CN103239594A - Topical pharmaceutical composition for preventing and treating canine acariasis disease and preparation method thereof - Google Patents
Topical pharmaceutical composition for preventing and treating canine acariasis disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a topical pharmaceutical composition for preventing and treating a canine acariasis disease and a preparation method thereof. The topical pharmaceutical composition comprises the following raw medicinal materials in parts by weight: 10-30 parts of fennel, 5-20 parts of wrinkled giant hyssop, 10-30 parts of black false hellebore, 5-15 parts of radix sophorae flavescentis, 5-15 parts of camphortree leaf, 10-30 parts of gamboges, 5-20 parts of Chinese violet and 10-30 parts of mint. The preparation method comprises the steps of alcohol extraction of a liquid medicine, concentration of an extract, and a preparation technology. The topical pharmaceutical composition has the beneficial effects that the characteristics of the medicament are combined on the basis of modern Chinese medicine research; the alcohol extraction technology is adopted aiming at the symptoms of the canine acariasis disease and excited bacterial infection; the extraction rate of the effective ingredients is improved; the percutaneous absorption ability of the medicament is enhanced by adopting a scientific preparation technology; the external Chinese medicine preparation for a dog is prepared; and acarids in endothelium and epidermis of the dog are completely killed. Compared with the traditional therapeutic medicament, the topical pharmaceutical composition has the advantages of being low in toxicity and suitable for all kinds of dogs.
Description
Technical field
The present invention relates to a kind of dog external herbal medicine, particularly be externally-applied medicinal composition of skin diseases such as the depilation that causes owing to reasons such as acarids of a kind of prophylactic treatment dog, dermatitis, infection and preparation method thereof.
Background technology
The dog acariasis is dog common skin disease, a kind of chronic parasitic dermatosis of the dog that is caused by acarid.Feature: dog show as play itch uneasiness, come off by hair and the dermatitis symptom many with chronic dermatitis, Pruritus, the affected part depilation, incrustation and whole body are stench distinguishes the flavor of.Though be not fatal disease, the course of disease is longer, if diagnosis and treatment are improper, can increase the weight of the state of an illness or secondary infection other diseases, cause comparatively serious consequence, bring certain difficulty to treatment.Acaricide is mainly in winter, Qiu Mo and at the beginning of the spring.Because these in season the irradiate light deficiency, dog hair is close and grow, particularly under bad, the moist situation of doghouse environmental health, growth and the breeding of suitable acarid.The acarid of common infected dogs is by acaricide and vermiform mite, based on acaricide.
The dog acariasis is multiple with pup, how to arise from head, the bridge of the nose earlier, and eye socket, ear and chest develop into trunk and extremity then.Sick skin rubefaction just has the brief summary of rash shape, and there are a large amount of wheat bran shape scurfs on the surface, so pachyderma, by hair come off, surface coverage crust, be full of cracks.Sick dog play is itched, and affected part can have purulent secretion when infection was arranged, and frowziness.Directly influence the sight of pet dog, after dog infects acarid, after the treatment recovery from illness, all can fall ill every year later on, and acariasis can infect to the people, influence human beings'health.
Now in the control of the acarid of dog, mainly take to inject the method for ivermectin, but ivermectin is invalid to the acarid that is in the worm's ovum phase, need life-time service, and ivermectin has stronger toxicity, can not use a large amount of uses, can not be used for Collie, and the price comparison height only is applicable to pet dog, and is inapplicable to the dog of other purposes.The main acarid that uses Amitraz to kill environment and body surface, toxicity is bigger, avoids during use poisoning.
Summary of the invention
Technical problem to be solved by this invention is, now in the control of the acarid of dog, mainly take to inject the method for ivermectin, but ivermectin is invalid to the acarid that is in the worm's ovum phase, needs life-time service, and ivermectin has stronger toxicity, a large amount of uses can not be used, Collie can not be used for, and the price comparison height, only be applicable to pet dog, inapplicable to the dog of other purposes.The main acarid that uses Amitraz to kill environment and body surface, toxicity is bigger, avoids during use poisoning.
