CN108057105A - It is a kind of for vegetable oil composition of the auxiliary treatment proliferation of mammary gland and preparation method thereof - Google Patents
It is a kind of for vegetable oil composition of the auxiliary treatment proliferation of mammary gland and preparation method thereof Download PDFInfo
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- CN108057105A CN108057105A CN201610977933.5A CN201610977933A CN108057105A CN 108057105 A CN108057105 A CN 108057105A CN 201610977933 A CN201610977933 A CN 201610977933A CN 108057105 A CN108057105 A CN 108057105A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
Abstract
The invention belongs to field of health care products, are related to a kind of for vegetable oil composition of the auxiliary treatment proliferation of mammary gland and preparation method thereof.Specifically, vegetable oil composition of the invention is made of following ingredients in parts by weight：4~8 parts of nutgrass galingale oils, 4~8 parts of oil of zedoary turmerics, 10~15 parts of motherwort oil and 1~6 part of centella oil.It is proved by pharmacological evaluation, the vegetable oil composition for the auxiliary treatment proliferation of mammary gland of the present invention can effectively alleviate the symptom of proliferation of mammary gland patient, and raw material is natural, non-stimulated, and preparation method is simple and easy to do, it is suitable for exploitation into the auxiliary product of the treatment proliferation of mammary gland, great market prospects.
Description
Technical field
The invention belongs to health product technology field, be related to a kind of vegetable oil composition for the auxiliary treatment proliferation of mammary gland and
Its preparation method.
Background technology
The proliferation of mammary gland (Hyperplasia of Mammary Glands, HMG) refers to that breast epithelium and fibr tissue increase
The growth of the retrogression pathological changes and progressive connective tissue of raw, breast tissue conduit and newborn leaflet in structure, be women most
Common breast disease.The pathogenic factor of the proliferation of mammary gland is varied, mainly including following several situations：(1) spirit is excessively tight
, mood it is excessively exciting；(2) multiple induced abortion；(3) estrogen definitely or relatively increases, progestational hormone is absolute or relative reduction；
(4) the long-term use of health products containing estrogen, contraceptive.
For the proliferation of mammary gland there are many types, some fully belongs to physiological hyperplasia (such as Simple proliferation of mammary gland, also known as breast
Pain), being not required to specially treated also can voluntarily disappear, and some then belongs to pathological proliferation (such as cystic hyperplasia), and there are cancers
The possibility of change is, it is necessary to active treatment, it is impossible to adopt a casual attitude.The proliferation of mammary gland can be divided into following 5 stages according to severity：
(1) hyperplasia of mammary glands (the I phases proliferation of mammary gland) is the initial stage hyperplasia of mammary gland, is mainly in 25~35 years old, Symptoms are lighter；(2)
Adenosis of mammary glands (also known as mammary duct ectasia, the II phases proliferation of mammary gland) is the further development of the I phase proliferations of mammary gland, from lobular hyperplasia
Mammary duct ectasia is developed to, is mainly in 30~45 years old, Symptoms are serious, easily draw attention, but often cure relatively more tired
Difficulty, obstinate cause depression, cause endocrine disturbance, and it is dark and gloomy etc. a series of irregular menstruation, insomnia and dreamful sleep, the colour of skin occur
Reaction；(3) cystic hyperplasia (also known as mammary duct ectasia merges epithelial hyperplasia disease, the III phases proliferation of mammary gland) is II phase mammary gland
The further development of hyperplasia, is mainly in 40~55 years old, and Symptoms are very serious, the canceration rate of III phase hyperplasia more than 70%,
It needs active treatment and inspects periodically, the III phases proliferation of mammary gland often brings depression and the feared state of mind to patient；(4) it is newborn
Adenocele disease (the IV phases proliferation of mammary gland) shows as breast ductal cells and epithelial cell bulk deposition is dead, is formed Cystic swollen
Block, canceration rate reach more than 90%；(5) breast cancer (the V phases proliferation of mammary gland) mostly by cystic hyperplasia and cystic disease further development and
Come, the preferred operation of early treatment of breast cancer should be as the case may be whether protecting breast.I phases and the II phase proliferations of mammary gland develop into breast
The probability of gland cancer is 1%~3%, and suffering from the proliferation of mammary gland must all treat in time, it is impossible to develop as one pleases.
