CN103520554B - A kind of oral care composition and preparation method thereof - Google Patents
A kind of oral care composition and preparation method thereof Download PDFInfo
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- CN103520554B CN103520554B CN201310513540.5A CN201310513540A CN103520554B CN 103520554 B CN103520554 B CN 103520554B CN 201310513540 A CN201310513540 A CN 201310513540A CN 103520554 B CN103520554 B CN 103520554B
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Abstract
The invention discloses a kind of oral care composition and preparation method thereof.In the present invention, take Herba Blumeae Balsamiferae as monarch drug, with Flos Lonicerae and Folium Eriobotryae for ministerial drug, being equipped with Fructus Phyllanthi, Herba Lophatheri, Herba Eupatorii, Herba Menthae, Herba Pogostemonis is adjuvant drug altogether, and Radix Glycyrrhizae, for making, plays the function of coordinating the actions of various ingredients in a prescription, guides all medicines to go directly focus.We's compatibility, brings out the best in each other, plays the merit of heat-clearing and toxic substances removing, anti-inflammatory analgetic, antibacterial bacteriostatic, cleaning oral cavity altogether.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of oral care composition and preparation method thereof.
Background technology
In daily life, people will brush teeth and cleaning oral cavity every day, but, always have some specific occasions, such as: before meeting with friend or client, have dinner or eat a piece after, before and after tooth treatment, or, during oral ulcer, people often expect, have been exactly collutory or oral nursing liquid.
World Health Organization (WHO) (WHO) the article pointed out at " oral hygiene strategy ": " oral health is the indivisible ingredient of whole body health, and oral health is the determiner of quality of life." oral health is the important component part of health, oral health refers to have good oral hygiene, sound oral cavity function and do not have oral disease.Along with comprehensive raising of Modern Live mode, oral hygiene and the healthy most attention being more and more subject to people.
Whole nation oral health epidemiological survey is carried out once for every 12 years.On June 13rd, 2007, the whole nation third time oral health epidemiological survey result display that Ministry of Public Health is announced, the oral health of compatriots causes anxiety really, compared with front twice survey result, although there is a change for the better, but adult occurs that the ratio of the oral pathology such as gingival hemorrhage, ulcer is more than 80%, and oral healthy condition does not fundamentally improve.
At present, commercially, although some oral health products can be seen, as collutory, oral nursing liquid or mouth washes liquid etc., its health-care effect or product taste again can not simultaneously accept by market, Patents " a kind of Chinese herbal medicine mouth washes liquid " (application number: 201210597374.7), " a kind of oral nursing liquid and processing technology thereof " (application number: 201210183903.9), " multifunctional gargle " (application number: 201010173234.8), 201210224092.2) and " oral nursing liquid " (201010563459.4) " oral nursing liquid of oral mucositis caused by a kind of Prophylactic chemotherapy " (application number:, although each has something to recommend him, but, still be difficult to meet medical market demand, therefore, study the novel oral nursing liquid accorded with the demands of the market, collection is clean, sterilization, sterilizing, health care, eliminate the unusual smell, and properties of product are stablized, be easy to carry, easy to use, become the duty-bound responsibility of medical personal.
Summary of the invention
The object of the present invention is to provide oral care composition and the preparation thereof of a kind of applicable many people.
Another object of the present invention is the preparation method providing described oral care composition and preparation thereof.
In order to realize foregoing invention object, the present invention by the following technical solutions:
A kind of oral care composition, its raw material comprises by weight:
Herba Blumeae Balsamiferae: 100-300 weight portion, Flos Lonicerae: 50-150 weight portion, Folium Eriobotryae: 50-150 weight portion, Fructus Phyllanthi: 10-90 weight portion, Herba Lophatheri: 10-90 weight portion, Herba Eupatorii: 10-90 weight portion, Herba Menthae: 10-70 weight portion, Herba Pogostemonis: 10-70 weight portion, Radix Glycyrrhizae: 10-90 weight portion.
