CN102727542A - Ointment with function of relieving swelling and pain - Google Patents
Ointment with function of relieving swelling and pain Download PDFInfo
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- CN102727542A CN102727542A CN2012102459215A CN201210245921A CN102727542A CN 102727542 A CN102727542 A CN 102727542A CN 2012102459215 A CN2012102459215 A CN 2012102459215A CN 201210245921 A CN201210245921 A CN 201210245921A CN 102727542 A CN102727542 A CN 102727542A
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- ointment
- herba sarcandrae
- commonly used
- extract
- alleviating pain
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Abstract
The invention relates to an ointment with a function of relieving swelling and pain and a preparation process of the ointment. The ointment is prepared by the steps of adding a common base material for ointments into glabrous sarcandra herb extract serving as an effective medicinal activity component, or adding borneol and the common base material for ointments into the glabrous sarcandra herb extract. According to the invention, glabrous sarcandra herb which has the functions of clearing away heat and toxic materials and activating meridians to stop pain is used as an externally applied ointment for the first time. The aqueous extract of glabrous sarcandra herb is subjected to macroporous absorption resin column chromatography to enrich phenolic acid, flavones and coumarin in the aqueous extract so as to prepare the ointment having the function of relieving swelling and pain. The ointment has the advantages of obvious effect, convenience in use, good patient compliance, few toxic and side effects and no anaphylaxis and is quite applicable to the treatment on soft tissue injury in cooperation with Chinese massage manipulation.
Description
Technical field
The present invention relates to a kind of reducing swelling and alleviating pain ointment and preparation technology thereof.
Background technology
Herba Sarcandrae has another name called Herba Pileae Scriptae, Herba Pileae Scriptae, synthetism tea etc., is that " Chinese pharmacopoeia is recorded Chinese crude drug, and all province the in China south and southwest used traditional herbal medicine always, is the dry herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Acrid in the mouth, hardship, property is flat.Effects such as anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain, the synthetism of stimulating the menstrual flow are arranged.The dosage form that Chinese Pharmacopoeia, ministry standard are recorded has ZHONGJIEFENG PIAN, XUEKANG KOUFUYE, QINGRE XIAOYANNING JIAONANG and ZHONGJIEFENG ZHUSHEYE.Do not put down in writing the Herba Sarcandrae exterior-applied formulation.
Summary of the invention
The object of the present invention is to provide a kind of is the reducing swelling and alleviating pain ointment of main component with the Herba Sarcandrae.
A kind of reducing swelling and alleviating pain ointment of the present invention, adopting Herba Sarcandrae extract is pharmaceutically active effective site, adds ointment substrate preparation commonly used.The weight ratio of Herba Sarcandrae extract and ointment substrate commonly used is 1:1-8.
More preferably, be main pharmaceutically active effective site with Herba Sarcandrae extract, add the substrate preparation commonly used of Borneolum Syntheticum and ointment.The weight ratio of said Herba Sarcandrae extract and ointment substrate commonly used is 1:1-10; The weight of said Borneolum Syntheticum accounts for the 0.6-6% of ointment substrate weight commonly used.
Said ointment substrate commonly used is selected from glycerol, stearic acid, octadecanol, liquid Paraffin, triethanolamine, tween 80, sorbic acid, the ethyl hydroxybenzoate one or more.
The preparation of said Herba Sarcandrae extract may further comprise the steps:
(1) get Herba Sarcandrae decocte with water 2-3 time, each 1-3 hour, collecting decoction filtered, the clear paste that it is 1.05-1.35 that filtrating is concentrated into 70 ℃ of relative densities, or the continuation drying obtains Herba Sarcandrae extractum;
(2) get Herba Sarcandrae clear paste or with the 5-10 times of dissolved Herba Sarcandrae extractum of water gaging; Go up nonpolar or Semi-polarity macroporous adsorptive resins; Absorption is with 1-3 times of column volume washing post, 2-4 times of column volume of washing back reuse 30-80% ethanol elution; Collect the eluent at phenolic acid, flavone and coumarin position, this eluent is reclaimed ethanol and be concentrated into 70 ℃ of relative densities the clear paste that is 1.10-1.20.
Said nonpolar macroporous adsorption resin comprises D101, XAD-4, and said Semi-polarity macroporous adsorbent resin comprises HPD-400.
