CN111358904A - Traditional Chinese medicine electric aromatherapy liquid with epidemic prevention function and preparation method and application thereof - Google Patents
Traditional Chinese medicine electric aromatherapy liquid with epidemic prevention function and preparation method and application thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The invention discloses a traditional Chinese medicine electric aromatherapy liquid with an epidemic prevention function, which is prepared from the following raw material medicines: folium Artemisiae Argyi, rhizoma Atractylodis, radix Angelicae Dahuricae, lignum Dalbergiae Odoriferae, rhizoma Ligustici Chuanxiong, rhizoma Acori Graminei, Atractylodis rhizoma, rhizoma Kaempferiae, herba Eupatorii and herba Menthae. The invention adopts the theory of dialectical treatment to screen the raw traditional Chinese medicine materials, and adopts the theory of dialectical treatment to select the raw traditional Chinese medicine materials to prepare the aromatherapy liquid or the aromatherapy tablet according to the traditional Chinese medicine theory, and adopts an electric heating mode to slowly volatilize the traditional Chinese medicine materials without obvious dense smoke, without irritating people, and the traditional Chinese medicine tablet has long duration, is suitable for various places and has good adaptability. The experimental results show that the traditional Chinese medicine electro-aromatherapy liquid with the epidemic prevention function can obviously improve the survival time of influenza model mice, has good effects of removing diseases and eliminating pathogenic factors, and has natural and safe medicine flavor and no adverse reaction.
Description
Technical Field
The invention relates to an electric aromatherapy liquid, in particular to a traditional Chinese medicine electric aromatherapy liquid with an epidemic prevention function, and a preparation method and application thereof.
Background
The traditional Chinese medicine aromatherapy is a method for epidemic prevention, insect expelling, mosquito repelling and evil expelling of doctors of all ages, and simultaneously has certain effects of tranquilizing, soothing the nerves, improving immunity and the like. However, most of the existing traditional Chinese medicine aromatherapy is made of single traditional Chinese medicine with volatility, smoke is large during combustion, the release time of active ingredients is short, and the effect is not obvious.
Seasonal influenza viruses are high in infectivity, are easy to spread in forms of droplets, aerosols and the like, and are difficult to epidemic prevention. The existing 84 disinfectant, alcohol and other disinfection modes have certain toxic and side effects and potential safety hazards, and certain damage is caused to human health after long-term large-scale use.
Therefore, it is necessary to research and develop an electric aromatherapy liquid prepared from pure natural traditional Chinese medicines with good safety, especially influenza and the like, on the basis of the prior art.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to solve the defects of the prior art and provides the traditional Chinese medicine electric aromatherapy liquid which is scientific and reasonable in proportion, exact in curative effect and convenient to use and has the functions of eliminating turbid pathogen with aromatics, eliminating evil and preventing epidemic and resisting virus, and the preparation method and the application thereof.
The technical scheme is as follows: in order to achieve the above purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine electric aromatherapy liquid with an epidemic prevention function is prepared from the following raw material medicines:
folium Artemisiae Argyi, rhizoma Atractylodis, radix Angelicae Dahuricae, lignum Dalbergiae Odoriferae, rhizoma Ligustici Chuanxiong, rhizoma Acori Graminei, Atractylodis rhizoma, rhizoma Kaempferiae, herba Eupatorii and herba Menthae.
As a preferred scheme, the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function is prepared from the following raw material medicines in parts by weight:
10-50 parts of folium artemisiae argyi, 10-50 parts of rhizoma atractylodis, 5-25 parts of radix angelicae, 5-25 parts of dalbergia wood, 5-25 parts of ligusticum wallichii, 5-25 parts of rhizoma acori graminei, 5-25 parts of rhizoma atractylodis macrocephalae, 5-25 parts of rhizoma kaempferiae, 5-25 parts of herba eupatorii and 5-25 parts of mint.
As a more preferable scheme, the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function is prepared from the following raw material medicines in parts by weight:
50 parts of folium artemisiae argyi, 50 parts of rhizoma atractylodis, 25 parts of radix angelicae, 25 parts of dalbergia wood, 25 parts of ligusticum wallichii, 25 parts of rhizoma acori graminei, 25 parts of rhizoma atractylodis macrocephalae, 20 parts of rhizoma kaempferiae, 20 parts of herba eupatorii and 15 parts of mint.