Described oral care composition each taste Chinese crude drug and the at all times brief introduction of ancient books and records paper are as follows:
Herba Blumeae Balsamiferae is leaf and the twig of feverfew Herba Blumeae Balsamiferae, latin name: Blumeabalsamifera (Linn.) DC.Grow in the torrid zone, subtropical zone, be distributed in Pakistan, India, Burma, Thailand, Malaysia, South East Asia Mainland.In China, all there is distribution in Hainan, Guangdong, Guangxi, Yunnan, Guizhou.Herba Blumeae Balsamiferae is the raw medicinal material extracting natural Broneolum Syntheticum (containing L-Borneol), nature and flavor: pungent; Micro-hardship; Warm in nature, there is warming middle-JIAO to invigorate blood circulation, effect of expelling wind and removing dampness, anti-inflammatory analgesic, can be used for the diseases such as treatment cold-damp dysentery, stomachache borborygmus, traumatic injury knife injury and hypertension." the SHENGCAO property of medicine standby will " calls it: " bitter in the mouth, warm in nature.To dispel the wind detumescence, dehumidifying of invigorating blood circulation.”
Flos Lonicerae: the flower that dry flower or band for caprifoliaceae plant Radix Ophiopogonis LonicerajaponicaThunb., Flos Lonicerae LonicerahypoglaucaMiq., Flos Lonicerae (hair calyx Radix Ophiopogonis) LoniceraconfusaDC. or hair style Radix Ophiopogonis LoniceradasystylaRehd. are just opened.Latin name: LonicerajaponicaThunb. function cures mainly: heat-clearing and toxic substances removing.Main epidemic febrile disease heating; Toxic-heat and blood stasis; Carbuncle furuncle; Sore throat and multi-infection disease." book on Chinese herbal medicine just ": " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea, Fructus Myricae rubrae, all poison of rheumatism, is really key medicine.”
Folium Eriobotryae: be the dried leaves of rosaceous plant Folium Eriobotryae.Latin name: Eriobotryajaponica (Thunb.) Lindl..Nature and flavor: bitter, pungent; Cold.Function cures mainly: clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.Compendium of Material Medica: " Folium Eriobotryae, controls the disease of lung stomach, mostly gets the merit ear of its therapeutic method to keep the adverse QI flowing downwards.Under gas then fire to fall expectorant suitable, and inverse person is not inverse, and habitual vomiter does not vomit, and thirsty person is thirsty, and the person of coughing does not cough.″
Fructus Phyllanthi is
radix Euphorbiae Pekinensis typethe dry mature fruit of phyllanthus emblica platymiscium Fructus Phyllanthi.Latin name: PhyllanthiFructus.Its fruit is eaten raw sour-sweet crisp and micro-puckery, and aftertaste is sweet, and therefore named emblic, has another name called pyhllanth usemhlica L., An Luoguo,
niuganguodeng." Chinese medicine voluminous dictionary " is illustrated as " reduce phlegm, give birth to dregs, cough-relieving, detoxify, cure cold heating, cough, pharyngalgia, diphtheria, restlessness and fever with thirst " the medical value of Fructus Phyllanthi." Chinese Pharmacopoeia " describes its function and cures mainly as clearing away heat and cooling blood, promoting digestion and invigorating the stomach, cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, dyspepsia, abdominal distention, cough, laryngalgia, xerostomia.The health-improving that ancient medicine great master Li Shizhen (1518-1593 A.D.) has affirmed fully Fructus Phyllanthi in Compendium of Material Medica to be had " clothes are made light of one's life by commiting suicide for a long time, prolong life long-living ".Modern study shows, Extracts from Leaves of Phyllanthus emblica L is to the inhibitory action of escherichia coli, staphylococcus aureus sensitive strain, staphylococcus aureus resistance strain, Candida albicans, Salmonella typhi, klebsiella pneumoniae, alpha streptococcus, group B streptococcus; Inhibitory action in various degree is all had in vitro to klebsiella pneumoniae, staphylococcus aureus sensitive strain, staphylococcus aureus resistance strain, escherichia coli, Salmonella typhi, Candida albicans.. Tang Materia Medica calls it: " main air deficiency-heat gas." " Nanning City's medicine will " call it: " refreshing and detoxicating controls sore throat.”
