CN104940887A - Application of drug combination - Google Patents
Application of drug combination Download PDFInfo
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- CN104940887A CN104940887A CN201510426216.9A CN201510426216A CN104940887A CN 104940887 A CN104940887 A CN 104940887A CN 201510426216 A CN201510426216 A CN 201510426216A CN 104940887 A CN104940887 A CN 104940887A
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Abstract
The invention relates to new application of a drug combination in the field of pharmacy, and belongs to the technical field of traditional Chinese medicine, wherein the drug combination includes curcuma longa, coral ginger and other ingredients The drug combination comprises 50 parts of curcuma longa, 50 parts of paris, 50 parts of perfoliate knotweed, 25 parts of chenopodium ambrosioides, 25 parts of goldenrod, 25 parts of rba gynostemae and 50 parts of the coral ginger. The drug combination has the functions of relieving acute soft tissue contusion swelling and improving pathological changes of tissue and can be used for treating traumatic injuries as well as tenosynovitis, lumbar disc herniation, hyperosteogeny and pruritus caused by medical diseases.
Description
Technical field
The present invention is a kind of purposes of pharmaceutical composition, belongs to the technical field of Chinese medicine.
Background technology
Eliminating acne turmeric liniment is OTC (over-the-counter) class liniment, and main component is Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Polygoni cymosi, Herba Solidaginis, Herba Chenopodii, Herb Gynostemmae Pentaphylli, Rhizoma Zingiberis corallini, for the acne (acne) caused by damp and hot strongly fragrant skin.The preparation method of existing product is as follows: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, and vapor distillation extracts volatile oil, for subsequent use.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, carry out percolation according to the percolation (Chinese Pharmacopoeia version in 2000 annex I O) under fluid extract and extractum item with 6 times amount 80% ethanol as solvent, collect liquid of filtering, for subsequent use.Get Herba Polygoni cymosi, Herba Chenopodii, decoct with water three times, 2 hours first times, second time 1.5 hours, 1 hour third time, collecting decoction, filter, it is 1.18 ~ 1.22(60 DEG C that filtrate is concentrated into relative density) clear paste, add ethanol and reach 50% to alcohol content, leave standstill 24 hours and filter, filtrate and above-mentioned liquid of filtering merge.Separately getting after volatile oil adds polyoxyethylene sorbitan monoleate emulsifying adds in above-mentioned medicinal liquid, mixing, filters, is adjusted to ormal weight, obtains final product.
Summary of the invention
The object of the present invention is to provide the novelty teabag of this Chinese patent medicine, the new opplication namely in pharmacy.
In fact, the present invention relates to activated feedstock be Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Polygoni cymosi, Herba Solidaginis, Herba Chenopodii, Herb Gynostemmae Pentaphylli, Rhizoma Zingiberis corallini pharmaceutical composition as preparation treatment traumatic injury medicine in application.
Relate to this pharmaceutical composition as the application in the medicine of preparation treatment tenosynovitis.
Relate to this pharmaceutical composition as the application in the medicine of preparation treatment prolapse of lumbar intervertebral disc.
Relate to this pharmaceutical composition as the application in the medicine of preparation treatment hyperosteogeny.
Relate to the application in the medicine of the pruritus that this pharmaceutical composition causes as preparation treatment internal disease.
The internal disease of the described pruritus that often occurs together has: chronic kidney hypofunction, cholestasis, gestation, polycythemia vera, anemia, hyperthyroidism, diabetes, multiple sclerosis, psychological psychosis, tumor, systemic parasitic disease, drug eruption, sjogren syndrome, HIV (human immunodeficiency virus) (HIV) infect.
Pharmacodynamic experiment result shows, this pharmaceutical composition has analgesia, alleviates the effect of acute soft tissue contusion swelling, and improve the pathological change of tissue, show as subcutaneous tissue and muscle tissue damage alleviates, neutrophil infiltrates reduces, tissue repair is very fast.Can be used for treating traumatic injury, tenosynovitis.
Pharmacodynamic experiment result shows, this pharmaceutical composition can improve microcirculation, slow down the effect of nerve root injury, has good therapeutic effect to the lumbago and skelalgia symptom that prolapse of lumbar intervertebral disc causes.
Pharmacodynamic experiment result also shows, this pharmaceutical composition can improve the blood viscosity of dextran acid anhydride blood stasis rabbit, Rat Tall Flick reaction caused by Carrageenan swollen feet, cott on pellet-induced granuloma formation and photo-thermal all has remarkable inhibitory action, can be used for treating hyperosteogeny.
