CN108144036A - A kind of resisting rheumatoid disease disease capsule - Google Patents

Abstract

The invention discloses a kind of prescriptions of resisting rheumatoid disease disease capsule, it is made of centipede, scorpio, zaocys dhumnade, earthworm, Moschus, stiff silkworm, insects, nidus vespae, frankincense, Rhizoma Chuanxiong, myrrh, the root of bidentate achyranthes, aconiti preparata,radix, Radix Glycyrrhizae and ginger and dateplum persimmon, it is characterised in that：It is monarch drug in a prescription by centipede, scorpio, zaocys dhumnade, earthworm, Moschus, stiff silkworm, insects, nidus vespae, frankincense, Rhizoma Chuanxiong, myrrh, the root of bidentate achyranthes, aconiti preparata,radix are ministerial drug, Radix Glycyrrhizae is adjutant, ginger and dateplum persimmon is make medicine, it makes up a prescription in Chinese medicine conventional method and pulverizes with after the drying mixing of sequence ratio, the filling capsule into 0.5 gram/.

Description

A kind of resisting rheumatoid disease disease capsule

Technical field

The present invention relates to a kind of resisting rheumatoid disease disease capsules, belong to technical field of Chinese medicine, are particularly suitable for clinically controlling Treat rheumatoid arthritis disease.

Background technology

Rheumatoid arthritis (rheumatoidarthritis, RA) is that the one kind for causing joint function disturbance and destroying is normal See autoimmune disease, five big difficult and complicated cases of the world are classified as by the World Health Organization.Though there is high amount of drug to can be used for controlling at present Treat, such as non-steroid anti-inflammatory drug, glucocorticoid, antirheumatic drug and costliness biological agent, these come out only century-old The west medicine energy respite state of an illness can not but cure the disease that such disability rate is high, seriously affects minimal invasive treatment and life quality Disease, and be discontinued easily repeatedly, it takes for a long time and also generates the toxic side effects such as dependence.

Developing motherland's medicine of thousands of years of history along with human growth, treatment rheumatoid arthritis is with a long history, from Ecological view such disease is concluded its because：It is the internal factor of morbidity to think physically weak sense heresy, and wind-cold damp pathogen is the external of morbidity Factor, the obstruction of meridians and collaterals that accumulates over a long period are the main pathogenesis of morbidity.I.e. three gas of wind, cold, wet (heresy) is miscellaneous to combined into numbness, and rheumatism is institute The names of disease of tcm for having rheumatoid disease is referred to as.In existing public technology, there are many Chinese prescription for treating rheumatoid arthritis, often With the mutual combination drug of the different Chinese herbal medicine of several pharmacological properties, i.e., using herbal medicine as monarch drug in a prescription, prescription amount is big, and herbal medicine type is more, and price is held high It is expensive and curative effect is generally palliative；Though also have animal kind medicine object is added in prescription in the prior art, generally still with grass Medicine is monarch drug in a prescription, and mostly using animal kind medicine object as ministerial drug, fail to play the drug effect of animal kind medicine object conscientiously.Such as Chinese patent The capsule prescription disclosed in 1156619 contains a kind of 30 Chinese medicine preparations, and drug is mainly disappeared by clearing and activating the channels and collaterals or stomach invigorating Poison achievees the effect that dispelling wind and eliminating dampness；The formula of Chinese patent 104352813 is even more that up to 46 kinds of Chinese medicines, medication is had in mind In liver kidney, using herbal drug as monarch drug in a prescription, Drug Prepared from Insects is ministerial drug, since medicament categories are excessive in above-mentioned formula, price is caused to hold high It is expensive and inevitably due to the interaction between drug, generate uncontrollable and unpredictable side effect, and due to The drug effect of herbal drug is low, it is difficult to obtain drug effect rapidly；In addition, the protein content of herbal drug is low, it is difficult to effectively improve patient The immunity of body, therefore rheumatoid disease is very easy to recur, how to control its recurrence rate is also that doctor is badly in need of what is solved One technical problem.

