CN103751307B - A kind of external application analgesic Chinese patent medicine and preparation technology thereof - Google Patents
A kind of external application analgesic Chinese patent medicine and preparation technology thereof Download PDFInfo
- Publication number
- CN103751307B CN103751307B CN201410011289.7A CN201410011289A CN103751307B CN 103751307 B CN103751307 B CN 103751307B CN 201410011289 A CN201410011289 A CN 201410011289A CN 103751307 B CN103751307 B CN 103751307B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese patent
- patent medicine
- flos caryophylli
- borneolum syntheticum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of external application analgesic Chinese patent medicine and preparation technology thereof.Described analgesia Chinese patent medicine is made primarily of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 5 ~ 36 parts, Radix Aconiti Kusnezoffii Preparata 3 ~ 24 parts, Flos Caryophylli 5 ~ 40 parts, Borneolum Syntheticum 0.2 ~ 1.5 part.Analgesia Chinese patent medicine reasonable recipe of the present invention, flavour of a drug are fewer but better, and each medicine produces synergism, can produce effect of good expelling wind and cold removing obstruction in the collateral to relieve pain.And prescription is gentle, to no skin irritation.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of external application analgesic Chinese patent medicine and preparation technology thereof.
Background technology
Chinese medicine will due to the positive QI-insufficiency of body, and defend solid outward, various pathogen is taken advantage of a weak point, and causes coagulation of QI-blood, and obstruction of meridians and collaterals causes is ache relatedly generically and collectively referred to as arthromyodynia.Main clinical table is all kinds of arthralgia, the arthralgia such as comprise neck, shoulder, waist, wrist, knee joint, refer to.
Chinese medicine have employed to arthromyodynia a series of method such as " regulating the flow of vital energy ", " invigorating blood circulation ", " cold expelling ", " food stagnation removing " to reach pain relieving basic goal to improve symptom.Domesticly apply for a collection of relevant patent in recent years, as: (1) black plaster for arthralgia pain, open (bulletin) number CN1795903A, application number 200410102446.1, applying date 2004-12-27, applicant's beam spring is flourish, with cold-dispelling, dredge the meridian passage and pain relieving is principle, is combined with Plumbum preparatium by medicine oil and the black plaster that formed, is widely used in rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, cervical spondylosis, lumbar muscle strain, apoplexy sequela.The party is made up of 23 taste Chinese medicines, utilizes the feature that the analgesic effects such as toxic herb Flos Rhododendri Mollis, Rhizoma Corydalis Decumbentis, Radix Zanthoxyli, Radix Aconiti, Radix Aconiti Kusnezoffii are fast.(2) a kind of Chinese medicine capsules for the treatment of rheumatic arthralgia and preparation method thereof, publication number 101455824A, application number 200710179519.0, applying date 2007-12-14, Tech-Sky Technology (Beijing) Co., Ltd..This is a kind of Chinese medicine capsules for the treatment of rheumatic arthralgia.This Chinese medicinal capsule is made up of Caulis Spatholobi, Squama Manis, Rhizoma Chuanxiong, Radix Aconiti Kusnezoffii Preparata, Radix Achyranthis Bidentatae, Myrrha, parasitism, Radix Angelicae Sinensis etc.(3) treat the tincture of pain, anemofrigid-damp arthralgia, authorize open (bulletin) number CN100423763C, application number 200510010521.6, applying date 2005-11-1, applicant Shao Li, Liu Hongtao.This is a kind of Chinese patent medicine that can play expelling wind and removing dampness, dispersing cold for relieving pain, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, the effect of detumescence solution disease.(4) preparation method for the Chinese medicine dripping pills of rheumatic arthritis is treated, CN102579625A, application number 201210057700.5, applying date 2012.03.07, applicant Nanjing Tongrentang Pharmaceutical Co., Ltd..This is that one has dispeiling pathogenic wind and removing dampness, and cold expelling is invigorated blood circulation, muscles and tendons relaxing to alleviate pain effect, for the preparation method of the Chinese medicine dripping pills of rheumatic arthritis and rheumatoid arthritis.(5) Baikangtie and preparation method thereof, publication number: CN1425451 application number 03100479.2, applicant Zhang Shuxia, Zhang Yingyan, Tang Chong, Zhang Shuhui.The function of this invention is mainly activating blood circulation to dissipate blood stasis, expansion blood vessel, anti-inflammatory analgetic, cold relieving, detumescence and promoting granulation and only wind of drawing out pus by applying a plaster to the affected part, cure mainly cervical vertebra, lumbar intervertebral disc protrudes, shoulder, elbow, wrist and knee endoprosthesis, rheumatoid, puerperal exposure to wind, be double-deck ointment, health be attractive in appearance, good permeability.
