CN105687795A - Ointment for treating facioplegia - Google Patents

Ointment for treating facioplegia Download PDF

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CN105687795A
CN105687795A CN201610149247.9A CN201610149247A CN105687795A CN 105687795 A CN105687795 A CN 105687795A CN 201610149247 A CN201610149247 A CN 201610149247A CN 105687795 A CN105687795 A CN 105687795A
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radix
radix angelicae
ointment
agkistrodon
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刘俊英
丁桂伟
逄金伟
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Abstract

The invention discloses an ointment for treating facioplegia. The ointment is prepared from, by weight, 10-20 parts of radix aconitilateralis preparata, 10-20 parts of radix aconiti preparata, 5-15 parts of olibanum, 20-40 parts of castor bean semen ricini, 0.5-1 part of borneol, 20-40 parts of long-noded pit viper, 10-20 parts of radix angelica sinensis, 10-20 parts of divaricate saposhnikovia roots, 10-20 parts of pubescent angelica roots, 10-20 parts of radix angelicae dahuricae, 10-20 parts of rhizoma gastrodiae, 5-15 parts of licorice roots, 5-15 parts of rhizoma cimicifugae, 20-40 parts of scorpions, 5-15 parts of stiff silkworms, 5-15 parts of chrysanthemum flowers, 5-15 parts of radix paeoniae rubra, 5-15 parts of flos carthami and 5-15 parts of suberect spatholobus stems. All the medicine materials are in dialectical compatibility to jointly perform the effects of dispelling wind and arresting convulsion, and invigorating blood to remove stasis. The ointment is free of toxic or side effects and capable of taking effect fast, and the relapse rate is low.

Description

One is used for treating prosopoplegic ointment
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of for treating prosopoplegic ointment。
Background technology
Facial paralysis is otherwise known as wapperijaw bar, wapperijaw etc., it is a kind of more complicated maxillofacial disease, be be principal character with facial expression muscle group dyskinesia a kind of commonly encountered diseases, general symptom is facial hemiparalysis, and patient facial region is often most basic to lift the actions such as eyebrow, eye closing, drum mouth and all cannot complete。
Treatment for facial paralysis at present adopts acupuncture, western medicine therapy etc., acupuncture and moxibustion therapy to take effect slowly more, and western medicine therapy controls recurrence rate after healing height。
Summary of the invention
In order to make up prior art deficiency in facial paralysis treatment, the invention provides a kind of for treating prosopoplegic ointment, this ointment has no side effect, instant effect and relapse rate low。
Technical solution of the present invention includes:
One is used for treating prosopoplegic ointment, and it is to be prepared from by the raw material of Chinese medicine of following weight:
RADIX ACONITILATERALIS PREPARATA 10～20 parts, Radix Aconiti Preparata 10～20 parts, Olibanum 5～15 parts, Semen Ricini 20～40 parts, Borneolum Syntheticum 0.5～1 part, Agkistrodon 20～40 parts, Radix Angelicae Sinensis 10～20 parts, Radix Saposhnikoviae 10～20 parts, Radix Angelicae Pubescentis 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, 10～20 parts of Rhizoma Gastrodiae, 5～15 parts of Radix Glycyrrhizae, Rhizoma Cimicifugae 5～15 parts, Scorpio 20～40 parts, Bombyx Batryticatus 5～15 parts, Flos Chrysanthemi 5～15 parts, Radix Paeoniae Rubra 5～15 parts, 5～15 parts of Flos Carthami, Caulis Spatholobi 5～15 parts；
Described Agkistrodon originates from White Cloud Mountain, Fujian。
