CN103751307A - External pain-relieving Chinese patent medicine and preparation process thereof - Google Patents
External pain-relieving Chinese patent medicine and preparation process thereof Download PDFInfo
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Abstract
The invention discloses an external pain-relieving Chinese patent medicine and a preparation process thereof. The pain-relieving Chinese patent medicine is mainly prepared from the following traditional Chinese medicinal materials in parts by mass: 5-36 parts of large-leaved gentian, 3-24 parts of prepared kusnezoff monkshood root, 5-40 parts of syzygium aromaticum and 0.2-1.5 parts of borneol. The external pain-relieving Chinese patent medicine is reasonable in formula and fewer and refined in medical flavors, and a synergistic effect is generated among the medicines, so that good effects of dispeling the wind, expelling cold and activating meridians to stop pain can be generated. Moreover, the external pain-relieving Chinese patent medicine is mild in formula and nonirritant to the skin.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of external application analgesic Chinese patent medicine and preparation technology thereof.
Background technology
Chinese medicine will be defended outward admittedly due to the positive QI-insufficiency of body, and various pathogens are taken advantage of a weak point, and cause coagulation of QI-blood, and the ache related arthromyodynia that is generically and collectively referred to as that obstruction of meridians and collaterals causes.Main clinical table is all kinds of arthralgias, the arthralgia such as comprise neck, shoulder, waist, wrist, knee joint, refer to.
Chinese medicine has adopted a series of methods such as " regulating the flow of vital energy ", " invigorating blood circulation ", " cold expelling ", " food stagnation removing " to improve symptom and has reached the basic goal of pain relieving to arthromyodynia.Recent years application a collection of relevant patent, as (1) black plaster for arthralgia pain, open (bulletin) number CN1795903A, application number 200410102446.1, applying date 2004-12-27, applicant's beam spring is flourish, with cold-dispelling, dredge the meridian passage and pain relieving is principle, is combined with Plumbum preparatium and the black plaster that forms by medicine oil, is widely used in rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, cervical spondylosis, lumbar muscle strain, apoplexy sequela.The party is made by 23 taste Chinese medicines, utilizes the fast features of analgesic effect such as toxic herb Flos Rhododendri Mollis, Rhizoma Corydalis Decumbentis, Radix Zanthoxyli, Radix Aconiti, Radix Aconiti Kusnezoffii.(2) a kind of Chinese medicine capsules for the treatment of rheumatic arthralgia and preparation method thereof, publication number 101455824A, application number 200710179519.0, applying date 2007-12-14, Tech-Sky Technology (Beijing) Co., Ltd..This is a kind of Chinese medicine capsules for the treatment of rheumatic arthralgia.This Chinese medicinal capsule is comprised of Caulis Spatholobi, Squama Manis, Rhizoma Chuanxiong, Radix Aconiti Kusnezoffii Preparata, Radix Achyranthis Bidentatae, Myrrha, parasitism, Radix Angelicae Sinensis etc.(3) tincture for the treatment of pain, anemofrigid-damp arthralgia, authorizes open (bulletin) number CN100423763C, application number 200510010521.6, applying date 2005-11-1, applicant Shao Li, Liu Hongtao.This is a kind of Chinese patent medicine that can bring into play expelling wind and removing dampness, dispersing cold for relieving pain, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, the effect of detumescence solution disease.(4) treat a preparation method for the Chinese medicine dripping pills of rheumatic arthritis, CN102579625A, application number 201210057700.5, applying date 2012.03.07, applicant Nanjing Tongrentang Pharmaceutical Co., Ltd..This is a kind of dispeiling pathogenic wind and removing dampness that has, and cold expelling is invigorated blood circulation, and muscles and tendons relaxing to alleviate pain effect, for the preparation method of the Chinese medicine dripping pills of rheumatic arthritis and rheumatoid arthritis.(5) Baikangtie and preparation method thereof, publication number: CN1425451 application number 03100479.2, applicant Zhang Shuxia, Zhang Yingyan, Tang Chong, Zhang Shuhui.The function of this invention is mainly activating blood circulation to dissipate blood stasis, expansion blood vessel, anti-inflammatory analgetic, cold relieving, detumescence and promoting granulation and the only wind of drawing out pus by applying a plaster to the affected part, cure mainly cervical vertebra, lumbar intervertebral disc protrusion, shoulder, elbow, wrist and knee endoprosthesis, rheumatoid, puerperal exposure to wind, be double-deck ointment, and health is attractive in appearance, good permeability.