As a preferred scheme, the preparation method of the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function comprises the following steps:
(1) extracting folium Artemisiae Argyi, rhizoma Atractylodis, radix Angelicae Dahuricae, lignum Dalbergiae Odoriferae, rhizoma Ligustici Chuanxiong, fructus Ulmus Preparatium, rhizoma Acori Graminei, Atractylodis rhizoma, rhizoma Kaempferiae, herba Eupatorii and herba Menthae by steam distillation or supercritical fluid extraction to obtain volatile oil;
(2) extracting the dregs of the decoction, which are subjected to the volatile oil extraction in the step (1), with ethanol for 1-3 times, filtering, combining the extracting solutions, and concentrating under reduced pressure to obtain a concentrate;
(3) and (3) uniformly mixing the volatile oil extracted in the step (1) and the concentrate obtained in the step (2), and refrigerating to obtain the product.
As a preferred scheme, the preparation method of the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function comprises the steps of (1) taking folium artemisiae argyi, rhizoma atractylodis, radix angelicae, lignum dalbergiae odoriferae, ligusticum wallichii, rhizoma acori graminei, rhizoma atractylodis macrocephalae, rhizoma kaempferiae, herba eupatorii and mint, adding 6-12 times of water, extracting for 1-2 hours by adopting a steam distillation method, and collecting volatile oil.
As a preferable scheme, in the preparation method of the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function, the extraction conditions of the supercritical fluid extraction method in the step (1) are as follows: the extraction pressure is 35-40 Mpa, the extraction temperature is 40-45 ℃, the extraction time is 0.5-2 hours, the entrainer is ethanol, and the amount of the entrainer is 10-20% of the total weight of the medicinal materials.
More preferably, the extraction pressure is 40Mpa, the extraction temperature is 40 ℃, the extraction time is 1 hour, the entrainer is ethanol, and the amount of the entrainer is 15 percent of the total weight of the medicinal materials.
Preferably, the preparation method of the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function comprises the steps of (2) adding ethanol with the volume 6-15 times of the weight of the medicinal materials, carrying out reflux extraction, continuous reflux extraction or ultrasonic extraction for 1-3 times, 0.5-2 hours each time, filtering, combining the extracting solutions, and carrying out reduced pressure concentration to obtain the concentrate.
A Chinese medicinal electric aromatherapy tablet with epidemic prevention function is prepared by soaking carrier with adsorbed medicinal liquid in the Chinese medicinal electric aromatherapy liquid of claim 1 or 2, taking out, and air drying.
An electrothermal aromatherapy device with epidemic prevention function comprises Chinese medicinal electric aromatherapy liquid and electronic constant temperature heater; the electronic constant temperature heater heats the core rod, so that the traditional Chinese medicine electric aromatherapy liquid reaches the top end of the core rod under the action of the hair gap to exert the epidemic prevention function.
An electrothermal aromatherapy device with epidemic prevention function comprises traditional Chinese medicine electric aromatherapy piece and electronic constant temperature heater.
Has the advantages that: according to the theory of traditional Chinese medicine, the invention selects the raw traditional Chinese medicine materials to prepare the aromatherapy liquid or the aromatherapy tablet by adopting the theory of dialectical treatment, slowly volatilizes by adopting an electric heating mode, has no obvious dense smoke, is not choked, has long duration, is suitable for various places and has good adaptability. Experimental results show that the traditional Chinese medicine electro-aromatherapy liquid with the epidemic prevention function can obviously improve the survival time of influenza model mice and has good effects of removing diseases and eliminating pathogenic factors. And the medicine has natural and safe taste and no adverse reaction.
Detailed Description
The present invention is further illustrated by the following examples, which are intended to be purely exemplary and are not intended to limit the scope of the invention, as various equivalent modifications of the invention will occur to those skilled in the art upon reading the present disclosure and fall within the scope of the appended claims.
Example 1
1. A preparation method of traditional Chinese medicine electric aromatherapy liquid with epidemic prevention function comprises folium Artemisiae Argyi 50g, rhizoma Atractylodis 50g, radix Angelicae Dahuricae 25g, lignum Dalbergiae Odoriferae 25g, rhizoma Ligustici Chuanxiong 25g, rhizoma Acori Graminei 25g, Atractylodis rhizoma 25g, rhizoma Kaempferiae 20g, herba Eupatorii 20g and herba Menthae 15 g.