In order to solve the problems of the technologies described above, the externally-applied medicinal composition that the invention provides that a kind of side effect is little, outstanding effect is used for control dog acariasis, described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 10～30 parts of 10～30 parts in Fructus Foeniculi, 5～20 parts of Herba Pogostemoniss, 10～30 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 5～15 parts of Radix Sophorae Flavescentiss, 5～15 parts of Folium cinnamomi camphorae, 10～30 parts of Resina garciniaes, 5～20 parts of Herba Violaes and Herba Menthaes.
Described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 10 parts of 10 parts in Fructus Foeniculi, 5 parts of Herba Pogostemoniss, 10 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Folium cinnamomi camphorae, 10 parts of Resina garciniaes, 5 parts of Herba Violaes and Herba Menthaes.
Described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 30 parts of 30 parts in Fructus Foeniculi, 20 parts of Herba Pogostemoniss, 30 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 15 parts of Radix Sophorae Flavescentiss, 15 parts of Folium cinnamomi camphorae, 30 parts of Resina garciniaes, 20 parts of Herba Violaes and Herba Menthaes.
Described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 20 parts of 20 parts in Fructus Foeniculi, 12.5 parts of Herba Pogostemoniss, 20 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Folium cinnamomi camphorae, 20 parts of Resina garciniaes, 12.5 parts of Herba Violaes and Herba Menthaes.
In order to realize that better foregoing invention purpose, the present invention also provide a kind of preparation method for the externally-applied medicinal composition of preventing and treating the dog acariasis, may further comprise the steps:
(1) alcohol extraction medicinal liquid step: each raw medicinal material is mixed by weight ratio, and ethanol percolate extraction obtains the alcohol extraction medicinal liquid after the filtration;
(2) concentrated extract step: the alcohol extraction medicinal liquid that obtains in the described alcohol extraction medicinal liquid step is concentrated, obtain concentrated extract;
(3) preparation process step: the concentrated extract that obtains in the described concentrated extract step is adopted preparation process, can make described pharmaceutical composition.
Wherein, described alcohol extraction medicinal liquid step comprises: each raw medicinal material is mixed by weight ratio, be positioned in the percolation jar, added 80%～95% soak with ethanol 6～12 hours by 2～5 times of amounts of raw medicinal material gross weight, add 80%～95% ethanol then, percolation extracts, be 8～15 times of raw medicinal material gross weight up to the volume of percolate, stop percolation and extract, filter percolate, obtain the alcohol extraction medicinal liquid.
Described concentrated extract step comprises: the alcohol extraction medicinal liquid in the alcohol extraction medicinal liquid step is put into concentrator, be-0.02 at pressure～-concentrate under the 0.05MPa, 40～70 ℃ of conditions of temperature, be concentrated into the thick paste shape, obtain concentrated extract.
Described preparation process step comprises: the concentrated extract in the concentrated extract step is added 100～200 milliliters of 80%～95% 60～100 milliliters of 10～30 milliliters of 50～100 milliliters of ethanol, azones, lanolines and liquid paraffin according to every kilogram of concentrated extract, be heated to 40～70 ℃, cooling obtains paste and is described pharmaceutical composition.
The present invention also provides a kind of using method for the externally-applied medicinal composition of preventing and treating the dog acariasis, is about to described pharmaceutical composition and directly is applied in the affected part.
The beneficial effect that the technical scheme that the embodiment of the invention provides is brought is: medicine of the present invention is on the basis of modern Chinese medicine research, characteristics in conjunction with said medicine, at to the symptom of dog acariasis and the bacterial infection that excites, adopt alcohol extraction process, improve extraction ratio of effective constituents, adopt the preparation process of science, strengthen the percutaneous absorbability of medicine, preparation is fit to the Chinese medicine for external application that dog is used, and kills the acarid of dog endothelium and epidermis comprehensively.Compare with traditional medicine, it is low to have toxicity, and is suitable for the advantage of all kind of dog.