20 generation of the present inventor's tcm family passes on, and Jiangsu Province's Yancheng City place (third batch) non-material cultural heritage passes People is held, to TCM Recipe medicine and distinguishes that disease treats handed down from the older generations of the family understanding mode.Can the comprehensive cause of disease by chill is damp and hot, deficient qi and blood, liver Kidney is all empty, all types of YANG QI deficiency are concluded, and expelling wind and clearing away cold, sharp key is taken to lead to numbness, strong liver kidney tonifying, distinguish disease principle based on tendon relaxing and bone strengthening； Wind-dispelling is formed, dredging collateral, promoting blood circulation, stagnation resolvation is repaired, warm to support, the complex treatment characteristic consolidated.Realize whole strengthening vital QI to eliminate pathogenic factors, tonifying liver temperature The animal of kidney cooperates with plant medicine, and eliminating evil just, avoids the side effect of various damage liver kidneys without hindering；Applicant knows very well Chinese medicine Medicinal material is different, and pharmacological property varies considerably, and is actually also what cannot be changed easily even seeming intimate drug, Shen It asks someone by Couple herbs for many years, traditional Chinese medical science prescription and diagnosis and treatment based on an overall analysis of the illness and the patient's condition theory is coordinated to obtain the formula of the application；Applicant The dosage for also deeply knowing from experience drug has curative effect conclusive influence, is progressed greatly by continuing to optimize, and prescription is accurate, and compatibility is rationally just In processing and taking, become the treatment rheumatoid disease drug needed for market.

Invention content

The present invention provides a kind of resisting rheumatoid disease disease capsule, can be effectively prevented from drug side-effect used in the prior art Greatly, the problem of medical expense recurs greatly and easily.

The resisting rheumatoid disease disease capsule of the present invention is by centipede, scorpio, zaocys dhumnade, earthworm, Moschus, stiff silkworm, insects, dew bee Room, frankincense, Rhizoma Chuanxiong, myrrh, the root of bidentate achyranthes, aconiti preparata,radix, Radix Glycyrrhizae and ginger and dateplum persimmon form, it is characterised in that：By centipede, entirely Scorpion, zaocys dhumnade, earthworm, Moschus, stiff silkworm, insects, nidus vespae are monarch drug in a prescription, and frankincense, Rhizoma Chuanxiong, myrrh, the root of bidentate achyranthes, aconiti preparata,radix are Ministerial drug, Radix Glycyrrhizae are adjutant, and ginger and dateplum persimmon are to make medicine, make up a prescription in Chinese medicine conventional method and are ground into after the drying mixing of sequence ratio Powder, the filling capsule into 0.5 gram/.

Specifically, wherein 2 to 4 grams of centipede, 2 to 5 grams of scorpio, 3 to 11 grams of zaocys dhumnade, 3 to 9 grams of earthworm, Moschus 0.03 It is monarch drug in a prescription to 0.08 gram, 2 to 10 grams of stiff silkworm, 2 to 10 grams of insects, 3 to 9 grams of nidus vespae, 2 to 8 grams of frankincense, Rhizoma Chuanxiong 2 to 10 Gram, 2 to 8 grams of myrrh, 2 to 10 grams of the root of bidentate achyranthes, 1.5 to 3 grams of aconiti preparata,radix be ministerial drug, 3 to 10 grams of Radix Glycyrrhizae is adjutant, ginger 2 to 5 Gram, 3 to 8 grams of dateplum persimmon to make medicine, make up a prescription in Chinese medicine conventional method and pulverize with after the drying mixing of sequence ratio, it is filling into 0.5 The capsule of gram/.