Herba Lophatheri is the dry stem and leaf of grass Herba Lophatheri.Latin name: LophatherumgracileBrongn. nature and flavor: sweet light, cold.Function cures mainly: clearing away heart-fire, heat clearing away and restlessness relieving, diuresis.Control calentura thirsty, vexed, hot urination, stranguria with turbid discharge, erosion of the oral mucosa tongue boil, gingival swelling and pain." modern Practical Chinese medicinal " thinks Herba Lophatheri: " refrigerant antipyretic, diuresis.Control calentura thirsty, difficulty and pain in micturition, dysphoria with smothery sensation is insomnia, gingival swelling and pain, stomatitis.”
Herba Eupatorii is the dry aerial parts of feverfew Herba Eupatorii.Latin name: EupatoriumfortuneiTurcz. nature and flavor: pungent is flat.Function cures mainly: removing dampness by means of aromatics, and appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest."
book on Chinese herbal medicine is just read": " Herba Eupatorii, the similar Herba Lycopi of function, and the gas of pungent perfume (or spice) crosses it, therefore energy resolving depression eliminating stagnation, kill diseases due to noxious agents produced by various parasites, except old, wash dirt greasy, exorcise evil spirits gas.As for the effect of row water expectorant, two things are similar ear also, but the property that Herba Lycopi harnesses the river is excellent, and the merit that Herba Eupatorii is regulated the flow of vital energy is victory, is again also different.”
Herba Menthae is herb or the leaf of labiate Herba Menthae, latin name: MenthahaplocalyxBriq.Function cures mainly: loose wind heat; Refresh oneself; Throat; Rash; Resolving depression.Main air hotlist is demonstrate,proved; Headache conjunctival congestion; Laryngopharynx swelling and pain; Measles without adequate eruption; Fall into rash pruritus; Hypochondriac pain due to stagnation of liverQI.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria." medicineization justice ": " Herba Menthae, acrid in the mouth can fall apart, cool in nature and clear, and the meeting head of tonneau six sun, dispels the ailment said due to cold or exposure of all heat.Get its property sharp and gently clear, benefaction women's head-ornaments, with controlling aphonia, treat ability to speak, clearing throat.”
Herba Pogostemonis is the herb of Labiatae herbaceos perennial Herba Pogostemonis, latin name: Agastacherugosa function cures mainly: fast gas, and in, ward off dirty, damp eliminating.Cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis." medicineization justice ": ＂ Herba Pogostemonis, its gas fragrance, benefaction gastric qi, in adjusting with this, stopping vomiting tells cholera, and with this fast gas, dirt eliminating jailbird is vexed.And fragrant energy and conjunction the five internal organs, if incoordination between the spleen and stomach, help stomach with it and enter diet, having the merit of appetizing of being amusing.“
Radix Glycyrrhizae: the dry root of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL..Latin name: GlycyrrhizauralensisFisch..Property flat, taste put down. there is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, go the function of phlegm and relieving cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The Li Dong Yuan of one of Au element: Radix Glycyrrhizae, " its performance emergency, and all medicines of coordinating, make it out of question, therefore its heat slow that the medicine of a warm nature obtains, slow its that cold medicine obtains is trembled with fear, and cold and heat are assorted person mutually, the get Qi Ping of use.”
A kind of oral care composition, its prescription have followed the basic principle of monarch.
