CN103585540B - Incense-fumigating oil of rhizoma atractylodis and folium artemisiae argyi - Google Patents
Incense-fumigating oil of rhizoma atractylodis and folium artemisiae argyi Download PDFInfo
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Abstract
The invention discloses incense-fumigating oil of rhizoma atractylodis and folium artemisiae argyi and relates to a natural plant medicament for external use. The incense-fumigating oil disclosed by the invention is composed of the following botanical medicinal materials in percentage by weight: 80-120 g of rhizoma atractylodis, 80-120 g of folium artemisiae argyi, 40-80 g of agastache rugosus, 40-80 g of herba eupatorii, 40-80 g of clove, 40-80 g of pepper, 40-80 g of amomum cardamomum, 40-80 g of herba elsholtziae, 40-80 g of rhizoma acori graminei, and 20-80 g of rhizoma kaempferiae. The incense-fumigating oil disclosed by the invention is an aromatic oily substance, and taken by way of being inhaled through a nasal cavity, so that the local medicament concentration of a nidus is much higher than that of the whole body, therefore, the incense-fumigating oil can directly act on the nidus part and then quickly kill pathogenic microorganisms; then, the incense-fumigating oil also can enter the blood to regulate the immune system, thereby improving the local sIgA (Immune Gloulin) content of the respiratory tract, protecting the integrity of local respiratory mucosa, and promoting the synthesis and secretion of sIgA. The incense-fumigating oil disclosed by the invention can be used as a preparation which is convenient to use, safe and effective, and has an effect of strengthening the local mucosal immune function, and enhances the mucosa which is the first defense line of the body.
Description
Technical field
The present invention relates to a kind of natural plant medicament, feature relates to a kind of topical agent.
Background technology
Acute upper respiratory tract infection (acute upper respire tract infection, AURI), be called for short " upper sense ", refer to the acutely inflamed general name of nasal cavity, pharynx or throat, common cold, pharyngitis, laryngitis, pharyngoconjunctival fever, bacillary pharynx-tonsillitis etc. can be divided into.Modern medicine is thought, causes the infective agent that AURI occurs, and based on virus, accounts for primary infection more than 85%
[1], but in developing country, children's AURI reaches 50% by antibacterial causer
[2].When virus causes AURI, very easily merge bacteriological infection.The nineties, developing country had the child of nearly 1,500,000 to cause deafness because of upper respiratory tract infection every year
[3], therefore upper respiratory tract infection can not be ignored the harm that child causes, and the preventing and controlling carrying out childhood upper respiratory tract infection are very important.
Acute upper respiratory tract infection western medical treatment mainly adopts general treatment now, etiological treatment combines with symptomatic treatment, only can kill bacteria, can not regulate systemic immune system simultaneously, act on single, and have an injection and take medicine not easily accept by child.A large amount of research data confirms: treatment by Chinese herbs upper respiratory tract infection has unique advantage, can effective cure diseases, reduces antibiotic on the impact of probiotic bacteria while kill bacteria, adjustment systemic immune system, enhancing human body immunity power
[4].But conventional dosage forms takes inconvenience, drug dose is large, is also not easily accepted by children's, have impact on the performance of important advantages.Although developed now the vaccine of upper respiratory infection, it can only for certain several specific virus, and the scope of application is little.Interferon also can improve local respiratory tract immunity function, but has certain side effect, and expensive, not easily promotes the use of.Suck to regulate local respiratory tract mucosal immunity function by nasal cavity at present, to prevent and treat the preparation of upper respiratory tract infection also rarely seen.Therefore, from natural drug, find a kind of effective, that there is enhancing local mucosal immunity function preparation easy to use, safe of development have important practical significance and medical value.
Summary of the invention
Object of the present invention is intended to the defect overcoming prior art, provides a kind of grey Chinese mugwort champignon oil that can be reached curative effect by external.
Grey Chinese mugwort champignon oil of the present invention, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80-120g, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-60g, Herba Eupatorii 40-60g, Flos Caryophylli 40-60g, Pericarpium Zanthoxyli 40-60g, Fructus Amomi Rotundus 40-60g, Herba Moslae 40-80g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g.