Compared with prior art, the beneficial effects of the invention are as follows：1st, Chinese medicine used in the present invention meets《The Chinese people are total to With state's pharmacopeia》Specification, original producton location pharmacological property is safe and reliable, without side-effects after the mutual synergy of prescription.2nd, the present invention is with animal Class drug is monarch drug in a prescription, not only has the function of " worm ant, which is searched, picks ", but also be respectively provided with animal protein, has spy to the help adjustment of body Different effect solves the disadvantage that in existing many Chinese prescriptions that vegetable soda is excessive and animal protein deficiency is difficult to righting.3rd, this group Side is curative for effect, and warming channel and expelling cold, the dispelling wind and eliminating dampness of energy, dredging collateral righting, the content of collagen is high, can significantly improve exempting from for body Epidemic disease power effectively treats various rheumatoid arthritis and uneasy to recur, efficient up to 97%.4th, medicament categories of the present invention subtract significantly Few, the toxic side effect predictability after being used as medicine greatly increases, so as to effectively reduce toxic side effect.5th, drug of the present invention is with nourishing the liver Based on, expensive tonifying kidney and strengthening yang drug is greatly reduced, so as to effectively reduce drug cost.6th, the present invention emphasize each prescription it Between coordination synergy, introduce suitable Moschus, with Drug Prepared from Insects collectively as monarch drug in a prescription coordinate synergy, it is significant in efficacy, effectively reduce The pain of patient.

Specific embodiment

It is explained and illustrated with reference to technical scheme of the present invention, but following embodiments are only the preferred reality of the present invention Example is applied, and not all.Based on the embodiment in embodiment, those skilled in the art are in the premise for not making creative work Lower obtained other embodiment, belongs to protection scope of the present invention.

Below in conjunction with drug used in a kind of resisting rheumatoid disease disease capsule of the present invention, all property of drug and pharmacology are made with reference to pharmacopeia With pharmacodynamics test and the clinical practice with the present invention and model case, that the present invention is further illustrated is as follows：

The hirudo leech of centipede ScolopendrasubspinipesmutilansL.Koch.

【Nature and flavor and channel tropism】It is acrid in flavour and warm in nature；It is toxic.Return liver warp.

【Function is with curing mainly】Ceases wind antispastic, removes obstruction in channels to relieve pain, dispersing pathogen accumulation.

【Pay attention to】Pregnant woman disables.

【Pharmacological action】Antitumor action, injection liquid energy make the spermatogonium of small white mouse necrose, disappear, illustrate to swollen Oncocyte has inhibiting effect.To cardiazol, strychnine, pure nicotine half of the amount of seizures caused by mice convulsion have confrontation make With.Flooding agent (1：4) in vitro to trichophyton, oidium schoenleinii, Microsporon audouini, groin epidermis The dermatophytes such as tinea bacterium, epidermophyton rubrum, fonsecaea compactum have different degrees of inhibiting effect.

The hirudo leech of scorpio ButhusmartensiiKarsch.

【Nature and flavor and channel tropism】It is pungent, it puts down；It is toxic.Return liver warp.

【Function is with curing mainly】Ceases wind antispastic, removes obstruction in channels to relieve pain, dispersing pathogen accumulation.

【Pay attention to】Pregnant woman disables.

【Pharmacological action】There is anticonvulsant action, act as inhibiting vasomotor center, expansion blood to cardiovascular system Pipe directly inhibits heart and to adrenolytic boosting

The hirudo leech of zaocys dhumnade Zaocysdhumnades (Cantor).

【Nature and flavor and channel tropism】Sweet and neutral.Return liver warp.

【Function is with curing mainly】Wind-dispelling, dredging collateral, relieving convulsion.

【Pharmacological action】Zaocys dhumnade decocting liquid and alcohol extract have anti-inflammatory, calm, analgesic activity.Its serum has five steps of confrontation Snake venom acts on.

The hirudo leech of earthworm PheretimavulgarisChen.

【Nature and flavor and channel tropism】It is salty, it trembles with fear.Return liver, spleen, bladder warp.

【Function is with curing mainly】Heat-clearing is calmed the frightened, and dredging collateral is relievingd asthma, diuresis.

【Pharmacological action】Earthworm extract or freeze-drying coarse powder are other than having urokinase sample fibrinolytic thrombolysis and anticoagulation, Shang You The effect of direct catalysis fibre proteolysis.It can make the significant reduction of Platelet, whole blood viscosity and plasma viscosity reduce, red Cell rigidity index reduces.Patient's leucocyte can be controlled to decline to inhibit growth of tumour cell by improving body immunity.

Earthworm extracting solution external application is effective to scleroderma circumscriptum, and curative effect is likely to partial denaturization collagenous fibres degradation institute It causes.Because of toxic component half-life short, so the multiple successive administration of earthworm does not easily cause accumulation of poisoning, relatively safety.