More than be used for the treatment of the patent of rheumatic Bi syndrome and achievement mainly with " expelling wind and cold ", " blood circulation promoting and blood stasis dispelling ", " bone and muscle strengthening dredging collateral " is basic therapy, based on medical materials such as Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Angelicae Sinensis, Myrrhas, can carry out palliative treatment to rheumatic arthralgia disease.But black plaster uses inconvenient, and easy pollution clothes, has certain stimulation to skin; The action time of tincture is shorter.Chinese medicine dripping pills for oral administration and capsule, drug effect is comparatively slow, and has larger zest to gastrointestinal tract, makes Clinical practice be subject to a definite limitation.
Summary of the invention
The object of the present invention is to provide a kind of safe, effective, side effect is little, compliance is good compound external-use Chinese medicine preparation.
Another object of the present invention is to provide the preparation technology of above-mentioned analgesia Chinese patent medicine.
To achieve these goals, the present invention, according to the theory of Chinese traditional treatment " arthralgia pain ", according to sick prisoner's pathogenic characteristic of rheumatic arthralgia, sums up clinical experience composition effective formula and drug for many years.In side, the pungent property of Radix Gentianae Macrophyllae bitter in the mouth is put down, and being " the profit agent in wind medicine ", having the merit of expelling wind and removing dampness, muscles and tendons relaxing to alleviate pain, is the monarch drug in side.Radix Aconiti Kusnezoffii Preparata acrid in the mouth is bitter, hot in nature, has the power of expelling wind and removing dampness, temperature three-way meridian, strong muscle eliminating impediment; Flos Caryophylli is sweet, pungent, hot greatly, removes wind, row water; The micro-sweet great Xin of Borneolum Syntheticum, the male power of gas is sharp, can granulation promoting pain relieving.We are based on the cold-damp medicine that dispels the wind, with medicine of a warm nature Flos Caryophylli for assistant, with the Borneolum Syntheticum of benefaction for making, Radix Gentianae Macrophyllae controls wind pain and without surely locating it " migratory arthralgia ", and Radix Aconiti Kusnezoffii Preparata cures mainly coldly to be contained pain and has and determine place's it " arthralgia aggravated by cold ", Flos Caryophylli is the product of large heat, Borneolum Syntheticum is walked and does not keep, and all medicines share, cold-dispelling damp, stimulate the menstrual flow cold expelling, controls wind, the wet arthralgia due to cold card be mingled with altogether.
Its prescription is as follows:
A kind of external application analgesic Chinese patent medicine, the Chinese crude drug primarily of following mass parts is made: Radix Gentianae Macrophyllae 5 ~ 36 parts, Radix Aconiti Kusnezoffii Preparata 3 ~ 24 parts, Flos Caryophylli 5 ~ 40 parts, Borneolum Syntheticum 0.2 ~ 1.5 part.
As preferably, above-mentioned external application analgesic Chinese patent medicine is made primarily of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 8 ~ 10 parts, Radix Aconiti Kusnezoffii Preparata 4 ~ 8 parts, Flos Caryophylli 8 ~ 12 parts, Borneolum Syntheticum 0.5 ~ 1.0 part.
As preferably, above-mentioned external application analgesic Chinese patent medicine, the Chinese crude drug primarily of following mass parts is made: Radix Gentianae Macrophyllae 9 parts, Radix Aconiti Kusnezoffii Preparata 6 parts, Flos Caryophylli 10 parts, Borneolum Syntheticum 0.5 part.
Also can add the substrate pharmaceutically allowed in above-described Chinese patent medicine and make external preparation.
The preparation method of above-described analgesia Chinese patent medicine, comprises the steps:
(1) each medicine is taken in proportion;
(2) Flos Caryophylli adopts extraction by steam distillation volatile oil;
(3) all the other medical materials adopt ethanol refluxing process to make extracting solution, and concentrated, drying under reduced pressure makes extract powder;
(4) merge Flos Caryophylli volatile oil and extract powder, add Borneolum Syntheticum, make analgesia Chinese patent medicine with appropriate substrate.