2. The preparation method of the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function comprises the following steps:
(1) taking 50g of folium artemisiae argyi, 50g of rhizoma atractylodis, 25g of radix angelicae, 25g of dalbergia wood, 25g of ligusticum wallichii, 25g of rhizoma acori graminei, 25g of rhizoma atractylodis macrocephalae, 20g of rhizoma kaempferiae, 20g of herba eupatorii and 15g of mint, adding 10 times of water by weight of the medicinal materials, and extracting for 2 hours by adopting a steam distillation method to obtain volatile oil (the yield of the volatile oil is 6.17%);
(2) extracting the residue after the volatile oil is extracted in step (1) with 8 times of ethanol for 2 times (1 hr each time), filtering, mixing extractive solutions, and concentrating under reduced pressure to obtain concentrate;
(3) and (3) uniformly mixing the volatile oil extracted in the step (1) and the concentrate obtained in the step (2), and refrigerating to obtain the product.
Example 2
1. A preparation method of traditional Chinese medicine electric aromatherapy liquid with epidemic prevention function comprises 25g of folium artemisiae argyi, 25g of rhizoma atractylodis, 12g of radix angelicae, 12g of lignum dalbergiae odoriferae, 12g of rhizoma ligustici wallichii, 12g of rhizoma acori graminei, 12g of rhizoma atractylodis macrocephalae, 10g of rhizoma kaempferiae, 10g of eupatorium and 8g of mint.
2. The preparation method of the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function comprises the following steps:
(1) taking 25g of folium artemisiae argyi, 25g of rhizoma atractylodis, 12g of radix angelicae, 12g of dalbergia wood, 12g of ligusticum wallichii, 12g of rhizoma acori graminei, 12g of rhizoma atractylodis macrocephalae, 10g of rhizoma kaempferiae, 10g of eupatorium fortunei and 8g of mint, and adopting supercritical CO2Extracting under 40Mpa at 40 deg.C for 1 hr with ethanol as entrainer in an amount of 15% of the total weight of the medicinal materials
Obtaining volatile oil (the yield of the volatile oil is 7.54%);
(2) extracting the residue after the volatile oil is extracted in step (1) with 8 times of ethanol for 2 times (1 hr each time), filtering, mixing extractive solutions, and concentrating under reduced pressure to obtain concentrate;
(3) and (3) uniformly mixing the volatile oil extracted in the step (1) and the concentrate obtained in the step (2), and refrigerating to obtain the product.
Example 3
A traditional Chinese medicine electric fragrance sheet with an epidemic prevention function is prepared by soaking mica in the extract prepared in example 1 and then drying the extract.
Embodiment 4 an electric heating aromatherapy device with epidemic prevention function, which consists of the traditional Chinese medicine electric aromatherapy liquid and an electronic constant temperature heater in embodiment 1; the electronic constant temperature heater heats the core rod, so that the traditional Chinese medicine electric aromatherapy liquid reaches the top end of the core rod under the action of the hair gap to exert the epidemic prevention function.
Example 5 mortality protection in H1N1 influenza Virus infected mice
1.1 Experimental materials
(1) Medicine
Example 4 the prepared electro-thermal aromatherapy device having an epidemic prevention function.
(2) Animal(s) production
SPF-grade BALB/C mice, female, 4-5 weeks old, body weight 14-16 g.
(3) Viral strains
Influenza A virus (H1N1) mouse lung-adapted strain was amplified with 9-day-old SPF chick embryos and the median Lethal Dose (LD) of mice was determined by the Reed-Muench method50)。
1.2 Experimental procedures
(1) Freezing and thawing the virus, diluting to 3 LD50。
(2) BALB/C mice were randomly grouped into 10 mice each, and a normal control group, a model group and a treatment group were set. Except for the normal group, after the mice were lightly anesthetized with ether, 40. mu.L/mouse of the nasal infection virus solution was dropped, and the normal control group was dropped with the same amount of normal saline.