" monarch " is the principles of formulating prescriptions of Chinese medicine.This principles of formulating prescriptions see "Nei Jing" the earliest.Huangdi's Internal Classics day: " add medicine to 120 kinds be monarch, main support life; 120 kinds, Chinese medicine is minister, and master nourishs one's nature; Put in poison 120 kinds and make for assistant, cure mainly disease; Medication must close monarch." " Plain Questions the most pure virginity will be discussed greatly " say: " the meaning monarch of principal agent, the drug in a prescription helping monarch-drug is called miniSter answer the meaning of minister to make." statement again in " Treatise on the spleen and stomach " of Yuan Dynasty's Li Dong Yuan: " monarch drug component is maximum, and ministerial drug takes second place, and medicine is taken second place again.Can not make minister too monarch, the monarch and his subjects are orderly, and Xiang Yuxuan takes the photograph, then can drive evil in sick.”
Qing Dynasty Wu Yi explains Lip river further: " main patient, the key medicine of suiting the medicine to the illness also, therefore the monarch of meaning.Monarch person's taste number is few and heavy, and what rely thinks master also.Assistant monarch thinks minister, and taste number is slightly many, and component is slightly light, thus the monarch that rectifies before not yet.Making of Ying Chenzhe meaning, number can be come in and gone out, and component is lighter, and institute prepares against making also of guide of passing through.This then monarch justice also." composition prescription medicine can be divided into monarch drug, ministerial drug, adjuvant drug, make medicine by its role in prescription, be referred to as monarch, minister, help, make.Monarch refers to the medicine playing primary treatment effect in prescription for main symptom.Minister refers to auxiliary monarch drug treatment main symptom, or the medicine of primary treatment accompanied symptoms.Monarch-minister drug treatment accompanied symptoms is closed in assistant assignment, or suppresses the toxicity of monarch-minister drug, or plays the medicine of using corrigent effect.Make guide lead all medicines to go directly diseased region or the medicine of coordinating the actions of various ingredients in a prescription.
In the present invention, with the famous medicine Herba Blumeae Balsamiferae of Hainan multitude's medicine of " warming middle-JIAO is invigorated blood circulation, effect of expelling wind and removing dampness, anti-inflammatory analgesic " for monarch drug, with cure mainly sore throat Flos Lonicerae and to cure mainly the thirsty Folium Eriobotryae of dysphoria with smothery sensation for ministerial drug, be equipped with that Fructus Phyllanthi is antibacterial, Herba Lophatheri cures gingival swelling and pain, Herba Eupatorii removes mouth saliva, Herba Menthae cures aphtha, Herba Pogostemonis dispels halitosis, be adjuvant drug altogether, Radix Glycyrrhizae, for making, plays the function of coordinating the actions of various ingredients in a prescription, and guide drugs is gone directly focus.All medicine compatibilities, bring out the best in each other, and play the merit of heat-clearing and toxic substances removing, anti-inflammatory analgetic, antibacterial bacteriostatic, cleaning oral cavity altogether.
As preferably, its raw material comprises by weight:
Herba Blumeae Balsamiferae: 150 ~ 250 weight portions, Flos Lonicerae: 80 ~ 120 weight portions, Folium Eriobotryae: 80 ~ 120 weight portions, Fructus Phyllanthi: 30 ~ 70 weight portions, Herba Lophatheri: 30 ~ 70 weight portions, Herba Eupatorii: 30 ~ 70 weight portions, Herba Menthae: 30-50 weight portion, Herba Pogostemonis: 30 ~ 50 weight portions, Radix Glycyrrhizae: 30 ~ 70 weight portions.
More preferably, its raw material comprises by weight:
Herba Blumeae Balsamiferae: 200 weight portions, Flos Lonicerae: 100 weight portions, Folium Eriobotryae: 100 weight portions, Fructus Phyllanthi: 50 weight portions, Herba Lophatheri: 50 weight portions, Herba Eupatorii: 50 weight portions, Herba Menthae: 40 weight portions, Herba Pogostemonis: 40 weight portions, Radix Glycyrrhizae: 50 weight portions.
The invention provides the Clinical Dosage Form of described oral care composition.Described compositions can be added the various customary adjuvant prepared needed for different dosage form by those skilled in the art, as filler, lubricant, binding agent etc., with traditional drug formulations method, directly or indirectly add pharmaceutically acceptable adjuvant, make conventional clinically conditioning liquid, collutory, chewable tablet, granule or oral liquid etc.
