CN103989767B - A kind of treat verruca plana pharmaceutical composition and preparation technology and application - Google Patents
A kind of treat verruca plana pharmaceutical composition and preparation technology and application Download PDFInfo
- Publication number
- CN103989767B CN103989767B CN201410244957.0A CN201410244957A CN103989767B CN 103989767 B CN103989767 B CN 103989767B CN 201410244957 A CN201410244957 A CN 201410244957A CN 103989767 B CN103989767 B CN 103989767B
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- rhizoma
- verruca plana
- parts
- herba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of treat verruca plana pharmaceutical composition and preparation technology and application, this pharmaceutical composition is prepared from by the Chinese crude drug of following weight proportion: Herba Blumeae Densiflorae 35-50 part, Herba Adenostemmatis 35-50 part, torch fruit 20-40 part, Rhizoma Panacis Majoris 16-25 part, Rhizoma Bergeniae purpurascentis 12-20 part, Calyx Kaki 12-20 part, Rhizoma Atractylodis 5-9 part, Caulis Piperis Kadsurae 12-20 part.Pharmaceutical composition of the present invention has heat-clearing and toxic substances removing, dampness, the effect of soothing the channels and quicking the network vessels, treats the evident in efficacy of verruca plana.
Description
Technical field
The present invention relates to a kind of treat verruca plana pharmaceutical composition and preparation technology and application, belong to technical field of Chinese medicines.
Background technology
Verruca plana is that human papillomavirus infects a kind of common skin diseases caused, and human papillomavirus is a kind of DNA viruses, spherical in shape, in eosinophilic inclusion in nucleus, and rarely found in Cytoplasm, virus is main in cell endoreduplication.People is the unique host of this virus, therefore to other animal no pathogenicities.Wound is also the important channel causing human papillomavirus to infect, and sends out as shaved the beard at the verruca plana Chang Yin at beard position.Many patient's lasting for years do not heal, and are one of beauty-injurying disease, have gentle contact infectiousness, can inspire the infection of this virus and general when human body cell immunodeficiency.
At present, the method for the treatment of verruca plana has a lot, and doctor trained in Western medicine adopts oral antiviral, improves immunity class medicine and external suppression virus breeding Drug therapy, but cure rate is very low; Or by freezing or electron ion and CO
2the treatments such as laser, but electron ion and laser therapy all likely cause face to leave cicatrix, affect appearance; If when wart body number is more, available treatment means is poor clinically, and cure rate is low, and easily recurs.
Summary of the invention
The object of the invention is to by prescription again after studying Chinese medicine pharmacology, provide a kind of pharmaceutical composition of rapid-action, treatment verruca plana that good effect, toxic and side effects are little and preparation technology thereof and pharmaceutical applications.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for verruca plana, described pharmaceutical composition is prepared from by the Chinese crude drug of following weight proportion: Herba Blumeae Densiflorae 35-50 part, Herba Adenostemmatis 35-50 part, fiery sour jujube 20-40 part, Rhizoma Panacis Majoris 16-25 part, Rhizoma Bergeniae purpurascentis 12-20 part, Calyx Kaki 12-20 part, Rhizoma Atractylodis 5-9 part, Caulis Piperis Kadsurae 12-20 part.
Preferably, the pharmaceutical composition of above-mentioned treatment verruca plana, wherein said pharmaceutical composition is prepared from by the Chinese crude drug of following weight proportion: Herba Blumeae Densiflorae 40-45 part, Herba Adenostemmatis 40-45 part, fiery sour jujube 26-32 part, Rhizoma Panacis Majoris 19-21 part, Rhizoma Bergeniae purpurascentis 15-17 part, Calyx Kaki 15-17 part, Rhizoma Atractylodis 7-8 part, Caulis Piperis Kadsurae 15-17 part.
In the present invention's most preferred embodiment, the pharmaceutical composition of described treatment verruca plana is prepared from by the Chinese crude drug of following weight proportion: Herba Blumeae Densiflorae 42 parts, Herba Adenostemmatis 42 parts, fiery sour jujube 28 parts, Rhizoma Panacis Majoris 20 parts, Rhizoma Bergeniae purpurascentis 16 parts, Calyx Kaki 16 parts, Rhizoma Atractylodis 8 parts, Caulis Piperis Kadsurae 16 parts.
Further preferably, the pharmaceutical composition of above-mentioned treatment verruca plana can be prepared as powder, and this powder decocts by patient before medication, and gained decocting liquid is used for fumigation and wash method affected part.