Said reducing swelling and alleviating pain ointment prepares by conventional emulsifiable paste method, like emulsion process.
The present invention exists with the form of external unguentum this traditional heat-clearing and toxic substances removing of Herba Sarcandrae, removing obstruction in the collateral to relieve pain Chinese crude drug for the first time as medicine.Through macroporous adsorbent resin column chromatography, enrichment is phenolic acid, flavone and coumarin position wherein, processes the ointment with anti-inflammatory analgetic with the Herba Sarcandrae the water extracted immersing paste.It is obvious that said preparation has effect, easy to use, good patient compliance, and toxic and side effects is few, and sensitization is not particularly useful for cooperating traditional Chinese massage manipulation soft tissue injury etc.
The specific embodiment
Below be several instance of the present invention, further describe the present invention, but the present invention be not limited only to this.
Embodiment 1
Get the Chinese medicinal material of sarcandra glaber decocte with water 2 times, each 2 hours, collecting decoction filtered, and it is 1.05 clear paste that filtrating is concentrated into 70 ℃ of relative densities, crosses the HPD-400 macroporous adsorptive resins.Appearance volume and resin volume ratio is 4:1 on the clear paste, washing 1BV (column volume) earlier, and reuse 80% ethanol elution volume 3BV collects this position eluent, eluent recovery ethanol and to be concentrated into density be 1.20 clear paste.Make ointment by following prescription and technology.
Prescription: clear paste 1-5g, water 1-5g, glycerol 1-5g, stearic acid 1-5g, octadecanol 0.5-2g, liquid Paraffin 1-5g, tween 80 0.5-2g, potassium sorbate 0.01-0.1g, Borneolum Syntheticum 0. 06-0.6g
Preparation technology: with oil phases such as above-mentioned stearic acid, liquid Paraffin, octadecanol, waters such as clear paste, glycerol, tween 80, potassium sorbate are respectively at heating mixing in the hot bath; Stir down, oil phase is slowly added the aqueous phase of same temperature (80-90 ℃), add Borneolum Syntheticum in the time of 60 ℃ again, stir, cooling, packing promptly gets ointment.
Embodiment 2
Get the Chinese medicinal material of sarcandra glaber decocte with water 3 times, each 1 hour, collecting decoction filtered, and filtrating concentrates, and spray drying gets extractum.Get Herba Sarcandrae extractum and add 10 times of water gagings, ultrasonic dissolution is crossed the XAD-4 macroporous adsorptive resins.Appearance volume and resin volume ratio are 3:1 on the solution, wash 2BV (column volume) earlier, and reuse 50% ethanol elution volume 4BV collects this position eluent.It is 1.10 clear paste that this eluent is concentrated into density.Make ointment by following prescription and technology.
Prescription: clear paste 1-5g, water 1-5g,, glycerol 1-5g, stearic acid 1-8g, octadecanol 0.5-3g, liquid Paraffin 1-5 g, triethanolamine 1-5g, ethyl hydroxybenzoate 0.01-0.1g, Borneolum Syntheticum 0.08-0.8g
Preparation technology: waters such as oil phases such as above-mentioned stearic acid, octadecanol, liquid Paraffin, clear paste, glycerol, triethanolamine are heated mixing respectively; Stir down, oil phase is slowly added aqueous phase, add Borneolum Syntheticum in the time of 55-60 ℃, be stirred to semi-solid, solidify, packing promptly gets ointment.
Embodiment 3
Get the Chinese medicinal material of sarcandra glaber decocte with water 2 times, each 3 hours, collecting decoction filtered, and it is 1.35 clear paste that filtrating is concentrated into 70 ℃ of relative densities, crosses the D101 macroporous adsorptive resins.Absorption, first washing 3BV (column volume), reuse 30% ethanol elution volume 2BV collects this position eluent, and eluent reclaims ethanol and is concentrated into density is 1.20 clear paste.Make ointment by following prescription and technology.
Prescription: clear paste 1-5g, water 1-5g, glycerol 1-5g, stearic acid 1-5g, octadecanol 0.5-2g, liquid Paraffin 1-5g, tween 80 0.5-2g, potassium sorbate 0.01-0.1g.Through conventional emulsion process preparation.