Since the proliferation of mammary gland and in vivo hormonal readiness are closely related, treatment key is the hormone for adjusting itself
Environment.At present, on the market common curing mammary gland hyperplasia medicine include RUHE SANJIE PIAN (main component is radix bupleuri, Radix Angelicae Sinensis, Radix Astragali,
Radix Curcumae, Radix Rhapontici seu Radix Echinopsis etc.), rupixiao tablets, rupixiao pian (main component for deer horn, dandelion, kelp, root of Chinese trichosanthes, Caulis Spatholobi etc.), RUKUAIXIAO KELI
(main component is tangerine leaf, Radix Salviae Miltiorrhizae, the seed of cowherb, Fructus meliae toosendan, earthworm etc.), RUZENGNING PIAN (main component be folium artemisiae argyi, Herba Epimedii,
Asparagus fern, radix bupleuri, Fructus meliae toosendan etc.) and rujie'an capsules (main component is Radix Astragali, Radix Salviae Miltiorrhizae, selfheal, seaweed, oyster etc.), still in
Based on medicine, by herbal treatment function of human body come to eliminate proliferation of mammary gland symptom be a kind of practicable means of prevention.Above-mentioned medicine
Object is the Chinese patent medicine preparation being administered orally, and by using to treat the oils product of the proliferation of mammary gland rare report so far in vitro
Road.
The content of the invention
This case that be effectively used for the oils product of the auxiliary treatment proliferation of mammary gland for current shortage, in order to make up product
Blank, it is an object of the invention to provide a kind of for vegetable oil composition of the auxiliary treatment proliferation of mammary gland and preparation method thereof.
To achieve these goals, the present invention adopts the following technical scheme that：
A kind of vegetable oil composition for the auxiliary treatment proliferation of mammary gland is made of following ingredients in parts by weight：4
~8 parts of nutgrass galingale oils, 4~8 parts of oil of zedoary turmerics, 10~15 parts of motherwort oil and 1~6 part of centella oil.
Preferably, above-mentioned vegetable oil composition is made of following ingredients in parts by weight：5~7 parts of nutgrass galingale oils, 5~7 parts
Oil of zedoary turmeric, 12~14 parts of motherwort oil and 2~4 parts of centella oil.
It is furthermore preferred that above-mentioned vegetable oil composition is made of following ingredients in parts by weight：6 parts of nutgrass galingale oils, 6 parts of curcuma zedoarys
Oil, 13 parts of motherwort oil and 3 parts of centella oil.
Rhizoma cyperi is the rhizome of Cyperaceae nutgrass flatsedge platymiscium nutgrass flatsedge (Cyperus rotundus L.), and main product is in Zhejiang, good fortune
It builds, the provinces such as Hunan.Autumn excavates, and mild-natured, acrid flavour, micro-sweet, slight bitter, Return liver, spleen, tri-jiao channel, for soothing liver-qi stagnation, qi-regulating is wide
In, menstruction regulating and pain relieving.Rich in sesquiterpenoids ingredient in nutgrass galingale oil, mainly including eudesmane-type (such as α-cyperolone) and patchoulane type
(such as rhizome of nutgrass flatsedge alkene).