As a preferred version of the present invention, the weight of each raw material of Chinese medicine is: RADIX ACONITILATERALIS PREPARATA 15 parts, Radix Aconiti Preparata 15 parts, Olibanum 10 parts, Semen Ricini 30 parts, Borneolum Syntheticum 0.9 part, Agkistrodon 30 parts, Radix Angelicae Sinensis 15 parts, Radix Saposhnikoviae 15 parts, Radix Angelicae Pubescentis 15 parts, the Radix Angelicae Dahuricae 15 parts, 15 parts of Rhizoma Gastrodiae, Radix Paeoniae Rubra 10 parts, 10 parts of Radix Glycyrrhizae, Rhizoma Cimicifugae 10 parts, Scorpio 30 parts, Bombyx Batryticatus 10 parts, Flos Chrysanthemi 10 parts, 10 parts of Flos Carthami, Caulis Spatholobi 10 parts。
The preparation method of above-mentioned ointment, comprises the following steps successively:
A weighs RADIX ACONITILATERALIS PREPARATA, Radix Aconiti Preparata, Olibanum, Semen Ricini, Radix Saposhnikoviae, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Radix Glycyrrhizae, Rhizoma Cimicifugae, Scorpio, Bombyx Batryticatus, Flos Chrysanthemi and Radix Paeoniae Rubra according to above-mentioned weight, is ground into fine powder respectively, and mix homogeneously after 60 mesh sieves, obtains mixture one excessively；
B weighs Agkistrodon, is decaptitated by Agkistrodon, puts into after tail and be ground into powder in pulverizer, soaks 1h after crossing 60 mesh sieves, and vacuum filtration obtains filtrate one and filtering residue one, soaks 1h in described filtering residue one, and vacuum filtration obtains filtrate two and filtering residue two；
Filtrate one and filtrate two are merged by c, concentrate at 0.9KPa and 70 DEG C with Rotary Evaporators, add ethyl acetate and carry out defat, stand water intaking phase after shaking up, and then add ethanol in this aqueous phase, and after standing 24h, sucking filtration obtains paste one；
D is ground after Borneolum Syntheticum, Radix Angelicae Sinensis, Flos Carthami and Caulis Spatholobi being mixed, and obtains mixture two；
Mixture one, paste one and mixture two are stirred by e, obtain ointment。
The pharmacology of the present invention and Advantageous Effects:
RADIX ACONITILATERALIS PREPARATA is used for treating anemofrigid-damp arthralgia, and Radix Aconiti Preparata is used for anemofrigid-damp arthralgia, and joint cold type of pain, colic of cold type is had a pain and narcotic analgesic；Olibanum has effect of analgesic therapy of invigorating blood circulation, detumescence and promoting granulation；Semen Ricini has detumescence and drawing out poison, rushes down lower logical stagnant effect；Radix Saposhnikoviae has inducing diaphoresis to dispel wind, victory wets, effect of relieving convulsion；Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation；The Radix Angelicae Dahuricae has effect of expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping；Rhizoma Gastrodiae has effect of suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion；Radix Glycyrrhizae cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.；Rhizoma Cimicifugae has yang invigorating, delivers, rash, removing toxic substances effect；Scorpio have dispel the wind, relieving convulsion, dredging collateral, removing toxic substances effect；Bombyx Batryticatus has effect of expelling wind for relieving convulsion, dissipating phlegm and resolving masses；Flos Chrysanthemi has effect of scattered wind, heat-clearing and toxic substances removing；Radix Paeoniae Rubra has effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling；