Three, easing pain and diminishing inflammation drug effect experiment
1, analgesia
Method: kunming mice, administration 1 time/day, totally 3 days, the depilation area was 2x3cm, (the every gram of 1. high, normal, basic dose groups sample emulsifiable paste contains Herba Sarcandrae extract respectively and is equivalent to raw medicinal herbs 4g, 2g, 1g reducing swelling and alleviating pain ointment experimental group; 2. to contain the Borneolum Syntheticum amount identical for the emulsifiable paste sample that lacks Herba Sarcandrae group and high, normal, basic dose groups; 3, emulsifiable paste lacks Borneolum Syntheticum group sample to contain the Herba Sarcandrae extract amount suitable with high dose group), dosage be 0.3g/ only, positive drug (diclofenac) be 0.05g/ only, injection 0.6% glacial acetic acid causes pain behind the last administration 1h, the interior mouse writhing number of times of calculating 20min.
The analgesic effect of the different groups of table 1
Show like table 1 experimental result:
(1), blank control group is compared p=0.972 (P＞0.05), there was no significant difference with emulsifiable paste matrix; Emulsifiable paste lacks the Herba Sarcandrae group and compares p=0.820, p=0,489 (P＞0.05), there was no significant difference with blank, emulsifiable paste matrix.
(2), the emulsifiable paste high dose compares with emulsifiable paste matrix, p=0.001 (P＜0.01) has utmost point significant difference, turns round the body suppression ratio and reaches 52.22%; Middle dose groups p=0.033 (P＜0.05); Low dose group p=0.089 (P＞0.05); Certain dose-effect relationship is arranged.The illustrative experiment medicine has significant analgesia role.
(3), emulsifiable paste lacks the Borneolum Syntheticum group and blank, emulsifiable paste matrix more all have utmost point significant difference, explains that the Herba Sarcandrae extract emulsifiable paste has analgesic activity.
(4), after the Herba Sarcandrae extract emulsifiable paste adds Borneolum Syntheticum, turn round the body suppression ratio and rise to 52.22% from 47.41%, improved the analgesic effect of experiment medicine.
2, antiinflammatory
Method: kunming mice, administration 1 day 3 times, totally 1 day; The depilation area is 2x3cm, reducing swelling and alleviating pain ointment experimental group (it is the same respectively to organize laboratory sample), and dosage is 0.3g/; Positive drug (compound recipe dexamethasone) is 0.1g/, behind the last administration 1h, is coated with the caused by dimethylbenzene xylene inflammation in mouse right ear; Behind the 1h, put to death and cut left and right sides ear, weigh with the card punch punching of 8mm.(swelling degree=auris dextra-left ear)
The antiinflammatory effect of the different groups of table 2
The result shows like table 2:
(1), blank and emulsifiable paste matrix group compares P=0.630 (P＞0.05), two groups of there was no significant differences.
(2), the high, normal, basic dosage of emulsifiable paste compares with emulsifiable paste matrix, p=0 (P＜0.01) has utmost point significant difference, inhibitory rate of intumesce reaches 48.89%, 46.55%, 47.67%, the illustrative experiment medicine has tangible antiinflammation.
(3), scarce Herba Sarcandrae group of emulsifiable paste and emulsifiable paste matrix group compare P=0.065 (P＞0.05), two groups of there was no significant differences; Emulsifiable paste lacks the Borneolum Syntheticum group to be compared with emulsifiable paste matrix, and p=0.005 (P＜0.01) has utmost point significant difference; Explain that the Herba Sarcandrae extract emulsifiable paste has tangible antiinflammation.
(4), scarce Borneolum Syntheticum group of emulsifiable paste and high dose group compare P=0.058 (P＞0.05), two groups of there was no significant differences; But the difference of their inhibitory rate of intumesce 29.26% and 48.89% should be found out: the emulsifiable paste antiinflammatory effect that adds Borneolum Syntheticum is than not adding.
In sum, the ointment that makes of Herba Sarcandrae extract has analgesia, antiinflammation.After adding a certain amount of Borneolum Syntheticum in the ointment prescription, possibly be the Transdermal absorption effect that has promoted medicine, can effectively strengthen the reducing swelling and alleviating pain effect of medicine.
Claims (6)
1. reducing swelling and alleviating pain ointment is characterized in that: adopting Herba Sarcandrae extract is pharmaceutically active effective site, adds ointment substrate preparation commonly used.