In an embodiment, present invention also offers oral nursing liquid of described oral care composition and preparation method thereof, due to directly in the face of focus, easy to use, evident in efficacy, deeply favor by patient.
Another object of the present invention is to the preparation method providing described oral care composition, this preparation method comprises following steps:
Step 1: get Fructus Phyllanthi and Radix Glycyrrhizae, soaks after 2-4 hour, adds Herba Blumeae Balsamiferae, Folium Eriobotryae, Herba Lophatheri and Herba Eupatorii, extracting in water 2-4 time, merge extractive liquid, filters, for subsequent use.
Step 2: extracting honeysuckle, Herba Menthae and Herba Pogostemonis, extracting in water 1-3 time, merge extractive liquid, filters, for subsequent use.
Step 3: get step 1 and step 2 gained filtrate, merges, and be concentrated into the clear paste that relative density is 1.30 (65 DEG C of heat are surveyed), precipitate with ethanol, gets supernatant and reclaim ethanol extremely without alcohol taste.
As preferably, step 1 is specially: get Fructus Phyllanthi and Radix Glycyrrhizae, soaks 3 hours, adds Herba Blumeae Balsamiferae, Folium Eriobotryae, Herba Lophatheri and Herba Eupatorii, add water, and extracts 3 times.The weight ratio of Chinese crude drug and water is: for the first time: 1: (8-10), extracts 2 hours; For the second time: 1: (5-7), extract 1.5 hours; For the third time: 1: (2-4), extract 1 hour.Three times extracting solution merges, and filters, for subsequent use.
As preferably, step 2 is specially: extracting honeysuckle, Herba Menthae and Herba Pogostemonis, add water, and extracts 2 times.The weight ratio of Chinese crude drug and water is: for the first time: 1: (8-10), extracts 1.5 hours; For the second time: 1: (5-7), extract 1 hour.Secondary raffinate merges, and filters, for subsequent use.
As preferably, step 3 is specially: get step 1 and step 2 gained filtrate, merges, and is evaporated to the clear paste that relative density is 1.30 (65 DEG C of heat are surveyed), lets cool to about 20 DEG C, slowly add ethanol under stirring, make alcohol content reach 78% ± 2%.Precipitate with ethanol 16 ± 2 hours, gets supernatant and reclaims ethanol extremely without alcohol taste.
The invention provides the oral nursing liquid of described oral care composition, by the extract of oral care composition prepared by said method, thin up 4-6 doubly, adjusted to ph be 6.6-7.1 (people under normal circumstances, the pH value in oral cavity is 6.6-7.1), to obtain final product.
The present invention, through clinical observation on the therapeutic effect, in the patient of 76 routine stomatitis, pharyngolaryngitis, aphtha or halitosis, uses oral nursing liquid of the present invention after 1 week, and cure 66 examples, cure rate accounts for 86.84%; Take a turn for the better 10 examples, and obvious effective rate accounts for 13.14%.The total effective rate that this group is observed is 100%.
The invention provides a kind of oral care composition, modern pharmacological research and clinical trial show: described oral care composition has the function of heat-clearing and toxic substances removing, anti-inflammatory analgetic, antibacterial bacteriostatic, cleaning oral cavity, are mainly used in that oral cavity cleaning, dysphoria with smothery sensation are thirsty, the disease such as mouth saliva halitosis, gingival swelling and pain, gingival hemorrhage, stomatitis and pharyngolaryngitis.Oral care composition of the present invention, to skin mucosa nonirritant, without anaphylaxis, has no side effect, and has comfort and the safety of height.