(3) 3h after infection of the virus, the model group mice and the treatment group mice are respectively placed in glass covers (the top ends of the glass covers are provided with air inlet and outlet holes) with the length, the width and the height of 80 x 60 x 40, the model group glass covers are internally provided with electric heating aromatherapy devices, and the medium is water. The electrothermal aromatherapy device with an epidemic prevention function prepared in example 4 is placed in the glass cover of the treatment group for fumigating 4 hours in the morning and fumigating 4 hours in the afternoon.
(4) Mice were observed daily for signs of morbidity, body weight, survival time and mortality for 15 days. Death during dosing was considered abnormal. From the observations, survival rates and mean survival times were calculated.
(5) Statistical treatment: mean survival time one-way anova was performed using SPSS17.0 software. p <0.05 and p <0.05 are statistically different.
1.3 results
The experimental results shown in table 1 show that: the mortality rate was significantly higher in the model group compared to the normal group (P <0.001), indicating that the model of influenza H1N1 infected mice was effective. The electrothermal aromatherapy with the epidemic prevention function has an obvious protection effect on mice infected with influenza virus H1N1, the death rate is low, and the death time is delayed compared with that of virus group mice.
TABLE 1 mortality protection of H1N1 influenza virus infected mice by different administration groups
Note: p <0.05, P <0.01 in comparison to the virus group
EXAMPLE 6 evaluation of clinical efficacy
1. Data and method
1.1 study object
20 subjects with poor resistance and susceptibility to cough were collected. 10 men and 10 women, age 7-67 years.
1.2 methods of treatment
By adopting the electrothermal aromatherapy device of the embodiment 4 of the invention, the fumigation is carried out for 2 hours in the morning and in the afternoon respectively and for 4 hours in the evening. 7 days is a course of treatment.
2. Clinical results
20 subjects adopt the aromatherapy device provided by the invention to fumigate, and good prevention and treatment effects are achieved:
TABLE 2 therapeutic Effect on 20 clinical patients
The experimental results of the above table 2 show that the fumigation device provided by the invention has an obvious auxiliary treatment effect on common cold diseases or respiratory cough and other symptoms of sufferers.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
1. The traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function is characterized by being prepared from the following raw material medicines:
folium Artemisiae Argyi, rhizoma Atractylodis, radix Angelicae Dahuricae, lignum Dalbergiae Odoriferae, rhizoma Ligustici Chuanxiong, rhizoma Acori Graminei, Atractylodis rhizoma, rhizoma Kaempferiae, herba Eupatorii and herba Menthae.
2. The traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function according to claim 1, is prepared from the following raw material medicines in parts by weight:
10-50 parts of folium artemisiae argyi, 10-50 parts of rhizoma atractylodis, 5-25 parts of radix angelicae, 5-25 parts of dalbergia wood, 5-25 parts of ligusticum wallichii, 5-25 parts of rhizoma acori graminei, 5-25 parts of rhizoma atractylodis macrocephalae, 5-25 parts of rhizoma kaempferiae, 5-25 parts of herba eupatorii and 5-25 parts of mint.
3. The preparation method of the traditional Chinese medicine electric aromatherapy liquid with epidemic prevention function according to claim 1 or 2, characterized by comprising the steps of:
(1) extracting folium Artemisiae Argyi, rhizoma Atractylodis, radix Angelicae Dahuricae, lignum Dalbergiae Odoriferae, rhizoma Ligustici Chuanxiong, rhizoma Acori Graminei, Atractylodis rhizoma, rhizoma Kaempferiae, herba Eupatorii and herba Menthae by steam distillation or supercritical fluid extraction to obtain volatile oil;
(2) extracting the dregs of the decoction, which are subjected to the volatile oil extraction in the step (1), with ethanol for 1-3 times, filtering, combining the extracting solutions, and concentrating under reduced pressure to obtain a concentrate;
(3) and (3) uniformly mixing the volatile oil extracted in the step (1) and the concentrate obtained in the step (2), and refrigerating to obtain the product.
4. The method for preparing Chinese medicinal electrical aromatherapy liquid with epidemic prevention function according to claim 3,
taking folium artemisiae argyi, rhizoma atractylodis, radix angelicae, lignum dalbergiae odoriferae, ligusticum wallichii, rhizoma acori graminei, rhizoma atractylodis macrocephalae, rhizoma kaempferiae, eupatorium fortunei and mint, adding 6-12 times of water, extracting for 1-2 hours by adopting a steam distillation method, and collecting volatile oil.