Described grey Chinese mugwort champignon oil, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80-120g, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-80g, Herba Eupatorii 40-80g, Flos Caryophylli 40-80g, Pericarpium Zanthoxyli 40-80g, Fructus Amomi Rotundus 40-80g, Herba Moslae 40-80g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g, Herba Asari 10-40g, Fructus Xanthii 40-80g.
Described grey Chinese mugwort champignon oil, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80-120g, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-60g, Herba Eupatorii 40-60g, Flos Caryophylli 40-60g, Pericarpium Zanthoxyli 40-60g, Fructus Amomi Rotundus 40-60g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g, Herba Menthae 40-80g, Fructus Xanthii 40-80g.
Described grey Chinese mugwort champignon oil, its extracting method is conventional extracting method, jointly soaks to decoct extract volatile oil by all medicines.After extracting volatile oil, the regular dosage form such as spray, volatilization tablet, slow release volatilizer, aromatherapy tablet, microsphere, drop can be prepared into according to actual needs.
Described grey Chinese mugwort champignon oil, Rhizoma Atractylodis, Folium Artemisiae Argyi removing dampness by means of aromatics in side, keeps away dirty removing toxic substances for monarch; Herba Pogostemonis, Herba Eupatorii, Herba Moslae removing dampness by means of aromatics, expelling superficial pathogens and clearing away summer-heat are minister; Flos Caryophylli, Pericarpium Zanthoxyli warming middle-JIAO to send down the adverse QI, parasite killing are assistant, and all medicines share, and play eliminating turbid pathogen with aromatics altogether, keep away the merit of dirty removing toxic substances.
Effect: eliminating turbid pathogen with aromatics, keep away dirty removing toxic substances, improves immunity.Be mainly used in the hypoimmunity caused by insufficiency of lung-QI, be in the place of the harmful substance such as flue dust, formaldehyde, easily upper respiratory tract infection occur, pharyngalgia, watery nasal discharge, aversion to cold, headache, nasal obstruction etc.
Grey Chinese mugwort champignon oil is the oily mater of fragrant odour, by nasal cavity inhalation, makes the drug level of focus local far above Systemic drug concentrations, can directly act on lesions position, rapid pathogenic microbe killing; Secondly can also enter blood energy immunity moderation system, improve respiratory tract local sIgA content, protect the integrity of local respiratory tract mucosa simultaneously, promote sIgA(secreting type mucosal immunity globulin A) synthesis and secretion.Can be used as easy to use, safe and effective, to have enhancing local mucosal immunity function preparation, strengthens mucosa and body the first line of defence.
Early-stage Study shows its volatile oil, has obvious bacteriostasis to common bacterial strains of AURI such as S. aureus L-forms, A type, group B streptococcus, streptococcus pneumoniae.Optimum extraction process, for add 8 times of water gagings at every turn, soaks 8 ~ 10 hours, extracts 6 ~ 8 hours.Grey Chinese mugwort champignon oil is on the basis of summing up clinical application experience, select that Rhizoma Atractylodis, Folium Artemisiae Argyi, Herba Pogostemonis, Herba Eupatorii, Flos Caryophylli, Pericarpium Zanthoxyli etc. are more containing volatile oil component, abnormal smells from the patient delicate fragrance, has a broad antifungal spectrum, antibacterial ability strong and the Chinese medicine of the immunity that improves is prescription.
Zoopery: the upper respiratory tract mucosa of grey Chinese mugwort champignon oil energy available protecting mice and mucosal immunity function, prevention upper respiratory tract infection.
Toxicity test method:
Acute toxicity test: the grey Chinese mugwort champignon oil gavage giving mice variable concentrations respectively, find out maximum lethal dose (Dm) and minimum lethal dose (Dn), be thinning rank coefficient with 0.8,5 dosage groups are set between Dm and Dn, observe the outward appearance of each group of mice, behavior and toxic reaction, and record the death toll of each group of mice, the LD of mice is calculated with improvement karber's method
50.
Respiratory tract irritation is tested: be fixed on by rabbit on frame, paper using barrel cover, in rabbit head, sprays into various dose grey Chinese mugwort champignon oil solution and normal saline respectively in paper cap, every day 1 time, continuous 7 days.Within after drug withdrawal 24 hours, put to death rabbit, perusal animal tissue, organ, respiratory mucosa are with or without pathological change.