Drying secretion in the ripe male body note capsules of Moschus Moschus moschiferus Linnaeus.

【Nature and flavor and channel tropism】It is acrid in flavour and warm in nature.The thoughts of returning home, the spleen channel.

【Function is with curing mainly】Inducing resuscitation of having one's ideas straightened out, invigorate blood circulation, swelling and pain relieving.

【Pay attention to】Pregnant woman disables.

【Pharmacological action】A small amount of excitements are act as to the effect Central nervous system of maincenter, it is a large amount of to inhibit.To breathing, The influence of the circulatory system has excitation, blood pressure can be made to increase, and respiration rate and frequency increase.It is in uterus in vitro and in place Appreciable stimulating action, the latter is more sensitive, pregnant more non-pregnant sensitivity again, non-pregnant excitation is occurred it is relatively slow but Relatively persistently.Test tube interior energy inhibits Escherichia coli and staphylococcus aureus.To the rat as caused by antigen of mycobacterium parenteral solution Arthritis, antiinflammation are better than buprofezin.

Stiff silkworm Beauveria bassiana (Bals.) Vuillant and lethal larva hirudo leech.

【Nature and flavor and channel tropism】It is salty, pungent, it puts down.Return liver, lung, stomach.

【Function is with curing mainly】Inflammation Zhijing, wind-expelling pain-stopping, reducing phlegm and resolving masses.

【Pharmacological action】There are anticonvulsant action and syngignoscism.

Cockroach insect

For the full worm of drying of Scarabaeidae insect dung shell dung beetle Catharsius molossus Linnaeus, i.e. aspongopus The hirudo leech of AspongopuschinensisDallas.

【Nature and flavor and channel tropism】It is salty, temperature.Return liver, spleen, kidney channel.

【Function is with curing mainly】Regulating qi-flowing for relieving pain, middle benefit gas are supporing yang.

【Pharmacological action】In vitro to golden yellowGrapeCoccus, typhoid fever Du bacterium, paratyphoid bacillus A and Fu ShiDysenteryDisease Bacillus has stronger inhibiting effect.

The nest of nidus vespae Polistes olivaceous.

【Nature and flavor and channel tropism】Sweet and neutral.Return stomach.

【Function is with curing mainly】Detoxicating and destroying parasites, wind-expelling pain-stopping.

Suitable amount used externally, grinds that oil dresses affected part or affected part is gargled or washed to pan-fried water.

【Pharmacological action】Alcohol, ether and the acetone extract of nidus vespae all play the role of promoting blood clotting, are soaked especially with acetone It is most strong to go out object.Each extract can enhance heart movement, blood pressure be made to decline when getting over, and have diuresis.

Frankincense is the resin of olive subject plant Boswellia carterii Boswellia carterii Birdw barks exudation.

【Nature and flavor and channel tropism】It is pungent, bitter, temperature.The thoughts of returning home, liver, the spleen channel.

【Function is with curing mainly】Promoting blood circulation analgesic therapy, detumescence and promoting granulation.

【Pay attention to】Pregnant woman and stomach weak person use with caution.

【Pharmacological action】Pharmacological testing proves there is anti-inflammatory activity, and anti-oxidant and anti-ulcer effect also has work to antitumor With.

The dry rhizome of Rhizoma Chuanxiong LigusticumchuanxiongHort.

【Nature and flavor and channel tropism】It is acrid in flavour and warm in nature.Return liver, courage, pericardium channel.

【Function is with curing mainly】Blood-activating and qi-promoting, wind-expelling pain-stopping.

【Pharmacological action】There is apparent sedation to cardiovascular and central nervous system.In vitro test to large intestine, dysentery, Deformation, green pus, typhoid fever, paratyphosum Bacterium and comma bacillus etc. have antibacterial inhibiting effect.

Myrrh is the dry resin of olive subject plant Chinese violet tree Commiphora myrrha Engl.

【Nature and flavor and channel tropism】It is pungent, bitter, it puts down.The thoughts of returning home, liver, the spleen channel.

【Function is with curing mainly】Scattered stasis pain detumescence and promoting granulations.

【Pay attention to】Pregnant woman and stomach weak person use with caution.