5. The method for preparing Chinese medicinal electrical aromatherapy liquid with epidemic prevention function according to claim 3,
the extraction conditions of the supercritical fluid extraction method in the step (1) are as follows: the extraction pressure is 35-40 Mpa, the extraction temperature is 40-45 ℃, the extraction time is 0.5-2 hours, the entrainer is ethanol, and the amount of the entrainer is 10-20% of the total weight of the medicinal materials.
6. The preparation method of the traditional Chinese medicine electric aromatherapy liquid with the epidemic prevention function according to claim 3, characterized in that ethanol with a volume 6-15 times of the weight of the medicinal materials is added in the step (2), reflux extraction, continuous reflux extraction or ultrasonic extraction is carried out for 1-3 times, 0.5-2 hours each time, filtration is carried out, the extracting solutions are combined, and the concentrate is obtained by reduced pressure concentration.
7. A traditional Chinese medicine electric aromatherapy tablet with epidemic prevention function is characterized in that a carrier with the function of adsorbing liquid medicine is soaked in the traditional Chinese medicine electric aromatherapy liquid according to claim 1 or 2, and then is taken out and dried to obtain the traditional Chinese medicine electric aromatherapy tablet.
8. An electric heating aromatherapy device with epidemic prevention function, which is characterized in that it is composed of the traditional Chinese medicine electric aromatherapy liquid of claim 1 or 2 and an electronic constant temperature heater; the electronic constant temperature heater heats the core rod, so that the traditional Chinese medicine electric aromatherapy liquid reaches the top end of the core rod under the action of the hair gap to exert the epidemic prevention function.
9. An electric heating aromatherapy device with epidemic prevention function, which is characterized by comprising the traditional Chinese medicine electric aromatherapy piece of claim 7 and an electronic constant temperature heater.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111821332A (en) * | 2020-07-29 | 2020-10-27 | 庆阳绣韵文化传播有限公司 | Sachet and making method thereof |
| CN111838206A (en) * | 2020-08-06 | 2020-10-30 | 柳州市中医医院 | Traditional Chinese medicine composition for removing dirt |
| CN112843197A (en) * | 2021-03-16 | 2021-05-28 | 长春中医药大学附属医院(吉林省中医院) | Epidemic prevention nose patch formula extracted from traditional Chinese medicine and preparation process |
| CN113209203A (en) * | 2021-05-18 | 2021-08-06 | 江西中医药大学 | Antiviral compound essential oil and application thereof |
| CN113491751A (en) * | 2020-04-02 | 2021-10-12 | 常州高新技术产业开发区三维工业技术研究所有限公司 | A medicated core for preventing influenza, Chinese medicinal composition, sachet, medicated bath bag, foot bath bag, and preparation method thereof |
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| CN101721618A (en) * | 2009-11-24 | 2010-06-09 | 中国人民解放军第二军医大学 | External Chinese medicinal health-care bag for dispelling filth and preventing and treating influenza |
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| CN101721618A (en) * | 2009-11-24 | 2010-06-09 | 中国人民解放军第二军医大学 | External Chinese medicinal health-care bag for dispelling filth and preventing and treating influenza |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113491751A (en) * | 2020-04-02 | 2021-10-12 | 常州高新技术产业开发区三维工业技术研究所有限公司 | A medicated core for preventing influenza, Chinese medicinal composition, sachet, medicated bath bag, foot bath bag, and preparation method thereof |
| CN111821332A (en) * | 2020-07-29 | 2020-10-27 | 庆阳绣韵文化传播有限公司 | Sachet and making method thereof |
| CN111838206A (en) * | 2020-08-06 | 2020-10-30 | 柳州市中医医院 | Traditional Chinese medicine composition for removing dirt |
| CN112843197A (en) * | 2021-03-16 | 2021-05-28 | 长春中医药大学附属医院(吉林省中医院) | Epidemic prevention nose patch formula extracted from traditional Chinese medicine and preparation process |
| CN113209203A (en) * | 2021-05-18 | 2021-08-06 | 江西中医药大学 | Antiviral compound essential oil and application thereof |
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