Containing substantial amounts of polysaccharide and total flavones in the Agkistrodon in White Cloud Mountain, Fujian, process through secondary vacuum sucking filtration, Rotary Evaporators concentrates, addition ethyl acetate can obtain substantial amounts of extract after carrying out defat, alcohol extraction, and the consumption of organic solvent is few, extract is mixed with other medicines, the disease such as apoplexy and numb limbs and tense tendons is meciless, spasm of muscles and vessels, facial hemiparalysis can be cured mainly；
Borneolum Syntheticum has logical all keys, dissipates effect of stagnated fire, reducing swelling and alleviating pain；Radix Angelicae Sinensis has effect of replenishing and activating blood；Flos Carthami has effect of promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving；Caulis Spatholobi is used for rheumatic arthralgia, numb hand and foot, quadriplegia, blood deficiency and yellow complexion。
Above-mentioned all taste medicines, through dialectical compatibility, play effect of expelling wind for relieving convulsion, blood circulation promoting and blood stasis dispelling altogether。
Clinical data
1, case selection
Randomly choose 100 example facial paralysis clinic clients, be divided into treatment group 50 example and matched group 50 example, in treatment group, women 35 example, male 15 example, oldest 60 years old, minimum 16 years old of age, in matched group, women 34 example, male 16 example, oldest 64 years old, minimum 18 years old of age；
Above-mentioned treatment group and matched group are through statistical procedures no significant difference in the state of an illness, sex, age, the course of disease etc., and all cases all meet facial paralysis diagnostic criteria。
2, Therapeutic Method
Matched group: adopt acupuncture and moxibustion therapy；
Treatment group: on the basis of acupuncture and moxibustion therapy, is coated with ointment of the present invention, changes dressings every day once, and after the drug of topical application, few patients's skin is itched, but does not affect treatment, and the acupuncture point effect such as the medicine Combined with Acupuncture sun of the present invention, ShiShimonoseki, dicang is more preferably；
3, exclusion standard:
1. less than 16 years old, over-65s, gestation, women breast-feeding their children。
2. the infectious disease such as hepatitis B it are associated with。
3. allergic constitution patient。
(all meet any of the above described 1 for Excluded cases)
4, points for attention: quit smoking, wine and pungent, raw and cold, greasy food, wind sheltering；
5, curative effect judging standard: (be coated with 7 days for one the course for the treatment of standard)
Standard with reference to " new Chinese medicine guideline of clinical investigations "。
Effective: cardinal symptom is obviously improved or close to normal；
Effective: cardinal symptom has improvement；
Invalid: cardinal symptom is without improvement。
6, therapeutic effect
As shown in table 1, one course for the treatment of of Drug therapy of the present invention, effective 35 examples for the treatment of group, effective 14 examples, invalid 1 example, total effective rate 98% are adopted。
Effective 10 examples of matched group, effective 12 examples, invalid 28 examples, effective percentage 44%。
Table 1
Classification Effective/example Effectively/example Invalid/example Total effectively example
Treatment group 35 14 1 49
Matched group 10 12 28 22
From above-mentioned table 1 it can be seen that between above-mentioned two groups, difference has very significant, and treatment group is substantially better than matched group。
7, model case