【Pharmacological action】Flooding agent, volatile oil have inhibiting effect to dermatophyte, moreover it is possible to reduce the blood courage of rabbit, rat and chicken Sterol levels, and have anti-inflammatory effect.

The root of bidentate achyranthes is the dry root of AchyranthesbidentataB1.

【Nature and flavor and channel tropism】It is bitter, sweet, sour, it puts down.Return liver and kidney channel.

【Function is with curing mainly】Dispelling stasis of blood and stimulating the menstrual flow, filling liver kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia draw

Blood downlink.

【Pay attention to】Pregnant woman uses with caution.

【Pharmacological action】With certain anti-inflammatory and analgesic effect and improve immunity.

Dry female root that aconiti preparata,radix is Aconitum carmichaeli Debx.

【Nature and flavor and channel tropism】It is pungent, bitter, heat；It is toxic.The thoughts of returning home, liver,kidney,spleen warp.

【Function is with curing mainly】Dispelling wind and eliminating dampness, antalgic.

【Pay attention to】Pregnant woman uses with caution；It should not be with the tuber of pinellia, Snakegourd Fruit, Chinese Drug Gualouzi, PERICARPIUM TRICHOSANTHIS, root of Chinese trichosanthes, bulbus fritillariae cirrhosae, fritillaria thunbergii, flat Fritillaria, Siberian fritillary bulb, Hupeh Fritillary Bulb, radix ampelopsis, bletilla are the same as use.

【Pharmacological action】Analgesic and anti-inflammatory effects analgesia index is 11.8, shows that it may be one of its anti-inflammatory mechanisms to inhibit PCE And immunosuppressive action, also there is apparent inhibit and lethal effect to stomach cancer cell by 409 parenteral solutions of preparation based on monkshood.The rhizome of Chinese monkshood Polysaccharide A 100mg/Kg intraperitoneal injections significantly reduce mouse euglycemia effect, are to enhance utilization of the body to glucose.

The dry root of Radix Glycyrrhizae Glycyrrhiza uralensis Fisch.

【Nature and flavor and channel tropism】Sweet and neutral.The thoughts of returning home, lung, spleen, stomach.

【Function is with curing mainly】It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.

【Pay attention to】It should not be with seaweed, Beijing spurge root, Knoxia valerianoide, the root of gansui, lilac daphne with use.

【Pharmacological action】There is stronger detoxication to diphtheria toxin, tetanus toxin, for some allergic disorders, move Object experimental hepatitis, fugutoxin and snake venom also have detoxication, have the function of anti-liver injury.

There are anti-inflammatory and antiallergic action and phlegm-dispelling functions.It is observed according to clinical with Pharmacology Lab, Radix Glycyrrhizae water extract can increase " osamine " ingredient of gastric mucosal cell, makes gastric mucosa preserve from.There is loose spasmolysis.

Adrenocortical hormones fuction：Radix Glycyrrhizae can reduce the urine volume of many animals and the discharge of sodium, and potassium discharge increases, Blood sodium rises, and blood calcium reduces, adrenal cortex zona glomerulosa atrophy, and can enhance adrenergic cardiac effect.

Radix Glycyrrhizae has shared adverse effect with lilac daphne：The toxicity of the two total immersion group significantly increases compared with sub-dip group, lilac daphne and Radix Glycyrrhizae With using, diuresis, discharge function are suppressed, and can enhance Radix Glycyrrhizae toxicity.

A kind of resisting rheumatoid disease disease capsule pharmacodynamics test of the present invention has carried out Wistar in Jilin Medical College:Kind rat The drug effect of (animal is provided by Jilin Medical College animal housing, is tested and is responsible for implementation by Jilin Medical College scientific research science) modeling Experiment is learned, for grouping rat after continuous gavage 28 days, experimental result is as follows：

(1) volume, thickness change：Administration group animal foot plantar swelling symptom is obviously improved, during off-test, administration group Foot plantar volume is obviously reduced, thickness is significantly thinning.

(2) changes of weight：This medicine has some improvement to the weight loss as caused by injection adjuvant.

