CN111265603A

CN111265603A - A Chinese medicinal powder for preventing and treating upper respiratory infection

Info

Publication number: CN111265603A
Application number: CN202010190383.9A
Authority: CN
Inventors: 郭潇; 李莉; 李肖婧; 宋辉; 龚婷婷
Original assignee: 郭潇
Priority date: 2020-03-18
Filing date: 2020-03-18
Publication date: 2020-06-12

Abstract

The invention discloses a traditional Chinese medicine powder for preventing and treating upper respiratory infection, which mainly comprises 10-14% of rhizoma atractylodis, 10-14% of chrysanthemum, 10-14% of mint, 10-14% of radix angelicae, 7-11% of wrinkled gianthyssop herb, 7-11% of anise, 4-8% of clove, 4-8% of calamus, 4-8% of folium artemisiae argyi, 4-8% of dried orange peel, 4-8% of white paeony root and 2-6% of liquorice, wherein the medicines are mixed and pulverized into powder, the powder is sieved by a 80-150-mesh sieve, and then packaged by a medicine bag, 10-20 g. The traditional Chinese medicine powder disclosed by the invention combines and prepares the medicines into powder, the synergistic effect is exerted, the pharmacodynamic activity is obviously improved, a new choice is provided for clinical medication, and the traditional Chinese medicine powder is convenient to prepare, free of secondary processing, very convenient to use, good in absorption effect and good in curative effect.

Description

A Chinese medicinal powder for preventing and treating upper respiratory infection

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to traditional Chinese medicine powder for preventing and treating upper respiratory infection.

Background

In daily life, upper respiratory tract infection is one of the most common diseases of human beings, and accounts for over fifty percent of acute respiratory tract diseases. The upper respiratory tract infection usually has a hidden disease, but the disease condition is mild, the disease course is short, the upper respiratory tract infection can be self-healed, and the prognosis is good. The early stage of the patient has pharyngeal discomfort, dryness, cough, sneeze, watery nasal discharge, nasal obstruction, toothache, pharyngalgia, headache, and hoarseness. The general symptoms are aversion to cold, low fever, skin ecchymosis, strawberry tongue and skin rash. The physical examination can find tonsil exudation, swelling of cervical lymph nodes, red swelling of nasal mucosa, sinus pressure pain and swelling, and serous or mucopurulent secretion in olfactory sulcus. According to epidemiological investigation, the disease frequency is high, and the spring, autumn and winter are high disease seasons, the number of adults is 2-4 per year on average, children can be 6-8 per year, and the children have certain infectivity and sometimes can be accompanied with serious complications.

Causes of upper respiratory tract infections: firstly, infection: about 70% -80% are caused by viruses. Mainly comprises influenza virus (A, B and C), parainfluenza virus, respiratory syncytial virus, adenovirus, rhinovirus, echovirus, coxsackie virus, measles virus and rubella virus. Bacterial infections can occur directly or following viral infections, with hemolytic streptococci being common, followed by haemophilus influenzae, pneumococcus and staphylococci, among others. Gram-negative bacilli are occasionally observed. There are also some patients who develop disease due to bacterial infection. Bacterial infections may be either directly invasive or secondary to viral infections, with hemolytic streptococci being the most common, secondary to pneumococci, staphylococci, haemophilus influenzae, and occasionally gram-negative bacilli. Second, physical and chemical factors: the inhalation of super-cooled air, dust, irritant gases or fumes (such as carbon dioxide, nitrogen dioxide, ammonia, chlorine, automobile exhaust, etc.) can also cause acute irritation to nasal cavities and tracheal-bronchial mucosa. Thirdly, anaphylactic reaction: common pathogens include inhalation of pollen, organic dust, fungal spores, etc.; larvae of hookworms and roundworms move in the lungs; or allergy to bacterial proteins, causing allergic inflammation of the trachea-bronchi, which can also lead to the disease.

Pathogenesis of upper respiratory tract infection: the general or local defense function is reduced due to cold, rain, overstrain or fatigue, and especially for the old, the young, the weak, the low immunity and the people with chronic respiratory diseases, the virus and the bacteria originally existing in the upper respiratory tract or invading from the outside are rapidly propagated to cause infection.