Further preferably, the pharmaceutical composition of above-mentioned treatment verruca plana can be prepared as external preparation, and described external preparation comprises lotion, gel, ointment.
The preparation technology of the pharmaceutical composition for the treatment of verruca plana of the present invention, its step comprises: pulverize after described Chinese crude drug mixing, soak 0.5-1.5h, decoct with water 1-3 time, decocting liquid filters, concentrated, concentrated solution is put 1-5 DEG C of deepfreeze 18-36h, cold preservation liquid is filtered again, after filtrate reconcentration, is prepared into lotion, gel or ointment.
Found by experimental study, the Drug therapy verruca plana prepared by the traditional Chinese medicinal material raw materials of said ratio rapid-action, good effect, the curative effect for the treatment of face flat wart is better than Western medicine A Da and is afraid of woods gel.Therefore, second object of the present invention is to provide a kind of new medical use, the application of namely above-mentioned pharmaceutical composition in the medicine of preparation treatment verruca plana.
According to Chinese medicine Historical Data Data About, the present invention's traditional Chinese medicinal material raw materials used has following function and cures mainly and originate:
Herba Blumeae Densiflorae: clearing away heat and cooling blood, preventing the attack (or recurrence) of malaria.Be generally used for treatment malaria, hypertension, enteritis, cat fever.Select the dry herb of Compositae Herba Blumeae Densiflorae Blumeadensiflora (Wall.) DC..
Herba Adenostemmatis: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Be generally used for the high heat for the treatment of flu, bronchitis, pharyngolaryngitis, tonsillitis, icterohepatitis; Carbuncle furuncle infections is controlled in external, venom.Compositae adenostemma laveniaKuntze is selected to belong to the dry herb of adenostemma laveniaKuntze Adenostemmalavenia (L.) Kuntze.
Fire sour jujube: spleen invigorating removing food stagnancy, promoting blood circulation and hemostasis.Be generally used for and control mass in the abdomen, food stagnation, have loose bowels, dysentery, metrorrhagia, puerperal blood stasis.Select the dry mature fruit of rosaceous plant fire sour jujube.
Rhizoma Panacis Majoris: tonifying the lung, yin nourishing, active, hemostasis.Be generally used for deficiency of both QI and YIN, dysphoria with smothery sensation is thirsty, cough due to consumptive disease, injury from falling down, arthralgia, hemoptysis, spits blood, traumatic hemorrhage.Select the dry rhizome of Araliaceae Rhizoma Panacis Majoris.
Rhizoma Bergeniae purpurascentis: hemostasia and promoting granulation; Stomach invigorating antidiarrheal.Generally cure mainly traumatic injury, traumatic hemorrhage, have blood in stool, food stagnation.Select the dry rhizome of saxifragaceae plant Rhizoma Seu Herba Bergeniae.
Calyx Kaki: lowering the adverse flow of QI.Be generally used for and control singultus.Select the dry Constellation calyx of Ebenaceae plant Fructus Kaki DiospyroskakiThunb..
Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Be generally used for distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Select the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodeslancea (Thunb.) DC..
Caulis Piperis Kadsurae: wind-damp dispelling, the meridian dredging, stopping numbness pain.For anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, joint stuffiness.Generally select the dry rattan of Piperaceae plant Radix seu Caulis fici Martinii Piperkadsura (Choisy) Ohwi.
The traditional Chinese medical science thinks that verruca plana is many by interspaces of skin and muscles being loose, wind-heat evil toxin invades skin, or it is dry by deficiency of the liver blood in body, muscle gas is not flourish, pyretic toxicity outgoing is smouldered skin and falls ill, control and work as heat-clearing and toxic substances removing, dampness, soothing the channels and quicking the network vessels, Herba Blumeae Densiflorae clearing away heat and cooling blood of the present invention, Herba Adenostemmatis induces sweat damp eliminating, be monarch drug altogether, fire sour jujube promoting blood circulation and hemostasis, Rhizoma Panacis Majoris promoting tissue regeneration by removing blood stasis, be ministerial drug altogether, promote the effect of monarch drug heat clearing and blood circulation promoting, Rhizoma Bergeniae purpurascentis hemostasia and promoting granulation, Calyx Kaki is regulated the flow of vital energy, be adjuvant drug altogether, Rhizoma Atractylodis, Caulis Piperis Kadsurae expelling wind and removing dampness is for making medicine, full side's compatibility, bring out the best in each other, common performance heat-clearing and toxic substances removing, dampness, soothing the channels and quicking the network vessels effect, reach the effect for the treatment of verruca plana.Especially, the present invention, with medicinal liquid washout affected part, directly gets disease institute, also combines and rubs wart body, effectively can improve local blood circulation, promote the infiltration of medicine and heighten the effect of a treatment with washout.