In above-mentioned vegetable oil composition, the nutgrass galingale oil is made using microwave radiation technology organic solvent extraction, specific mistake
Journey is as follows：It is crushed after rhizoma cyperi is cleaned, crosses 30~80 mesh sieves, obtain rhizoma cyperi powder；According to rhizoma cyperi powder:Ethyl acetate=1g:3~
Rhizoma cyperi powder is added in ethyl acetate by the dosage of 8mL, in room temperature Microwave Extraction 5~8 under the conditions of power is 300~600W
Minute；Residue is filtered out after extraction, filtrate decompression is concentrated into solvent-free taste, obtains nutgrass galingale oil.
In above-mentioned vegetable oil composition, the weight percent of α-cyperolone is more than 20% in the nutgrass galingale oil.
Curcuma zedoary is Zingiber curcuma zedoary (Curcuma phaeocaulis Val.), Guangxi zedoary (Curcuma
Kwangsiensis S.G.Lee et C.F.Liang) or Curcuma wenyujin (Curcuma wenyujin Y.H.Chen et
C.Ling rhizome), main product are also distributed in the provinces and regions such as Taiwan, Fujian, Jiangxi, Guangxi, India to Malaysia.Winter cauline leaf
It is excavated after withered, warm-natured, acrid flavour, hardship, Return liver, the spleen channel, for promoting the circulation of qi, Xie Yu, broken stasis of blood, analgesic.Sequiterpene is rich in oil of zedoary turmeric
Class (such as curdione and curzerene) ingredient.
In above-mentioned vegetable oil composition, the oil of zedoary turmeric is made using organic solvent ultrasonic extraction, and detailed process is such as
Under：It is crushed after curcuma zedoary is cleaned, crosses 30~80 mesh sieves, obtain curcuma zedoary powder；According to curcuma zedoary powder:Ether=1g:The use of 5~10mL
Amount, curcuma zedoary powder was added in ether, in room temperature ultrasonic extraction 10~30 minutes；Residue is filtered out after extraction, filtrate subtracts
Pressure is concentrated into solvent-free taste, obtains oil of zedoary turmeric.
In above-mentioned vegetable oil composition, the weight percent of curdione is more than 15% in the oil of zedoary turmeric, curzerene
Weight percent be more than 10%.
Motherwort is Labiatae mother wort plant motherwort (Leonurus artemisia (Laur.) S.Y.Hu F)
Aerial part, in all over China, Russia, Korea, Japan and America are also distributed main product.Shoot and leaf growth is vigorous, every plant open
It is harvested during Hua Dasan/bis-, cold nature, acrid flavour, hardship, the thoughts of returning home, liver, bladder warp, for promoting blood circulation and removing blood stasis, inducing diuresis for removing edema.Motherwort
Alkenes (such as 1-OCOL) ingredient there are many containing in oil.
In above-mentioned vegetable oil composition, the motherwort oil is made using microwave radiation technology organic solvent extraction, specifically
Process is as follows：It is crushed after motherwort is cleaned, crosses 30~80 mesh sieves, obtain motherwort powder；According to motherwort powder:Acetone=1g:5
The dosage of~10mL, motherwort powder is added in acetone, power under the conditions of 300~600W in room temperature Microwave Extraction 5~
10 minutes；Residue is filtered out after extraction, filtrate decompression is concentrated into solvent-free taste, obtains motherwort oil.
In above-mentioned vegetable oil composition, the weight percent of 1-OCOL is more than 20% in the motherwort oil.
Centella is the overground part of Umbelliferae Centella plant Centella asiatica (Centella asiatica (L.) Urban)
Point, be distributed in the provinces and regions such as Shaanxi, Jiangsu, Anhui, Zhejiang, Jiangxi, India, Malaysia, Indonesia and in non-be also distributed.Summer and autumn
Two seasons harvested, cold in nature, bitter, pungent, Return liver, spleen, kidney channel, for clearing heat and promoting diuresis, removing toxicity for detumescence.Sequiterpene is rich in centella oil
Enol class (such as 12 carbon triolefin -1- alcohol of 3,7,11- trimethyls-(E, Z) -2,6,10- and 3,7,11- trimethyls-(E, E) -2,6,
12 carbon triolefin -1- alcohol of 10-) ingredient.