Mrs Wang, 33 years old, in JIUYUE, 2013 was gone to a doctor。Main suit: bimester before an evening, go home after eating up chaffy dish sleep, owing to heat turns on air-conditioning, one the entire night does not close, and second day early morning woke up, it has been found that the corners of the mouth sialorrhea of oneself, one looks in the mirror finds that mouth strabismus is askew, and period has adopted acupuncture and moxibustion therapy, but effect is bad；Check: be diagnosed as facial paralysis。Treatment: smear ointment of the present invention, once a day, the Combined with Acupuncture sun, ShiShimonoseki, dicang acupuncture point, acupuncture every day three times；After one course for the treatment of, patient makes moderate progress；Continuing to smear a course for the treatment of, patient fully recovers, efficacy determination: effectively。
Detailed description of the invention
Embodiment 1:
Weigh RADIX ACONITILATERALIS PREPARATA 10g, Radix Aconiti Preparata 10g, Olibanum 5g, Semen Ricini 20g, Borneolum Syntheticum 0.5g, Agkistrodon 20g, Radix Angelicae Sinensis 10g, Radix Saposhnikoviae 10g, Radix Angelicae Pubescentis 20g, Radix Angelicae Dahuricae 20g, Rhizoma Gastrodiae 20g, Radix Glycyrrhizae 5g, Rhizoma Cimicifugae 5g, Scorpio 40g, Bombyx Batryticatus 5g, Flos Chrysanthemi 5g, Radix Paeoniae Rubra 15g, Flos Carthami 15g, Caulis Spatholobi 15g are raw material, prepare ointment by following method。
Specifically comprise the following steps that
A, by Radix Aconiti Lateralis Preparata, Radix Aconiti Preparata, Olibanum, Semen Ricini, Radix Saposhnikoviae, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Radix Glycyrrhizae, Rhizoma Cimicifugae, Scorpio, Bombyx Batryticatus, Flos Chrysanthemi and Radix Paeoniae Rubra, is ground into fine powder respectively, and mix homogeneously after 60 mesh sieves, obtains mixture one excessively；
B weighs Agkistrodon, being decaptitated by Agkistrodon (White Cloud Mountain, Fujian), put into after tail and be ground into powder in pulverizer, soak 1h after crossing 60 mesh sieves, vacuum filtration obtains filtrate one and filtering residue one, soaking 1h in described filtering residue one, vacuum filtration obtains filtrate two and filtering residue two；
Filtrate one and filtrate two are merged by c, concentrate at 0.9KPa and 70 DEG C with Rotary Evaporators, add ethyl acetate and carry out defat, stand water intaking phase after shaking up, and then add ethanol in this aqueous phase, and after standing 24h, sucking filtration obtains paste one；This extracting method can extract the maximum amount of polysaccharide and total flavones；
D is ground after Borneolum Syntheticum, Radix Angelicae Sinensis, Flos Carthami and Caulis Spatholobi being mixed, and obtains mixture two after crossing 90 mesh sieves；
Mixture one, paste one and mixture two are stirred by e, obtain ointment of the present invention。
The using method of the present embodiment ointment:
Before the drug of topical application with hot Rhizoma Zingiberis wipe affected part, wipe to contrafluxion, ointment of the present invention is coated in affected part, on to temple, down to dicang, wide about 3 centimetres, use gauze mulching, immobilization with adhesive tape, with hot water bag hot compress on gauze, change dressings every day 1 time, till transference cure。
Embodiment 2:
Weigh RADIX ACONITILATERALIS PREPARATA 20g, Radix Aconiti Preparata 20g, Olibanum 5g, Semen Ricini 40g, Borneolum Syntheticum 1g, Agkistrodon 40g, Radix Angelicae Sinensis 20g, Radix Saposhnikoviae 20g, Radix Angelicae Pubescentis 10g, Radix Angelicae Dahuricae 10g, Rhizoma Gastrodiae 10g, Radix Glycyrrhizae 15g, Rhizoma Cimicifugae 15g, Scorpio 20g, Bombyx Batryticatus 15g, Flos Chrysanthemi 15g, Radix Paeoniae Rubra 5g, Flos Carthami 5g, Caulis Spatholobi 5g are raw material。