More than be used for the treatment of the patent of rheumatic Bi syndrome and achievement mainly with " expelling wind and cold ", " blood circulation promoting and blood stasis dispelling ", " bone and muscle strengthening dredging collateral " is basic therapy, take the medical materials such as Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Angelicae Sinensis, Myrrha as main, can carry out palliative treatment to rheumatic arthralgia disease.But black plaster is used inconvenient, easily pollution clothes, has certain stimulation to skin; The action time of tincture is shorter.Chinese medicine dripping pills for oral administration and capsule, drug effect is slower, and gastrointestinal tract is had to larger zest, makes clinical use be subject to certain limitation.
Summary of the invention
The object of the present invention is to provide a kind of safe, effective, side effect is little, compliance is good compound external-use Chinese medicine preparation.
Another object of the present invention is to provide the preparation technology of above-mentioned analgesia Chinese patent medicine.
To achieve these goals, the present invention, according to the theory of Chinese traditional treatment " arthralgia pain ", according to sick prisoner's pathogenic characteristic of rheumatic arthralgia, sums up clinical experience for many years and forms effective formula and drug.In side, the pungent property of Radix Gentianae Macrophyllae bitter in the mouth is flat, is " the profit agent in wind medicine ", has the merit of expelling wind and removing dampness, muscles and tendons relaxing to alleviate pain, is the monarch drug in side.Radix Aconiti Kusnezoffii Preparata acrid in the mouth is bitter, hot in nature, has the power of expelling wind and removing dampness, temperature three-way meridian, strong muscle eliminating impediment; Flos Caryophylli is sweet, pungent, hot greatly, removes wind, row water; The micro-sweet great Xin of Borneolum Syntheticum, the male power of gas is sharp, can granulation promoting pain relieving.We be take and dispeled the wind cold-damp medicine as main, take medicine of a warm nature Flos Caryophylli as assistant, with the Borneolum Syntheticum of benefaction, for making, Radix Gentianae Macrophyllae is controlled wind pain and without surely locating it " migratory arthralgia ", and Radix Aconiti Kusnezoffii Preparata cures mainly coldly to be contained pain and has place's of determining it " arthralgia aggravated by cold ", Flos Caryophylli is the product of large heat, Borneolum Syntheticum is walked and is not kept, and all medicines share, cold-dispelling damp, the cold expelling that stimulates the menstrual flow, controls wind, the wet arthralgia due to cold card being mingled with altogether.
Its prescription is as follows:
An external application analgesic Chinese patent medicine, is mainly made by the Chinese crude drug of following mass parts: 5～36 parts of Radix Gentianae Macrophyllae, 3～24 parts of Radix Aconiti Kusnezoffii Preparatas, 5～40 parts of Flos Caryophyllis, 0.2～1.5 part of Borneolum Syntheticum.
As preferably, above-mentioned external application analgesic Chinese patent medicine is mainly made by the Chinese crude drug of following mass parts: 8～10 parts of Radix Gentianae Macrophyllae, 4～8 parts of Radix Aconiti Kusnezoffii Preparatas, 8～12 parts of Flos Caryophyllis, 0.5～1.0 part of Borneolum Syntheticum.
As preferably, above-mentioned external application analgesic Chinese patent medicine, is mainly made by the Chinese crude drug of following mass parts: 9 parts of Radix Gentianae Macrophyllae, 6 parts of Radix Aconiti Kusnezoffii Preparatas, 10 parts of Flos Caryophyllis, 0.5 part of Borneolum Syntheticum.