(3) pathological section：Model group most animals synovium of joint cells of superficial layer has different degrees of hyperplasia and hypertrophy, synovial membrane There are different degrees of blood vessel dilatation, oedema, cell infiltration in tissue.Also there is above-mentioned lesion in administration group joint of animal, compared with mould Type group has significantly reduction, mitigates.

(4) rheumatoid factor and anti-" O "：Each group is feminine gender.

(5)NO：Administration group is less than normal group and model group.

(6)SOD:Each group counts not statistically significant through spss11.5.

(7) organ wet weight：Animal is put to death after the test, takes spleen and thymus gland, and after measurement, administration group spleen increases with thymus gland Greatly (with normal and model group ratio)；Prevention group spleen gland reduces, and thymus gland is more normally organized greatly, smaller than model group and administration group.

In experiment, blood parameters and other indexs have no abnormal changes, and have not observed adverse reaction.According to more than Surveyed index, Kangleifengshi capsules have resisting rheumatoid disease effect.

The clinical practice of the present invention is gone to a doctor between 1 year June in 2017 in Jiangsu Province's Yancheng City to be originated from June, 2016 100 treatment cases of Tinghu District Xu Shi bone fracture rheumatism research institute outpatient service, wherein male is 45, women 55；Age from By 81 years old, average age 48.6 years old, the course of disease most short person 90 days, most elder was up to 20 years or more within 20 years old.Diagnosis and the standard of curative effect evaluation Using American society of rheumatism x-ray criteria for classification (1987) and《New Chinese medicine guideline of clinical investigations》Control performs.Disease Example diagnosis, disease, curative effect foundation：With reference to People's Republic of China's traditional Chinese medicine industry standard《Chinese medical disease Standardization of diagnosis and curative effect》In Corresponding related provision content.

Clinical treatment：Resisting rheumatoid disease disease capsule oral dosage for oral administration is 2 grams/times, 4 times a day, respectively at after meal half Hour takes and is taken before sleeping, three months courses for the treatment of, general one to three courses for the treatment of.

Model case：

Zhang, man 20 years old.Double knee joint swells and ache March, and X-ray examination shows double knee joint degenerative change.Diagnosis：Knee closes Section is scorching, rheumatoid arthritis.Treatment：Resisting rheumatoid disease disease capsule oral 3 months, swelling and pain disappear, and follow-up is not recurred.

Lee, female 37 years old.The stiff function limitation of medical both hands, lumbar vertebrae, double knee joint swelling and pain；X-ray examination is shown：Lumbar vertebrae Degenerative change, double knee joint oedema, both hands joint change.Diagnosis：Rheumatoid arthritis, the protrasion of the lumbar intervertebral disci, double knees close Section is scorching.Treatment：Take resisting rheumatoid disease disease capsule oral 3 months, swelling and pain disappear, and follow-up is not recurred.

Mr. Wang, female 41 years old.Double wrist swelling and pain are medical, check：Rheumatism is conventional, and immunoglobulin, Rf are positive, and X-ray examination is shown Show that sclerotin obscures.Diagnosis：RA.Resisting rheumatoid disease disease capsule oral 3 months, pain relief swell and disappear, can be engaged in light physical labor, Non- follow-up.

Week certain, female 58 years old.Suffer from rheumatoid arthritis nearly 12 years, have no resolution through Western medicine multi-treatment.Patient's articulations digitorum manus is shown in inspection It is red and swollen apparent, refer to stiff deformation, the visible metacarpal bone of X-ray examination, knucklebone are loose, neck, protrusion of lumber intervertebral disc.It checks：Class wind Wet factor positive, Immunoglobulin IgG1 9.3g/L (reference value 8-16g/L), complement C0.72g/L (reference value 0.9-1.5g/ L)。

Treatment：Take resisting rheumatoid disease disease capsule oral 3 months, swelling and pain sings and symptoms disappear, and follow-up half a year does not recur.

Sun, female 79 years old.It is poor that function is bent and stretched in double knee joint swelling and pain, both hands ten refer to it is stiff bend and stretch difference, X-ray examination is shown： Double knee joint hyperplasia, two fingers ten, which refer to, to be changed.Diagnosis：Rheumatoid arthritis, gonitis.Treatment：Take resisting rheumatoid disease disease capsule More than 3 months oral, swelling and pain symptom mitigates, and function improves, non-follow-up.

