CN102499973A - Compound propolis composition for treating dog and cat scabies and preparation method thereof - Google Patents
Compound propolis composition for treating dog and cat scabies and preparation method thereof Download PDFInfo
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- CN102499973A CN102499973A CN2011104431012A CN201110443101A CN102499973A CN 102499973 A CN102499973 A CN 102499973A CN 2011104431012 A CN2011104431012 A CN 2011104431012A CN 201110443101 A CN201110443101 A CN 201110443101A CN 102499973 A CN102499973 A CN 102499973A
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Abstract
The invention relates to a compound propolis composition for treating dog and cat scabies and a preparation method thereof, belonging to the field of animal medicine. The preparation method of the compound propolis composition comprises the following steps: (1) weighting 5-10 parts by weight of propolis ethanol extract, 5-10 parts by weight of golden larch bark ethanol extract, 5-10 parts by weight ofradix stemonae ethanol extract, 5-10 parts by weight of sophora flavescens ethanol extract, 5-10 parts by weight of felwort ethanol extract, 45 parts by weight of 75% ethanol and 20-45 parts by weight of distilled water; (2) putting the propolis ethanol extract, the golden larch bark ethanol extract and the radix stemonae ethanol extract into 25 parts of 75% ethanol, and stirring uniformly for 5-10 minutes; (3) taking 15 parts of 75% ethanol, adding the sophora flavescens ethanol extract and the felwort ethanol extract in sequence, and stirring for dissolving; and (4) mixing the solution prepared in the steps (2) and (3), stirring uniformly, standing for 15-20 minutes, and adding the left 5 parts of 75% ethanol and the 20-45 parts of distilled water after the liquid medicine is clear, stirring uniformly and filtering. The compound propolis composition has reasonable components, is easy to prepare and use and has significant curative effect.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment dog cat acaricide and preparation method thereof.
Background technology
Dog cat acaricide is to parasitize the dermatosis that causes in the dog cat skin skin by sarcoptes canis or cat back of the body anus demodicid mite; Infection site is spread to whole body by the part, and erythema, pimple, incrustation, depilation appear in pars affecta skin, can bring out septicemia like secondary infection; Be that ill dog cat becomes thin gradually, until death.The dog cat of various ages and kind all can be taken place, and case fatality rate is all between 1%-10%.Primary disease all can take place throughout the year, is one of principal disease of house pets such as serious harm dog cat.
This disease almost spreads all over house pets such as all dog cats of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine, antimicrobial drug and anthelmintic, Chinese medicine is because its prescription is unreasonable or be simple powder, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug and anthelmintic be because life-time service be prone to produce drug resistance, its clinical effectiveness worse and worse, thereby make the use of antimicrobial drug receive very big restriction.
Therefore researching and developing a kind of specific medicament of treating the generation that has no drug resistance of dog cat acaricide is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, bioavailability is high, effect is obvious and effective compound bee-glue composition of treating dog cat acaricide of having no drug resistance and preparation method thereof.
Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of compound bee-glue composition of treating dog cat acaricide, by following component by weight mixed preparing form: propolis ethanol extract 5-10 part, Cortex Pseudolaricis ethanol extract 5-10 part, Radix Stemonae ethanol extract 5-10 part, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water.
On the basis of such scheme, said various component optimum ratio amounts are: 8 parts of propolis ethanol extract, 7 parts of Cortex Pseudolaricis ethanol extract, 8 parts of Radix Stemonae ethanol extract, 8 parts of Radix Sophorae Flavescentis ethanol extract, 7 parts of Radix Gentianae ethanol extract, 45 parts of 75% ethanol, 35 parts of distilled water.
A kind of method for preparing of treating the compound bee-glue composition of dog cat acaricide, carry out as follows:
(1) takes by weighing 5～10 parts of propolis ethanol extract, 5～10 parts of Cortex Pseudolaricis ethanol extract, 5～10 parts of Radix Stemonae ethanol extract, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water by weight;
(2) said propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 25 parts 75% ethanol, stirred 5～10 minutes to evenly;
(3) get 15 parts of 75% ethanol, add Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of said umber successively, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, kept 15～20 minutes, treat that the clear and bright back of medicinal liquid adds 5 parts of said residue 75% ethanol, 20～45 parts of distilled water, stirring to filter gets final product.