Detailed description of the invention
The invention discloses a kind of oral care composition and preparation method thereof, those skilled in the art can use for reference content of the present invention, and modification process parameter can realize a little.It is important to note that all similar modifications or substitute, will be readily apparent to persons skilled in the art, they are all deemed to be included in the present invention.Product of the present invention and application thereof, be described by embodiment, related personnel not departing from spirit of the present invention, content and scope, suitably combine methods and applications as herein described, modify or substituting, realize or apply the present invention completely.
Below in conjunction with embodiment, explain the present invention further.
The preparation of embodiment 1 oral care composition
A kind of oral care composition, its formula is made up of following weight ratio:
Herba Blumeae Balsamiferae: 100g, Flos Lonicerae: 50g Folium Eriobotryae: 50g Fructus Phyllanthi: 10g, Herba Lophatheri: 10g, Herba Eupatorii: 10g, Herba Menthae: 10g, Herba Pogostemonis: 10g, Radix Glycyrrhizae: 10g
The preparation method of this oral care composition is:
Step 1: get Fructus Phyllanthi and Radix Glycyrrhizae, soaks 3 hours, adds Herba Blumeae Balsamiferae, Folium Eriobotryae, Herba Lophatheri and Herba Eupatorii, add water, and extracts 3 times.The weight ratio of Chinese crude drug and water is: for the first time: 1: (8-10), extracts 2 hours; For the second time: 1: (5-7), extract 1.5 hours; For the third time: 1: (2-4), extract 1 hour.Three times extracting solution merges, and filters, for subsequent use.
Step 2: extracting honeysuckle, Herba Menthae and Herba Pogostemonis, add water, extracts 2 times.The weight ratio of Chinese crude drug and water is: for the first time: 1: (8-10), extracts 1.5 hours; For the second time: 1: (5-7), extract 1 hour.Secondary raffinate merges, and filters, for subsequent use.
Step 3: get step 1 and step 2 gained filtrate, merges, and is evaporated to the clear paste that relative density is 1.30 (65 DEG C of heat are surveyed), lets cool to about 20 DEG C, slowly add ethanol under stirring, make alcohol content reach 78% ± 2%.Precipitate with ethanol 16 ± 2 hours, gets supernatant and reclaims ethanol extremely without alcohol taste.
The preparation of embodiment 2 oral care composition
A kind of oral care composition, its formula is made up of following weight ratio:
Herba Blumeae Balsamiferae: 300g, Flos Lonicerae: 150g Folium Eriobotryae: 150g Fructus Phyllanthi: 90g, Herba Lophatheri: 90g,
Herba Eupatorii: 90g, Herba Menthae: 70g, Herba Pogostemonis: 70g, Radix Glycyrrhizae: 90g
The preparation method of this oral care composition is identical with the preparation method of embodiment 1.
The preparation of embodiment 3 oral care composition
A kind of oral care composition, its formula is made up of following weight ratio:
Herba Blumeae Balsamiferae: 200g, Flos Lonicerae: 100g Folium Eriobotryae: 100g Fructus Phyllanthi: 50g, Herba Lophatheri: 50g, Herba Eupatorii: 50g, Herba Menthae: 40g, Herba Pogostemonis: 40g, Radix Glycyrrhizae: 50g
The preparation method of this oral care composition is identical with the preparation method of embodiment 1.
Embodiment 4 prepares oral nursing liquid of the present invention
By oral care composition extract prepared by formula described in embodiment 1 and preparation method, be diluted to 5 times amount of crude drug with water for injection, stir, adjusted to ph is 6.6-7.1, namely suitable with human mouth pH value under normal circumstances, be distributed into bottle, obtain oral nursing liquid of the present invention.
Embodiment 5 prepares collutory of the present invention
By oral care composition extract prepared by formula described in embodiment 2 and preparation method, be diluted to 5 times amount of crude drug with water for injection, stir, adjusted to ph is 6.6-7.1, namely suitable with human mouth pH value under normal circumstances, be distributed into bottle, obtain collutory of the present invention.
Embodiment 6 prepares granule of the present invention
By oral care composition extract prepared by formula described in embodiment 3 and preparation method, spraying dry, mixes with customary adjuvant, conventionally prepares granule of the present invention.