Result
Acute toxicity test: mouse stomach gives the LD of grey Chinese mugwort champignon oil
50for 3.47ml/kg, be equivalent to the maximum using dosage of clinical child (by clinical plan preparation specification 10ml containing volatile oil 3%, plans consumption is 0.0168ml/ days, and child's body weight is by 12 kilograms) 2478.57 times.95% fiducial limit interval is 3.09 ~ 4.58 ml/kg.
Poisoning manifestations is mainly spontaneous activity and reduces ， Curled contracting, until dead.Animal starts to occur death after 35min, and through gross anatomy perusal, main organs shows no obvious abnormalities change.Experiment terminates rear execution mice, each main organs of perusal also no abnormality seen.
Respiratory tract irritation test: grey Chinese mugwort champignon oil solution to rabbit respiratory system without obvious stimulation.Detailed description of the invention
Below this patent is described further, but is not limited to embodiment.
Embodiment 1
Grey Chinese mugwort champignon oil of the present invention, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80-120g, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-60g, Herba Eupatorii 40-60g, Flos Caryophylli 40-60g, Pericarpium Zanthoxyli 40-60g, Fructus Amomi Rotundus 40-60g, Herba Moslae 40-80g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g.Described grey Chinese mugwort champignon oil, its extracting method is conventional extracting method, jointly soaks to decoct extract volatile oil by all medicines.After extracting volatile oil, the regular dosage form such as spray, volatilization tablet, slow release volatilizer, aromatherapy tablet, microsphere, drop can be prepared into according to actual needs.Grey Chinese mugwort champignon oil, by nasal cavity inhalation, has eliminating turbid pathogen with aromatics, keeps away dirty removing toxic substances, improve effect of immunity.Be mainly used in the hypoimmunity caused by insufficiency of lung-QI, be in the place of the harmful substance such as flue dust, formaldehyde, easily upper respiratory tract infection occur, pharyngalgia, watery nasal discharge, aversion to cold, headache, nasal obstruction etc.
Embodiment 2
Described grey Chinese mugwort champignon oil, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80-120g, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-80g, Herba Eupatorii 40-80g, Flos Caryophylli 40-80g, Pericarpium Zanthoxyli 40-80g, Fructus Amomi Rotundus 40-80g, Herba Moslae 40-80g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g, Herba Asari 10-40g, Fructus Xanthii 40-80g.All the other are with embodiment 1.
Embodiment 3
Described grey Chinese mugwort champignon oil, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80-120g, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-60g, Herba Eupatorii 40-60g, Flos Caryophylli 40-60g, Pericarpium Zanthoxyli 40-60g, Fructus Amomi Rotundus 40-60g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g, Herba Menthae 40-80g, Fructus Xanthii 40-80g.All the other are with embodiment 1.
Embodiment 4
Grey Chinese mugwort champignon oil of the present invention, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80g, Folium Artemisiae Argyi 80g, Herba Pogostemonis 40g, Herba Eupatorii 40g, Flos Caryophylli 40g, Pericarpium Zanthoxyli 40g, Fructus Amomi Rotundus 40g, Herba Moslae 40g, Rhizoma Acori Graminei 40g, Rhizoma Kaempferiae 20g.All the other are with embodiment 1.
Embodiment 5
Grey Chinese mugwort champignon oil of the present invention, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 120g, Folium Artemisiae Argyi 120g, Herba Pogostemonis 60g, Herba Eupatorii 60g, Flos Caryophylli 60g, Pericarpium Zanthoxyli 60g, Fructus Amomi Rotundus 60g, Herba Moslae 80g, Rhizoma Acori Graminei 80g, Rhizoma Kaempferiae 80g.All the other are with embodiment 1.
Embodiment 6
Grey Chinese mugwort champignon oil of the present invention, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 100g, Folium Artemisiae Argyi 100g, Herba Pogostemonis 50g, Herba Eupatorii 50g, Flos Caryophylli 50g, Pericarpium Zanthoxyli 50g, Fructus Amomi Rotundus 50g, Herba Moslae 60g, Rhizoma Acori Graminei 60g, Rhizoma Kaempferiae 60g.All the other are with embodiment 1.