The upper respiratory tract infection belongs to the category of the disease of the cold in the traditional Chinese medicine, and the cold is mainly caused by external wind evil as long as the internal classic. Su Wen & Gu Spatient say: when wind is a common disease, … … wind enters from the outside, causing cold, sweating, headache, heavy body and aversion to cold. The ' Shangzhongjing ' Shangshi Han Lun & dialectical Taiyang syndrome-treatment of the Han Dynasty ' already discusses the syndrome treatment of cold caused by cold pathogen, indicates that the cold is different in degree and severity, and lays a foundation for the dialectical treatment of cold. Sui is pointed out by the theory of all pathogenic factors and wind-heat syndrome; wind-heat qi also flows from the skin to the lung. … … its shape makes people averse to wind and chill, want to get rid of eyes, and have nasal discharge, … … has purplish yellow running nose, it has been recognized that wind-heat pathogen can cause cold and describe its clinical symptoms more accurately. The name of the disease of common cold is recorded in Bei Song "ren Zhai Zhi Fang, all kinds of wind", which is commonly used by physicians of later generations and is also called cold and common cold. Yuan Ling-Wen Xin Fang (Danxi Heart method, common Cold) clearly indicates that the disease is located in the lung, so it is indicated for the treatment of pungent-warm or pungent-cool herbs. Ming "Wan Bing Chun, Shang Han Fu Shang Feng" (all diseases and rejuvenescence diseases): for cold in four seasons, it is advisable to relieve exterior syndrome. The pathogenesis of the disease is invasion of six excesses, disharmony between defensive and exterior and failure of lung qi to disperse. It is mainly the disharmony between defensive and exterior because the pathogenic factors are in the exterior and exterior. The treatment should be relieved from the exterior due to the guiding of the trend, and the clinical dialectical treatment mostly treats the root cause by pungent-warm sweating, pungent-cool clearing and relieving, qi tonifying and yin nourishing, ascending the clear and descending the turbid, clearing summer heat and eliminating dampness, relieving the exterior syndrome, relieving swelling and pain, clearing and soothing the throat, and dispelling wind and freeing the nose.

At present, western medicine proposes a comfortable environment, more drinking water and more rest for mild patients; patients with severe symptoms are advised to rest in bed and take measures to avoid direct transmission of upper respiratory tract infections. Meanwhile, according to the clinical manifestations of patients, the traditional Chinese medicine composition has the effects of relieving fever and pain, relieving nasal congestion, and relieving nasal symptoms by using antihistamine medicines, if the patients have induced infection, the traditional Chinese medicine composition uses antibiotics for treatment, but the clinical curative effect and the control effect on the short-time relapse of the patients are not ideal. Moreover, the adoption of western medicines for treating the upper respiratory tract infection has the disadvantages of high cost and even high cost, and the western medicines contain a certain amount of hormone components, so that the western medicines can generate inestimable side effects on patients after long-term use. Meanwhile, the use of western medicines in large quantity can also cause environmental pollution.

Generally, the existing traditional Chinese and western medicine therapy for treating upper respiratory tract infection generally has the defects of complex raw material components, more preparation procedures, higher cost, limited effect, relatively low possibility of absorption of effective components and the like. Moreover, in order to maintain the effect of the medicine, the medicine is changed frequently, so that the consumption of the medicine and the treatment workload are increased, and the treatment period of a patient is prolonged.

Disclosure of Invention

The invention aims to solve the defects of complex raw material components, multiple preparation processes, frequent dressing change, strong side effect and the like of traditional Chinese and western medicines for treating upper respiratory tract infection in the prior art, and provides a novel traditional Chinese medicine powder for preventing and treating upper respiratory tract infection. The specific technical scheme is as follows:

a Chinese medicinal powder for preventing and treating upper respiratory infection: the traditional Chinese medicine composition mainly comprises 10-14% of rhizoma atractylodis, 10-14% of chrysanthemum, 10-14% of mint, 10-14% of radix angelicae, 7-11% of wrinkled gianthyssop, 7-11% of anise, 4-8% of clove, 4-8% of calamus, 4-8% of folium artemisiae argyi, 4-8% of dried orange peel, 4-8% of radix paeoniae alba and 2-6% of liquorice.

According to the improved technical scheme, the traditional Chinese medicine powder mainly comprises 11-13% of rhizoma atractylodis, 11-13% of chrysanthemum, 11-13% of mint, 11-13% of radix angelicae, 8-10% of wrinkled gianthyssop, 8-10% of star anise, 5-7% of clove, 5-7% of calamus, 5-7% of folium artemisiae argyi, 5-7% of pericarpium citri reticulatae, 5-7% of radix paeoniae alba and 3-4% of liquorice.

As a further improved technical scheme of the invention, the traditional Chinese medicine powder mainly comprises 12% of rhizoma atractylodis, 12% of chrysanthemum, 12% of mint, 12% of radix angelicae, 9% of wrinkled gianthyssop, 9% of anise, 6% of clove, 6% of calamus, 6% of folium artemisiae argyi, 6% of dried orange peel, 6% of white paeony root and 4% of liquorice.

The preparation method of the traditional Chinese medicine powder comprises the following steps: mixing the medicines, pulverizing into powder, sieving with a 80-150 mesh sieve, packaging with a medicine bag, and standing at normal temperature.