In above-mentioned vegetable oil composition, the centella oil is made using organic solvent reflux extraction, detailed process
It is as follows：It is crushed after centella is cleaned, crosses 30~80 mesh sieves, obtain accumulated snow grass meal；According to accumulated snow grass meal:Acetone=1g:5~
Accumulated snow grass meal is added in acetone by the dosage of 10mL, when refluxing extraction 0.5~2 is small；Residue is filtered out after extraction, is filtered
Liquid is concentrated under reduced pressure into solvent-free taste, obtains centella oil.
In above-mentioned vegetable oil composition, 3,7,11- trimethyls-(E, E) -2 in the centella oil, 6,10- ten two carbon
The weight percent of triolefin -1- alcohol is more than 15%, 3,7,11- trimethyls-(E, Z) -2, the weight of 6,10- ten two carbon triolefin -1- alcohol
It measures percentage and is more than 10%.
A kind of preparation method of vegetable oil composition for the auxiliary treatment proliferation of mammary gland, includes the following steps：It will match somebody with somebody
Nutgrass galingale oil, oil of zedoary turmeric, motherwort oil, centella oil and the olive oil mixing just measured, are stirred at room temperature uniformly, obtain aiding in
Treat the vegetable oil composition of the proliferation of mammary gland.
In above-mentioned preparation method, the stirring is completed by mechanically or magnetically power agitating device.
The application method of the above-mentioned vegetable oil composition for the auxiliary treatment proliferation of mammary gland is as follows：Take 1mL or so plants daily
Object fluid composition is placed in the centre of the palm, with the hands smears uniformly, is subsequently placed at breast, massage of drawing a circle after being mixed with isometric olive oil
It is allowed to fully absorb within 5~10 minutes, each 1 time daily morning and evening, be used continuously 6 months.In addition, the present invention's is newborn for auxiliary treatment
The vegetable oil composition of gland hyperplasia also can be by being administered orally：1mL or so vegetable oil compositions are taken, each clothes after waking up daily and before sleeping
With 1 time, it is used continuously 3~6 months.
It is proved by pharmacological evaluation, the vegetable oil composition for the auxiliary treatment proliferation of mammary gland of the invention can effectively contract
The newborn block size of small proliferation of mammary gland patient, while alleviate mastodynia shape, and raw material is natural, non-stimulated, and preparation method is easy easily
Row is suitable for exploitation into the auxiliary product of the treatment proliferation of mammary gland, great market prospects.
Specific embodiment
Technical scheme is made below in conjunction with specific embodiment further elucidated above.The following example is only used
In the explanation and illustration present invention, and should not be taken as limiting the scope of the invention.Unless otherwise stated, institute in the following example
Instrument, reagent, material for using etc. can be obtained by routine business means.
Embodiment 1：The preparation of nutgrass galingale oil.
Dry, crushing after 1kg Sanming, Fujian Provinces production rhizoma cyperi is eluted with water, crosses 50 mesh sieves, obtains rhizoma cyperi powder, be then added to
In 5L ethyl acetate, Microwave Extraction machine (power 500W) is used in room temperature Microwave Extraction 6min.It is filtered out after extraction residual
Filtrate is placed in Rotary Evaporators and is concentrated under reduced pressure into solvent-free taste by slag, obtain nutgrass galingale oil (about 5.5g's, wherein α-cyperolone
Content is 23.9wt%).
Embodiment 2：The preparation of oil of zedoary turmeric.
Dry, crushing after 1kg Wenzhou District of Zhejiang Province production curcuma zedoary is eluted with water, crosses 50 mesh sieves, obtains curcuma zedoary powder, be then added to
In 8L ether, ultrasonic extractor (frequency 30kHz) is used in room temperature ultrasonic extraction 20min.It is filtered out after extraction residual
Slag, filtrate, which is placed in Rotary Evaporators, is concentrated under reduced pressure into solvent-free taste, and obtaining oil of zedoary turmeric, (about 6.2g's, wherein curdione contains
It measures as 18.1wt%, the content of curzerene is 12.1wt%).