Embodiment 7 prepares chewable tablet of the present invention
By oral care composition extract prepared by formula described in embodiment 1 and preparation method, spraying dry, mixes with customary adjuvant, conventionally prepares chewable tablet of the present invention.
Embodiment 8 prepares oral liquid of the present invention
By oral care composition extract prepared by formula described in embodiment 2 and preparation method, mix with customary adjuvant, conventionally prepare oral liquid of the present invention.
The observation of curative effect of embodiment 9 oral care composition of the present invention
Observe the curative effect of application oral care composition treatment of the present invention mouth saliva halitosis, gingival swelling and pain, gingival hemorrhage, stomatitis and pharyngolaryngitis.
Method: 152 all kinds of patients of routine above-mentioned stomatitis are divided into experimental group and matched group at random, experimental group 76 example, matched group 76 example, oral care composition prepared by experimental group Application Example 1-8 and preparation, the collutory that the control group is commercially available or oral nursing liquid.Treatments period stops other western medicines in treatment.
Diagnostic criteria: with reference to clinical criteria.
In an experiment, the present invention achieves good curative effect, in the patient of the routine stomatitis of experimental group 76, pharyngolaryngitis, aphtha or gingival swelling and pain, uses oral care composition formulations of the present invention after 1 week, and cure 66 examples, cure rate accounts for 86.84%; Take a turn for the better 10 examples, and obvious effective rate accounts for 13.14%.The total effective rate that this group is observed is 100%.Oral nursing liquid of the present invention, collutory, granule, chewable tablet and oral liquid, no difference of science of statistics between group.Matched group cure rate 60.0%, total effective rate 84.5%, two groups compares significant difference (P<0.05).
Conclusion: oral care composition of the present invention and preparation thereof, in the curative effect for the treatment of mouth saliva halitosis, gingival swelling and pain, gingival hemorrhage, stomatitis, pharyngolaryngitis and mouth care, Be very effective, to skin mucosa nonirritant, without anaphylaxis, have no side effect, there is comfort and the safety of height, be worthy of promotion and application.
Claims (10)
1. an oral care composition, its raw material is by weight:
Herba Blumeae Balsamiferae: 100-300 weight portion, Flos Lonicerae: 50-150 weight portion, Folium Eriobotryae: 50-150 weight portion, Fructus Phyllanthi: 10-90 weight portion, Herba Lophatheri: 10-90 weight portion, Herba Eupatorii: 10-90 weight portion, Herba Menthae: 10-70 weight portion, Herba Pogostemonis: 10-70 weight portion, Radix Glycyrrhizae: 10-90 weight portion.
2. oral care composition according to claim 1, it is characterized in that, its raw material is by weight: Herba Blumeae Balsamiferae: 200 weight portions, Flos Lonicerae: 100 weight portions, Folium Eriobotryae: 100 weight portions, Fructus Phyllanthi: 50 weight portions, Herba Lophatheri: 50 weight portions, Herba Eupatorii: 50 weight portions, Herba Menthae: 40 weight portions, Herba Pogostemonis: 40 weight portions, Radix Glycyrrhizae: 50 weight portions.
3. the Clinical Dosage Form of oral care composition described in any one of claim 1-2.
4. Clinical Dosage Form according to claim 3, is characterized in that, described dosage form is conditioning liquid, collutory, chewable tablet, granule, oral liquid.
5. the preparation method of oral care composition described in any one of claim 1-2, comprises following steps:
Step 1: get Fructus Phyllanthi and Radix Glycyrrhizae, soaks after 2-4 hour, adds Herba Blumeae Balsamiferae, Folium Eriobotryae, Herba Lophatheri and Herba Eupatorii, extracting in water 2-4 time, merge extractive liquid, filters, for subsequent use;
Step 2: extracting honeysuckle, Herba Menthae and Herba Pogostemonis, extracting in water 1-3 time, merge extractive liquid, filters, for subsequent use;
Step 3: get step 1 and step 2 gained filtrate, merges, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.30, precipitate with ethanol, gets supernatant and reclaims ethanol to without alcohol taste.
