CN116602940A - Traditional Chinese medicine emplastrum for improving primary dysmenorrhea and preparation method thereof - Google Patents
Traditional Chinese medicine emplastrum for improving primary dysmenorrhea and preparation method thereof Download PDFInfo
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- CN116602940A CN116602940A CN202310285952.1A CN202310285952A CN116602940A CN 116602940 A CN116602940 A CN 116602940A CN 202310285952 A CN202310285952 A CN 202310285952A CN 116602940 A CN116602940 A CN 116602940A
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- 239000003814 drug Substances 0.000 title claims abstract description 58
- 206010013935 Dysmenorrhoea Diseases 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 24
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940116229 borneol Drugs 0.000 claims abstract description 19
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 19
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 19
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Classifications
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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Abstract
The application relates to the technical field of medical products, in particular to a traditional Chinese medicine emplastrum for improving primary dysmenorrhea and a preparation method thereof. The traditional Chinese medicine emplastrum comprises the following raw materials in parts by weight: 30-40 parts of rhizoma corydalis, 10-15 parts of radix angelicae, 6-10 parts of Chinese angelica, 20-25 parts of antler slice, 15-20 parts of radix astragali preparata, 10-30 parts of caulis sinomenii, 8-10 parts of rhizoma curcumae, 2-5 parts of prepared radix aconiti lateralis preparata, 3-7 parts of folium artemisiae argyi and 4-6 parts of borneol. The ten ingredients of the whole prescription are compatible, the effects of regulating qi and blood, tonifying qi and strengthening spleen, dredging collaterals and relieving pain are achieved by mutual matching, the traditional Chinese medicine emplastrum is adopted, the irritation of oral medicine to gastrointestinal tract is avoided, the toxic and side effects of oral medicine to liver and kidney are avoided, the application range is enlarged, the primary dysmenorrhea can be effectively relieved, the abdominal pain time is shortened, and the menstrual condition and the accompanying symptoms are improved.
Description
Technical Field
The application relates to the technical field of medical products, in particular to a traditional Chinese medicine emplastrum for improving primary dysmenorrhea and a preparation method thereof.
Background
Dysmenorrhea is one of the most common gynecological symptoms, namely pain and distension of the lower abdomen before and after menstruation or during menstrual period, with soreness of waist or other discomfort, and the symptoms seriously affect the quality of life. The genital organs without obvious organic lesions are called primary dysmenorrhea, accounting for more than 90% of dysmenorrhea. Dysmenorrhea is common to teenager women, the incidence rate is high, the incidence rate of dysmenorrhea reported by different research groups is between 30% and 80%, and about three fourths of dysmenorrhea patients can influence normal work and life quality.
At present, pain-relieving sedatives, nonsteroidal anti-inflammatory drugs, oral contraceptives, calcium channel blockers and vitamins are commonly used for treating dysmenorrhea by Western medicine, but the problems of short curative effect, obvious toxic and side effects and the like exist. The traditional Chinese medicine preparation for treating primary dysmenorrhea has various methods, definite curative effect and few side effects, but is an oral preparation, and the traditional Chinese medicine preparation for treating dysmenorrhea mainly adopts addition and subtraction of a menstruation formula, such as four-ingredient soup, a female golden tablet and the like, is mainly administered in an oral mode, and has the characteristics of slower effect, poor taste, difficult wide acceptance and the like, and the oral preparation is easy to stimulate the gastrointestinal tract. Therefore, a traditional Chinese medicine emplastrum with strong drug release permeability for effectively relieving primary dysmenorrhea is urgently needed.
Disclosure of Invention
The first aim of the application is to provide a traditional Chinese medicine emplastrum for improving primary dysmenorrhea and a traditional Chinese medicine emplastrum for improving primary dysmenorrhea, which has strong drug release permeability, can effectively relieve primary dysmenorrhea, shorten abdominal pain time, improve menstruation conditions and accompanying symptoms, and avoid irritation of oral drugs to gastrointestinal tracts.
The second aim of the application is to provide a preparation method of the traditional Chinese medicine emplastrum for improving primary dysmenorrhea.