The condition that step (2) extracts the vapor distillation technology of the many employings of Flos Caryophylli volatile oil is: add 8 ~ 12 times of water, soaks 0.5 ~ 1h, extracts 3 ~ 5h.
The technical conditions of step (3) described ethanol refluxing process are: 65 ~ 75% alcohol reflux 1 ~ 3 time, each 1 ~ 3h, filter, merging filtrate, decompression recycling ethanol, concentrated, dry, obtained compound extract powder.
The concrete operations of step (3) are: select hydrophilic high molecular material to be substrate, even with the medicament mixed such as extract extract powder, Flos Caryophylli volatile oil and Borneolum Syntheticum, 45 ~ 55 DEG C of refinings and 0.5 ~ 1.5h, be coated with, 45 ~ 55 DEG C of drying 2.5 ~ 3h, obtained analgesia gel cream.
The invention has the beneficial effects as follows:
1, prescription of the present invention is compared with treating the prescription of similar disease at present, reasonable recipe, and flavour of a drug are fewer but better, and each medicine produces synergism, can produce effect of good expelling wind and cold removing obstruction in the collateral to relieve pain.And prescription is gentle, to no skin irritation.
2, preparation process research design of the present invention is rationally careful, pharmacodynamics is combined with active component and has formulated extraction process, basis, good analgesic farthest removes impurity, ensure that the drug effect of prescription, reduce injection volume again, for the Study on Forming of preparation is laid a good foundation.
3, the present invention is analgesia Chinese patent medicine dosage form series, comprises ointment, gel ointment, patch, medicated wine or other dosage forms etc.These dosage forms all have the advantages such as easy to use, good stability, quality controllability are good, patient adaptability is good.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, but be not limited thereto.
Embodiment 1
A kind of external application analgesic Chinese patent medicine, is made up of the Chinese crude drug of following mass parts: 5 parts, Radix Aconiti Kusnezoffii Preparata 24 parts, Flos Caryophylli 40 parts, Borneolum Syntheticum 0.2 part.
Embodiment 2
A kind of external application analgesic Chinese patent medicine, is made up of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 8 parts, Radix Aconiti Kusnezoffii Preparata 8 parts, Flos Caryophylli 8 parts, Borneolum Syntheticum 0.5 part
Embodiment 3
A kind of external application analgesic Chinese patent medicine, is made up of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 10 parts, Radix Aconiti Kusnezoffii Preparata 4 parts, Flos Caryophylli 12 parts, Borneolum Syntheticum 1.0 parts.
Embodiment 4
A kind of external application analgesic Chinese patent medicine, is made up of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 9 parts, Radix Aconiti Kusnezoffii Preparata 6 parts, Flos Caryophylli 10 parts, Borneolum Syntheticum 0.5 part.
The preparation of embodiment 5 one kinds of ointment that ease pain
By following technique, the Chinese patent medicine of embodiment 1 ~ 4 is made a kind of analgesia ointment, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil component, obtain extract A.Vapor distillation technology is: add 10 times of water, soaks 0.5h, extracts 4h.
(2) Radix Gentianae Macrophyllae of recipe quantity and Radix Aconiti Kusnezoffii Preparata are mixed, add 8 times of 70% ethanol extraction, 2 each 2h, merge extractive liquid, decompression recycling ethanol, concentrated, extract powder is made in vacuum decompression drying, obtains extract B.
(3) aqueous phase: glycerol 2.5g, distilled water 30ml; Oil phase: stearic acid 6g, white vaseline 0.5g, lanoline 2.5g, liquid paraffin 5ml; Emulsifier component: triethanolamine 0.2g.Triethanolamine adds aqueous phase, and extract A and B and Borneolum Syntheticum add oil phase, and oil phase is placed in 75 DEG C of water-bath heating and melting, is slowly added in oil phase by the aqueous phase of isothermal, is constantly stirred to room temperature, namely make.
Using method: be applied to affected part.
Embodiment 6 is eased pain the preparation of gel
By following technique, the Chinese patent medicine of embodiment 1 ~ 4 is made a kind of analgesia gel, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil, obtain extract A.Vapor distillation technology is: add 10 times of water, soaks 0.5h, extracts 4h.
(2) by Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata mixing, add 8 times of 70% ethanol extraction, 2 each 2h, merge extractive liquid, decompression recycling ethanol, concentrated, extract powder is made in vacuum decompression drying, obtains extract B.