The medicinal property of each component is following:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function that anti-inflammation, pain relieving are only overworked, promote tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Cortex Pseudolaricis: hot, warm, return lung, spleen channel, have parasite killing, end overworked function; Cure mainly scabies pruritus etc.
The Radix Stemonae: sweet, bitter, return lung meridian, have nourishing the lung to arrest cough, parasiticidal function; Cure mainly cough, enterobiasis, ascariasis, scabies, body louse etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, the heart, stomach, large intestine, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery, scabies etc.
Radix Gentianae: bitter, cold, return liver, gallbladder meridian, have eliminating pathogen in the liver gallbladder excess-fire, remove the function of damp-heat in lower-JIAO; It is overworked etc. to cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema scabies.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism, clinical symptoms and the pathological change of dog cat acaricide, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no drug resistance, and cost is low, and it is wide to draw materials, and method for using simply, is directly smeared disease sites, curative effect highly significant.The present invention optimizes this Chinese medicine of the five flavours according to Chinese veterinarian's traditional theory, and makes them form pure Chinese medicine liquid according to optimum ratio, and clinical practice proves that treatment dog cat acaricide is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition of treating dog cat acaricide and preparation method thereof: carry out as follows: (every part by 10g)
(1) takes by weighing 50 parts of propolis ethanol extract, 50 parts of Cortex Pseudolaricis ethanol extract, 50 parts of Radix Stemonae ethanol extract, 50 parts of Radix Sophorae Flavescentis ethanol extract, 50 parts of Radix Gentianae ethanol extract, 450 parts of 75% ethanol, 350 parts of distilled water by weight;
(2) said propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 250 parts 75% ethanol, stirred 5～10 minutes to evenly;
(3) get 150 parts of 75% ethanol, add Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of said umber successively, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, kept 15～20 minutes, treat that the clear and bright back of medicinal liquid adds 50 parts of said residue 75% ethanol, 350 parts of distilled water, stirring to filter gets final product.
Embodiment 2
A kind of compound bee-glue composition of treating dog cat acaricide and preparation method thereof: carry out as follows: (every part by 10g)
(1) takes by weighing 80 parts of propolis ethanol extract, 70 parts of Cortex Pseudolaricis ethanol extract, 80 parts of Radix Stemonae ethanol extract, 70 parts of Radix Sophorae Flavescentis ethanol extract, 80 parts of Radix Gentianae ethanol extract, 450 parts of 75% ethanol, 350 parts of distilled water by weight;
(2) said propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 250 parts 75% ethanol, stirred 5～10 minutes to evenly;
(3) get 150 parts of 75% ethanol, add Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of said umber successively, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, kept 15～20 minutes, treat that the clear and bright back of medicinal liquid adds 50 parts of said residue 75% ethanol, 350 parts of distilled water, stirring to filter gets final product.
Embodiment 3
A kind of compound bee-glue composition of treating dog cat acaricide and preparation method thereof: carry out as follows: (every part by 10g)
(1) takes by weighing 100 parts of propolis ethanol extract, 100 parts of Cortex Pseudolaricis ethanol extract, 100 parts of Radix Stemonae ethanol extract, 100 parts of Radix Sophorae Flavescentis ethanol extract, 100 parts of Radix Gentianae ethanol extract, 450 parts of 75% ethanol, 450 parts of distilled water by weight;
(2) said propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 250 parts 75% ethanol, stirred 5～10 minutes to evenly;
(3) get 150 parts of 75% ethanol, add Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of said umber successively, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, kept 15～20 minutes, treat that the clear and bright back of medicinal liquid adds 50 parts of said residue 75% ethanol, 450 parts of distilled water, stirring to filter gets final product.
Clinical trial:
Product of the present invention is directly smeared the skin of ill dog cat, and wet skin gets final product, every day 2-3 time, logotype 5-7 day.