6. preparation method according to claim 5, is characterized in that, described step 1 is specially: get Fructus Phyllanthi and Radix Glycyrrhizae, soaks 3 hours, adds Herba Blumeae Balsamiferae, Folium Eriobotryae, Herba Lophatheri and Herba Eupatorii, extracting in water 3 times; The weight ratio of Chinese crude drug and water is: for the first time: 1: (8-10), extracts 2 hours; For the second time: 1: (5-7), extract 1.5 hours: for the third time: 1: (2-4), extract 1 hour; Three times extracting solution merges, and filters, for subsequent use.
7. preparation method according to claim 5, is characterized in that, described step 2 is specially: extracting honeysuckle, Herba Menthae and Herba Pogostemonis, add water, and extracts 2 times; The weight ratio of Chinese crude drug and water is: for the first time: 1: (8-10), extracts 15 hours; For the second time: 1: (5-7), extract 1 hour; Secondary raffinate merges, and filters, for subsequent use.
8. preparation method according to claim 5, it is characterized in that, described step 3 is specially: get step 1 and step 2 gained filtrate, merge, when being evaporated to 65 DEG C, relative density is the clear paste of 1.30, let cool to about 20 DEG C, under stirring, slowly add ethanol, make alcohol content reach 78% ± 2%; Precipitate with ethanol 16 ± 2 hours, gets supernatant and reclaims ethanol extremely without alcohol taste.
9. the oral care composition that according to any one of claim 5-8 prepared by preparation method.
10. an oral nursing liquid, is characterized in that, by oral care composition according to claim 9, doubly, adjusted to ph is 6.6-7.1 and get final product thin up 4-6.
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| CN103908595A (en) * | 2014-04-02 | 2014-07-09 | 李志强 | Oral health lozenge and preparation method thereof |
| MX365609B (en) * | 2014-12-23 | 2019-06-07 | Colgate Palmolive Co | Oral care composition and method of use. |
| CN104800616A (en) * | 2015-04-07 | 2015-07-29 | 范永启 | Compound essential oil for preventing and curing stomatitis |
| CN104873418A (en) * | 2015-05-18 | 2015-09-02 | 李学刚 | Oral care solution |
| CN105998694A (en) * | 2016-06-29 | 2016-10-12 | 何勤 | Smoker mouth care agent |
| CN106075243A (en) * | 2016-06-29 | 2016-11-09 | 何勤 | A kind of alcohol user's oral cavity nursing agent |
| CN107213244B (en) * | 2017-06-27 | 2020-11-24 | 江西天元药业有限公司 | Chewable tablet beneficial to treatment of gingival bleeding and preparation method thereof |
| CN108578298A (en) * | 2018-07-02 | 2018-09-28 | 李雪萍 | A kind of herbaceous plant oral care formulations |
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| CN1583034A (en) * | 2004-06-03 | 2005-02-23 | 杨再溥 | Perfume spray liquid |
| CN101020001A (en) * | 2007-03-12 | 2007-08-22 | 杨再溥 | Chinese medicine buccal tablet for cleaning oral cavity |
| CN101985026A (en) * | 2010-10-26 | 2011-03-16 | 朱新华 | Pure Chinese medicinal preparation for rapidly treating halitosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583034A (en) * | 2004-06-03 | 2005-02-23 | 杨再溥 | Perfume spray liquid |
| CN101020001A (en) * | 2007-03-12 | 2007-08-22 | 杨再溥 | Chinese medicine buccal tablet for cleaning oral cavity |
| CN101985026A (en) * | 2010-10-26 | 2011-03-16 | 朱新华 | Pure Chinese medicinal preparation for rapidly treating halitosis |
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| "口喉宁"治疗口咽病82例;王明辉;《辽宁中医杂志》;19931231(第01期);22-23 * |
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