(3) mass fraction is the swelling 2h of 0.2%CMC-Na, adds extract A under stirring; Extract B and Borneolum Syntheticum join in glycerol, and limit edged stirs; Above-mentioned two mixings, add EDTA2g subsequently, add water to enough, grind well, divided dose, and packaging, to obtain final product.
Using method: be applied to affected part.
Embodiment 7 is eased pain the preparation of gel ointment
By following technique, the Chinese patent medicine of embodiment 1 ~ 4 is made a kind of analgesia gel ointment, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil component, obtain extract A; Vapor distillation technology is: add 10 times of water, soaks 0.5h, extracts 4h;
(2) by Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata mixing, add 8 times of 70% ethanol extraction, 2 each 2h, merge extractive liquid, decompression recycling ethanol, concentrated, extract powder is made in vacuum decompression drying, obtains extract B;
(3) take hydrophilic high molecular material as substrate, mix, extract: substrate=5:100 with extract A, extract B and Borneolum Syntheticum, 50 DEG C of refinings and 1h, coating, put dry 2.5 ~ 3h in 50 DEG C of baking ovens, lid backing layer, airtight package, to obtain final product.
Using method: get this product one bag, throw off lid lining, be affixed on affected part, one day 1.
Embodiment 8 is eased pain the preparation of powder
By following technique, the Chinese patent medicine of embodiment 1 ~ 4 is made a kind of analgesia powder, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil component, obtain extract A, vapor distillation technology is: add 8 times of water, soaks 1h, extracts 3h;
(2) by Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata mixing, add 8 times of 65% ethanol extraction, 3 each 2h, merge extractive liquid, decompression recycling ethanol, concentrated, extract powder is made in vacuum decompression drying, sieve No. 6, obtain extract B;
(3) extract A and B and Borneolum Syntheticum mixes with appropriate solid adjuvant material, dry, pulverize, cloth bag packs, to obtain final product.
Using method: external, 1 ~ 2 time on the one.With the moistening medicated bag of Chinese liquor, apply after steaming in affected part, the available xeothermic article insulation in outside.Each hot compress should keep uniform temperature and time (about 20 minutes).Often bag medicine can Reusability 10 times.
Embodiment 9 is eased pain the preparation of tincture
By following technique, the Chinese patent medicine of embodiment 1 ~ 4 is made a kind of analgesia powder, concrete steps are as follows:
(1) take the Flos Caryophylli of recipe quantity, adopt vapor distillation technology to extract volatile oil component, obtain extract A; Vapor distillation technology is: add 12 times of water, soaks 0.5h, extracts 4h;
(2) by Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata mixing, add 8 times of 75% ethanol extraction, 3 each 2h, merge extractive liquid, decompression recycling ethanol, concentrated, extract powder is made in vacuum decompression drying, obtains extract B; By extract A and Borneolum Syntheticum anhydrous alcohol solution, extract B 70% dissolve with ethanol, merges A and B, mixing, and to adjust alcohol content be 70%, is 20g/ml containing crude drug amount.
Using method: external, embrocates in affected part, one time 3 ~ 5 times.
Embodiment 10 is eased pain the preparation of lotion
By following technique, the Chinese patent medicine of embodiment 1 ~ 4 is made a kind of analgesia lotion, concrete steps are as follows:
(1) take the Flos Caryophylli of recipe quantity, adopt vapor distillation technology to extract volatile oil component, obtain extract A; Vapor distillation technology is: add 10 times of water, soaks 0.5h, extracts 4h;
(2) by Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata mixing, add 8 times of 70% ethanol extraction, 2 each 2h, merge extractive liquid, decompression recycling ethanol, concentrated, extract powder is made in vacuum decompression drying, obtains extract B;
(3) Borneolum Syntheticum is used a small amount of anhydrous alcohol solution, add extract A, grind well; Separately add appropriate extract B, stir, then add residue extract B gradually, continue to stir, treat that uniform color is consistent, be loaded in plastic bag, sealing, to obtain final product.
Using method: get this product one bag, heating water 2000ml dissolves, first stifling patient part 5 ~ 10min, until water temperature be down to easily accept to skin time, then soak 10min.