2. reducing swelling and alleviating pain ointment according to claim 2 is characterized in that: the weight ratio of Herba Sarcandrae extract and ointment substrate commonly used is 1:1-8.
3. reducing swelling and alleviating pain ointment, it is characterized in that: with Herba Sarcandrae extract is main pharmaceutically active effective site, adds Borneolum Syntheticum and prepares with ointment substrate commonly used.
4. reducing swelling and alleviating pain ointment according to claim 3 is characterized in that: the weight ratio of said Herba Sarcandrae extract and ointment substrate commonly used is 1:1-10; The weight of said Borneolum Syntheticum accounts for the 0.6-6% of ointment substrate weight commonly used.
5. reducing swelling and alleviating pain ointment according to claim 1 and 2 is characterized in that: said ointment substrate commonly used is selected from glycerol, stearic acid, octadecanol, liquid Paraffin, triethanolamine, tween 80, sorbic acid, the ethyl hydroxybenzoate one or more.
6. according to claim 1,2,3 or 4 described reducing swelling and alleviating pain ointments, it is characterized in that: the preparation of said Herba Sarcandrae extract may further comprise the steps:
(1) get Herba Sarcandrae decocte with water 2-3 time, each 1-3 hour, collecting decoction filtered, the clear paste that it is 1.05-1.35 that filtrating is concentrated into 70 ℃ of relative densities, or the continuation drying obtains Herba Sarcandrae extractum;
(2) get Herba Sarcandrae clear paste or with the 5-10 times of dissolved Herba Sarcandrae extractum of water gaging; Go up nonpolar or Semi-polarity macroporous adsorptive resins; Absorption is with 1-3 times of column volume washing post, 2-4 times of column volume of washing back reuse 30-80% ethanol elution; Collect the eluent at phenolic acid, flavone and coumarin position, this eluent is reclaimed ethanol and be concentrated into 70 ℃ of relative densities the clear paste that is 1.10-1.20.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102459215A CN102727542A (en) | 2012-07-17 | 2012-07-17 | Ointment with function of relieving swelling and pain |
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| CN2012102459215A CN102727542A (en) | 2012-07-17 | 2012-07-17 | Ointment with function of relieving swelling and pain |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599204A (en) * | 2013-11-28 | 2014-02-26 | 湖北融谷药业有限公司 | Traditional Chinese medicine composition and its preparation method and use |
| CN108670973A (en) * | 2018-05-07 | 2018-10-19 | 福建中医药大学 | A kind of Chloranthus glaber anti-influenza virus activity extract and preparation method thereof |
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| CN1814084A (en) * | 2005-11-28 | 2006-08-09 | 蓝子花 | Collateral-flow-activating pain-relieving ointment of Herba Blumeae Laciniatae for treating affection by dampness |
| CN101574385A (en) * | 2009-04-29 | 2009-11-11 | 沈在杰 | Traditional Chinese medicine compound for treating orthopedic trauma and topical agent containing same |
| CN101574381A (en) * | 2009-02-02 | 2009-11-11 | 江中药业股份有限公司 | Extractive of effective part of chloranthus glaber and preparation method thereof |
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2012
- 2012-07-17 CN CN2012102459215A patent/CN102727542A/en active Pending
Patent Citations (5)
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| CN1660184A (en) * | 2004-12-11 | 2005-08-31 | 徐国良 | Combination of medicaiton containing extractive of herb of glabrous sarcandra, and preparation method and application |
| CN1814084A (en) * | 2005-11-28 | 2006-08-09 | 蓝子花 | Collateral-flow-activating pain-relieving ointment of Herba Blumeae Laciniatae for treating affection by dampness |
| CN101574381A (en) * | 2009-02-02 | 2009-11-11 | 江中药业股份有限公司 | Extractive of effective part of chloranthus glaber and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599204A (en) * | 2013-11-28 | 2014-02-26 | 湖北融谷药业有限公司 | Traditional Chinese medicine composition and its preparation method and use |
| CN103599204B (en) * | 2013-11-28 | 2016-03-16 | 濮存海 | Chinese medicine composition and its preparation method and application |
| CN108670973A (en) * | 2018-05-07 | 2018-10-19 | 福建中医药大学 | A kind of Chloranthus glaber anti-influenza virus activity extract and preparation method thereof |
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Application publication date: 20121017 |