The application provides a traditional Chinese medicine emplastrum for improving primary dysmenorrhea, which comprises the following raw materials in parts by weight: 30-40 parts of rhizoma corydalis, 10-15 parts of radix angelicae, 6-10 parts of Chinese angelica, 20-25 parts of antler slice, 15-20 parts of radix astragali preparata, 10-30 parts of caulis sinomenii, 8-10 parts of rhizoma curcumae, 2-5 parts of prepared radix aconiti lateralis preparata, 3-7 parts of folium artemisiae argyi and 4-6 parts of borneol.
Preferably, 30-35 parts of rhizoma corydalis, 10-12 parts of radix angelicae, 7-9 parts of angelica sinensis, 20-23 parts of antler slice, 17-20 parts of radix astragali preparata, 15-20 parts of caulis sinomenii, 8-9 parts of rhizoma curcumae, 2-4 parts of prepared aconite, 5-7 parts of folium artemisiae argyi and 4-5 parts of borneol.
Preferably, 33 parts of rhizoma corydalis, 11 parts of radix angelicae, 9 parts of Chinese angelica, 21 parts of antler slice, 19 parts of radix astragali preparata, 16 parts of caulis sinomenii, 8 parts of rhizoma curcumae, 4 parts of prepared accessory slice, 5 parts of folium artemisiae argyi and 5 parts of borneol.
Preferably, the traditional Chinese medicine emplastrum consists of a backing layer, a paste and an anti-sticking layer.
The application also provides a preparation method of the traditional Chinese medicine emplastrum for improving primary dysmenorrhea, which comprises the following steps of:
step one: grinding Borneolum Syntheticum into fine powder, and sieving;
step two: weighing the raw materials of the traditional Chinese medicines, crushing the raw materials into particles, adding 75% ethanol for soaking, heating, refluxing and extracting, and filtering to obtain filtrate;
step three: concentrating the filtrate obtained in the second step into an extract, adding the borneol fine powder obtained in the first step into the extract, and uniformly stirring to obtain a paste for improving primary dysmenorrhea;
step four: and (3) coating the paste obtained in the step (III) on a backing layer, drying, and covering an anti-sticking layer to obtain the traditional Chinese medicine emplastrum for improving primary dysmenorrhea.
Preferably, in the first step, the borneol is sieved by a 200-mesh sieve.
Preferably, the specific steps of the second step are that all Chinese medicinal materials are weighed, crushed into particles, sieved by a 150-mesh sieve, soaked in 5-7 times of 75% ethanol for 2-3 hours, then heated and reflux extracted for 0.5-2 hours, and filtered to obtain filtrate.
Preferably, the relative density of the extract in the third step is 1.06-1.12.
Preferably, the relative density of the extract in the third step is 1.08.
Preferably, in the fourth step, the drying temperature is 30-40 ℃ and the drying time is 9-14h.
The beneficial effects are that:
the corydalis tuber, the angelica and the mugwort leaf in the formula adopted by the application enter liver and spleen channels, warm channels to stop bleeding, dispel cold to stop pain, sooth liver and regulate qi, activate blood to remove meridian obstruction and stop pain as monarch drugs; the deer horn slices have the effects of tonifying kidney yang, replenishing essence and blood, promoting blood circulation and relieving swelling, the roasted astragalus root enters the lung and spleen channels, tonifying qi and tonifying middle-jiao, the caulis sinomenii enters the lung and spleen channels, tonifying qi and tonifying middle-jiao, the prepared accessory slices enter the heart channel, the spleen channel and the kidney channel, return yang and rescue the reverse, tonify fire and invigorate yang, dispel cold and remove dampness, and the deer horn slices, roasted astragalus root, caulis sinomenii and the prepared accessory slices are ministerial drugs, assist monarch drugs in nourishing blood and tonifying qi, dispel cold and remove dampness; the guiding drug is rhizoma zedoariae and radix angelicae, and is used for dispelling wind and eliminating dampness, removing food retention and relieving pain; the borneol is led downwards to promote the absorption of the medicine. Ten ingredients of the whole prescription are compatible, and the effects of regulating qi and blood, tonifying qi and strengthening spleen, dredging collaterals and relieving pain are achieved by mutual matching.