Chen, man 81 years old.Because both hands refer to swelling and pain, cervical vertebra, lumbar vertebrae, which ache to influence to sleep, goes to a doctor.Diagnosis：Arthritis.It takes anti- Rheumatoid disease capsule oral 3 months, both hands refer to swelling and pain symptom and improve, and cervical vertebra, lumbar vertebrae are ached mitigation, non-follow-up.

As a result：Healing 76, effective 12, effective 9, invalid 3, cure rate 76%, total effective rate 97.0%.

Conclusion：Kangleifengshi capsules oral medication rheumathritis can mitigate patient's swelling and pain, and it is true to improve function of joint curative effect It cuts, realizes warming channel and expelling cold, dispeling wind and dehumidification, strong liver kidney tonifying, the active target of righting treats rheumatoid arthritis stability and no relapse Small side effects.

Specific embodiment

It is further complete by embodiment to technical scheme of the present invention below in order to make advantages of the present invention clearer Ground description is described as follows：

The present invention provide implement a kind of resisting rheumatoid disease disease capsule, by centipede, scorpio, zaocys dhumnade, earthworm, Moschus, stiff silkworm, Insects, nidus vespae, frankincense, Rhizoma Chuanxiong, myrrh, the root of bidentate achyranthes, aconiti preparata,radix, Radix Glycyrrhizae and ginger and dateplum persimmon form, and are preferably implemented One of scheme：3 grams of centipede, 4 grams of scorpio, 10 grams of zaocys dhumnade, 8 grams of earthworm, 0.03 gram of Moschus, 10 grams of stiff silkworm, 5 grams of insects, dew 5 grams of honeycomb, 8 grams of frankincense, 10 grams of Rhizoma Chuanxiong, 8 grams of myrrh, 8 grams of the root of bidentate achyranthes, 3 grams of aconiti preparata,radix, 9 grams of Radix Glycyrrhizae, 3 grams of ginger, dateplum persimmon 6 Gram, it pulverizes after ratio drying mixing in order, the filling capsule into 0.5 gram/.

The two of its preferred embodiment：4 grams of centipede, 3 grams of scorpio, 9 grams of zaocys dhumnade, 9 grams of earthworm, 0.06 gram of Moschus, stiff silkworm 8 Gram, 10 grams of insects, 9 grams of nidus vespae, 6 grams of frankincense, 10 grams of Rhizoma Chuanxiong, 10 grams of myrrh, 10 grams of the root of bidentate achyranthes, 2 grams of aconiti preparata,radix, Radix Glycyrrhizae 9 grams, 5 grams of ginger, 6 grams of dateplum persimmon, in order ratio drying mixing after pulverize, the filling capsule into 0.5 gram/.

The three of its preferred embodiment：5 grams of centipede, 3 grams of scorpio, 10 grams of zaocys dhumnade, 9 grams of earthworm, 0.08 gram of Moschus, stiff silkworm 10 grams, 8 grams of insects, 6 grams of nidus vespae, 8 grams of frankincense, 10 grams of Rhizoma Chuanxiong, 6 grams of myrrh, 10 grams of the root of bidentate achyranthes, 3 grams of aconiti preparata,radix, Radix Glycyrrhizae 10 grams, 5 grams of ginger, 6 grams of dateplum persimmon, in order ratio drying mixing after pulverize, the filling capsule into 0.5 gram/.

A kind of resisting rheumatoid disease disease capsule oral dosage of the present invention is 2 grams/times, and 4 times a day, a course for the treatment of is general within 3 months It cures, the mesh that taking dose and the course for the treatment of equally can reach healing then can be adjusted accordingly to sick weak older different cases long Mark.

Above-described is the preferred embodiment of the present invention, and form not made for the present invention limits.It should be pointed out that For any one of skill in the art, it is possible to use above-mentioned technology contents are changed with similar Chinese medicine and replaced as enlightenment Or improve the equivalent embodiment that variable is equivalent variations.In every case in the essence without departing from the claims in the present invention and compatibility structure Under the premise of, several replace can also be made and improve and equally retouch, these replacements improve and equivalent retouch still should be regarded as this hair Bright protection domain.