In above-described Chinese patent medicine, also can add the substrate pharmaceutically allowing to make external preparation.
The preparation method of above-described analgesia Chinese patent medicine, comprises the steps:
(1) take in proportion each medicine;
(2) Flos Caryophylli adopts extraction by steam distillation volatile oil;
(3) all the other medical materials adopt ethanol refluxing process to make extracting solution, and concentrated, drying under reduced pressure is made extract powder;
(4) merge Flos Caryophylli volatile oil and extract powder, add Borneolum Syntheticum, make analgesia Chinese patent medicine with suitable substrate.
The condition that step (2) is extracted the Flos Caryophylli volatile oil vapor distillation technology that adopt more is: add 8～12 times of water, soak 0.5～1h, extract 3～5h.
The technical conditions of the described ethanol refluxing process of step (3) are: 65～75% alcohol reflux 1～3 time, and each 1～3h, filters, merging filtrate, decompression recycling ethanol, concentrated, dry, make compound extract powder.
The concrete operations of step (3) are: selecting hydrophilic high molecular material is substrate, even with the medicament mixed such as extract extract powder, Flos Caryophylli volatile oil and Borneolum Syntheticum, 45～55 ℃ of refinings and 0.5～1.5h, coating, 45～55 ℃ of dry 2.5～3h, make analgesia gel cream.
The invention has the beneficial effects as follows:
1, prescription of the present invention is compared with the prescription of current treatment similar disease, reasonable recipe, and flavour of a drug are fewer but better, and each medicine produces synergism, can produce the effect of good expelling wind and cold removing obstruction in the collateral to relieve pain.And prescription is gentle, to skin nonirritant.
2, preparation process research design of the present invention is careful rationally, pharmacodynamics is combined and formulated extraction process with active component, on basis, good analgesic, farthest remove impurity, guaranteed the drug effect of prescription, dwindled again injection volume, for the Study on Forming of preparation is laid a good foundation.
3, the present invention, for analgesia Chinese patent medicine dosage form series, comprises ointment, gel ointment, patch, medicated wine or other dosage forms etc.The advantages such as that these dosage forms all have is easy to use, good stability, quality controllability is good, patient adaptability is good.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated, but be not limited to this.
Embodiment 1
An external application analgesic Chinese patent medicine, by the Chinese crude drug of following mass parts, made: 5 parts, 24 parts of Radix Aconiti Kusnezoffii Preparatas, 40 parts of Flos Caryophyllis, 0.2 part of Borneolum Syntheticum.
Embodiment 2
An external application analgesic Chinese patent medicine, is made by the Chinese crude drug of following mass parts: 8 parts of Radix Gentianae Macrophyllae, 8 parts of Radix Aconiti Kusnezoffii Preparatas, 8 parts of Flos Caryophyllis, 0.5 part of Borneolum Syntheticum
Embodiment 3
An external application analgesic Chinese patent medicine, is made by the Chinese crude drug of following mass parts: 10 parts of Radix Gentianae Macrophyllae, 4 parts of Radix Aconiti Kusnezoffii Preparatas, 12 parts of Flos Caryophyllis, 1.0 parts of Borneolum Syntheticums.
Embodiment 4
An external application analgesic Chinese patent medicine, is made by the Chinese crude drug of following mass parts: 9 parts of Radix Gentianae Macrophyllae, 6 parts of Radix Aconiti Kusnezoffii Preparatas, 10 parts of Flos Caryophyllis, 0.5 part of Borneolum Syntheticum.
The preparation of 5 one kinds of ointment that ease pain of embodiment
Can the Chinese patent medicine of embodiment 1～4 be made to a kind of analgesia ointment by following technique, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil component, obtain extract A.Vapor distillation technology is: add 10 times of water, soak 0.5h, extract 4h.