Pharmacodynamic experiment result also shows, this pharmaceutical composition can suppress the isolated ileum segments in guinea pigs smooth muscle anaphylaxis caused by ovalbumin (OA) to be shunk; The mast cell granule that remarkable suppression OA causes; Significantly can suppress the lymphocytic conversion of T in Freund's complete adjuvant sensitized rats blood.The foot swelling that can significantly suppress OA to cause, and reduce the content of PGE in inflammatory tissue; Excite dermatitis skin lesion to be that tissue has obvious therapeutic action to OA sensitization, and reduce the content of IL-2 in delayed hypersensitivity tissue caused by Freund's complete adjuvant; The Mice licking response that remarkable suppression 4-aminopyridine brings out., can be used for the pruritus that treatment internal disease causes.
Comprehensive above-mentioned experimental result, can draw and the invention has the advantages that:
(1) the present invention has excavated new medical application to known Chinese patent medicine eliminating acne turmeric liniment, has opened up new application.
(2) product of the present invention can be prepared into the external preparation such as liniment, gel, Emulsion, spray.
concrete embodiment
Embodiment 1: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, vapor distillation extracts volatile oil, for subsequent use.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, carry out percolation according to the percolation (Chinese Pharmacopoeia version in 2000 annex I O) under fluid extract and extractum item with 6 times amount 80% ethanol as solvent, collect liquid of filtering, for subsequent use.Get Herba Polygoni cymosi, Herba Chenopodii, decoct with water three times, 2 hours first times, second time 1.5 hours, 1 hour third time, collecting decoction, filter, it is 1.18 ~ 1.22(60 DEG C that filtrate is concentrated into relative density) clear paste, add ethanol and reach 50% to alcohol content, leave standstill 24 hours and filter, filtrate and above-mentioned liquid of filtering merge.Separately getting after volatile oil adds polyoxyethylene sorbitan monoleate emulsifying adds in above-mentioned medicinal liquid, mixing, filters, is adjusted to ormal weight, obtains liniment.
Usage and dosage: external.Medicine is applied to affected part, outer wiping every day 2-3 time.
Embodiment 2: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, and vapor distillation extracts volatile oil, adds appropriate propylene glycol and dissolves rear for subsequent use.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, carry out percolation according to the percolation (Chinese Pharmacopoeia version in 2000 annex I O) under fluid extract and extractum item with 6 times amount 80% ethanol as solvent, collect liquid of filtering, for subsequent use.Get Herba Polygoni cymosi, Herba Chenopodii, decoct with water three times, 2 hours first times, second time 1.5 hours, 1 hour third time, collecting decoction, filter, it is 1.18 ~ 1.22(60 DEG C that filtrate is concentrated into relative density) clear paste, add ethanol and reach 50% to alcohol content, leave standstill 24 hours and filter, filtrate and above-mentioned liquid of filtering merge.Reclaiming ethanol to relative density is 1.04 ~ 1.06(60 DEG C) for subsequent use.Get stearic acid 100g, lanoline 50g, paraffin 100g, liquid paraffin 80ml mix homogeneously, be heated to 85 DEG C, stirring adds above-mentioned medicinal liquid after dissolving, mix and blend 20 minutes, stop heating, treat that temperature of charge is reduced to less than 40 DEG C, add the propylene glycol solution of above-mentioned volatile oil, stir and obtain ointment.
Usage and dosage: external.Ointment is applied to affected part, outer wiping every day 2-3 time.
Embodiment 3: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, and vapor distillation extracts volatile oil, for subsequent use after adding appropriate dissolve with ethanol.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, carry out percolation according to the percolation (Chinese Pharmacopoeia version in 2000 annex I O) under fluid extract and extractum item with 6 times amount 80% ethanol as solvent, collect liquid of filtering, for subsequent use.Get Herba Polygoni cymosi, Herba Chenopodii, decoct with water three times, 2 hours first times, second time 1.5 hours, 1 hour third time, collecting decoction, filter, it is 1.18 ~ 1.22(60 DEG C that filtrate is concentrated into relative density) clear paste, add ethanol and reach 50% to alcohol content, leave standstill 24 hours filter, the alcoholic solution of filtrate and above-mentioned filter liquid and volatile oil merges, mix homogeneously, is dispensed in pressure vessel, pours compressed nitrogen and namely obtains spray.
Usage and dosage: external.Medicine is sprayed at affected part, outer wiping every day 2-3 time.
