait to do the back and cover polypropylene film, cut into 10 * 12cm specification, promptly get the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's medicine cataplasma finished product.This product adopts Franz diffusion cell method and high effective liquid chromatography for measuring, and it is 47.82% that this product accumulation of Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) element in three-dimensional rat skin 48 hours sees through percentage rate.
Embodiment 4
Solution of the present invention
Press embodiment 1 weighting raw materials.
Preparation method: all the other the described crude drug except that Camphora, Borneolum Syntheticum, benzene Hai Lamin are pulverized, extracted extracting liquid filtering with 95% ethanol, four stream extraction methods; Medicinal residues with behind the extraction composition add the duple decocting of medicinal residues amount again and boil twice, and collecting decoction filters; Above-mentioned ethanol extract and decocting liquid are merged, camphorate, Borneolum Syntheticum, benzene Hai Lamin mix homogeneously, add water, filter, 100 ℃ of steam sterilizations are made the 1000ml solution.
Embodiment 5
Unguentum of the present invention
Press embodiment 3 weighting raw materials.
Preparation method: the described crude drug of except that Camphora, Borneolum Syntheticum, benzene Hai Lamin all the other are pulverized, and making relative density with 95% ethanol reflux extraction is 1.15 fluid extract; Medicinal residues with extracting behind the composition add the duple decocting of medicinal residues amount again and boil twice, and collecting decoction filters, and it is that 1.25 thick paste is standby that filtrate is concentrated into relative density; The fluid extract of above-mentioned ethanol extraction and decocting thick paste are merged, camphorate after cooling, Borneolum Syntheticum, benzene Hai Lamin mix homogeneously make extractum, ultraviolet is sterilized promptly.
Claims (10)
1, a kind of treatment fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition, be by the medicament that comprises that following parts by weight of component is made: mountain Semen Momordicae 5-25, mountain pit crab 5-25, Semen Strychni 1-20, Eupolyphaga Seu Steleophaga 1-10, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 2-10, copper sheet gagger 2-25, golden hands are worn 1-10, Radix Et Rhizoma Rhei 2-20, Olibanum (processed) 1-15, Myrrha (processed) 1-15, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 2-15, Os Draconis 1-15, Camphora 0.1-2, Borneolum Syntheticum 0.1-2, quick 0.1-3 is drawn in the benzene sea
2, treatment fracture according to claim 1 and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition, described compositions is following parts by weight of component: mountain Semen Momordicae 12-17, mountain pit crab 12-17, Semen Strychni 3-7, Eupolyphaga Seu Steleophaga 3-7, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12, copper sheet gagger 8-12, golden hands are worn 3-7, Radix Et Rhizoma Rhei 8-12, Olibanum (processed) 3-7, Myrrha (processed) 3-7, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 6-10, Os Draconis 3-7, Camphora 0.8-1.0, Borneolum Syntheticum 0.8-1.0, quick 0.2-0.4 is drawn in the benzene sea
3, treatment according to claim 1 fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition, described compositions is following parts by weight of component: mountain Semen Momordicae 15, mountain pit crab 15, Semen Strychni 5, Eupolyphaga Seu Steleophaga 5, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10, copper sheet gagger 10, golden hands wear 5, Radix Et Rhizoma Rhei 10, Olibanum (processed) 5, Myrrha (processed) 5, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 8, Os Draconis 5, Camphora 0.8, Borneolum Syntheticum 0.8, benzene sea draw quick 0.4.
4, treatment fracture according to claim 1 and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition, described medicament is cataplasma, solution, unguentum, patch.
5, a kind of preparation method for the treatment of fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition, may further comprise the steps: the weighting profit requires the raw material of one of 1-5, is mixed in proportion, and adopts the Chinese medicine conventional method to extract, filtering and concentrating, the preparation method is made institute's regular dosage form routinely again; Perhaps, the weighting profit requires the raw material of one of 1-5, is mixed in proportion, and mills and sieves, and the preparation method is made required dosage form routinely again.
6, a kind of treatment fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition cataplasma comprise supporting layer, hypothallus and backing layer, and described hypothallus comprises the drug composition principal agent 5-15 of the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong, the medicinal substrate adjuvant 75-95 of following weight portion ratio component: one of claim 1-3.
7, treatment fracture according to claim 6 and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition cataplasma, described hypothallus comprises following weight portion ratio component: the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's drug composition principal agent 10 of one of described claim 1-3, medicinal substrate adjuvant 100.
8, treatment fracture according to claim 6 and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition cataplasma, described supporting layer is selected from cellulose acetate, spun rayon cloth, medical adhesive-bonded fabric; Described backing layer is selected from polypropylene thin film, polyethylene thin film, cellophane, mylar; Described medicinal substrate adjuvant comprises following parts by weight of component: gelatin 1-10, sodium polyacrylate 0.5-9, sodium carboxymethyl cellulose 0.5-9, polyvinyl alcohol 0.5-5, Kaolin 3-15, glycerol 3-35, sorbitol 5-30, castor oil 1-10,25% glutaraldehyde solution, 2-12, azone 0.5-5 and water are an amount of.
9, treatment fracture according to claim 8 and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition cataplasma, the following parts by weight of component of described medicinal substrate adjuvant: gelatin 5.5, sodium polyacrylate 5, polyvinyl alcohol 3, sodium carboxymethyl cellulose, Kaolin 10, glycerol 22, sorbitol 13, Oleum Ricini 1.5,25% glutaraldehyde 6, azone 1, water 31.