Embodiment 11 ease pain gel ointment treatment rheumatic arthralgia pharmacodynamic experiment
One, mice hot water contracting tail experiment
Method and result:
Arrange blank group, positive controls (conventional commercial analgesia commercially available medicine), embodiment 1 ~ 4 the gel ointment group made of Chinese patent medicine, totally 7 groups.
Get body weight 20 ± 2g mice, mouse tail is placed in 48 ± 0.1 DEG C of waters bath with thermostatic control, immersion length is 3cm ~ 5cm, using afterbody retraction as pain reaction index, record mice puts into water to the time starting to bounce back from afterbody, prediction mice pain threshold is considered as the qualified mice in the threshold of pain (measure 2 times, interval 1h, averages) with >5s, <30s.Qualified for the threshold of pain 84 mices are divided into 7 groups at random, often organize 12, carry out grouping administration by 2.1.Each group of medicine is applied in mouse tail and abdominal part, and area is respectively 1cm
2and 2cm
2, administration every day 2 times, successive administration 4d, measures pain threshold respectively after last administration.Average pain threshold × 100% before analgesia rate=(after administration the front average pain threshold of average pain threshold one administration)/administration.Experimental result is in table 1.
Table 1 mice hot water contracting tail method experimental result
Note: compare with blank group, * P<0.05, * * P<0.01.
Experimental result shows: positive controls energy significant prolongation mice pain threshold (p<0.01).Compare with blank group, gel ointment energy significant prolongation mice pain threshold (p<0.05) of the present invention.
Two, mouse writhing experiment
Get body weight 20 ± 2g mice 84, by 2.1 grouping administrations.Each group of medicine is applied in mouse tail and abdominal part, and area is respectively 1cm
2and 2cm
2, administration every day 2 times, successive administration 4d, injects 0.6% acetic acid 0.2ml/ only in last administration pneumoretroperitoneum, records the writhing number of times that each Mus in time (i.e. incubation period) of the 1st writhing response and 15min appears in each Mus simultaneously.Analgesia rate=(the average writhing number of times one administration group of blank group average writhing number of times)/average writhing number of times × 100% of blank group.Experimental result is in table 2.
Table 2 mouse writhing method experimental result
Note: compare with blank group, * P<0.05, * * P<0.01.
Experimental result shows: positive controls energy highly significant reduces mouse writhing number of times (p<0.05).Compare with blank group, gel ointment group of the present invention all can reduce mouse writhing number of times (p<0.01) by highly significant.
Three, anti-inflammation test
After grouping and medication mice adaptability are fed 3 days, application table of random number is carried out completely random and is divided 4 groups, that is: blank group, positive controls (conventional commercial analgesia commercially available medicine), embodiment 1 ~ 4 analgesia gel ointment group, often organize 10 mouse.Positive controls is affixed on back 1cm
2with abdominal part 2cm
2; Analgesia gel ointment group is affixed on back, and area is respectively 2cm
2.Administration every day 2 times, successive administration 4d.
1, the inhibitory action of mice ear
Mice male and female half and half, grouping and administration, successive administration 3 days, after the 4th day administration 30min, every mouse right ear uniform application dimethylbenzene, positive and negative is all smeared, after causing scorching 30min, mice is taken off cervical vertebra and put to death, sweep away left and right auricle with the card punch of diameter 8mm, after weighing on electronic balance respectively, calculate the ear swelling rate of every mice respectively.Experimental result is in table 3.
Table 3 mice ear experimental result (unit: %)
Experimental result shows: each administration group compares * P<0.05 with blank group.
Ear swelling rate=(auris dextra weight-left ear weight)/left ear weight × 100%
2, mice capillary permeability experiment
Mice male and female half and half, grouping (often organizing 10 mices) and administration, successive administration 3 days, in the 4th day every mouse tail vein injection 1% azovan blue 0.2ml/ only, and mice only, after 30min, is taken off cervical vertebra and puts to death by lumbar injection 0.6% acetic acid 0.2ml/ simultaneously, cut off abdominal cavity, with 16ml normal saline flushing abdominal cavity, draw abdominal cavity eluate with suction pipe and be about 16ml, the centrifugal 15min of 1000r/min, get supernatant, measure absorbance at ultraviolet spectrophotometer 590nm place.Measure the vascular permeability of every mice respectively, average.Experimental result is in table 4.
Table 4 mice capillary permeability experimental result
Experimental result shows: each administration group compares * * P<0.01 with blank group.