Preparation method, using method and embodiment 1 are identical。
Embodiment 3:
Weigh RADIX ACONITILATERALIS PREPARATA 15g, Radix Aconiti Preparata 15g, Olibanum 10g, Semen Ricini 30g, Borneolum Syntheticum 0.9g, Agkistrodon 30g, Radix Angelicae Sinensis 15g, Radix Saposhnikoviae 15g, Radix Angelicae Pubescentis 15g, Radix Angelicae Dahuricae 15g, Rhizoma Gastrodiae 15g, Radix Glycyrrhizae 10g, Rhizoma Cimicifugae 10g, Scorpio 30g, Bombyx Batryticatus 10g, Flos Chrysanthemi 10g, Radix Paeoniae Rubra 10g, Flos Carthami 10g, Caulis Spatholobi 10g are raw material。
Preparation method, using method and embodiment 1 are identical。
Embodiment 4:
Weigh RADIX ACONITILATERALIS PREPARATA 10g, Radix Aconiti Preparata 20g, Olibanum 5g, Semen Ricini 40g, Borneolum Syntheticum 0.5g, Agkistrodon 40g, Radix Angelicae Sinensis 10g, Radix Saposhnikoviae 20g, Radix Angelicae Pubescentis 10g, Radix Angelicae Dahuricae 10g, Rhizoma Gastrodiae 10g, Radix Glycyrrhizae 15g, Rhizoma Cimicifugae 5g, Scorpio 20g, Bombyx Batryticatus 15g, Flos Chrysanthemi 5g, Radix Paeoniae Rubra 15g, Flos Carthami 5g, Caulis Spatholobi 15g are raw material。
Preparation method, using method and embodiment 1 are identical。
Embodiment 5:
Weigh RADIX ACONITILATERALIS PREPARATA 15g, Radix Aconiti Preparata 10g, Olibanum 5g, Semen Ricini 30g, Borneolum Syntheticum 0.5g, Agkistrodon 30g, Radix Angelicae Sinensis 15g, Radix Saposhnikoviae 10g, Radix Angelicae Pubescentis 20g, Radix Angelicae Dahuricae 15g, Rhizoma Gastrodiae 15g, Radix Glycyrrhizae 10g, Rhizoma Cimicifugae 10g, Scorpio 40g, Bombyx Batryticatus 15g, Flos Chrysanthemi 5g, Radix Paeoniae Rubra 5g, Flos Carthami 15g, Caulis Spatholobi 15g are raw material。
Preparation method, using method and embodiment 1 are identical。
Embodiment 6:
Weigh RADIX ACONITILATERALIS PREPARATA 20g, Radix Aconiti Preparata 15g, Olibanum 10g, Semen Ricini 35g, Borneolum Syntheticum 0.9g, Agkistrodon 20g, Radix Angelicae Sinensis 15g, Radix Saposhnikoviae 15g, Radix Angelicae Pubescentis 20g, Radix Angelicae Dahuricae 10g, Rhizoma Gastrodiae 10g, Radix Glycyrrhizae 10g, Rhizoma Cimicifugae 10g, Scorpio 20g, Bombyx Batryticatus 10g, Flos Chrysanthemi 10g, Radix Paeoniae Rubra 15g, Flos Carthami 5g, Caulis Spatholobi 15g are raw material。
Preparation method, using method and embodiment 1 are identical。
Embodiment 7:
Weigh RADIX ACONITILATERALIS PREPARATA 18g, Radix Aconiti Preparata 18g, Olibanum 5g, Semen Ricini 30g, Borneolum Syntheticum 0.5g, Agkistrodon 40g, Radix Angelicae Sinensis 15g, Radix Saposhnikoviae 15g, Radix Angelicae Pubescentis 20g, Radix Angelicae Dahuricae 15g, Rhizoma Gastrodiae 15g, Radix Glycyrrhizae 5g, Rhizoma Cimicifugae 5g, Scorpio 40g, Bombyx Batryticatus 5g, Flos Chrysanthemi 10g, Radix Paeoniae Rubra 5g, Flos Carthami 15g, Caulis Spatholobi 5g are raw material。
Preparation method, using method and embodiment 1 are identical。
Embodiment 8:
Weigh RADIX ACONITILATERALIS PREPARATA 20g, Radix Aconiti Preparata 15g, Olibanum 10g, Semen Ricini 40g, Borneolum Syntheticum 0.5g, Agkistrodon 40g, Radix Angelicae Sinensis 20g, Radix Saposhnikoviae 10g, Radix Angelicae Pubescentis 20g, Radix Angelicae Dahuricae 20g, Rhizoma Gastrodiae 20g, Radix Glycyrrhizae 15g, Rhizoma Cimicifugae 10g, Scorpio 30g, Bombyx Batryticatus 5g, Flos Chrysanthemi 10g, Radix Paeoniae Rubra 5g, Flos Carthami 10g, Caulis Spatholobi 10g are raw material。
Preparation method, using method and embodiment 1 are identical。