(2) Radix Gentianae Macrophyllae of recipe quantity and Radix Aconiti Kusnezoffii Preparata are mixed, add 2 each 2h of 8 times of 70% ethanol extraction, merge extractive liquid,, decompression recycling ethanol, concentrated, vacuum decompression is dry makes extract powder, obtains extract B.
(3) water: glycerol 2.5g, distilled water 30ml; Oil phase: stearic acid 6g, white vaseline 0.5g, lanoline 2.5g, liquid paraffin 5ml; Emulsifier component: triethanolamine 0.2g.Triethanolamine adds water, and extract A and B and Borneolum Syntheticum add oil phase, and oil phase is placed in 75 ℃ of water-bath heating and melting, and the water of isothermal is slowly added in oil phase, is constantly stirred to room temperature, i.e. system.
Using method: be applied to affected part.
The preparation of embodiment 6 analgesia gels
Can the Chinese patent medicine of embodiment 1～4 be made to a kind of analgesia gel by following technique, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil, obtain extract A.Vapor distillation technology is: add 10 times of water, soak 0.5h, extract 4h.
(2) Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata are mixed, add 2 each 2h of 8 times of 70% ethanol extraction, merge extractive liquid,, decompression recycling ethanol, concentrated, vacuum decompression is dry makes extract powder, obtains extract B.
(3) mass fraction is 0.2%CMC-Na swelling 2h, under stirring, adds extract A; Extract B and Borneolum Syntheticum join in glycerol, and limit edged stirs; Above-mentioned two mix, and add subsequently EDTA2g, add water to enoughly, grind well, and divided dose, packing, obtains.
Using method: be applied to affected part.
The preparation of embodiment 7 analgesia gel ointments
Can the Chinese patent medicine of embodiment 1～4 be made to a kind of analgesia gel ointment by following technique, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil component, obtain extract A; Vapor distillation technology is: add 10 times of water, soak 0.5h, extract 4h;
(2) Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata are mixed, add 2 each 2h of 8 times of 70% ethanol extraction, merge extractive liquid,, decompression recycling ethanol, concentrated, vacuum decompression is dry makes extract powder, obtains extract B;
(3) take hydrophilic high molecular material as substrate, mix with extract A, extract B and Borneolum Syntheticum, extract: substrate=5:100,50 ℃ are refined and 1h, and dry 2.5～3h in 50 ℃ of baking ovens is put in coating, lid backing layer, airtight package, obtains.
Using method: get one bag of this product, throw off lid lining, be affixed on affected part, one day 1.
The preparation of embodiment 8 analgesia powders
Can the Chinese patent medicine of embodiment 1～4 be made to a kind of analgesia powder by following technique, concrete steps are as follows:
(1) take recipe quantity Flos Caryophylli, adopt vapor distillation technology to extract volatile oil component, obtain extract A, vapor distillation technology is: add 8 times of water, soak 1h, extract 3h;
(2) Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata are mixed, add 3 each 2h of 8 times of 65% ethanol extraction, merge extractive liquid,, decompression recycling ethanol, concentrated, the dry extract powder of making of vacuum decompression,, sieve No. 6, obtain extract B;
(3) extract A and B and Borneolum Syntheticum mix with appropriate solid adjuvant material, be dried, pulverizing, cloth bag packing, obtain.
Using method: external, 1～2 time on the one.With the moistening medicated bag of Chinese liquor, after steaming, apply in affected part the available xeothermic article insulation in outside.Each hot compress should keep uniform temperature and time (about 20 minutes).Every bag medicine can Reusability 10 times.
The preparation of embodiment 9 analgesia tinctures
Can the Chinese patent medicine of embodiment 1～4 be made to a kind of analgesia powder by following technique, concrete steps are as follows:
(1) take the Flos Caryophylli of recipe quantity, adopt vapor distillation technology to extract volatile oil component, obtain extract A; Vapor distillation technology is: add 12 times of water, soak 0.5h, extract 4h;
(2) Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata are mixed, add 3 each 2h of 8 times of 75% ethanol extraction, merge extractive liquid,, decompression recycling ethanol, concentrated, vacuum decompression is dry makes extract powder, obtains extract B; By extract A and Borneolum Syntheticum anhydrous alcohol solution, extract B 70% dissolve with ethanol, merges A and B, mixes, and adjusts containing alcohol amount to be 70%, containing crude drug amount, to be 20g/ml.