Embodiment 3：The preparation of motherwort oil.
Dry, crushing after 1kg Jiangsu Huaian production motherwort is eluted with water, crosses 50 mesh sieves, obtains motherwort powder, Ran Houjia
Enter into 8L acetone, use Microwave Extraction machine (power 500W) in room temperature Microwave Extraction 8min.It is filtered out after extraction residual
Filtrate is placed in Rotary Evaporators and is concentrated under reduced pressure into solvent-free taste by slag, obtains motherwort oil (about 2.4g, wherein 1- octenes -3-
The content of alcohol is 20.2wt%).
Embodiment 4：The preparation of centella oil.
Dry, crushing after 1kg Hanzhongs production centella is eluted with water, crosses 50 mesh sieves, obtains accumulated snow grass meal, Ran Houjia
Enter into 8L acetone, be heated to flowing back under mechanical agitation, extract 1h, filter out residue after extraction, filtrate is put
Solvent-free taste is concentrated under reduced pressure into Rotary Evaporators, obtain centella oil (about 4.7g, wherein 3,7,11- trimethyls-(E, E)-
The content of 2,6,10- ten two carbon triolefin -1- alcohol is 17.2wt%, 3,7,11- trimethyls-(E, Z) -2,6,10- ten two carbon triolefins -
The content of 1- alcohol is 11.5wt%).
Embodiment 5- embodiments 9：For the preparation of the vegetable oil composition of the auxiliary treatment proliferation of mammary gland.
The vegetable oil composition for the auxiliary treatment proliferation of mammary gland is prepared according to the formula in table 1, preparation process is as follows：
By nutgrass galingale oil, oil of zedoary turmeric, motherwort oil and centella oil mixing, stirred evenly, used using mechanical stirring device in room temperature
In the vegetable oil composition of the auxiliary treatment proliferation of mammary gland.
Table 1. is used for the prescription and dosage of the vegetable oil composition of the auxiliary treatment proliferation of mammary gland
According to the test method in the People's Republic of China's standard GB/T/T26516-2011 massage essential oils to above-mentioned use
It is detected in the vegetable oil composition of the auxiliary treatment proliferation of mammary gland, the results are shown in Table 2.As shown in Table 2, use of the invention
Meet standard requirement in the vegetable oil composition of the auxiliary treatment proliferation of mammary gland, possess development prospect.
Table 2. is used for the Testing index result of the vegetable oil composition of the auxiliary treatment proliferation of mammary gland
Experimental example：For the effect experiment of the vegetable oil composition of the auxiliary treatment proliferation of mammary gland.
60 people of women (average age 52.2 years old) made a definite diagnosis with the proliferation of mammary gland for 45~60 years old is selected, is randomly divided into 6 groups, often
10 people of group are respectively 9 groups of blank control group, 5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment and embodiment.It controls
Treatment group takes 1mL or so vegetable oil compositions to be placed in the centre of the palm, with the hands smears uniformly, is subsequently placed in after being mixed with isometric olive oil
At breast, massage of drawing a circle is allowed to fully absorb for 5~10 minutes, each 1 time daily morning and evening, is used continuously 6 months, blank control group is only
It using olive oil, is equally carried out continuously 6 months, scores according to the therapeutic effect standard in table 3, the results are shown in Table 4.