Claims (3)

1. one kind is used for treating prosopoplegic ointment, it is characterised in that it is to be prepared from by the raw material of Chinese medicine of following weight:
RADIX ACONITILATERALIS PREPARATA 10～20 parts, Radix Aconiti Preparata 10～20 parts, Olibanum 5～15 parts, Semen Ricini 20～40 parts, Borneolum Syntheticum 0.5～1 part, Agkistrodon 20～40 parts, Radix Angelicae Sinensis 10～20 parts, Radix Saposhnikoviae 10～20 parts, Radix Angelicae Pubescentis 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, 10～20 parts of Rhizoma Gastrodiae, 5～15 parts of Radix Glycyrrhizae, Rhizoma Cimicifugae 5～15 parts, Scorpio 20～40 parts, Bombyx Batryticatus 5～15 parts, Flos Chrysanthemi 5～15 parts, Radix Paeoniae Rubra 5～15 parts, 5～15 parts of Flos Carthami, Caulis Spatholobi 5～15 parts；
Described Agkistrodon originates from White Cloud Mountain, Fujian。
2. according to claim 1 for treating prosopoplegic ointment, it is characterized in that, the weight of each raw material of Chinese medicine is: RADIX ACONITILATERALIS PREPARATA 15 parts, Radix Aconiti Preparata 15 parts, Olibanum 10 parts, Semen Ricini 30 parts, Borneolum Syntheticum 0.9 part, Agkistrodon 30 parts, Radix Angelicae Sinensis 15 parts, Radix Saposhnikoviae 15 parts, Radix Angelicae Pubescentis 15 parts, the Radix Angelicae Dahuricae 15 parts, 15 parts of Rhizoma Gastrodiae, 10 parts of Radix Glycyrrhizae, Rhizoma Cimicifugae 10 parts, Scorpio 30 parts, Bombyx Batryticatus 10 parts, Flos Chrysanthemi 10 parts, Radix Paeoniae Rubra 10 parts, 10 parts of Flos Carthami, Caulis Spatholobi 10 parts。
3. the preparation method of ointment according to claim 1 and 2, it is characterised in that comprise the following steps successively:
A weighs RADIX ACONITILATERALIS PREPARATA, Radix Aconiti Preparata, Olibanum, Semen Ricini, Radix Saposhnikoviae, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Glycyrrhizae, Rhizoma Cimicifugae, Scorpio, Bombyx Batryticatus and Flos Chrysanthemi according to above-mentioned weight, is ground into fine powder respectively, and mix homogeneously after 60 mesh sieves, obtains mixture one excessively；
B weighs Agkistrodon, is decaptitated by Agkistrodon, puts into after tail and be ground into powder in pulverizer, soaks 1h after crossing 60 mesh sieves, and vacuum filtration obtains filtrate one and filtering residue one, soaks 1h in described filtering residue one, and vacuum filtration obtains filtrate two and filtering residue two；
Filtrate one and filtrate two are merged by c, concentrate at 0.9KPa and 70 DEG C with Rotary Evaporators, add ethyl acetate and carry out defat, stand water intaking phase after shaking up, and then add ethanol in this aqueous phase, and after standing 24h, sucking filtration obtains paste one；
D is ground after Borneolum Syntheticum, Radix Angelicae Sinensis, Flos Carthami and Caulis Spatholobi being mixed, and obtains mixture two；
Mixture one, paste one and mixture two are stirred by e, obtain ointment。
CN201610149247.9A 2016-03-16 2016-03-16 Ointment for treating facioplegia Pending CN105687795A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102641490A (en) * 2012-04-16 2012-08-22 朱廷学 Medicinal extract for treating facial nerve paralysis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102641490A (en) * 2012-04-16 2012-08-22 朱廷学 Medicinal extract for treating facial nerve paralysis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
孙显军 等: "《土单方》", 31 December 2014, 江西科学技术出版社 *
进生 等: "《中国民间秘方大全》", 31 August 1992, 世界图书出版公司 *

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Application publication date: 20160622