Using method: external, embrocate in affected part one time 3～5 times.
The preparation of embodiment 10 analgesia lotions
Can the Chinese patent medicine of embodiment 1～4 be made to a kind of analgesia lotion by following technique, concrete steps are as follows:
(1) take the Flos Caryophylli of recipe quantity, adopt vapor distillation technology to extract volatile oil component, obtain extract A; Vapor distillation technology is: add 10 times of water, soak 0.5h, extract 4h;
(2) Radix Gentianae Macrophyllae, Radix Aconiti Kusnezoffii Preparata are mixed, add 2 each 2h of 8 times of 70% ethanol extraction, merge extractive liquid,, decompression recycling ethanol, concentrated, vacuum decompression is dry makes extract powder, obtains extract B;
(3) Borneolum Syntheticum is used to a small amount of anhydrous alcohol solution, added extract A, grind well; Separately add appropriate extract B, stir, then add gradually residue extract B, continue to stir, treat color and luster uniformity, be loaded in plastic bag, sealing, obtains.
Using method: get one bag of this product, heating water 2000ml dissolves, first stifling patient part 5～10min, is down to while easily accepting to skin until water temperature, then soaks 10min.
The pharmacodynamic experiment of embodiment 11 analgesia gel ointment treatment rheumatic arthralgia
One, mice hot water contracting tail experiment
Method and result:
The gel ointment group that blank group, the Chinese patent medicine of positive controls (conventional commercially available analgesia commercially available medicine), embodiment 1～4 are made is set, totally 7 groups.
Get body weight 20 ± 2g mice, mouse tail is placed in to 48 ± 0.1 ℃ of waters bath with thermostatic control, immersion length is 3cm～5cm, the afterbody of usining retraction is as pain reaction index, record mice and put into water to the time that starts retraction from afterbody, prediction mice pain threshold is considered as the qualified mice in the threshold of pain (measure 2 times, interval 1h, averages) with >5s, <30s.84 mices that the threshold of pain is qualified are divided into 7 groups at random, and 12 every group, by 2.1 administrations of dividing into groups.Each group medicine is applied in to mouse tail and abdominal part, and area is respectively 1cm
2and 2cm
2, administration every day 2 times, successive administration 4d measures respectively pain threshold after last administration.Average pain threshold * 100% before analgesia rate=(the front average pain threshold of average pain threshold one administration after administration)/administration.Experimental result is in Table 1.
Table 1 mice hot water contracting tail method experimental result
Note: with the comparison of blank group, * P<0.05, * * P<0.01.
Experimental result shows: positive controls energy significant prolongation mice pain threshold (p<0.01).With the comparison of blank group, gel ointment energy significant prolongation mice pain threshold of the present invention (p<0.05).
Two, mouse writhing experiment
Get 84 of body weight 20 ± 2g mices, by 2.1 grouping administrations.Each group medicine is applied in to mouse tail and abdominal part, and area is respectively 1cm
2and 2cm
2, administration every day 2 times, successive administration 4d, only injects 0.6% acetic acid 0.2ml/ in last administration pneumoretroperitoneum, records each Mus simultaneously and occurs the time (being incubation period) of the 1st writhing response and the writhing number of times of interior each Mus of 15min.Analgesia rate=(the average writhing number of times of the average writhing number of times one administration group of blank group)/average writhing number of times * 100% of blank group.Experimental result is in Table 2.
Table 2 mouse writhing method experimental result
Note: with the comparison of blank group, * P<0.05, * * P<0.01.