The application adopts the form of Chinese medicine emplastrum, avoids the stimulation of oral medicine to gastrointestinal tract, avoids the toxic and side effects of oral medicine to liver and kidney, expands the application range, and can effectively relieve primary dysmenorrhea, shorten abdominal pain time and improve menstruation condition and accompanying symptoms.
Detailed Description
It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular forms also include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.
The technical solutions of the present application will be clearly and completely described in connection with the embodiments, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Example 1
A traditional Chinese medicine emplastrum for improving primary dysmenorrhea comprises the following raw materials in parts by weight: 33 parts of rhizoma corydalis, 11 parts of radix angelicae, 9 parts of Chinese angelica, 21 parts of antler slice, 19 parts of radix astragali preparata, 16 parts of caulis sinomenii, 8 parts of rhizoma curcumae, 4 parts of prepared accessory slice, 5 parts of folium artemisiae argyi and 5 parts of borneol. The Chinese medicinal patch comprises a backing layer, a paste and an anti-sticking layer.
The preparation method comprises the following steps:
step one: grinding Borneolum Syntheticum into fine powder, and sieving with 200 mesh sieve;
step two: weighing the raw materials of each traditional Chinese medicine, crushing into particles, sieving with a 150-mesh sieve, adding 7 times of 75% ethanol for soaking for 3 hours, heating, refluxing and extracting for 1.5 hours, and filtering to obtain filtrate;
step three: concentrating the filtrate obtained in the second step into extract with the relative density of 1.08, adding the borneol fine powder obtained in the first step into the extract, and uniformly stirring to obtain the ointment for improving primary dysmenorrhea;
step four: and (3) coating the paste obtained in the step (III) on a backing layer, drying at 30 ℃ for 14 hours, and covering an anti-sticking layer to obtain the traditional Chinese medicine emplastrum for improving primary dysmenorrhea.
Example 2
A traditional Chinese medicine emplastrum for improving primary dysmenorrhea comprises the following raw materials in parts by weight: 30 parts of rhizoma corydalis, 10 parts of radix angelicae, 10 parts of Chinese angelica, 25 parts of antler slice, 20 parts of radix astragali preparata, 20 parts of caulis sinomenii, 9 parts of rhizoma curcumae, 5 parts of prepared accessory slice, 7 parts of folium artemisiae argyi and 6 parts of borneol. The Chinese medicinal patch comprises a backing layer, a paste and an anti-sticking layer.
The preparation method comprises the following steps:
step one: grinding Borneolum Syntheticum into fine powder, and sieving with 200 mesh sieve;
step two: weighing the raw materials of each traditional Chinese medicine, crushing into particles, sieving with a 150-mesh sieve, adding 6 times of 75% ethanol for soaking for 2.5 hours, heating, refluxing and extracting for 1 hour, and filtering to obtain filtrate;
step three: concentrating the filtrate obtained in the second step into extract with the relative density of 1.12, adding the borneol fine powder obtained in the first step into the extract, and uniformly stirring to obtain the ointment for improving primary dysmenorrhea;
step four: and (3) coating the paste obtained in the step (III) on a backing layer, drying at 35 ℃ for 12 hours, and covering an anti-sticking layer to obtain the traditional Chinese medicine emplastrum for improving primary dysmenorrhea.
Example 3
A traditional Chinese medicine emplastrum for improving primary dysmenorrhea comprises the following raw materials in parts by weight: 40 parts of rhizoma corydalis, 15 parts of radix angelicae, 6 parts of Chinese angelica, 20 parts of antler slice, 15 parts of radix astragali preparata, 10 parts of caulis sinomenii, 10 parts of rhizoma curcumae, 2 parts of prepared accessory slice, 3 parts of folium artemisiae argyi and 4 parts of borneol. The Chinese medicinal patch comprises a backing layer, a paste and an anti-sticking layer.