Embodiment 7
Grey Chinese mugwort champignon oil of the present invention, is made up of the medicinal plants of following percentage by weight: Rhizoma Atractylodis 80g, Folium Artemisiae Argyi 120g, Herba Pogostemonis 43g, Herba Eupatorii 58g, Flos Caryophylli 50g, Pericarpium Zanthoxyli 46g, Fructus Amomi Rotundus 52g, Herba Moslae 61g, Rhizoma Acori Graminei 80g, Rhizoma Kaempferiae 20g.All the other are with embodiment 1.
Claims (3)
1. a grey Chinese mugwort champignon oil, it is characterized in that, be made up of the medicinal plants of following percentage by weight/mass percent: Rhizoma Atractylodis 80-120g, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-80g, Herba Eupatorii 40-80g, Flos Caryophylli 40-80g, Pericarpium Zanthoxyli 40-80g, Fructus Amomi Rotundus 40-80g, Herba Moslae 40-80g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g.
2. a grey Chinese mugwort champignon oil, is characterized in that, be made up of: Rhizoma Atractylodis 80-120g the medicinal plants of following percentage by weight/mass percent, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-80g, Herba Eupatorii 40-80g, Flos Caryophylli 40-80g, Pericarpium Zanthoxyli 40-80g, Fructus Amomi Rotundus 40-80g, Herba Moslae 40-80g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g, Herba Asari 10-40g, Fructus Xanthii 40-80g.
3. a grey Chinese mugwort champignon oil, is characterized in that, be made up of: Rhizoma Atractylodis 80-120g the medicinal plants of following percentage by weight/mass percent, Folium Artemisiae Argyi 80-120g, Herba Pogostemonis 40-80g, Herba Eupatorii 40-80g, Flos Caryophylli 40-80g, Pericarpium Zanthoxyli 40-80g, Fructus Amomi Rotundus 40-80g, Herba Moslae 40-80g, Rhizoma Acori Graminei 40-80g, Rhizoma Kaempferiae 20-80g, Herba Menthae 40-80g, Fructus Xanthii 40-80g.
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| CN106511125A (en) * | 2015-09-09 | 2017-03-22 | 佩兰生物科技(上海)股份有限公司 | Eupatorium fortunei turcz compound solid-state essential oil and uses thereof, eupatorium fortunei turcz compound solid-state essential oil capsule preparation method |
| CN106797966A (en) * | 2017-01-12 | 2017-06-06 | 高康日化集团有限公司 | A kind of Chinese medicine antiseptic |
| CN108719350A (en) * | 2018-06-13 | 2018-11-02 | 江西中医药大学 | Sunstroke prevention mosquito-repellent essential oil and preparation method thereof and application method |
| CN110664962B (en) * | 2019-10-22 | 2022-01-04 | 安徽鑫泰药业有限公司 | Pure traditional Chinese medicine oil for relaxing tendons and activating collaterals and preparation method thereof |
| CN111265603A (en) * | 2020-03-18 | 2020-06-12 | 郭潇 | A Chinese medicinal powder for preventing and treating upper respiratory infection |
| CN111494469B (en) * | 2020-04-30 | 2022-03-08 | 云南白药集团股份有限公司 | Antibacterial and antiviral medicinal composition and application thereof |
| CN111904059A (en) * | 2020-06-20 | 2020-11-10 | 南方医科大学中西医结合医院 | Epidemic prevention traditional Chinese medicine mask |
| CN113332400B (en) * | 2021-05-18 | 2022-12-13 | 江西中医药大学 | Antiviral traditional Chinese medicine volatile oil composition and application thereof |
| CN113577139A (en) * | 2021-09-07 | 2021-11-02 | 云南白药集团股份有限公司 | Application of plant composition in preparation of medicine for treating rhinitis |
| CN116370591A (en) * | 2023-04-24 | 2023-07-04 | 云南中医药大学 | A Chinese medicinal external preparation for treating rhinitis, and its preparation method and quality control method |
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| CN102349991A (en) * | 2011-05-29 | 2012-02-15 | 王红芳 | Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition |
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