Embodiment 4: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, and vapor distillation extracts volatile oil, for subsequent use after adding appropriate dissolve with ethanol.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, carry out percolation according to the percolation (Chinese Pharmacopoeia version in 2000 annex I O) under fluid extract and extractum item with 6 times amount 80% ethanol as solvent, collect liquid of filtering, for subsequent use.Get Herba Polygoni cymosi, Herba Chenopodii, decoct with water three times, 2 hours first times, second time 1.5 hours, 1 hour third time, collecting decoction, filter, it is 1.18 ~ 1.22(60 DEG C that filtrate is concentrated into relative density) clear paste, add ethanol and reach 50% to alcohol content, leave standstill 24 hours and filter, the alcoholic solution of filtrate and above-mentioned filter liquid and volatile oil merges, mix homogeneously, decompression recycling ethanol to relative density ρ=1.05 ~ 1.08(60 DEG C), add 2 times of water to stir, add the 940 type carbomers of 1% again, stir 1 hour, add the propylene glycol solution of volatile oil again, homogenizing 30 minutes, pH=6 ~ 7 are regulated with triethanolamine, homogenizing 30 minutes again, obtain gel.
Claims (6)
1. the application of following pharmaceutical composition in the medicine of preparation treatment traumatic injury:
50 parts, Rhizoma Curcumae Longae, Rhizoma Paridis 50 parts, Herba Polygoni cymosi 50 parts, Herba Chenopodii 25 parts, Herba Solidaginis 25 parts, Herb Gynostemmae Pentaphylli 25 parts, Rhizoma Zingiberis corallini 50 parts
Above-mentioned number is weight portion.
2. the application of pharmaceutical composition according to claim 1 in the medicine of preparation treatment tenosynovitis.
3. the application of pharmaceutical composition according to claim 1 in the medicine of preparation treatment hyperosteogeny.
4. the application of pharmaceutical composition according to claim 1 in the medicine of preparation treatment prolapse of lumbar intervertebral disc.
5. pharmaceutical composition according to claim 1 treats the application in the medicine of the pruritus that internal disease causes in preparation.
6. application according to claim 5, wherein internal disease comprises chronic kidney hypofunction, cholestasis, gestation, polycythemia vera, anemia, hyperthyroidism, diabetes, multiple sclerosis, psychological psychosis, tumor, systemic parasitic disease, drug eruption, sjogren syndrome, HIV (human immunodeficiency virus) infection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510426216.9A CN104940887A (en) | 2015-07-20 | 2015-07-20 | Application of drug combination |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510426216.9A CN104940887A (en) | 2015-07-20 | 2015-07-20 | Application of drug combination |
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| Publication Number | Publication Date |
|---|---|
| CN104940887A true CN104940887A (en) | 2015-09-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510426216.9A Pending CN104940887A (en) | 2015-07-20 | 2015-07-20 | Application of drug combination |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159352A (en) * | 2021-12-16 | 2022-03-11 | 广州温雅日用化妆品有限公司 | Bacteriostatic and itching-relieving foam shampoo |
| CN118001366A (en) * | 2024-01-31 | 2024-05-10 | 明远药业有限公司 | Special medicine for treating acne and acnes in puberty and preparation process thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895632A (en) * | 2006-06-15 | 2007-01-17 | 贵阳舒美达制药厂有限公司 | Compound turmeric acne-eliminating gel and its preparation |
| CN101524509A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Curcuma acne eliminating gel paste for treating acne |
-
2015
- 2015-07-20 CN CN201510426216.9A patent/CN104940887A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895632A (en) * | 2006-06-15 | 2007-01-17 | 贵阳舒美达制药厂有限公司 | Compound turmeric acne-eliminating gel and its preparation |
| CN101524509A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Curcuma acne eliminating gel paste for treating acne |
Non-Patent Citations (2)
| Title |
|---|
| 陈嬝嬝等: "姜黄消痤搽剂对大、小鼠炎症组织的抗炎作用", 《中国实验方剂学杂志》 * |
| 陈嬝嬝等: "姜黄消痤搽剂抗过敏及止痒作用的实验研究", 《现代中医药》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159352A (en) * | 2021-12-16 | 2022-03-11 | 广州温雅日用化妆品有限公司 | Bacteriostatic and itching-relieving foam shampoo |
| CN114159352B (en) * | 2021-12-16 | 2024-06-28 | 广州温雅日用化妆品有限公司 | Foam shampoo with antibacterial and antipruritic effects |
| CN118001366A (en) * | 2024-01-31 | 2024-05-10 | 明远药业有限公司 | Special medicine for treating acne and acnes in puberty and preparation process thereof |
| CN118001366B (en) * | 2024-01-31 | 2025-08-15 | 明远药业有限公司 | Special medicine for treating acne and acnes in puberty and preparation process thereof |
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Application publication date: 20150930 |
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