3. curing mammary gland hyperplasia effect assessment table of table
The effect of the 4. vegetable oil composition auxiliary treatment proliferation of mammary gland of table
| Group | Average score |
| Blank control group | 0.2 |
| 5 groups of embodiment | 1.5 |
| 6 groups of embodiment | 1.2 |
| 7 groups of embodiment | 1.4 |
| 8 groups of embodiment | 1.5 |
| 9 groups of embodiment | 1.9 |
As seen from the above table, by the treatment of 6 months, proliferation of mammary gland patient use the present invention vegetable oil composition it
Afterwards, most of newborn block diameter reduces, and newborn pain phenomenon is alleviated, compared with the control group significant effect.Be suitable for exploitation into
The product of the auxiliary treatment proliferation of mammary gland.In addition, by the continuous use of 6 months, treatment group patient did not reflect there is any discomfort
Symptom, showing the vegetable oil composition of the present invention has certain security, can be safe to use.
Claims (9)
1. a kind of vegetable oil composition for the auxiliary treatment proliferation of mammary gland is made of following ingredients in parts by weight：4~
8 parts of nutgrass galingale oils, 4~8 parts of oil of zedoary turmerics, 10~15 parts of motherwort oil and 1~6 part of centella oil.
2. the vegetable oil composition according to claim 1 for the auxiliary treatment proliferation of mammary gland, it is characterised in that：
The vegetable oil composition is made of following ingredients in parts by weight：5~7 parts of nutgrass galingale oils, 5~7 parts of oil of zedoary turmerics, 12~
14 parts of motherwort oil and 2~4 parts of centella oil.
3. the vegetable oil composition according to claim 1 for the auxiliary treatment proliferation of mammary gland, it is characterised in that：
The vegetable oil composition is made of following ingredients in parts by weight：6 parts of nutgrass galingale oils, 6 parts of oil of zedoary turmerics, 13 portions of motherworts
Oil and 3 parts of centella oil.
4. the vegetable oil composition according to any one of claim 1 to 3 for the auxiliary treatment proliferation of mammary gland, feature
It is：
The weight percent of α-cyperolone is more than 20% in the nutgrass galingale oil.
5. the vegetable oil composition according to any one of claim 1 to 3 for the auxiliary treatment proliferation of mammary gland, feature
It is：
The weight percent of curdione is more than 15% in the oil of zedoary turmeric, and the weight percent of curzerene is more than 10%.
6. the vegetable oil composition according to any one of claim 1 to 3 for the auxiliary treatment proliferation of mammary gland, feature
It is：
The weight percent of 1-OCOL is more than 20% in the motherwort oil.
7. the vegetable oil composition according to any one of claim 1 to 3 for the auxiliary treatment proliferation of mammary gland, feature
It is：
The weight percent of 12 carbon triolefin -1- alcohol of 3,7,11- trimethyls-(E, Z) -2,6,10- is more than in the centella oil
15%, 3,7,11- trimethyls-(E, E) -2, the weight percent of 6,10- ten two carbon triolefin -1- alcohol is more than 10%.
8. a kind of vegetable oil composition according to any one of claim 1 to 7 for the auxiliary treatment proliferation of mammary gland
Preparation method includes the following steps：Nutgrass galingale oil, oil of zedoary turmeric, the motherwort oil of formula ratio and centella oil are mixed, in room temperature
It stirs evenly, obtains for the vegetable oil composition of the auxiliary treatment proliferation of mammary gland.
9. preparation method according to claim 8, it is characterised in that：
The stirring is completed by mechanically or magnetically power agitating device.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451452A (en) * | 2020-09-30 | 2021-03-09 | 美丽链接生物科技研究院(广东)有限公司 | Oat mammary gland dredging essential oil and preparation method thereof |
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2016
- 2016-11-08 CN CN201610977933.5A patent/CN108057105A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103550678A (en) * | 2013-09-23 | 2014-02-05 | 海南绿康元健康养生有限公司 | External essential oil composition for treating mammary gland hyperplasia and mammary gland tumor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112451452A (en) * | 2020-09-30 | 2021-03-09 | 美丽链接生物科技研究院(广东)有限公司 | Oat mammary gland dredging essential oil and preparation method thereof |
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Application publication date: 20180522 |