The preparation method comprises the following steps:
step one: grinding Borneolum Syntheticum into fine powder, and sieving with 200 mesh sieve;
step two: weighing the raw materials of each traditional Chinese medicine, crushing into particles, sieving with a 150-mesh sieve, adding 5 times of 75% ethanol for soaking for 2 hours, heating, refluxing and extracting for 2 hours, and filtering to obtain filtrate;
step three: concentrating the filtrate obtained in the second step into extract with the relative density of 1.06, adding the borneol fine powder obtained in the first step into the extract, and uniformly stirring to obtain the ointment for improving primary dysmenorrhea;
step four: and (3) coating the paste obtained in the step (III) on a backing layer, drying at 40 ℃ for 9 hours, and covering an anti-sticking layer to obtain the traditional Chinese medicine emplastrum for improving primary dysmenorrhea.
Comparative example 1
A traditional Chinese medicine emplastrum for improving primary dysmenorrhea comprises the following raw materials in parts by weight: 40 parts of rhizoma corydalis, 15 parts of herba lycopi, 6 parts of Chinese angelica, 15 parts of radix astragali preparata, 10 parts of caulis sinomenii, 10 parts of rhizoma curcumae, 2 parts of prepared aconite, 3 parts of folium artemisiae argyi and 4 parts of borneol. The Chinese medicinal patch comprises a backing layer, a paste and an anti-sticking layer.
The preparation method is the same as in example 1.
Comparative example 2
A traditional Chinese medicine emplastrum for improving primary dysmenorrhea comprises the following raw materials in parts by weight: 40 parts of rhizoma corydalis, 15 parts of radix angelicae, 6 parts of Chinese angelica, 20 parts of antler slice, 15 parts of honey-fried licorice root, 10 parts of caulis sinomenii, 10 parts of rhizoma curcumae, 2 parts of prepared accessory slice, 3 parts of folium artemisiae argyi and 4 parts of borneol. The Chinese medicinal patch comprises a backing layer, a paste and an anti-sticking layer.
The preparation method is the same as in example 1.
Chinese medicine emplastrum curative effect test
1. Inclusion of case criteria: 600 patients diagnosed with primary dysmenorrhea in a hospital had the following diagnostic symptoms: obvious symptoms such as abdominal pain, abdominal dropsy and the like appear in the period of 1-2 days before menstruation or menstrual period, and secondary dysmenorrhea and early endometriosis are eliminated. Every 100 patients were grouped into six groups.
2. The treatment method comprises the following steps: the Chinese medicinal patch is applied 1 day before menstrual period and on 1 inch half part below umbilicus (three inches below the navel Shen acupoint, the lower abdomen Guanyuan acupoint), and is replaced once daily until menstrual period is completed, and the menstrual period is a course of treatment, and the curative effect is observed after three courses of treatment.
Test group: the traditional Chinese medicine emplastrum prepared in example 1 was used.
Test two groups: the traditional Chinese medicine emplastrum prepared in example 2 was used.
Three groups were tested: the traditional Chinese medicine emplastrum prepared in example 3 was used.
Comparison of one group: the traditional Chinese medicine emplastrum prepared in comparative example 1 was used.
Comparison of two groups: the traditional Chinese medicine emplastrum prepared in comparative example 2 was used.
Blank group: adopts a blank matrix Chinese medicine emplastrum without active ingredients.
3. Therapeutic effect judgment criterion
It is mainly observed in symptoms such as menstrual abdominal pain.
And (3) healing: after 3 treatment courses, the menstrual abdominal pain disappears, and the dysmenorrhea does not appear in the follow-up half year.
The effect is shown: after 3 treatment courses, the menstrual abdominal pain is obviously relieved, or the pain relieving tablet is not needed to be taken for relieving pain during the menstrual period.
The method is effective: for 3 treatment courses, the menstrual abdominal pain is relieved, or the analgesic tablet is taken for a small amount of pain relief during the menstrual period.
Invalidation: after 3 treatment courses, the menstrual abdominal pain is not obviously improved.
4. Test results
The status of the treatment after 3 treatment courses for six groups of patients is shown in table 1.