Claims (5)

1. a kind of resisting rheumatoid disease disease capsule, by centipede, scorpio, zaocys dhumnade, earthworm, Moschus, stiff silkworm, insects, nidus vespae, system breast Perfume, Rhizoma Chuanxiong, myrrh, the root of bidentate achyranthes, aconiti preparata,radix, Radix Glycyrrhizae and ginger and dateplum persimmon form, it is characterised in that：By centipede, scorpio, the black tip Snake, earthworm, Moschus, stiff silkworm, insects, nidus vespae are monarch drug in a prescription, and frankincense, Rhizoma Chuanxiong, myrrh, the root of bidentate achyranthes, aconiti preparata,radix are ministerial drug, sweet Grass is adjutant, and ginger and dateplum persimmon are to make medicine, makes up a prescription in Chinese medicine conventional method and pulverizes with after the drying mixing of sequence ratio, filling Into the capsule of 0.5 gram/.

2. a kind of resisting rheumatoid disease disease capsule as described in claim 1, it is characterised in that：2 to 4 grams of centipede, 2 to 5 grams of scorpio, crow 3 to 11 grams of tip snake, 3 to 9 grams of earthworm, 0.03 to 0.08 gram of Moschus, 2 to 10 grams of stiff silkworm, 2 to 10 grams of insects, nidus vespae 3 to 9 Gram, 2 to 8 grams of frankincense, 2 to 10 grams of Rhizoma Chuanxiong, 2 to 8 grams of myrrh, 2 to 10 grams of the root of bidentate achyranthes, 1.5 to 3 grams of aconiti preparata,radix, Radix Glycyrrhizae 3 to 10 Gram, 2 to 5 grams of ginger, 3 to 8 grams of dateplum persimmon are pulverized after ratio drying mixing in order, the filling capsule into 0.5 gram/.

3. a kind of resisting rheumatoid disease disease capsule as described in claim 1, it is characterised in that：4 grams of centipede, 3 grams of scorpio, zaocys dhumnade 9 Gram, 9 grams of earthworm, 0.06 gram of Moschus, 8 grams of stiff silkworm, 10 grams of insects, 9 grams of nidus vespae, 6 grams of frankincense, 10 grams of Rhizoma Chuanxiong, myrrh 10 grams, 10 grams of the root of bidentate achyranthes, 2 grams of aconiti preparata,radix, 9 grams of Radix Glycyrrhizae, 5 grams of ginger, 6 grams of dateplum persimmon, in order ratio drying mixing after pulverize, The filling capsule into 0.5 gram/.

4. a kind of resisting rheumatoid disease disease capsule as described in claim 1, it is characterised in that：3 grams of centipede, 4 grams of scorpio, zaocys dhumnade 10 Gram, 8 grams of earthworm, 0.03 gram of Moschus, 10 grams of stiff silkworm, 5 grams of insects, 5 grams of nidus vespae, 8 grams of frankincense, 10 grams of Rhizoma Chuanxiong, myrrh 8 Gram, 8 grams of the root of bidentate achyranthes, 3 grams of aconiti preparata,radix, 9 grams of Radix Glycyrrhizae, 3 grams of ginger, 6 grams of dateplum persimmon, in order ratio drying mixing after pulverize, fill Dress up the capsule of 0.5 gram/.

5. a kind of resisting rheumatoid disease disease capsule as described in claim 1, it is characterised in that：5 grams of centipede, 3 grams of scorpio, zaocys dhumnade 10 Gram, 9 grams of earthworm, 0.08 gram of Moschus, 10 grams of stiff silkworm, 8 grams of insects, 6 grams of nidus vespae, 8 grams of frankincense, 10 grams of Rhizoma Chuanxiong, myrrh 6 Gram, 10 grams of the root of bidentate achyranthes, 3 grams of aconiti preparata,radix, 10 grams of Radix Glycyrrhizae, 5 grams of ginger, 6 grams of dateplum persimmon, in order ratio drying mixing after pulverize, The filling capsule into 0.5 gram/.