Four, irritation test
Get adult healthy white rabbit, male and female half and half, body weight 2.2 ~ 2.3kg, before experiment, family's rabbit back spinal column diamond wool is taken off by 48h, and depilation area is 100cm
2, symmetrical, rinsing well, be divided into 2 groups at random, is intact skin group and damaged skin group.Test adopts consubstantiality symmetrical self-contrast, and as a control group, analgesia gel ointment of the present invention is pasted in unhairing district, left side to unhairing district, right side, and point cage is fed, and takes off after 24h, with warm water cleaning, in 1,24,48,72h observes skin erythema and edema phenomenon.Experimental result is in table 5.
Skin irritation reaction standards of grading:
Scores of erythema standard: without erythema 0 point; Visible 1 point reluctantly; Obviously visible 2 points; Moderate is to severe erythema 3 points; Aubergine erythema also has incrustation formation 4 points.
Edema standards of grading: without edema 0 point; Visible 1 point reluctantly; Visible 2 points; Cutaneous protuberance is about 1mm, clear-cut 3 points; Cutaneous protuberance is about more than 1mm, and expanded range 4 points.
Skin irritation strength criterion: 0-0.49 is divided into nonirritant; 0.5-2.999 is slight zest; 3-5.999 be moderate zest; 6-8 is strong and stimulating.
Table 5 irritation test result
Experimental result: by the known analgesia gel ointment of the present invention of experiment to intact skin and damaged skin all without skin irritation.
Above experimental data shows, external application analgesic Chinese patent medicine of the present invention has effect of good expelling wind and cold removing obstruction in the collateral to relieve pain, and prescription is gentle, to no skin irritation.
Claims (8)
1. an external application analgesic Chinese patent medicine, is characterized in that, is made up of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 5 ~ 36 parts, Radix Aconiti Kusnezoffii Preparata 3 ~ 24 parts, Flos Caryophylli 5 ~ 40 parts, Borneolum Syntheticum 0.2 ~ 1.5 part.
2. external application analgesic Chinese patent medicine according to claim 1, is characterized in that, is made up of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 8 ~ 10 parts, Radix Aconiti Kusnezoffii Preparata 4 ~ 8 parts, Flos Caryophylli 8 ~ 12 parts, Borneolum Syntheticum 0.5 ~ 1.0 part.
3. external application analgesic Chinese patent medicine according to claim 2, is characterized in that, is made up of the Chinese crude drug of following mass parts: Radix Gentianae Macrophyllae 9 parts, Radix Aconiti Kusnezoffii Preparata 6 parts, Flos Caryophylli 10 parts, Borneolum Syntheticum 0.5 part.
4. Chinese patent medicine according to any one of claims 1 to 3, is characterized in that, also can add the substrate pharmaceutically allowed and make external preparation in described Chinese patent medicine.
5. the preparation method of the analgesia Chinese patent medicine described in any one of Claims 1 to 4, comprises the steps:
(1) each medicine is taken in proportion;
(2) Flos Caryophylli adopts extraction by steam distillation volatile oil;
(3) all the other medical materials adopt ethanol refluxing process to make extracting solution, and concentrated, drying under reduced pressure makes extract powder;
(4) merge Flos Caryophylli volatile oil and extract powder, add Borneolum Syntheticum, make analgesia Chinese patent medicine with appropriate substrate.
6. preparation method according to claim 5, is characterized in that, the condition extracting the vapor distillation technology of the many employings of Flos Caryophylli volatile oil is: add 8 ~ 12 times of water, soaks 0.5 ~ 1h, extracts 3 ~ 5h.
7. preparation method according to claim 5, is characterized in that, the technical conditions of step (3) described ethanol refluxing process are: 65 ~ 75% alcohol reflux 1 ~ 3 time, each 1 ~ 3h, filter, merging filtrate, decompression recycling ethanol, concentrated, dry, obtained compound extract powder.