Further, the medicines are mixed and then pulverized into powder, the powder is sieved by a sieve of 90-120 meshes, the powder is packaged by a medicine bag, 10-20 g of each bag is packaged, and the powder is used at normal temperature.

Furthermore, the medicines are mixed and pulverized into powder, the powder is sieved by a 100-mesh sieve, and the powder is packaged by a medicine bag, wherein each bag contains 15g of the medicine, and the medicine is used at normal temperature.

The using method of the traditional Chinese medicine powder comprises the following steps: the traditional Chinese medicine powder is taken three times a day, 10-20 g of the powder is taken each time, 10-20 g of the powder is made into a sachet, each sachet is worn in front of the chest, the powder is smelled in front of the nose for 0.5-2 minutes every 1-2 hours, the powder is placed under a pillow at night, and the powder is replaced 1 time every 8-12 days for 10-14 weeks.

The using method of the traditional Chinese medicine powder comprises the following steps: taking the powder three times a day, 15g each time, making into sachet, 15g each bag, wearing in front of chest, smelling in front of nose for 1 min every 1 hr, placing under pillow at night, changing 1 time every 10 days, and using for 12 weeks.

Pharmacological analysis:

cang Zhu is pungent and bitter in flavor and warm in nature. It enters spleen, stomach and liver meridians. Has the effects of eliminating dampness, strengthening spleen, dispelling pathogenic wind, dispelling cold, and improving eyesight. Can be used for treating damp obstruction of middle warmer, abdominal distention, diarrhea, edema, tinea pedis, atrophic debility cramped, rheumatalgia, wind-cold type common cold, night blindness, dim eyesight, and astringency. Compendium of materia Medica: "big wind arthralgia, weak muscles and bones, dispelling wind, removing dampness and resolving stagnation; the juice is used for brewing wine to treat all rheumatic arthralgia and myalgia. The herbal supplement: dryness in the stomach and strengthening the spleen, sweating and dehumidification, and rising the yang-qi in the stomach; stopping vomiting and diarrhea, expelling phlegm and water ". Pharmacological research also shows that the compound has the effects of resisting oxidation, inhibiting the center, protecting the liver and resisting tumors.

Chrysanthemum is bitter and sweet in taste and slightly cold in nature. It enters lung and liver meridians. Has the effects of dispelling wind, clearing heat, calming liver, improving eyesight, and clearing away heat and toxic materials. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, dim eyesight, sore, carbuncle, and toxic swelling. Compendium of materia Medica: wind-heat, eye pain and eye pain, lacrimal passage, nourishing eyes and eliminating blindness, and improving eyesight by using the pillow. The modern pharmacological research has the effects of resisting bacteria and viruses, regulating immunity, resisting tumors, resisting platelet aggregation, and protecting nerves and cardiovascular system.

Mint is pungent in flavor and cool in nature. Enter lung and liver meridians. Has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and promoting qi circulation. Can be used for treating wind-heat common cold, headache, sore throat, food stagnation, flatulence, aphtha, toothache, scabies, urticaria, early stage of epidemic febrile disease, rubella pruritus, stagnation of qi due to depression of the liver, chest distress, and hypochondriac pain. Compendium of materia Medica: the mint can disperse pungent flavor, cool and clear and benefit, and is specially used for dispelling wind and dissipating heat; so headache, wind-heat in the head, eyes, throat and mouth and teeth, infantile convulsions, scrofula, sores and scabies are the key herbs. The New plains of materia Medica: herba Menthae is not particularly good at dispelling pathogenic wind, especially good at dispelling melancholy, rhizoma Cyperi is used for dispelling melancholy, and herba Menthae is not used for dispelling melancholy; mint enters liver and gallbladder meridians, and is good at releasing half exterior and half interior pathogens, so it is more mild and clear than chai Hu. Modern pharmacological research shows that the medicine has the functions of resisting bacteria, resisting virus, relieving pain, relieving cough, etc.

Bai Zhi is pungent in flavor and warm in nature. Enter lung, spleen and stomach meridians. Has the functions of dispelling wind, eliminating dampness, relieving swelling and alleviating pain. Has the main functions of relieving exterior syndrome and dispelling cold, dispelling wind and relieving pain, dredging nasal orifice, eliminating dampness and stopping leukorrhagia, reducing swelling and expelling pus, and dispelling wind and arresting itching. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): radix Angelicae Dahuricae, pungent in flavor and nontoxic in temperature, has strong fragrance, and is also fragrant in grass; entering yang-Ming of hand and foot, taiyin of foot, qi system and blood system, ascending more than descending, yang is also involved. It is good at dispelling wind and removing pus, so the housewives have red and white discharge. Pungent herbs are dispersed and warm in nature, and fragrant in spleen, so they can block blood, block yin and swell, and cause cold and heat, wind-heat invading eyes and tear-out. Pungent and fragrant smell dispel nodulation to enter blood and alleviate pain, so it can promote skin growth. Fragrant and pungent, so it can moisten. Pungent, fragrant and warm in nature, so it can treat chronic diarrhea due to wind pathogen and wind can expel dampness. It can be used to induce diuresis and stop vomiting. It also has the actions of treating hypochondriac pain, dizziness, itching eyes and dispelling wind. Modern pharmacological research shows that the compound has the effects of resisting bacteria, relieving fever and pain, relieving spasm, resisting cancer and the like.

Huoxiang is pungent in flavor and warm in nature. It enters spleen, stomach and lung meridians. Has the effects of resolving dampness, activating spleen, removing dirt, regulating the middle warmer, relieving summer-heat and relieving exterior syndrome. Can be used for treating syndrome of dampness obstruction of spleen and stomach, abdominal distention, early stage of damp-warm syndrome, emesis, diarrhea, summer-heat dampness, fever with aversion to cold, and chest and abdominal fullness. The book of materia Medica: the medicine is a key medicine for summer-damp syndrome, because the medicine is gentle and warm, good at treating Zhongzhou damp turbidity phlegm saliva, and is a medicine for enlivening the spleen and stomach, vibrating the clear-yang wonderful … … cholera and abdominal pain, and suddenly dispersing and stirring the damp turbidity blocking and damaging the qi of clear-yang in spleen soil, and vomiting and diarrhea colic, and the medicine is fragrant and capable of assisting Zhongzhou clear qi, eliminating dampness and avoiding dirt. Compendium of materia Medica: the key herb is the spleen-stomach vomiting when ascending and descending all qi. Modern pharmacological research finds that the compound has the effects of resisting fungi, resisting leptospira, resisting viruses and the like.

Octagonal is pungent, sweet and warm in nature. Enter spleen and kidney meridians. Has the functions of warming yang, dispelling cold and regulating qi. It can be used for treating abdominal pain due to hernia of cold type, lumbago due to kidney deficiency, emesis due to stomach cold, and abdominal psychroalgia. The herbal Zhenzhen: the said "Da Feng Zi" is carried by the book, and the work is specially done to the liver and kidney, so it is indicated for cholera due to cold pertinence. It is indicated for hernia of cold type, swelling of yin, lumbago, dry and damp beriberi, and deficiency fire of liver meridian, and it is indicated for the patients with upper left headache. Fennel, cinnamon and evodia fruit are all herbs of Jueyin dryness, but Yu enters intestines and stomach, Gui enters liver and kidney, so it is light and enters meridians. The must salt is introduced into the kidney to send out yin pathogen, so the hernia can be effectively treated. The taste of star anise is chewed and treated finely, although the taste is fragrant, the taste is very sweet, the property is warm but not intense, and the taste is different from the tastes of evodia rutaecarpa, argy wormwood leaf and the like, and if the taste is sweet like star anise, the effect of removing cold and pertinence is similar to the reason that the taste is obstructed. Parching with saline water to obtain liquor. Modern pharmacological research has found that the aniseed has the effects of inhibiting bacteria, increasing white, easing pain, inhibiting platelet aggregation and the like.

Clove is pungent in flavor and warm in nature. It enters spleen, stomach, lung and kidney meridians. Has the effects of warming the middle-jiao, lowering the adverse flow of qi, tonifying the kidney and supporting yang. It can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia emesis, diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency. The bibliography: wind-damp-toxin swelling, cholera and cardiodynia, and removing bad breath. "Kaibao" (open treasure): warming spleen and stomach, stopping cholera, swelling, wind-toxicity and malnutrition of teeth. Can emit various fragrances. Compendium of materia Medica: treatment of vomiturition, vomiting and diarrhea in children, acne and stomach deficiency and grey-white hair. The main component eugenol has various pharmacological activities of bacteriostasis, anesthesia, fever reduction, tumor resistance, oxidation resistance and the like.

Calamus is pungent in flavor and slightly warm in nature. Enter heart, liver and spleen meridians. Has effects of inducing resuscitation, eliminating phlegm, regulating qi-flowing, promoting blood circulation, dispelling pathogenic wind, and eliminating dampness. Has the main functions of relieving exterior syndrome and dispelling cold, dispelling wind and relieving pain, dredging nasal orifice, eliminating dampness and stopping leukorrhagia, reducing swelling and expelling pus, and dispelling wind and arresting itching. Compendium of materia Medica: for deficiency syndrome of heart qi, Chang Pu is also indicated for tonifying the mother. The liver is bitter and urgent, and % is pungent and tonify. Chongqingtang (Chongqingtang along with pen): rhizoma Acori Graminei can soothe heart, refresh mind, refresh mood, benefit mind, and be used as a wonderful medicine. Clearing and relieving the action of herbs relies on dispelling the turbid of phlegm and expelling the pathogenic factors to defend the uterus, nourishing the herbs to release the heart and mind. The book Ben Cao Hui Yan (treatise on materia Medica): shi Chang Pu is indicated for qi stagnation and resuscitation because it can remove phlegm-fire pathogen away from the body fluid, so it is suitable for oral administration. For deficiency of middle qi, mental retardation is felt, qi orifices do not move with yang qi, and often the ten-ingredient tonics soup is used to exert a great deal of work without the grassleaf sweelflag rhizome asking for it. Modern pharmacological research finds that the traditional Chinese medicine composition has the effects of calming, dilating coronary artery, resisting fungi, relieving asthma and the like.

Folium artemisiae argyi is dry leaf of folium artemisiae argyi of the family Compositae, is recorded in famous medical records of the Liang Dynasty, is recorded in the Chinese pharmacopoeia of 2015 edition at present, is pungent, warm and bitter in taste, enters liver, spleen and kidney channels, and has the effects of warming channels to stop bleeding, dispelling cold to stop pain, and dispelling dampness and relieving itching for external use. Can be used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, fetal leakage, lower abdomen psychroalgia, menoxenia, and infertility due to cold womb; it can be used for treating skin pruritus. Vinegar moxa charcoal can warm meridians and stop bleeding, and is indicated for bleeding due to deficiency-cold. Compendium of materia Medica: warming, expelling cold and removing dampness. The treatments of moxa fumigation and moxibustion are recorded in the prescription of fifty-two diseases. Modern researchers find that the folium artemisiae argyi and the extract thereof have pharmacological effects of resisting bacteria, viruses and oxidation, protecting the liver, benefiting gallbladder, stopping bleeding, resisting coagulation, resisting allergy, regulating immunity, resisting cancers and the like. In addition, it has tranquilizing, analgesic, blood sugar lowering, uterus exciting, uric acid solubilizing, sore healing promoting, and parasite killing effects. The folium Artemisiae Argyi volatile oil can inhibit inflammatory cell (mainly neutrophil) infiltration, has the effect of promoting wound granulation tissue growth, and can reduce histiocyte desquamation and necrosis.

Tangerine peel is bitter and pungent in flavor and warm in nature. It enters lung and spleen meridians. Has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm. It is mainly used for treating abdominal distention, anorexia, vomiting, diarrhea, cough and excessive phlegm. The miscellaneous records of famous physicians: to check qi and stop vomiting. Compendium of materia Medica: "treating vomitus and regurgitation stomach upset, vomiting clear water". Modern pharmacological research shows that the volatile oil has the effects of protecting liver and resisting tumors, and the volatile oil has the effects of relieving asthma, relieving cough and resisting allergic inflammation.

White peony root, radix Paeoniae alba is bitter and sour in taste and slightly cold in nature. It enters liver and spleen meridians. Has the functions of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain and suppressing liver yang. Can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm and pain, headache, and vertigo. The book Jing: the Chinese medicinal composition has the effects of treating abdominal pain due to pathogenic factors, removing blood stagnation, breaking hard mass, treating hernia due to cold and heat, relieving pain, promoting urination and tonifying qi. The bibliography: promoting blood circulation, relieving epigastric distention, dispersing blood stasis, expelling blood stasis, removing water and qi, benefiting bladder, large intestine and small intestine, and eliminating carbuncle and swelling. Modern pharmacological research finds that the traditional Chinese medicine composition has the effects of analgesia, anti-inflammation, spasmolysis, blood vessel expansion, antibiosis, antivirus and the like.

Licorice root, radix Glycyrrhizae is sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the medicines. Mainly treats weakness of the spleen and the stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough and excessive phlegm, abdominal and limb spasm and pain, carbuncle and swelling and sore toxicity, and relieves toxicity and pungency of medicaments.

"the previous medical treatment of disease" was originally derived from the Huangdi's internal classic: "the former is treating the disease before the disease is treated, but not treating the disease, this is also called; namely, the occurrence and the development of the disease are prevented by corresponding measures. The causes of upper respiratory tract infection are mostly transmitted by droplets, aerosols and unclean air. The traditional Chinese medicine considers that the volatile smell of the traditional Chinese medicine can be spread throughout the whole body through the oral and nasal mucosa, skin and hair orifices, meridian points and circulation of qi and blood veins, and has the functions of regulating qi activity and dredging meridians, so as to achieve the effects of removing dirt with fragrance, eliminating evil and detoxifying. Modern researches also find that the Chinese herbal medicines give off rich fragrance, form a high-concentration small environment around the human body and enter the human body through a respiratory tract, and the aromatic fragrance can excite a nervous system, stimulate nasal mucosa, improve the content of secretory immunoglobulin on the nasal mucosa, continuously stimulate an immune system of an organism, promote the generation of antibodies, inhibit the growth of various pathogenic bacteria and improve the disease resistance of the body. The Chinese herbal medicines are prepared into powder, which is more beneficial to the hair growth of the efficacy, so as to achieve the effect of treating the disease in the traditional Chinese medicine.

Has the advantages that:

the traditional Chinese medicine powder for preventing and treating upper respiratory infection takes folium artemisiae argyi, rhizoma atractylodis and calamus as monarch drugs; radix Angelicae Dahuricae, flos Caryophylli, fructus Anisi Stellati, herba Agastaches, and flos Chrysanthemi as ministerial drugs; pericarpium Citri Tangerinae and herba Menthae as guiding drugs; radix Paeoniae alba and Glycyrrhrizae radix are used as adjuvant drugs. The Chinese atractylodes is used for eliminating dampness, the folium artemisiae argyi is used for warming channels and dispelling cold, the calamus is used for removing dirt and inducing resuscitation, qi is released and phlegm is removed, the angelica dahurica is used for promoting qi circulation and inducing resuscitation, the wrinkled gianthyssop is used for removing summer heat and eliminating dampness, the chrysanthemum is used for dispelling wind and clearing heat, the clove, the aniseed and the dried orange peel are used for regulating qi and warming middle energizer, the mint is used for relieving exterior syndrome and promoting eruption, and the white paeony root is used for soothing. Thereby playing the roles of 'exorcising evil spirits' and 'strengthening the body resistance' in preventing diseases and playing the roles of relieving exterior syndrome, clearing qi, eliminating dampness and inducing resuscitation when treating the early-stage diseases of the upper respiratory tract infection. The invention combines the medicines, exerts the synergistic effect, obviously improves the pharmacodynamic activity and provides a new choice for clinical medication.

The invention is suitable for preventing and treating pharyngeal discomfort, dryness, cough, sneeze, watery nasal discharge, nasal obstruction, toothache, pharyngalgia, headache and hoarseness caused by upper respiratory infection of a patient, and systemic symptoms such as chilly, low fever, skin ecchymosis, strawberry tongue, rash and the like, and has certain inhibiting effect on relapse of upper respiratory infection.

The traditional Chinese medicine has the advantages of fewer raw materials, easiness in obtaining, fewer manufacturing procedures, no need of secondary processing of a patient, and lower economic cost and labor cost. The invention is filled into the medicine bag by powder and worn in front of the chest, and the medicine bag is not in front of the nose and smells intermittently, so that the medicine effect can reach the disease focus directly, the effect can be exerted more effectively, the clinical symptoms can be relieved, and the progress of the disease can be prevented.

The invention does not contain hormone components and components harmful to the environment.

Drawings

FIG. 1 is the mortality protection rate of example 1;

FIG. 2 is the mortality protection rate of example 2;

FIG. 3 is the mortality protection factor of example 3.

Detailed Description

The present invention will now be described in detail with reference to specific embodiments thereof for the purpose of clearly understanding the present invention by those skilled in the art.

Example 1

Preparing traditional Chinese medicine powder: mixing rhizoma atractylodis, chrysanthemum, mint, angelica dahurica, agastache rugosus, star anise, clove, calamus, folium artemisiae argyi, dried orange peel, white paeony root and liquorice, pulverizing into powder, sieving with a 100-mesh sieve, and subpackaging with 15g of medicine bags at normal temperature for later use.

Formula 1:

formulation 2

Formulation 3

Formulation 4

Formulation 5

Grouping experiments: 160 KM mice are taken, the SPF level is achieved, the weight is 18-22 g, the male and female parts are respectively half, the KM mice are randomly divided into a normal group, a model group, a positive group, a formula 1 group, a formula 2 group, a formula 3 group, a formula 4 group and a formula 5 group, and each group is 20 mice.

Administration and infection: each experimental group was administered by gavage at 1mg/10g body weight 1 time a day for 7 consecutive days starting 7 days before the mouse virus infection. On the day after the last administration, each experimental group of mice was administered with rhinovirus by nasal drip to induce respiratory tract infection, and the administration was continued for 7 days after the model was made. And (3) observation: symptoms of disease after infection of animals, the number of deaths of mice within 14 days after infection was recorded and the mortality protection rate was calculated.

Experimental results and conclusions: as can be seen from fig. 1, the mortality rate of the mice in the model group was significantly increased compared to the normal group; compared with a model group, the mortality of mice in the formula 1-5 groups is obviously reduced; the mortality rate was also significantly reduced in formula 3 mice compared to the positive group. Pharmacological experiments show that 5 kinds of traditional Chinese medicine powder with different proportions in the experiment have different degrees of treatment effects on acute upper respiratory infection of mice, wherein the treatment effect is the best according to formula 3, namely the traditional Chinese medicine powder prepared from 12% of rhizoma atractylodis, 12% of chrysanthemum, 12% of mint, 12% of radix angelicae, 9% of wrinkled gianthyssop, 9% of anise, 6% of clove, 6% of calamus, 6% of folium artemisiae argyi, 6% of dried orange peel, 6% of white paeony root and 4% of liquorice, and.

Example 2

Mixing rhizoma atractylodis 12%, chrysanthemum 12%, mint 12%, angelica dahurica 12%, wrinkled gianthyssop herb 9%, anise 9%, clove 6%, calamus 6%, folium artemisiae argyi 6%, dried orange peel 6%, white peony root 6% and liquorice 4%, pulverizing into powder, sieving with 80-mesh, 90-mesh, 100-mesh, 120-mesh and 150-mesh sieves, and subpackaging with 15g of medicine bags at normal temperature for later use.

Grouping experiments: 140 KM mice are taken, the SPF level is achieved, the weight is 18-22 g, the male and female halves are randomly divided into a normal group, a model group, an 80-mesh group, a 90-mesh group, a 100-mesh group, a 120-mesh group and a 150-mesh group, and each group comprises 20 mice.

Experimental results and conclusions: as can be seen from fig. 2, the mortality rate was significantly reduced in the 80, 90, 100, 120 and 150 mesh groups of mice as compared with the model group. Wherein the 100-150 mesh group has better curative effect. Considering the manufacturing cost, 100 mesh is preferable.

Example 3

Mixing 12% of rhizoma atractylodis, 12% of chrysanthemum, 12% of mint, 12% of angelica dahurica, 9% of wrinkled gianthyssop herb, 9% of anise, 6% of clove, 6% of calamus, 6% of folium artemisiae argyi, 6% of dried orange peel, 6% of white paeony root and 4% of liquorice, pulverizing into powder, sieving by a 100-mesh sieve, and subpackaging by a medicine bag, 15g of each bag, and standing at. Making the medicated bag into fragrant bag, and standing at room temperature. Grouping experiments: 80 KM mice are taken, the mice are SPF-grade, the weights of the KM mice are 18-22 g, and the KM mice are divided into a normal group, a model group, a fragrance-free bag group and a fragrance bag group at random.

Administration and infection: the sachet group was administered 1 time per day for 7 consecutive days starting 7 days before the mouse virus infection with 1mg/10g of body weight by gavage, while placing sachets around the mouse. On the day after the last administration, the mice in the sachet group are dropped with rhinovirus from nostrils by nose dropping method to induce respiratory tract infection, administration is continued for 7 days after molding, and sachets are placed around the mice. The non-sachet group is the same as the sachet group except that no sachet is placed around the mouse. And (3) observation: symptoms of disease after infection of animals, the number of deaths of mice within 14 days after infection was recorded and the mortality protection rate was calculated.

Experimental results and conclusions: as can be seen from FIG. 3, the mortality rate was significantly reduced in both the non-sachet group and the sachet group compared to the model group. Wherein, the sachet is arranged around the mouse, which can obviously improve the death protection rate.

Example 4

Mixing 12% of rhizoma atractylodis, 12% of chrysanthemum, 12% of mint, 12% of angelica dahurica, 9% of wrinkled gianthyssop herb, 9% of anise, 6% of clove, 6% of calamus, 6% of folium artemisiae argyi, 6% of dried orange peel, 6% of white paeony root and 4% of liquorice, pulverizing into powder, sieving by a 100-mesh sieve, and subpackaging by a medicine bag, 15g of each bag, and standing at.

In order to further investigate the medicinal efficacy of the traditional Chinese medicine powder provided by the embodiment of the invention, clinical trial research is carried out on patients suffering from upper respiratory tract infection, and all patients voluntarily receive treatment, so that the traditional Chinese medicine powder is good in response and free of obvious toxic and side effects.

The test population: meets the diagnosis standard of upper respiratory tract infection, the disease course is within 3 days, and 97 people are aged between 18 and 65 years.

The treatment method comprises the following steps: the sachet is taken three times a day, worn in front of chest, and is just shorter than sniffing in front of nose for about 1 minute per hour, placed under the pillow at night, and changed for 1 time every 10 days for 12 weeks. The follow-up treatment effect.

Treatment effect judgment standard: refer to the guideline for clinical research of new Chinese medicine. And (3) healing: the body temperature returns to normal within 3 days after treatment, and cold symptoms disappear completely; the effect is shown: the body temperature is normal within 3 days after treatment, and most symptoms of cold disappear; the method has the following advantages: the body temperature is reduced within 3 days of treatment compared with the prior art, and the main symptoms of the cold partially disappear; and (4) invalidation: the body temperature is not reduced or increased within 3 days after the treatment, and the main symptoms of the cold are not improved.

