CN102302703B - Medicament for treating chloasma - Google Patents

Abstract

The invention discloses a medicament for treating chloasma. The medicament is prepared by uniformly mixing selected angelica dahurica, white peony root, white silkworm, rhizoma atractylodis macrocephalae, coix seed, yam, bletilla striata, cortex dictamni, talc, kudzuvine root, semen cassia, pharbitis seed, tuckahoe and tree peony bark which have been cleaned by clean water, grinding into powder with 100 to 120 meshes and sterilizing. The medicament has the effects of invigorating spleen and excreting dampness, keeping yin qi and wei qi balance, promoting flow of qi and blood circulation, and expelling wind and removing toxin; and the medicament can fulfill the aim of no side effects and high cure rate when used for treating chloasma.

Description

A kind of medicine for the treatment of chloasma

Technical field

The present invention relates to a kind of medicine for the treatment of chloasma, particularly relate to a kind of medicine of the treatment chloasma for preparing take Chinese medicine as crude drug.

Background technology

Chloasma is also referred to as chloasma hepaticum and butterfly spot, is a kind of symptom of facial melanosis, is the pigmentation spots that occurs in face.Mainly because of the female incretion imbalance, stress is large for chloasma, lacks the stimulation of vitamin and external chemicals in various diseases (hepatic and kidney function obstacle, gynaecopathia, diabetes) etc. and the body and causes.

Chloasma serious harm women happiness, chloasma spreads not second to indirectly disfeaturing face, therefore most women lose beauty and glamour, become self-doubt, depression is felt oneself inferior, and is unwilling in the face of friend, and the emotion of constraining in the course of time causes endocrine further to be lacked of proper care, expedite the emergence of more melanin and be deposited in face, so just caused the more long more phenomenons of chloasma.

At present the treatment primary disease be divided into the methods such as dietetic therapy, medication, naturopathy, but how undesirable therapeutic effect is, and wherein naturopathy is expensive and cure the symptoms, not the disease; The dietetic therapy onset is slow, need to take good care of for a long time; The Western medicine side effect is large.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of chloasma, this medicine is comprised of Chinese medicine, has spleen invigorating eliminating dampness by diuresis, harmonizing yingfen and weifen, promoting flow of QI and blood, an effect of the detoxifcation of dispeling the wind, can play the treatment of chloasma have no side effect, purpose that cure rate is high.

Medicine of the present invention is that the Chinese medicine by following parts by weight is that crude drug prepares:

The Radix Angelicae Dahuricae 5～9 Radix Paeoniae Albas 6～10 Bombyx Batryticatus 6～10

The Rhizoma Atractylodis Macrocephalae 6～10 Semen Coiciss 6～10 Rhizoma Dioscoreaes 6～10

The Pseudobulbus Bletillae (Rhizoma Bletillae) 4～8 Cortex Dictamni 4～6 Talcums 4～8

Radix Puerariae 5～9, Semen Cassiae 4～6 Semen Pharbitidiss 4～8

Poria 6～10 Cortex Moutans 4～6.

The concrete preparation method of medicine of the present invention being made powder is:

Said medicine is cleaned mix homogeneously by described parts by weight, be ground into 100～120 purpose medicated powder, sterilization makes the powder product.

The using method of powder of the present invention is: with milk (glycerol, Oleum sesami) powder of the present invention is reconciled into paste, evenly smear the affected part.

The traditional Chinese medical science thinks that the pathogenic factor of chloasma is impairment caused by overstrain spleen soil, the deficiency-weakness of spleen-QI inability of food and drink to be digested and transported is precise and tiny, so see lustreless complexion, to give birth in the insufficiency of the spleen then phlegm-damp, phlegm-damp and coagulation of QI-blood are among skin, can not evacuate, the coalescent speckle that forms, the mass-tone of yellow color referring to the spleen, temper stalwartness then yellow skin and evenly, bright, deficiency of spleen-QI is yellow skin and dark stagnating then, so see brown spot.The Therapeutic Principle should be the spleen invigorating eliminating dampness by diuresis, harmonizing yingfen and weifen, promoting flow of QI and blood, the detoxifcation of dispeling the wind.The Radix Angelicae Dahuricae is dispersed, the circulation of qi promoting promoting the circulation of blood; Radix Puerariae expelling pathogenic factors from muscles by diaphoresis, loosing the interspaces of skin and muscles; Bombyx Batryticatus dispelling pathogenic wind and eliminating phlegm, the circulation of qi promoting of stimulating the menstrual flow; The Radix Paeoniae Alba nourish blood yin fluid astringing, harmonizing yingfen and weifen; Rhizoma Dioscoreae invigorating the spleen and replenishing QI, transporting phlegm-damp; The Poria promoting diuresis to eliminate damp pathogen; The Semen Coicis promoting diuresis to eliminate damp pathogen; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, consolidating superficial resistance are driven evil; Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation; Cortex Moutan blood circulation promoting and blood stasis dispelling, blood circulation promoting; The Semen Pharbitidis relieving constipation by purgation; Talcum dampness removing sore; Cortex Dictamni heat clearing and damp drying, the detoxifcation of dispeling the wind; Semen Cassiae liver heat removing and eyesight improving, beneficial nourishing liver-YIN.All medicines share, the effect that can play spleen invigorating eliminating dampness by diuresis, harmonizing yingfen and weifen, promoting flow of QI and blood, dispel the wind and detoxify.The purpose that the treatment that is used for chloasma can be played and have no side effect, cure rate is high.