Table is the field applicable cases contrast of the present invention and other medicines treatment dog cat acaricide:
| Numbering | Group | Case fatality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 5.5 | 77.0 | 17.5 |
| II | Acaricide spirit group | 4.3 | 84.9 | 10.8 |
| III | Present composition group | 1.5 | 92.8 | 5.7 |
This clinical effectiveness is through statistical analysis, and present composition treatment group is being compared difference extremely significantly (P＜0.01) with acaricide spirit group aspect the cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment dog cat acaricide and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition of treating dog cat acaricide, it is characterized in that by following component by weight mixed preparing form: propolis ethanol extract 5-10 part, Cortex Pseudolaricis ethanol extract 5-10 part, Radix Stemonae ethanol extract 5-10 part, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water.
2. the compound bee-glue composition of treatment according to claim 1 dog cat acaricide, it is characterized in that by following component by weight mixed preparing form: 8 parts of propolis ethanol extract, 7 parts of Cortex Pseudolaricis ethanol extract, 8 parts of Radix Stemonae ethanol extract, 8 parts of Radix Sophorae Flavescentis ethanol extract, 7 parts of Radix Gentianae ethanol extract, 45 parts of 75% ethanol, 35 parts of distilled water.
3. the method for preparing of the compound bee-glue composition of a treatment according to claim 1 and 2 dog cat acaricide is characterized in that carrying out as follows:
(1) takes by weighing 5～10 parts of propolis ethanol extract, 5～10 parts of Cortex Pseudolaricis ethanol extract, 5～10 parts of Radix Stemonae ethanol extract, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water by weight;
(2) said propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 25 parts 75% ethanol, stirred 5～10 minutes to evenly;
(3) get 15 parts of 75% ethanol, add Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of said umber successively, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, kept 15～20 minutes, treat that the clear and bright back of medicinal liquid adds 5 parts of said residue 75% ethanol, 20～45 parts of distilled water, stirring to filter gets final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110443101.2A CN102499973B (en) | 2011-12-27 | 2011-12-27 | Compound propolis composition for treating dog and cat scabies and preparation method thereof |
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| CN201110443101.2A CN102499973B (en) | 2011-12-27 | 2011-12-27 | Compound propolis composition for treating dog and cat scabies and preparation method thereof |
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| CN102499973A true CN102499973A (en) | 2012-06-20 |
| CN102499973B CN102499973B (en) | 2014-04-09 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239594A (en) * | 2013-05-31 | 2013-08-14 | 王磊 | Topical pharmaceutical composition for preventing and treating canine acariasis disease and preparation method thereof |
| CN103385927A (en) * | 2013-07-16 | 2013-11-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for the treatment of animal acariasis |
| WO2017010858A1 (en) * | 2015-07-15 | 2017-01-19 | Flores Samaniego Beatriz | Composition based on extracts of heliopsis longipes and propolis for the control and/or elimination of ticks |
| CN107582943A (en) * | 2017-11-08 | 2018-01-16 | 山西农业大学 | A kind of herbal mixture transdermal spray agent for preventing and treating animal psoroptic mange and preparation method |
-
2011
- 2011-12-27 CN CN201110443101.2A patent/CN102499973B/en not_active Expired - Fee Related
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| 张丁华等: "猫皮肤真菌病的诊治及预防 ", 《兽医导刊》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239594A (en) * | 2013-05-31 | 2013-08-14 | 王磊 | Topical pharmaceutical composition for preventing and treating canine acariasis disease and preparation method thereof |
| CN103385927A (en) * | 2013-07-16 | 2013-11-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for the treatment of animal acariasis |
| WO2017010858A1 (en) * | 2015-07-15 | 2017-01-19 | Flores Samaniego Beatriz | Composition based on extracts of heliopsis longipes and propolis for the control and/or elimination of ticks |
| CN107582943A (en) * | 2017-11-08 | 2018-01-16 | 山西农业大学 | A kind of herbal mixture transdermal spray agent for preventing and treating animal psoroptic mange and preparation method |
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| CN102499973B (en) | 2014-04-09 |
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