10, a kind of preparation method for the treatment of fracture and analgesia the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong drug composition cataplasma, may further comprise the steps: the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's drug composition principal agent extracts preparation; The preparation of crust cloth based substrate mastic;
Described extract drugs preparation method comprises: the weighting profit requires the crude drug of one of 1-3, all the other described crude drug except that Camphora, Borneolum Syntheticum, benzene Hai Lamin are pulverized, conventional method extracts, and extracting solution camphorates, Borneolum Syntheticum, that benzene Hai Lamin mix homogeneously is made extractum is standby.
The preparation of described crust cloth based substrate mastic comprises: the weighting profit requires the substrate adjuvant of one of 8-9, makes crust cloth based substrate mastic according to a conventional method.
Described drug extract is added the catablasm base material mastic, mix, coat equably on the supporting layer, cover the described backing layer thin film of claim 8,, promptly get the She nationality, distributed over Fujian, Zhejiang, Jiangxi and Guangdong's medicine cataplasma finished product by the specification section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03149638 CN1579450A (en) | 2003-08-05 | 2003-08-05 | She medicinal composition for treating bone fracture and relieving pain, and its cataplasm and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03149638 CN1579450A (en) | 2003-08-05 | 2003-08-05 | She medicinal composition for treating bone fracture and relieving pain, and its cataplasm and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1579450A true CN1579450A (en) | 2005-02-16 |
Family
ID=34579611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03149638 Pending CN1579450A (en) | 2003-08-05 | 2003-08-05 | She medicinal composition for treating bone fracture and relieving pain, and its cataplasm and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1579450A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110668A (en) * | 2013-03-01 | 2013-05-22 | 俞忠明 | Transdermal sustained-release drug delivery system and preparation and application method thereof |
| CN103536750A (en) * | 2013-10-11 | 2014-01-29 | 陈英娣 | Traditional Chinese medicine for treating sciatica |
| CN103816110A (en) * | 2013-08-19 | 2014-05-28 | 郭宏昌 | Preparation method of drug transdermal absorbent promoting fracture healing |
-
2003
- 2003-08-05 CN CN 03149638 patent/CN1579450A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110668A (en) * | 2013-03-01 | 2013-05-22 | 俞忠明 | Transdermal sustained-release drug delivery system and preparation and application method thereof |
| CN103816110A (en) * | 2013-08-19 | 2014-05-28 | 郭宏昌 | Preparation method of drug transdermal absorbent promoting fracture healing |
| CN103536750A (en) * | 2013-10-11 | 2014-01-29 | 陈英娣 | Traditional Chinese medicine for treating sciatica |
| CN103536750B (en) * | 2013-10-11 | 2016-01-13 | 青岛市市立医院 | A kind of Chinese medicine for the treatment of sciatica |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101214286B (en) | Chinese medicine white spirit preparations for effectively treating rheumatic pain diseases | |
| CN103041173B (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| CN103169928B (en) | Externally applied traditional Chinese medicine composition for treating dysmenorrhea, as well as preparation method and application thereof | |
| CN1742939A (en) | Medicine for treating pulmonary fibrosis and preparing method | |
| CN102166278B (en) | Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof | |
| CN104274546B (en) | A kind of external medicine composition, traditional Chinese medicine for outer use and its preparation method and application | |
| CN104689226A (en) | Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof | |
| CN103751734B (en) | Blood circulation invigorating and pain relieving adhesive plaster and preparation method thereof | |
| CN102178810B (en) | Chinese medicinal paste film for treating skin ulcer and preparation method thereof | |
| CN113768975A (en) | Traditional Chinese medicine composition for treating arthralgia, traditional Chinese medicine patch, and preparation method and use method thereof | |
| CN101732389A (en) | Chinese medicinal composition for treating traumatic injury and promoting fracture healing and preparation method thereof | |
| CN100335094C (en) | Notoginseng pain relieving plaster and its preparation method | |
| CN1695682A (en) | External use preparation for treating rheumatisma and bone injuries | |
| CN1827150A (en) | External-use emulsion membrane for treating rheumatism and preparation method thereof | |
| CN1256120C (en) | Medicine for treating chronic pelvic inflammation and its preparing method | |
| CN1579450A (en) | She medicinal composition for treating bone fracture and relieving pain, and its cataplasm and preparation process thereof | |
| CN1857680A (en) | Chinese medicine ointment for treating bone disease and its preparing method | |
| CN1724055A (en) | Medicinal composition for treating traumatic surface | |
| CN110141622B (en) | Traditional Chinese medicine composition for treating pain and preparation method and application thereof | |
| CN111759905A (en) | Cataplasm for treating osteoarthritis and preparation method thereof | |
| CN110123976A (en) | It is a kind of to treat hemorrhoid dai medicine smearing cream and preparation method thereof | |
| CN110384785A (en) | A kind of external application Chinese medicine medical fluid and preparation method thereof for treating virus flu | |
| CN1903314A (en) | Traditional Chinese medicine composition for treating head-ache, ahypnia, palpitate and feeble, and its prepn. method | |
| CN100393352C (en) | Local external application medicine for treating appendicitis and preparing method | |
| CN114767804B (en) | Acupoint application for treating bronchial asthma and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |