CN105250385A - Nasal drops for treating infant nasal obstruction - Google Patents

Abstract

The invention provides nasal drops for treating infant nasal obstruction. The nasal drops are prepared from 2-15 parts of folium mori, 2-18 parts of chrysanthemum, 3-10 parts of magnolia flowers, 1-10 parts of centipeda minima, 1-8 parts of mint and 40-90 parts of sesame oil. The nasal drops contain no traditional Chinese medicine which acts on the nerves, the medicinal property is mild, no toxic or side effect exists, the nasal drops are applicable to infants, easy to prepare, little in toxic and side effect, convenient to use, obvious in effect, simple in preparation method and capable of being subjected to industrialized production, and certain social value is achieved.

Description

A kind of nasal drop for the treatment of infant nasal obstruction

Technical field

The invention belongs to infant field of medicaments, especially relate to a kind of nasal drop for the treatment of infant nasal obstruction.

Background technology

Normally unobstructed breathing is even more important concerning infant, because the resistance of infant is lower, is easily upset, and their respiratory system of itself is also perfect not in addition, so easily cause nasal obstruction.Nasal obstruction is comparatively common phenomenon, and a lot of situation all may cause infant to have a stuffy nose: such as, and child must catch a cold or after rhinitis, the nasal obstruction caused, causes dyspnea, cries and screams more than; Nose crust is exactly nose dung, and its essence is exactly secretions aggregation, because infant is than more sensitive cause, slight stimulation and foreign body intrusion all can cause strong reaction, and the amount of secretions will increase, and sticks and just forms nose crust at nasal cavity.Infant can because of nasal obstruction dyspnea, in order to abundant oxygen uptake is had to mouth breathing; Also because of for hypoxgia, the similar emotions such as dysphoria can be shown.

In principle without the nasal drop of vasoconstrictor during infant nasal obstruction, because infant blood vessel itself is not also grown, mucosa is fragile, more easily cause medicamentous rhinitis, general nasal drop contains the pressor compositions such as ephedrine hydrochloride, find one not containing pressor, the nasal drop alleviating infant nasal obstruction becomes a kind of urgent needs of pediatrician.

Summary of the invention

The object of this invention is to provide that one is prepared simply, toxic and side effects is little, the easy to use nasal drop being used for the treatment of infant nasal obstruction, specifically the present invention realizes like this.

Technical scheme of the present invention is: a kind of nasal drop for the treatment of infant nasal obstruction, comprise Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae and Oleum Sesami, wherein each composition is respectively according to weight ratio: Folium Mori 2-15 part, Flos Chrysanthemi 2-18 part, Flos Magnoliae 3-10 part, Herba Centipedae 1-10 part, Herba Menthae 1-8 part, Oleum Sesami 40-90 part.

Preferably obtain following component to above-mentioned weight portion, preferred weight portion is: Folium Mori 5-10 part, Flos Chrysanthemi 5-10 part, Flos Magnoliae 4-8 part, Herba Centipedae 2-5 part, Herba Menthae 2-3 part, Oleum Sesami 50-70 part.

In order to obtain better technique effect, particularly, each composition is respectively according to weight ratio: 8 parts, Folium Mori, Flos Chrysanthemi 8 parts, Flos Magnoliae 5 parts, Herba Centipedae 4 parts, Herba Menthae 2 parts and 60 parts, Oleum Sesami.

Second object of the present invention is, a kind of be used for the treatment of infant nasal obstruction nasal drop, concrete preparation method be into:

1) Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae Chinese medicine of the five flavours are fully pulverized, roguing is for subsequent use;

2) first grind with a small amount of Oleum Sesami, after fully grinding, add the Oleum Sesami of surplus, filter medicinal residues after fully dissolving, get supernatant and namely obtain nasal drop.

In invention, in nasal drop, the effect of each taste Chinese medicine is as follows:

Folium Mori, bitter in the mouth; Sweet; Cold in nature.Effect: dispelling wind and heat pathogens, for anemopyretic cold and conjunctival congestion and swelling pain, often joins Flos Chrysanthemi; Clearing away lung-heat and moistening for dryness, this product bitter cold eliminating heat from the lung, sweet cold tonifying YIN, cool lung moistening is dry; Suppressing liver-YANG, liver heat removing and eyesight improving, cooling blood for hemostasis.

Flos Chrysanthemi, improving eyesight liver heat removing, the eyes caused hot-tempered, excess eye-using are dry and astringent also good curative effect; Refreshment, chrysanthemum scented tea gives off a strong fragrance, refreshment, also there is certain lax nerve, releive headache effect.

Flos Magnoliae, pungent loose temperature is led to, energy dispersing wind-cold, a surname's clearing the nasal passage.With controlling affection of exogenous wind-cold, the closing of lung key, fever with aversion to cold, headache nasal obstruction person, can the wind-cold-dispersing medicinal such as compatibility Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari.If anemopyretic cold and the headache person that has a stuffy nose, also in the dispelling wind and heat pathogens medicines such as Herba Menthae, Flos Lonicerae, Flos Chrysanthemi, can drink and add this product, to strengthen the power of clearing the nasal passage, loose ailment said due to cold or exposure.

Herba Centipedae, pungent, temperature; Dispel the wind, cold expelling, victory is wet, removing nebula, stuffy nose relieving plug.Cure cold, asthma of cold-type, sore throat, pertussis, eruptive disease is suffered from abdominal pain, antiinflammatory, preventing phlegm from forming and stopping coughing and relievining asthma, antiallergic and allergic effect.

Herba Menthae, herb can be used as medicine again, and acrid in the mouth is cool in nature.Return lung, Liver Channel, have and disperse wind heat, clearing throat, rash is detoxified, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to the disease such as cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, colic, dysentery and scrofula, external has slight analgesic effect.

Oleum Sesami is Radix Angelicae Dahuricae Oleum Sesami, and it is the fatty oil squeezed from Hu section plant sesame seed; also known as linum, spunyarn, sesame, Oleum sesami etc., Oleum Sesami nature and flavor are sweet, cool, effect for moisturizing, fluid infusion, endogenous wind stopping, removing toxic substances, parasite killing and all skin ulcers that disappears swell; protection blood vessel, loosening bowel to relieve constipation etc.Compendium of Material Medica is recorded: " have moisturize, detoxify, pain relieving, detumescence merit ".Clinically also decoct plaster with Oleum Sesami, have granulation promoting meat, the effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.

This nasal drop is not containing any to the effective Chinese medicine of nerve, the property of medicine is gentle, have no side effect, be applicable to infant to use, provided by the invention for one prepare simply, toxic and side effects is little, easy to use, and a kind of nasal drop of successful, nasal drop preparation method is simple, can carry out industrialized great production.

Detailed description of the invention

Embodiment 1:

2 grams, Folium Mori, Flos Chrysanthemi 2 grams, Flos Magnoliae 3 grams, Herba Centipedae 1 gram, Herba Menthae 1 gram, 40 grams, Oleum Sesami.

Be used for the treatment of a Chinese medicine composition for infant nasal drop, its concrete preparation method is:

1) Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae Chinese medicine of the five flavours are fully pulverized, roguing is for subsequent use;

2) first grind with a small amount of Oleum Sesami, after fully grinding, add the Oleum Sesami of surplus, filter medicinal residues after fully dissolving, after filtration, obtain nasal drop 35ml.

Embodiment 2:

15 grams, Folium Mori, Flos Chrysanthemi 18 grams, Flos Magnoliae 10 grams, Herba Centipedae 10 grams, Herba Menthae 8 grams, 90 grams, Oleum Sesami.

Be used for the treatment of a Chinese medicine composition for infant nasal drop, its concrete preparation method is:

1) Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae Chinese medicine of the five flavours are fully pulverized, roguing is for subsequent use;

2) first grind with a small amount of Oleum Sesami, after fully grinding, add the Oleum Sesami of surplus, filter medicinal residues after fully dissolving, after filtration, obtain nasal drop 67ml.

Embodiment 3:

5 grams, Folium Mori, Flos Chrysanthemi 5 grams, Flos Magnoliae 4 grams, Herba Centipedae 2 grams, Herba Menthae 2 grams, 50 grams, Oleum Sesami.

Be used for the treatment of a Chinese medicine composition for infant nasal drop, its concrete preparation method is:

1) Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae Chinese medicine of the five flavours are fully pulverized, roguing is for subsequent use;

2) first grind with a small amount of Oleum Sesami, after fully grinding, add the Oleum Sesami of surplus, filter medicinal residues after fully dissolving, after filtration, obtain nasal drop 40ml.

Embodiment 4:

10 grams, Folium Mori, Flos Chrysanthemi 10 grams, Flos Magnoliae 8 grams, Herba Centipedae 5 grams, Herba Menthae 3 grams, 70 grams, Oleum Sesami.

Be used for the treatment of a Chinese medicine composition for infant nasal drop, its concrete preparation method is:

1) Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae Chinese medicine of the five flavours are fully pulverized, roguing is for subsequent use;

2) first grind with a small amount of Oleum Sesami, after fully grinding, add the Oleum Sesami of surplus, filter medicinal residues after fully dissolving, after filtration, obtain nasal drop 55ml.

Embodiment 5:

8 grams, Folium Mori, Flos Chrysanthemi 8 grams, Flos Magnoliae 5 grams, Herba Centipedae 4 grams, Herba Menthae 2 grams and 60 grams, Oleum Sesami.

Be used for the treatment of a Chinese medicine composition for infant nasal drop, its concrete preparation method is:

1) Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae Chinese medicine of the five flavours are fully pulverized, roguing is for subsequent use;

2) first grind with a small amount of Oleum Sesami, after fully grinding, add the Oleum Sesami of surplus, filter medicinal residues after fully dissolving, after filtration, obtain nasal drop 45ml.

Embodiment 6: clinical efficacy is identified:

6.1, basic document in

During 1 year June of-2015 years in July, 2014, treat the nasal obstruction patient of 242 infant (0-3 year), the mean age is 1.5 years old.Its medium-term and long-term nasal obstruction infant 66 example, common nasal obstruction infant 176 example is divided into four groups at random, and namely have a stuffy nose for a long time infant and treatment group of matched group is had a stuffy nose infant for a long time, often organizes 88 examples; Matched group common nasal obstruction infant and the common nasal obstruction infant for the treatment of group, often organize 33 examples.

6.2, therapeutic scheme

Matched group: Bitongning Drops, nasal cavity drop, external, collunarium: a time 1-2 drips, 2-3 time on the one;

Treatment group: instillation nasal drop 1-3 drips, nasal cavity drop, external, collunarium: a time 1-2 drips, 2-3 time on the one;

6.3, diagnostic criteria

Fully effective: in 10 minutes, smooth breathing person is effective;

Part is effective: within 10-30 minute, have symptom to have alleviation person for partly effective;

Invalid: instillation nasal drop was still had a stuffy nose as invalid after 30 minutes;

Effective percentage: (fully effective+part effectively)/this organizes total diseased individuals.

It should be noted that for long-term nasal obstruction (time is greater than 1 week) patient, in 3 days, have alleviation to be effective.

242 infant tested altogether by nasal drop of the present invention, wherein meet evaluation condition to be 238 (abandon using or improper use because mismatching for other 4, be not counted in result, be infant of having a stuffy nose for a long time, matched group and each 2 examples for the treatment of group), wherein fully effective 67 examples for the treatment of group common nasal obstruction infant, part is effectively 18 examples, and effective percentage reaches 96.8%; Complete 17 examples for the treatment of long-term nasal obstruction infant, part is effectively 10, and effective percentage is 87.1%; Wherein complete 30 examples of matched group nasal obstruction infant, part is effectively 38 examples, and effective percentage reaches 77.3%; Complete 8 examples for the treatment of long-term nasal obstruction infant, part is effectively 13, and effective percentage is 67.7%.Detailed results is in table 1.