8. preparation method according to claim 5, it is characterized in that, the concrete operations of step (4) are: select hydrophilic high molecular material to be substrate, mix homogeneously with extract extract powder, Flos Caryophylli volatile oil and Borneolum Syntheticum, 45 ~ 55 DEG C of refinings and 0.5 ~ 1.5h, coating, 45 ~ 55 DEG C of drying 2.5 ~ 3h, obtained analgesia gel cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410011289.7A CN103751307B (en) | 2014-01-09 | 2014-01-09 | A kind of external application analgesic Chinese patent medicine and preparation technology thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410011289.7A CN103751307B (en) | 2014-01-09 | 2014-01-09 | A kind of external application analgesic Chinese patent medicine and preparation technology thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103751307A CN103751307A (en) | 2014-04-30 |
| CN103751307B true CN103751307B (en) | 2015-12-30 |
Family
ID=50518734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410011289.7A Active CN103751307B (en) | 2014-01-09 | 2014-01-09 | A kind of external application analgesic Chinese patent medicine and preparation technology thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103751307B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922232A (en) * | 2015-05-25 | 2015-09-23 | 梁泽华 | Compound analgesic medicine and preparation method thereof |
| CN105832927A (en) * | 2016-06-12 | 2016-08-10 | 佛山市腾瑞医药科技有限公司 | Chinese patent medicine for clearing away heat, dispelling wind, alleviating pain and removing nebula and preparation process of Chinese patent medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251875A (en) * | 2012-02-16 | 2013-08-21 | 上海市南洋模范中学 | Pain-relieving traditional Chinese medicine preparation and preparation method thereof |
-
2014
- 2014-01-09 CN CN201410011289.7A patent/CN103751307B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251875A (en) * | 2012-02-16 | 2013-08-21 | 上海市南洋模范中学 | Pain-relieving traditional Chinese medicine preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 秦艽药理作用及临床应用研究进展;张玉红等;《全国第3届临床中药学学术研讨会论文集》;20101231;摘要 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103751307A (en) | 2014-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101810685B (en) | Chinese medicinal composition for treating gonitis and preparation method thereof | |
| CN102188623A (en) | Liquid plaster for treating osseous rheumatism and preparation method thereof | |
| CN106822316A (en) | A kind of invigorate blood circulation smokeless moxibustion bar and preparation method thereof | |
| CN101856421A (en) | Medicament for treating herpes zoster and preparation method thereof | |
| CN104491220B (en) | A kind of traditional Chinese medicine composition for herpes | |
| CN103751307B (en) | A kind of external application analgesic Chinese patent medicine and preparation technology thereof | |
| CN103251741B (en) | Chinese medicine composition for treating toxoplasmosisinswine, and preparation method and application thereof | |
| CN103877454A (en) | Chinese traditional medicine plaster special for local anaesthesia and analgesia and preparation method of plaster | |
| CN104274795A (en) | Series of traditional Chinese medicine liniments for treating internal illness by external treatment | |
| CN103341013B (en) | A kind of Chinese medicine for the treatment of lumbago and skelalgia | |
| CN103705791B (en) | Medicament for clinical anesthesia and preparation method thereof | |
| CN104288255A (en) | Traditional Chinese medicine preparation for treating severe acute pancreatitis | |
| CN101708292B (en) | Chinese medicament for treating rheumatic and rheumatoid diseases | |
| CN101632756B (en) | Traditional Chinese medicine for treating malignant tumours and preparation method thereof | |
| CN104707041B (en) | For the care drug of postoperation | |
| CN102949544B (en) | Chinese medicinal composition for specifically treating swelling of hands and feet of hemiplegic patients | |
| CN103893701B (en) | A kind of Chinese medicine composition alleviating patients suffering from postoperative pain and promote wound healing | |
| CN104873615A (en) | Cinnamon oil containing externally applied medicine for treating traumatic injury | |
| CN104984313A (en) | Traditional Chinese medicine medicinal wine for treating chilblain | |
| CN108434299B (en) | Pharmaceutical composition for treating scapulohumeral periarthritis and preparation method and spray thereof | |
| CN105250923A (en) | Traditional Chinese medicine composition for treating rheumatism and rheumatoid | |
| CN104771531A (en) | Traditional Chinese medicine capsule for treating prosopalgia and preparation method thereof | |
| CN104189818A (en) | Externally applied anti-inflammatory antalgic medicine composition | |
| CN109303909A (en) | The preparation method of liquid medicine for promoting blood circulation, removing blood stasis and relieving pain | |
| CN103877335A (en) | Medicine for curing rheumatoid arthritis and preparation method of medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 510240 40 Haizhuqu District, Guangdong, Guangzhou. Patentee after: Guangdong Pharmaceutical University Address before: 510006 No. 280 East Ring Road, Guangzhou City University, Guangdong Patentee before: Guangdong Pharmaceutical University |