The specific embodiment
Medicine of the present invention is on the basis of modern Chinese medicine research, in conjunction with the characteristics of said medicine, to the symptom of dog acariasis and the bacterial infection that excites, select suitable Chinese medicine, adopt rational technology, strengthen the percutaneous absorbability of medicine, kill the acarid of dog endothelium and epidermis.Fructus Foeniculi is the dry mature fruit of samphire Fructus Foeniculi, the energy pain relieving, and antibacterial, wherein volatile oil component has the parasite of killing effect; Herba Pogostemonis is the herb of dicotyledon medicine labiate Herba Pogostemonis or Herba Pogostemonis, and its extract has inhibitory action to fungus and antibacterial; Rhizoma et radix veratri (Radix Rhizoma Veratri) is the root and rhizome of dicotyledon medicine liliaceous plant RADIX ET RHIZOMA VERATRI NIGRI, has heat-clearing and toxic substances removing, disinsection efficiency, is used for the treatment of scabies; Radix Sophorae Flavescentis is the root of the plant of pulse family Radix Sophorae Flavescentis genus, and the external insecticidal action is used for pudendal pruritus; Scabies; Skin pruritus; The treatment of noxious dampness skin infection; Folium cinnamomi camphorae is the leaf of dicotyledon medicine canella Camphor tree, has parasite killing, antibacterial effect; Resina garciniae is the colloid resin of dicotyledon medicine Guttiferae plant Resina garciniae, and is inhibited to staphylococcus aureus; The herb of Herba Violae Violaceae Chinese violet can be used in the treatment of sore and toxic, and Herba Menthae is herb or the leaf of dicotyledon medicine labiate Herba Menthae or tame Herba Menthae; External can sterilize, antipruritic.
Embodiment 1
The embodiment of the invention provides a kind of externally-applied medicinal composition for control dog acariasis, and it is made up of following raw medicinal material: Fructus Foeniculi 100g, Herba Pogostemonis 50g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 100g, Radix Sophorae Flavescentis 50g, Folium cinnamomi camphorae 50g, Resina garciniae 100g, Herba Violae 50g and Herba Menthae 100g.
The embodiment of the invention also provides a kind of preparation method for the externally-applied medicinal composition of preventing and treating the dog acariasis, may further comprise the steps:
(1) alcohol extraction medicinal liquid step: get Fructus Foeniculi 100g, Herba Pogostemonis 50g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 100g, Radix Sophorae Flavescentis 50g, Folium cinnamomi camphorae 50g, Resina garciniae 100g, Herba Violae 50g and Herba Menthae 100g and mix, the percolation extraction pot is put in the raw medicinal material mixing, the ethanol of adding 80% in the percolation extraction pot, the amount of alcohol that adds is 2 times of mixed material medical material gross weight, soaked 6 hours, add 80% ethanol then, percolation extracts, be 8 times of raw medicinal material gross mass up to the volume that obtains percolate, stop to extract, the percolate that obtains is filtered and the collection medicinal liquid, obtain the ethanol extraction medicinal liquid;
(2) concentrated extract step: utilize concentrator to concentrate above-mentioned ethanol extraction medicinal liquid, concentrate pressure for-0.02Mpa, temperature are 40 ℃, until the ethanol extraction medicinal liquid being concentrated into the thick paste shape, obtain concentrated extract;
(3) preparation process step: will add 100 milliliters of 80% 60 milliliters of 10 milliliters of 50 milliliters of ethanol, azones, lanolines and liquid paraffin according to every kilogram of concentrated extract in the concentrated extract of concentrated extract step, be heated to 40 ℃, cooling obtains paste and is described pharmaceutical composition.
Embodiment 2
The embodiment of the invention provides a kind of externally-applied medicinal composition for control dog acariasis, and it is made up of raw medicinal material: get Fructus Foeniculi 300g, Herba Pogostemonis 200g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 300g, Radix Sophorae Flavescentis 150g, Folium cinnamomi camphorae 150g, Resina garciniae 300g, Herba Violae 200g and Herba Menthae 300g.