Table 1 treatment group and treatment of control group situation compare

Group	Fully effective	Part effectively	Invalid	Effective percentage (%)
					The common nasal obstruction infant of matched group	30	38	20	77.3
Matched group is had a stuffy nose infant for a long time	8	13	10	67.7
					The common nasal obstruction infant for the treatment of group	67	18	3	96.8
Treatment group is had a stuffy nose infant for a long time	17	10	4	87.1

6.4, model case

Case 1: infant is happy, 1 one full year of life, is in hospital because suffering from an inflammation of the lungs, multiple sense in rehabilitation course, cold symptoms is serious, has a stuffy nose obstructed, open one's mouth in bed to breathe, cry and scream and can not sleep peacefully, dripping 2 nasal drop of the present invention when falling asleep respectively at infant both sides nasal cavity, after instillation, slowly rubbing twice, it is made fully to incorporate nasal cavity, after five minutes, smooth breathing, sleeps stable.

Case 2: infant Nan Nan, 201 months one full year of life, because flu has two weeks, do not return to one's perfect health, and during flu, nasal cavity often has nose dung to block, conventional hands scratches nasal cavity, and child's hands is unclean, more easily cause recurrent infection, the therapeutic scheme of this infant is collunarium 3-4 time every day, and each 2-3 drips, doctor's advice is performed by the head of a family, within 1 day, symptom has alleviation, and after 3 days, rhinostegnosis situation solves.

Case 3: infant Citroen zx, 102 months one full year of life, the environment of life is comparatively dry, and in family, heating installation is excessively warm, infant phenomenon of having a stuffy nose for a long time is serious, to snore in addition evening phenomenon, often touch and pick the nose, cause infection, take nasal drop of the present invention, every day, 1-3 dripped, every day collunarium 2-3 time, nasal obstruction phenomenon solves substantially after 3 days.

Above specific embodiments of the invention have been described in detail, but described content being only preferred embodiment of the present invention, can not being considered to for limiting practical range of the present invention.All equalizations done according to the present patent application scope change and improve, and all should still belong within patent covering scope of the present invention.

Claims (6)

1. treat a nasal drop for infant nasal obstruction, it is characterized in that: comprise Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae and Oleum Sesami.

2. nasal drop according to claim 1, is characterized in that: be made up of the crude drug of following weight portion: Folium Mori 2-15 part, Flos Chrysanthemi 2-18 part, Flos Magnoliae 3-10 part, Herba Centipedae 1-10 part, Herba Menthae 1-8 part, Oleum Sesami 40-90 part.

3. nasal drop according to claim 1, is characterized in that, is made up of the crude drug of following weight portion: Folium Mori 5-10 part, Flos Chrysanthemi 5-10 part, Flos Magnoliae 4-8 part, Herba Centipedae 2-5 part, Herba Menthae 2-3 part, Oleum Sesami 50-70 part.

4. nasal drop according to claim 1, is characterized in that, is made up of the crude drug of following weight portion: 8 parts, Folium Mori, Flos Chrysanthemi 8 parts, Flos Magnoliae 5 parts, Herba Centipedae 4 parts, Herba Menthae 2 parts and 60 parts, Oleum Sesami.

5. prepare a preparation method for the nasal drop described in any one of claim 1-4, it is characterized in that, concrete step is:

1) Folium Mori, Flos Chrysanthemi, Flos Magnoliae, Herba Centipedae, Herba Menthae Chinese medicine of the five flavours are fully pulverized, roguing is for subsequent use;

2) first grind with a small amount of Oleum Sesami, after fully grinding, add the Oleum Sesami of surplus, filter medicinal residues after fully dissolving, get supernatant and namely obtain nasal drop.

6. nasal drop according to claim 1, is characterized in that: the application of described nasal drop in preparation treatment infant nose turunda thing.