Experimental result shows: positive controls energy highly significant reduces mouse writhing number of times (p<0.05).With the comparison of blank group, gel ointment group of the present invention all can reduce mouse writhing number of times (p<0.01) by highly significant.
Three, antiinflammatory test
After grouping is fed 3 days with medication mice adaptability, application table of random number is carried out completely random and is divided 4 groups, that is: blank group, the analgesia gel ointment group of positive controls (conventional commercially available analgesia commercially available medicine), embodiment 1～4, every group of 10 mouse.Positive controls is affixed on back 1cm
2with abdominal part 2cm
2; Analgesia gel ointment group is affixed on back, and area is respectively 2cm
2.Administration every day 2 times, successive administration 4d.
1, the inhibitory action of mice ear
Mice male and female half and half, grouping and administration, successive administration 3 days, after the 4th day administration 30min, every mouse right ear is evenly smeared dimethylbenzene, positive and negative is all smeared, cause after scorching 30min, the de-cervical vertebra of mice is put to death, with the card punch of diameter 8mm, sweep away left and right auricle, after weighing respectively, calculate respectively the ear swelling rate of every mice on electronic balance.Experimental result is in Table 3.
Table 3 mice ear experimental result (unit: %)
Experimental result shows: each administration group compares * P<0.05 with blank group.
Ear swelling rate=(auris dextra weight-left ear weight)/left ear weight * 100%
2, mice capillary permeability experiment
Mice male and female half and half, grouping (every group of 10 mices) and administration, successive administration 3 days, in the 4th day every mouse tail vein injection 1% azovan blue 0.2ml/ only, and lumbar injection 0.6% acetic acid 0.2ml/ only, after 30min, puts to death the de-cervical vertebra of mice simultaneously, cut off abdominal cavity, with 16ml normal saline flushing abdominal cavity, with suction pipe, draw the about 16ml of abdominal cavity eluate, the centrifugal 15min of 1000r/min, get supernatant, at ultraviolet spectrophotometer 590nm place, measure absorbance.Measure respectively the vascular permeability of every mice, average.Experimental result is in Table 4.
Table 4 mice capillary permeability experimental result
Experimental result shows: each administration group compares * * P<0.01 with blank group.
Four, irritation test
Get adult healthy white rabbit, male and female half and half, body weight 2.2～2.3kg, before experiment, 48h takes off family's rabbit back spinal column diamond wool, and depilation area is 100cm
2, symmetrical, rinse well, be divided at random 2 groups, be intact skin group and damaged skin group.Test adopts the symmetrical self-contrast of consubstantiality, and as a control group, analgesia gel ointment of the present invention is pasted in unhairing district, left side to unhairing district, right side, and minute cage is fed, and takes off, with warm water cleaning, in 1,24,48,72h observes skin erythema and edema phenomenon after 24h.Experimental result is in Table 5.
Skin irritation reaction standards of grading:
Scores of erythema standard: without erythema 0 minute; Visible 1 minute reluctantly; Obviously visible 2 minutes; Moderate was to severe erythema 3 minutes; Aubergine erythema also has incrustation to form 4 minutes.
Edema standards of grading: without edema 0 minute; Visible 1 minute reluctantly; Visible 2 minutes; The about 1mm of cutaneous protuberance, clear-cut 3 minutes; More than the about 1mm of cutaneous protuberance, and expanded range 4 minutes.
Skin irritation strength criterion: 0-0.49 is divided into nonirritant; 0.5-2.999 is slight zest; 3-5.999 be moderate zest; 6-8 is strong and stimulating.
Table 5 irritation test result
Experimental result: by the known analgesia gel ointment of the present invention of experiment to intact skin and damaged skin all without skin irritation.
Above experimental data shows, external application analgesic Chinese patent medicine of the present invention has the effect of good expelling wind and cold removing obstruction in the collateral to relieve pain, and prescription is gentle, to skin nonirritant.