The embodiment of the invention also provides a kind of preparation method for the externally-applied medicinal composition of preventing and treating the dog acariasis, may further comprise the steps:
(1) alcohol extraction medicinal liquid step: get Fructus Foeniculi 300g, Herba Pogostemonis 200g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 300g, Radix Sophorae Flavescentis 150g, Folium cinnamomi camphorae 150g, Resina garciniae 300g, Herba Violae 200g and Herba Menthae 300g mix, the percolation extraction pot is put in the raw medicinal material mixing, the ethanol of adding 95% in the percolation extraction pot, the amount of alcohol that adds is 5 times of mixed material medical material gross weight, soaked 12 hours, add 95% ethanol then, percolation extracts, be 15 times of raw medicinal material gross mass up to the volume that obtains percolate, stop to extract, the percolate that obtains is filtered and the collection medicinal liquid, obtain the ethanol extraction medicinal liquid;
(2) concentrated extract step: utilize concentrator to concentrate above-mentioned ethanol extraction medicinal liquid, concentrate pressure for-0.05Mpa, temperature are 70 ℃, until the ethanol extraction medicinal liquid being concentrated into the thick paste shape, obtain concentrated extract;
(3) preparation process step: will add 200 milliliters of 95% 100 milliliters of 30 milliliters of 100 milliliters of ethanol, azones, lanolines and liquid paraffin according to every kilogram of concentrated extract in the concentrated extract of concentrated extract step, be heated to 70 ℃, cooling obtains paste and is described pharmaceutical composition.
Embodiment 3
The embodiment of the invention provides a kind of externally-applied medicinal composition for control dog acariasis, and it is made up of following raw medicinal material: Fructus Foeniculi 200g, Herba Pogostemonis 125g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 200g, Radix Sophorae Flavescentis 100g, Folium cinnamomi camphorae 100g, Resina garciniae 200g, Herba Violae 125g and Herba Menthae 200g.
The embodiment of the invention also provides a kind of preparation method for the externally-applied medicinal composition of preventing and treating the dog acariasis, may further comprise the steps:
(1) alcohol extraction medicinal liquid step: get Fructus Foeniculi 200g, Herba Pogostemonis 125g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 200g, Radix Sophorae Flavescentis 100g, Folium cinnamomi camphorae 100g, Resina garciniae 200g, Herba Violae 125g and Herba Menthae 200g mix, the percolation extraction pot is put in the raw medicinal material mixing, the ethanol of adding 90% in the percolation extraction pot, the amount of alcohol that adds is 4 times of mixed material medical material gross weight, soaked 9 hours, add 90% ethanol then, percolation extracts, be 12 times of raw medicinal material heavy amount up to the volume that obtains percolate, stop to extract, the percolate that obtains is filtered and the collection medicinal liquid, obtain the ethanol extraction medicinal liquid;
(2) concentrated extract step: utilize concentrator to concentrate above-mentioned ethanol extraction medicinal liquid, concentrate pressure for-0.04Mpa, temperature are 55 ℃, until the ethanol extraction medicinal liquid being concentrated into the thick paste shape, obtain concentrated extract;
(3) preparation process step: will add 150 milliliters of 85% 75 milliliters of 20 milliliters of 75 milliliters of ethanol, azones, lanolines and liquid paraffin according to every kilogram of concentrated extract in the concentrated extract of concentrated extract step, be heated to 55 ℃, cooling obtains paste and is described pharmaceutical composition.
The using method of externally-applied medicinal composition of the present invention is directly pharmaceutical composition directly to be applied in the affected part, one day 2-4 time.
Application test and effect:
1, Chongqing City pet clinic, in April, 2010,12 pet dog of suffering from acariasis of seeing and treating patients by microscopy, are all found the acaricide polypide at the dog endothelium.Therapeutic Method: will suffer from the dog whole body and push away hair, find that skin has red lesser tubercle, the position of incrustation, this place namely is the acarid parasitic site, washes the affected part with soap, this invention medicine is evenly smeared in the affected part, smears every day 3 times, uses for 1 week continuously.Find that red lesser tubercle disappears, it is normal that illing skin recovers.
2, Weifang City, Shandong Province veterinary station, in April, 2011,1 German shepherd of seeing and treating patients, the depilation of whole body many places, and have a place to fester, smelly.Be diagnosed as mite infection through microscopy, treat the untimely severe bacterial infections that excites.Because this dog is Collie, can not use the ivermectin injection for curing, after therefore, to this dog rotten position debridement treatment, pushing away hair, cleaning, uses medicine of the present invention directly to smear the affected part, smear every day 4 times, used for 2 weeks after, skin recovers normally behind microscopy.