For further investigating clinical efficacy and the safety of medicine of the present invention, select 45 routine patient with chloasma that the curative effect of medicine of the present invention has been carried out clinical observation.

45 routine cases are divided into two groups at random, treatment group 25 examples, matched group 20 examples.The diagnostic criteria of " chloasma clinical diagnosis and criterion of therapeutical effect (revised draft in 2003) " that all cases is all formulated according to CAIM (Chinese Association Of Integrative Medicine) Dermatology Professional Committee pigment disease group is diagnosed as chloasma.

Diagnostic criteria

1, facial filbert to dark brown, well-defined patch, symmetry distributes usually, NIP performance and squama;

2, without obvious subjective symptoms;

3, the women is multiple, mainly occur in adolescence after;

4, the state of an illness can have seasonality, and the Chang Xiachong winter is light;

5, get rid of the pigmentation that Other diseases causes.

Methods of marking and standard: the scoring of skin lesion area: 0 is without skin lesion; 1 is area＜2cm ²2 is area 2～4 cm ²3 is skin lesion area＞4cm ²The scoring of skin lesion color: 0 is the normal colour of skin; 1 is filbert; 2 is brown; 3 is dark brown.Total mark=area scoring+color scoring.4, point system decline index calculation method: total mark before decline index=(total mark after total mark before the treatment-treatment)/treatment.

Therapeutic Method

Matched group adopts vitamin C, and is oral, one time 2,3 times on the one, the topical Retinoids frost is wiped the affected part every day outward 1 time simultaneously.Treatment group adopts powder agent medicine of the present invention to treat, and every day 2 times powder agent medicine of the present invention is reconciled into paste with milk, smears the affected part.30 days is a course for the treatment of, uses altogether 2 courses for the treatment of.

Criterion of therapeutical effect

According to the criterion of therapeutical effect in chloasma clinical diagnosis and the criterion of therapeutical effect (revised draft in 2003), cure: 1. naked eyes are looked the mottle area and are disappeared〉90%, color disappears substantially; 2. point system is calculated the rear decline index for the treatment of 〉=0.8; Produce effects: 1. naked eyes look the mottle area and disappear＞60%, color is obviously thin out; 2. point system is calculated the rear decline index for the treatment of 〉=0.5.Invalid: 1. naked eyes look the mottle area and disappear＜30%, change color is not obvious; 2. point system is calculated the rear decline index for the treatment of≤0.

The curative effect comparative result sees Table 1 after two groups of case treatments.

Curative effect relatively after the table 1 liang group case treatment

Group	The example number	Cure n(%)	Produce effects n(%)	Invalid n(%)	Total effective rate n(%)
						Matched group	20	5（25）	10（50）	5（25）	15（75）
Treatment group	25	16（64）	7（28）	2（8）	23（92）

Statistical result showed, the treatment group curative effect obviously is better than matched group, and two group differences are remarkable, P＜0.05.

The specific embodiment

Embodiment 1

Get Radix Angelicae Dahuricae 50g, Radix Paeoniae Alba 60g, Bombyx Batryticatus 60g, Rhizoma Atractylodis Macrocephalae 60g, Semen Coicis 60g, Rhizoma Dioscoreae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g, Cortex Dictamni 40g, Talcum 40g, Radix Puerariae 50g, Semen Cassiae 40g, Semen Pharbitidis 40g, Poria 60g, Cortex Moutan 40g mix homogeneously selected, that clear water is cleaned, be ground into 100～120 medicated powder, sterilization makes the powder product.

Embodiment 2

Get Radix Angelicae Dahuricae 70g, Radix Paeoniae Alba 80g, Bombyx Batryticatus 80g, Rhizoma Atractylodis Macrocephalae 80g, Semen Coicis 80g, Rhizoma Dioscoreae 80g, Pseudobulbus Bletillae (Rhizoma Bletillae) 60g, Cortex Dictamni 50g, Talcum 60g, Radix Puerariae 70g, Semen Cassiae 50g, Semen Pharbitidis 60g, Poria 80g, Cortex Moutan 50g mix homogeneously selected, that clear water is cleaned, be ground into 100～120 medicated powder, sterilization makes the powder product.

Claims (1)

1. medicine for the treatment of chloasma is that crude drug prepares by the Chinese medicine of following portions by weight:

The Radix Angelicae Dahuricae 5～9 Radix Paeoniae Albas 6～10 Bombyx Batryticatus 6～10

The Rhizoma Atractylodis Macrocephalae 6～10 Semen Coiciss 6～10 Rhizoma Dioscoreaes 6～10

The Pseudobulbus Bletillae (Rhizoma Bletillae) 4～8 Cortex Dictamni 4～6 Talcums 4～8

Radix Puerariae 5～9, Semen Cassiae 4～6 Semen Pharbitidiss 4～8

Poria 6～10 Cortex Moutans 4～6,

With milk, glycerol or Oleum sesami medicine is reconciled into paste, smear the affected part.