Claims (8)
1. an external application analgesic Chinese patent medicine, is characterized in that, mainly by the Chinese crude drug of following mass parts, is made: 5～36 parts of Radix Gentianae Macrophyllae, 3～24 parts of Radix Aconiti Kusnezoffii Preparatas, 5～40 parts of Flos Caryophyllis, 0.2～1.5 part of Borneolum Syntheticum.
2. external application analgesic Chinese patent medicine according to claim 1, is characterized in that, mainly by the Chinese crude drug of following mass parts, is made: 8～10 parts of Radix Gentianae Macrophyllae, 4～8 parts of Radix Aconiti Kusnezoffii Preparatas, 8～12 parts of Flos Caryophyllis, 0.5～1.0 part of Borneolum Syntheticum.
3. external application analgesic Chinese patent medicine according to claim 2, is characterized in that, mainly by the Chinese crude drug of following mass parts, is made: 9 parts of Radix Gentianae Macrophyllae, 6 parts of Radix Aconiti Kusnezoffii Preparatas, 10 parts of Flos Caryophyllis, 0.5 part of Borneolum Syntheticum.
4. according to Chinese patent medicine described in claim 1～3 any one, it is characterized in that, in described Chinese patent medicine, also can add the substrate pharmaceutically allowing to make external preparation.
5. the preparation method of the analgesia Chinese patent medicine described in claim 1～4 any one, comprises the steps:
(1) take in proportion each medicine;
(2) Flos Caryophylli adopts extraction by steam distillation volatile oil;
(3) all the other medical materials adopt ethanol refluxing process to make extracting solution, and concentrated, drying under reduced pressure is made extract powder;
(4) merge Flos Caryophylli volatile oil and extract powder, add Borneolum Syntheticum, make analgesia Chinese patent medicine with suitable substrate.
6. preparation method according to claim 5, is characterized in that, the condition of extracting the Flos Caryophylli volatile oil vapor distillation technology that adopt is more: add 8～12 times of water, soak 0.5～1h, extract 3～5h.
7. preparation method according to claim 5, is characterized in that, the technical conditions of the described ethanol refluxing process of step (3) are: 65～75% alcohol reflux 1～3 time, each 1～3h, filter merging filtrate, decompression recycling ethanol, concentrated, dry, make compound extract powder.
8. preparation method according to claim 5, it is characterized in that, the concrete operations of step (3) are: selecting hydrophilic high molecular material is substrate, even with medicament mixed such as extract extract powder, Flos Caryophylli volatile oil and Borneolum Syntheticums, 45～55 ℃ of refinings and 0.5～1.5h, coating, 45～55 ℃ of dry 2.5 ~ 3h, make analgesia gel cream.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922232A (en) * | 2015-05-25 | 2015-09-23 | 梁泽华 | Compound analgesic medicine and preparation method thereof |
| CN105832927A (en) * | 2016-06-12 | 2016-08-10 | 佛山市腾瑞医药科技有限公司 | Chinese patent medicine for clearing away heat, dispelling wind, alleviating pain and removing nebula and preparation process of Chinese patent medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251875A (en) * | 2012-02-16 | 2013-08-21 | 上海市南洋模范中学 | Pain-relieving traditional Chinese medicine preparation and preparation method thereof |
-
2014
- 2014-01-09 CN CN201410011289.7A patent/CN103751307B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251875A (en) * | 2012-02-16 | 2013-08-21 | 上海市南洋模范中学 | Pain-relieving traditional Chinese medicine preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张玉红等: "秦艽药理作用及临床应用研究进展", 《全国第3届临床中药学学术研讨会论文集》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922232A (en) * | 2015-05-25 | 2015-09-23 | 梁泽华 | Compound analgesic medicine and preparation method thereof |
| CN105832927A (en) * | 2016-06-12 | 2016-08-10 | 佛山市腾瑞医药科技有限公司 | Chinese patent medicine for clearing away heat, dispelling wind, alleviating pain and removing nebula and preparation process of Chinese patent medicine |
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