The treatment effect is shown in table 1, the serum Ig a, Ig G and Ig M values before and after the intervention in the patient group are shown in table 2, and the upper respiratory tract infection recurrence rate after the patient visit for 3 months is shown in table 3.

Table 1: therapeutic effects

Group of	n	Recovery method	Show effect	Is effective	Invalidation	Effective rate%
							Treatment group	97	49	27	16	5	94.8

Table 2: serum Ig A, Ig G and Ig M values before and after patient group intervention

Group of	n		IgA	IgM	IgG
						Treatment group	97	Before intervention	257±69	191±59	1079±259
		One week after intervention	271±74a	211±64a	1242±271a

A P <0.05 compared to the same group before treatment;

table 3: recurrence rate of upper respiratory tract infection after 3 months of patient

Group of	3 months old
		Treatment group	9.3％

As can be seen from Table 1, the traditional Chinese medicine powder has obvious curative effect on patients with upper respiratory tract infection. As can be seen from Table 2, the prognosis of the patients with dry serum Ig A, Ig G and Ig M are all significantly increased compared to those before intervention. Vernier 3 shows that after the traditional Chinese medicine powder is used for treating dry disease, the recurrence rate of patients is very low. The traditional Chinese medicine powder has obvious curative effect.

The invention can also be prepared into granules according to the conventional preparation technology of traditional Chinese medicines. Proved by a large amount of clinical data, the prescription has definite, quick and safe clinical curative effect, has no obvious adverse reaction, can shorten the course of disease of a patient and has better effect of preventing relapse.

The embodiments of the present invention have been described in detail. However, the present invention is not limited to the above-described embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the spirit of the present invention.

Claims

1. A traditional Chinese medicine powder for preventing and treating upper respiratory tract infection is characterized in that: the traditional Chinese medicine composition mainly comprises 10-14% of rhizoma atractylodis, 10-14% of chrysanthemum, 10-14% of mint, 10-14% of radix angelicae, 7-11% of wrinkled gianthyssop, 7-11% of anise, 4-8% of clove, 4-8% of calamus, 4-8% of folium artemisiae argyi, 4-8% of dried orange peel, 4-8% of white paeony root and 2-6% of liquorice, the medicines are mixed and pulverized into powder, the powder is sieved by a 80-150-mesh sieve, and packaged by a medicine.

2. The traditional Chinese medicine powder according to claim 1, characterized in that: the traditional Chinese medicine powder mainly comprises 11-13% of rhizoma atractylodis, 11-13% of chrysanthemum, 11-13% of mint, 11-13% of radix angelicae, 8-10% of wrinkled gianthyssop, 8-10% of star anise, 5-7% of clove, 5-7% of calamus, 5-7% of folium artemisiae argyi, 5-7% of dried orange peel, 5-7% of radix paeoniae alba and 3-4% of liquorice.

3. The traditional Chinese medicine powder according to claim 2, characterized in that: the traditional Chinese medicine powder mainly comprises 12% of rhizoma atractylodis, 12% of chrysanthemum, 12% of mint, 12% of radix angelicae, 9% of wrinkled gianthyssop herb, 9% of anise, 6% of clove, 6% of calamus, 6% of folium artemisiae argyi, 6% of dried orange peel, 6% of radix paeoniae alba and 4% of liquorice.

4. The traditional Chinese medicine powder according to claim 1, characterized in that: mixing the medicines, pulverizing into powder, sieving with a 90-120-mesh sieve, subpackaging with medicine bags, 10-20 g each bag, and standing at normal temperature for later use.

5. The traditional Chinese medicine powder according to claim 4, characterized in that: the medicines are pulverized into powder, the powder is sieved by a 100-mesh sieve, and the powder is subpackaged by medicine bags, wherein each bag contains 15g of the medicine, and the medicine is used at normal temperature.

6. The traditional Chinese medicine powder according to claim 1, characterized in that: the traditional Chinese medicine is taken for three times every day, 10-20 g of the traditional Chinese medicine is taken each time, and the traditional Chinese medicine is taken for 3-7 days; meanwhile, the traditional Chinese medicine powder is prepared into sachets, each sachet is 10-20 g, the sachet is worn in front of the chest, the sachet is smelled in front of the nose for 0.5-2 minutes every 1-2 hours, the sachet is placed under the pillow at night, and the sachet is replaced 1 time every 8-12 days, and the sachet is used for 10-14 weeks.

7. The traditional Chinese medicine powder according to claim 6, characterized in that: taking the powder three times a day, 15g each time, taking 3, making into sachet, 15g each bag, wearing in front of chest, smelling in front of nose for 1 min every 1 hr, standing under pillow at night, changing 1 time every 10 days, and using for 12 weeks.

8. The traditional Chinese medicine powder for preventing and treating upper respiratory tract infection according to any one of claims 1 to 7: can be used for treating upper respiratory infection caused by rhinovirus.