TABLE 1
| Group of | Healing of the wound | Has obvious effect | Effective and effective | Invalidation of | The total effective rate is% |
| Test group | 32 | 43 | 15 | 10 | 90 |
| Test group II | 27 | 38 | 18 | 17 | 83 |
| Test three groups | 30 | 36 | 21 | 13 | 87 |
| Contrast group | 19 | 29 | 16 | 36 | 64 |
| Comparison of two groups | 23 | 33 | 19 | 25 | 75 |
| Blank group | 0 | 0 | 6 | 94 | 6 |
From Table 1, it can be seen that the Chinese medicinal patches prepared in examples 1-3 have far better curative effects than those of comparative examples 1-2 and blank groups, and are effective in regulating qi and blood, invigorating qi and spleen, dredging collaterals and relieving pain, and improving primary dysmenorrhea; the total effective rate of the traditional Chinese medicine emplastrum prepared according to the formula adopted in comparative examples 1-2 is reduced. The traditional Chinese medicine emplastrum prepared in the embodiment 1 has the best effect, the total effective rate is 90 percent, and the traditional Chinese medicine emplastrum has the effects of soothing liver, regulating qi, activating blood and relieving pain and reducing the abdominal pain degree of patients.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the application has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the application.
Claims (10)
1. The traditional Chinese medicine emplastrum for improving primary dysmenorrhea is characterized by comprising the following raw materials in parts by weight: 30-40 parts of rhizoma corydalis, 10-15 parts of radix angelicae, 6-10 parts of Chinese angelica, 20-25 parts of antler slice, 15-20 parts of radix astragali preparata, 10-30 parts of caulis sinomenii, 8-10 parts of rhizoma curcumae, 2-5 parts of prepared radix aconiti lateralis preparata, 3-7 parts of folium artemisiae argyi and 4-6 parts of borneol.
2. The traditional Chinese medicine emplastrum according to claim 1, wherein the traditional Chinese medicine emplastrum is characterized by comprising 30-35 parts of rhizoma corydalis, 10-12 parts of radix angelicae, 7-9 parts of angelica sinensis, 20-23 parts of antler slice, 17-20 parts of radix astragali preparata, 15-20 parts of caulis sinomenii, 8-9 parts of rhizoma curcumae, 2-4 parts of prepared aconite, 5-7 parts of folium artemisiae argyi and 4-5 parts of borneol.
3. The traditional Chinese medicine emplastrum according to claim 1, wherein 33 parts of rhizoma corydalis, 11 parts of radix angelicae, 9 parts of Chinese angelica, 21 parts of antler slice, 19 parts of radix astragali preparata, 16 parts of caulis sinomenii, 8 parts of rhizoma curcumae, 4 parts of prepared aconite, 5 parts of mugwort leaf and 5 parts of borneol.
4. The traditional Chinese medicine patch according to claim 1, wherein the traditional Chinese medicine patch is composed of a backing layer, a paste and an anti-sticking layer.
5. A method for preparing a traditional Chinese medicine emplastrum for improving primary dysmenorrhea as claimed in claims 1 to 4, comprising the following steps:
step one: grinding Borneolum Syntheticum into fine powder, and sieving;
step two: weighing the raw materials of the traditional Chinese medicines, crushing the raw materials into particles, adding 75% ethanol for soaking, heating, refluxing and extracting, and filtering to obtain filtrate;
step three: concentrating the filtrate obtained in the second step into an extract, adding the borneol fine powder obtained in the first step into the extract, and uniformly stirring to obtain a paste for improving primary dysmenorrhea;
step four: and (3) coating the paste obtained in the step (III) on a backing layer, drying, and covering an anti-sticking layer to obtain the traditional Chinese medicine emplastrum for improving primary dysmenorrhea.
6. The process according to claim 5, wherein in the first step, the ice flakes are sieved with a 200-mesh sieve.
7. The preparation method according to claim 5, wherein the specific steps of the second step are that the raw materials of the traditional Chinese medicinal materials are weighed, crushed into particles, sieved by a 150-mesh sieve, soaked in 5-7 times of 75% ethanol for 2-3 hours, heated and refluxed for 0.5-2 hours, and filtered to obtain filtrate.
8. The method according to claim 5, wherein the extract in the third step has a relative density of 1.06-1.12.
9. The method according to claim 8, wherein the extract in step three has a relative density of 1.08.
10. The method according to claim 5, wherein the drying temperature in the fourth step is 30-40℃and the drying time is 9-14 hours.
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