Detailed description of the invention
Be below preparation embodiment of the present invention and clinical practice example, technical scheme of the present invention is done and describes further, but protection scope of the present invention be not limited to these embodiments.
The preparation of embodiment 1 Chinese powder medicine
Take Herba Blumeae Densiflorae 0.42kg, Herba Adenostemmatis 0.42kg, fiery sour jujube 0.28kg, Rhizoma Panacis Majoris 0.20kg, Rhizoma Bergeniae purpurascentis 0.16kg, Calyx Kaki 0.16kg, Rhizoma Atractylodis 0.08kg, Caulis Piperis Kadsurae 0.16kg, clean roguing, dry, be ground into granule, by every bag of 200 grams of subpackages.
The preparation of embodiment 2 Chinese powder medicine
Take Herba Blumeae Densiflorae 0.45kg, Herba Adenostemmatis 0.50kg, fiery sour jujube 0.26kg, Rhizoma Panacis Majoris 0.16kg, Rhizoma Bergeniae purpurascentis 0.17kg, Calyx Kaki 0.20kg, Rhizoma Atractylodis 0.09kg, Caulis Piperis Kadsurae 0.12kg, clean roguing, dry, be ground into granule, by every bag of 200 grams of subpackages.
The preparation of embodiment 3 Chinese medicine lotion
Take Herba Blumeae Densiflorae 0.35kg, Herba Adenostemmatis 0.42kg, fire sour jujube 0.32kg, Rhizoma Panacis Majoris 0.20kg, Rhizoma Bergeniae purpurascentis 0.12kg, Calyx Kaki 0.12kg, Rhizoma Atractylodis 0.08kg, Caulis Piperis Kadsurae 0.20kg, clean roguing, dry, be ground into granule, again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1h, pull out medical material put multi-functional extraction fill with in decoct with water secondary, add up the water of medical material 10 times amount for the first time, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decoct 2h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15, concentrated solution is put 5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 1.0g crude drug amount, and 0.1% adds antiseptic ethyl hydroxybenzoate, by every bag of 50 milliliters of subpackages to every milliliter by weight percentage.
The preparation of embodiment 4 Chinese medicine lotion
Take Herba Blumeae Densiflorae 0.40kg, Herba Adenostemmatis 0.45kg, fire sour jujube 0.40kg, Rhizoma Panacis Majoris 0.25kg, Rhizoma Bergeniae purpurascentis 0.16kg, Calyx Kaki 0.15kg, Rhizoma Atractylodis 0.05kg, Caulis Piperis Kadsurae 0.15kg, clean roguing, dry, be ground into granule, again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1h, pull out medical material put multi-functional extraction fill with in decoct with water secondary, add up the water of medical material 10 times amount for the first time, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 2h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.10, concentrated solution is put 4 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 1.2g crude drug amount, and 0.1% adds antiseptic ethyl hydroxybenzoate, by every bag of 50 milliliters of subpackages to every milliliter by weight percentage.
Embodiment 5 Chinese medicine fumigation and washing is to the effectiveness study of verruca plana patient
According to clinical manifestation and pathologic finding be diagnosed as face flat wart patient 56 example, show as: (1) skin lesion place be the grain of rice to the flat pimple of Sorghum vulgare Pers. grain size, smooth surface, isolate be dispersed in, khaki or normal skin color, some patients is micro-itches; (2) tissue pathology checking: spinous layer of epidermis is plump, papillomatous hyperplasia and hyperkeratosis, companion's parakeratosis.Spinous layer top and granular layer have Empity veside cell, nuclear hyperchromatism, basophilia.Patient is divided at random Chinese drug-treated group (28 example), matched group (28 example).16 ~ 38 years old Chinese drug-treated group age, average (23.38 ± 2.15) year, the course of disease average 0.5 ~ April; 16 ~ 40 years old matched group age, average (23.76 ± 2.62) year, the course of disease average 0.8 ~ April.Two groups of equal not statistically significants of difference in age, course of disease distribution etc., have comparability.