3, Qingdao of Shandong province pet clinic, 3～May in 2012, the see and treat patients Shelties of suffering from acariasis, Border Collie, Scotland shepherd dogs etc. amount to 9, after pushing away hair, cleaning treatment, adopt Drug therapy of the present invention, smear every day 2 times, through the treatment in 1 week half, acariasis disappears, and 9 dogs all recover normal.
The above only is preferred embodiment of the present invention, and is in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. externally-applied medicinal composition that is used for control dog acariasis, it is characterized in that described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 10～30 parts of 10～30 parts in Fructus Foeniculi, 5～20 parts of Herba Pogostemoniss, 10～30 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 5～15 parts of Radix Sophorae Flavescentiss, 5～15 parts of Folium cinnamomi camphorae, 10～30 parts of Resina garciniaes, 5～20 parts of Herba Violaes and Herba Menthaes.
2. according to claim 1 for the externally-applied medicinal composition of preventing and treating the dog acariasis, it is characterized in that described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 10 parts of 10 parts in Fructus Foeniculi, 5 parts of Herba Pogostemoniss, 10 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Folium cinnamomi camphorae, 10 parts of Resina garciniaes, 5 parts of Herba Violaes and Herba Menthaes.
3. according to claim 1 for the externally-applied medicinal composition of preventing and treating the dog acariasis, it is characterized in that described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 30 parts of 30 parts in Fructus Foeniculi, 20 parts of Herba Pogostemoniss, 30 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 15 parts of Radix Sophorae Flavescentiss, 15 parts of Folium cinnamomi camphorae, 30 parts of Resina garciniaes, 20 parts of Herba Violaes and Herba Menthaes.
4. according to claim 1 for the externally-applied medicinal composition of preventing and treating the dog acariasis, it is characterized in that described pharmaceutical composition comprises the raw medicinal material of following ratio of weight and number: 20 parts of 20 parts in Fructus Foeniculi, 12.5 parts of Herba Pogostemoniss, 20 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Folium cinnamomi camphorae, 20 parts of Resina garciniaes, 12.5 parts of Herba Violaes and Herba Menthaes.
5. preparation method as any described externally-applied medicinal composition for control dog acariasis of claim 1-4 is characterized in that preparation method may further comprise the steps:
(1) alcohol extraction medicinal liquid step: each raw medicinal material is mixed by weight ratio, and ethanol percolate extraction obtains the alcohol extraction medicinal liquid after the filtration;
(2) concentrated extract step: the alcohol extraction medicinal liquid that obtains in the described alcohol extraction medicinal liquid step is concentrated, obtain concentrated extract;
(3) preparation process step: the concentrated extract that obtains in the described concentrated extract step is adopted preparation process, can make described pharmaceutical composition.
6. the preparation method of the externally-applied medicinal composition for control dog acariasis according to claim 5, it is characterized in that, described alcohol extraction medicinal liquid step comprises: each raw medicinal material is mixed by weight ratio, be positioned in the percolation jar, added 80%～95% soak with ethanol 6～12 hours by 2～5 times of amounts of raw medicinal material gross weight, add 80%～95% ethanol then, percolation extracts, be 8～15 times of raw medicinal material gross weight up to the volume of percolate, stopping percolation extracting, filter percolate, obtain the alcohol extraction medicinal liquid.
7. according to claim 5 or 6 described preparation methoies for the externally-applied medicinal composition of preventing and treating the dog acariasis, it is characterized in that, described concentrated extract step comprises: the alcohol extraction medicinal liquid in the alcohol extraction medicinal liquid step is put into concentrator, be-0.02 at pressure～-concentrate under the 0.05MPa, 40～70 ℃ of conditions of temperature, be concentrated into the thick paste shape, obtain concentrated extract.
8. according to any described preparation method for the externally-applied medicinal composition of preventing and treating the dog acariasis of claim 5-7, it is characterized in that, described preparation process step comprises: the concentrated extract in the concentrated extract step is added 100～200 milliliters of 80%～95% 60～100 milliliters of 10～30 milliliters of 50～100 milliliters of ethanol, azones, lanolines and liquid paraffin according to every kilogram of concentrated extract, be heated to 40～70 ℃, cooling obtains paste and is described pharmaceutical composition.
9. the using method as any described externally-applied medicinal composition for control dog acariasis of claim 1-8 is characterized in that, described pharmaceutical composition directly is applied in the affected part.
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