After matched group patient cleans face, be coated with 0.1% adapalene gel (authentication code: the accurate word H20113373 of traditional Chinese medicines, production unit: Jiangsu Fubang .Pharm Co., Ltd.) directly outward, in evening 1 time every day, after being used in conjunction 4 weeks, evaluate curative effect.
Chinese drug-treated group patient treat as follows: get Chinese powder medicine 1 bag prepared by the embodiment of the present invention 1,1h is soaked with 3L clear water, then slow fire decocts to 200mL (about 0.5h), remove slag and get filtrate, first smoke affected part while hot, after medicinal liquid slightly temperature, then dip medicinal liquid with 4 ~ 6 layers of gauze and slightly firmly repeatedly rub affected part.Every day 1 time, rub 15 ~ 20min at every turn, with skin sensation scorching hot and be not damaged into degree.Within 7 days, be 1 course for the treatment of, after treating 4 weeks, evaluate curative effect.
Treatments period does not use other antiviral to take orally or medicine for external use, and efficacy assessment standard is as follows:
Recovery from illness: skin lesion all disappears.
Effective: skin lesion disappears or flatten >=and 75%.
Effective: 50%≤skin lesion disappears or the < 75% that flattens.
Invalid: skin lesion disappears or the < 50% that flattens
Chinese drug-treated group and matched group comparitive study are in table 1.Can be found out by the result of the test of table 1, after Chinese drug-treated group patient treatment, total effective rate is 96.42%, and matched group is 71.43%, and the total effective rate of Chinese drug-treated group treatment face flat wart is obviously better than matched group.
Table 1 liang group patient clinical comparitive study [example (%)]
Chinese drug-treated group compared in table 2 with matched group onset time.Can be found out by the result of the test of table 2, the onset time of Chinese drug-treated group is fast, and comparing matched group has significant difference (P < 0.05 or P < 0.01).
Ask when the onset of patient organized by table 2 liang and compare (d)
Compare with matched group,
★p < 0.05;
★ ★p < 0.01.
Claims (7)
1. treat a pharmaceutical composition for verruca plana, it is characterized in that: described pharmaceutical composition is prepared from by the Chinese crude drug of following weight proportion: Herba Blumeae Densiflorae 35-50 part, Herba Adenostemmatis 35-50 part, fiery sour jujube 20-40 part, Rhizoma Panacis Majoris 16-25 part, Rhizoma Bergeniae purpurascentis 12-20 part, Calyx Kaki 12-20 part, Rhizoma Atractylodis 5-9 part, Caulis Piperis Kadsurae 12-20 part.
2. the pharmaceutical composition for the treatment of verruca plana according to claim 1, is characterized in that: described pharmaceutical composition is prepared from by the Chinese crude drug of following weight proportion: Herba Blumeae Densiflorae 40-45 part, Herba Adenostemmatis 40-45 part, fiery sour jujube 26-32 part, Rhizoma Panacis Majoris 19-21 part, Rhizoma Bergeniae purpurascentis 15-17 part, Calyx Kaki 15-17 part, Rhizoma Atractylodis 7-8 part, Caulis Piperis Kadsurae 15-17 part.
3. the pharmaceutical composition for the treatment of verruca plana according to claim 2, is characterized in that: described pharmaceutical composition is prepared from by the Chinese crude drug of following weight proportion: Herba Blumeae Densiflorae 42 parts, Herba Adenostemmatis 42 parts, fiery sour jujube 28 parts, Rhizoma Panacis Majoris 20 parts, Rhizoma Bergeniae purpurascentis 16 parts, Calyx Kaki 16 parts, Rhizoma Atractylodis 8 parts, Caulis Piperis Kadsurae 16 parts.
4. the pharmaceutical composition of the treatment verruca plana according to claim 1 or 2 or 3, is characterized in that: described pharmaceutical composition is powder.
5. the pharmaceutical composition of the treatment verruca plana according to claim 1 or 2 or 3, is characterized in that: described pharmaceutical composition is external preparation, and described external preparation comprises lotion, gel, ointment.
6. treat the preparation technology of the pharmaceutical composition of verruca plana according to claim 5, it is characterized in that: this technique comprises to be pulverized after described Chinese crude drug mixing, soak 0.5-1.5h, decoct with water 1-3 time, decocting liquid filters, concentrated, concentrated solution is put 1-5 DEG C of deepfreeze 18-36h, cold preservation liquid is filtered again, after filtrate reconcentration, is prepared into lotion, gel or ointment.
7. claim 1 or the pharmaceutical composition described in 2 or 3 application in the medicine of preparation treatment verruca plana.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410244957.0A CN103989767B (en) | 2014-06-03 | 2014-06-03 | A kind of treat verruca plana pharmaceutical composition and preparation technology and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410244957.0A CN103989767B (en) | 2014-06-03 | 2014-06-03 | A kind of treat verruca plana pharmaceutical composition and preparation technology and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103989767A CN103989767A (en) | 2014-08-20 |
| CN103989767B true CN103989767B (en) | 2015-11-25 |
Family
ID=51304267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410244957.0A Active CN103989767B (en) | 2014-06-03 | 2014-06-03 | A kind of treat verruca plana pharmaceutical composition and preparation technology and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103989767B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104706699A (en) * | 2015-02-13 | 2015-06-17 | 新昌县大成生物科技有限公司 | Blumea densiflora extract and application of blumea densiflora extract in treating gastritis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049443A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine of treating flat wart |
| CN101612336A (en) * | 2009-07-09 | 2009-12-30 | 蒋勇 | A kind of topical agent for the treatment of verruca plana |
-
2014
- 2014-06-03 CN CN201410244957.0A patent/CN103989767B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103989767A (en) | 2014-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1322885C (en) | Plaster medicine composition with multiple purpose for treating affection pain due to dampness | |
| CN104740583B (en) | It is a kind of to be used to alleviate Chinese medicine preparation of Crohn disease and preparation method thereof | |
| CN102000164A (en) | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof | |
| CN104491220B (en) | A kind of traditional Chinese medicine composition for herpes | |
| CN103989767B (en) | A kind of treat verruca plana pharmaceutical composition and preparation technology and application | |
| CN104940691A (en) | Treatment medicine for novel bunyaviridae infection | |
| CN104784346A (en) | Pruritus treating traditional Chinese medicine lotion preparation method | |
| CN105106634A (en) | Traditional Chinese medicine preparation for treating acute appendicitis and application thereof | |
| CN105878454A (en) | Pharmaceutical composition for treating apoplectic hemiplegia and rheumatic arthralgia and preparation method of pharmaceutical composition | |
| CN104998158A (en) | Pharmaceutical composition for treating liver cirrhosis and application thereof | |
| CN101422577B (en) | External traditional Chinese medicine for treating scald and burn and preparation method thereof | |
| CN105250946A (en) | Solid dispersion for treating peptic ulcers | |
| CN103751624B (en) | A kind of medicine and preparation method for the treatment of numb limbs and tense tendons after apoplexy | |
| CN103356959B (en) | Pharmaceutical composition for treating hyperplasia of mammary glands | |
| CN104189608A (en) | Traditional Chinese medicine preparation for treating recurrent oral ulceration and preparation method thereof | |
| CN104922595A (en) | Traditional Chinese medicinal preparation for herpes zoster and preparation method thereof | |
| CN103784633B (en) | A kind of Chinese medicine composition treating infantile rhinitis and preparation method thereof | |
| CN104027746B (en) | A kind of spray quickly alleviating postoperative pain and preparation method | |
| CN103920091A (en) | Medicine for improving immunity of HIV (Human Immunodeficiency Virus) infected people and preparation method thereof | |
| CN113975324A (en) | Traditional Chinese medicine composition for treating psoriasis | |
| CN103566333A (en) | Pharmaceutical composition for relieving swelling and pain and preparation method thereof | |
| CN102451249A (en) | Drug for treating burn and scald, and application thereof | |
| CN105687795A (en) | Ointment for treating facioplegia | |
| CN105079179A (en) | External preparation for treating sciatica and preparation method | |
| CN105311283A (en) | Preparation for treating hyperplasia of mammary glands and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Chen Hongjin Inventor after: Gu Ning Inventor after: Zeng Li Inventor after: Gu Yunfei Inventor after: Yang Bailin Inventor after: Chen Yiqi Inventor after: He Xiaoli Inventor before: Zhang Shaobo Inventor before: Liu Jian Inventor before: Wang Xiaodong |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20151021 Address after: 138 No. 210023 Jiangsu city of Nanjing province Xianlin University City Xianlin Avenue Applicant after: Nanjing University of Chinese Medicine Address before: Room 502, dormitory building, Lishui People's Hospital, 15 Dazhong street, Liandu District, Zhejiang, Lishui, 323000 Applicant before: Zhang Shaobo |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |