CN102670936A - Traditional Chinese medicine preparation for treating viral enteritis and diarrhea - Google Patents

Abstract

A traditional Chinese medicine preparation for treating viral enteritis and diarrhea relates to a Chinese patent medicine product for treating viral enteritis and diarrhea, belongs to the technical field of Chinese veterinarians, and is mainly used for canine parvovirus, diarrhea caused by animal bacterial, viral and parasitic injection, and physiological peptic diarrhea. The traditional Chinese medicine preparation has following components: 50 g rhizoma coptidis, 30 g atractylis ovata, 50 g terminalia chebula, 30 g Chinese violet, 30 g cyrtomium rhizome, 25 g hairyvein agrimony, 30 g magnolia officinalis, 60 g allium sativum, 25 g radix saposhnikoviae and 25 g magnolia officinalis. The traditional Chinese medicine preparation has the effects of fever reducing, detoxication, inflammation diminishing, sterilization, virus inhibiting, desinsectization, diarrhea checking, constringency, hemostasis, spleen strengthening, qi tonifying, diuresis promoting, spleen invigorating and qi replenishing. The traditional Chinese medicine preparation can not only treat diarrhea caused by animal bacterial, viral and parasitic injection and protect the intestinal mucosa, but also has no drug resistance, and the effect is greatly superior to the chemical drug and single traditional Chinese medicine preparations used at present. Active ingredients in medicine are extracted through adopting a technology of applying the organic solvent extraction method, and the dosage use is 30% of original drug.

Description

A kind of Chinese medicine preparation of treating viral enteritis and dysentery

 

Technical field

The present invention relates to treat a kind of Chinese medicine and the formulation preparation of Animal diseases, is used to treat the technology of dog and livestock and poultry virus enteritis and dysentery.

Background technology

At present; Known zoosis toxicity disease all is to prevent by vaccine injection; Do not have effective medicine to be used for prevention and treatment viral disease, depend merely on vaccinate and prevent, because the regularity of vaccine injection, vaccine preservation, injecting method etc. are to the interference of vaccine injection effect; And animal immune suppresses the influence of factor, in production practices, often immuning failure occurs and causes the animal mortality; On the other hand, the characteristic of virus variation also is the key factor that influences immune effect of vaccine.At present, the Chinese herbal and crude drugs preparations of employing treatment dysentery is also arranged, but compatibility of drugs is unreasonable, effect is single, is not suitable for producing actual needs, causes the product therapeutic effect dissatisfied.

Summary of the invention

In order to overcome the defective that only relies on vaccine prevention; Reduce because the loss that the viral enteritis dysentery brings to animal feeding, especially vast rural area middle and small scale plant produces practical situation and is: the enteritis dysentery of clinical generation is antibacterial often, and is a kind of or MOI causes in virus or the parasite; And; Most of plants do not have technological means to differentiate that the enteritis dysentery is viral, still bacteroidal, or parasite causes; The present invention provides cover Chinese herbal medicine formula and a preparation oral liquid and an injection technology of preparing, and compatibility is following:

The windproof 25g Cortex Magnoliae Officinalis of Rhizoma Coptidis 50g Folium Isatidis 40g Rhizoma Atractylodis Macrocephalae 30g Fructus Chebulae 50g Herba Violae 30g Rhizoma Osmundae 30g Herba Agrimoniae 25g Cortex Magnoliae Officinalis 30g Bulbus Allii 60g 25g

Monarch drug:Rhizoma Coptidis Folium Isatidis Fructus Chebulae Herba Violae Rhizoma Osmundae Bulbus Allii: heat clearing away, detoxifcation, antiinflammatory, antibacterial suppresses virus, anthelmintic, antidiarrheal

Ministerial drug: Rhizoma Atractylodis Macrocephalae Cortex Magnoliae Officinalis is windproof: invigorating middle warmer, spleen invigorating, QI invigorating, inducing diaphoresis to dispel wind, dehumidifying.

Adjuvant drug: Herba Agrimoniae: astringing to arrest bleeding, invigorating the spleen and replenishing QI, bowel relieving antidiarrheal.

Enteritis dysentery majority is that bacterial poison causes because damp and hot.Enteritis and dysentery association often are in the same place, and generally take heat-clearing and toxic substances removing, anti-inflammation, antiviral; Warming the spleen dampness, parasite killing, the method control of relieving diarrhea with astringents is with Rhizoma Coptidis; Folium Isatidis, Kuo Zi etc. are got rid of evils for monarch drug, the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis; Windproofly set upright for ministerial drug, and Bulbus Allii, the immunocyte effect can be improved, the enhancing human body immunity function; Herba Agrimoniae is that effect is set upright in the messenger drug consolidation, above compatibility, and promptly drug combination reaches ideal combined therapy effect.

The invention has the beneficial effects as follows: completely different with chemical medicine treatment mechanism and effect, chemical medicine can only specific aim be treated the disease of an aspect, if the drug combination amount is excessive, is easy to generate big side effect and drug dependence.Above compatibility not only can effectively be prevented and treated parvovirus, porcine circovirus, the dysentery that viruses such as TGE cause; And, also can prevent and treat escherichia coli, staphylococcus, dysentery bacteriums etc. are bacillary; The dysentery that coccidiosis causes, protection intestinal mucosa or the like combined therapy effect, and, can not produce drug dependence; Particularly in production practices, clinical case is more complicated often, single or mixed infection, and most plants do not possess conditions for diagnostics; The acute enteritis dysentery course of disease is short, can cause animal depleted dead in 1-2 days, adopts compound Chinese medicinal preparation to be used for clinical treatment, especially has realistic meaning.

 

The specific embodiment:Intestinal tract disease is with oral medication, and is auxiliary relatively good with vein and intramuscular injection pesticide supplying effect.Their early stage or dysentery are not serious, adopt in time that above compatibility agent is oral can receive desirable curative effect, if morbidity is serious; After at first controlling the dysentery symptom; Can cooperate the treatment of antibiotics antibiotic medicine, the oral treatment that combines with intravenous injection also can reach satisfied therapeutic effect.On the other hand, the dosage form of medicine, drug concentrations, the technology of pharmaceutical preparation and quality control are very big to the therapeutic effect relationship of medicine.Adopt modern advanced solvent low temperature leach extraction method, extract effective ingredient, adjust drug level as required, produce then to meet and culture clinical needs packing specification product.

Concrete technological process is following:

The oral liquid preparation method:

Raw material screening → compatibility raw material measures → soaks → decoct → filter → precipitate → refilter → sterilizes → fill

The injection preparation method:

Raw material screening → compatibility raw material measures → soaks → decoct → filter → evaporation and concentration → add ethanol → deposition → filtration → recovery ethanol → cold preservation → add benzyl alcohol, tween 80, injection water → mixing filtration → embedding → sterilization

The technological process explanation

The oral liquid preparation method:

At first, raw material must pass through quality testing, and screening is rejected the raw material that does not meet prescription, then; According to prescription and production lot dosage, soaked 1 hour, decoct 40min, filtration, residue decocte with water 2 times again; Merging filtrate, evaporation and concentration in vaporizer to syrupy shape, adds doubly 95% ethanol of 2-3; Stir, deposition is filtered, and reclaims ethanol.Till being filtered to deposit-free for 2-3 time by above-mentioned repetition, the embedding of sterilizing then promptly gets oral liquid.

The injection preparation:

Prepare on the basis at oral liquid, filter the no post precipitation of filtrating, cold preservation adds benzyl alcohol, tween 80, adds injection water and is diluted to 200ml, and mixing filters, embedding, and sterilization promptly gets injection products.

 

Clinical case:

One, morbidity animal: 37-42 age in days ablactational baby pig 3 nests, totally 27.

Two, clinical symptoms: acute watery diarrhea, lethargy, happiness is slept, and major part is searched for food and is sharply descended, and few part has on a small quantity searches for food.

Three, treatment:

Compatibility: the windproof 25g Cortex Magnoliae Officinalis of Rhizoma Coptidis 50g Folium Isatidis 40g Rhizoma Atractylodis Macrocephalae 30g Fructus Chebulae 50g Herba Violae 30g Rhizoma Osmundae 30g Herba Agrimoniae 25g Cortex Magnoliae Officinalis 30g Bulbus Allii 60g 25g

Compatibe drug is processed preserved material, supply oral and intramuscular injection.Every piglet is injected 2 times every day, each 2ml, and head is irritated clothes 3ml, every day 1 time simultaneously.

Four, therapeutic effect: more than oral and injection for curing for three days on end, diarrhoea obviously alleviates, only observe first and second every day, but that the mental status still shows is bad, happiness is slept.Continuous use to 5 day, baby pig diarrhoea stops fully, and piglet searches for food and recovers to some extent, and the 7th day, the performance of the piglet mental status was active, has only a feces rare partially, and mental status is poor, and it is not joyous to search for food.The back observation of 2 weeks has a recurrence, isolates for treatment.

Five, result: fall ill 27, cure 26, wherein recur 1, cure rate is cured 26, cure rate 96.3% 92.59%, 2 time.

Claims (3)

1. a Chinese medicine preparation of treating viral enteritis and dysentery is characterized in that: be made up of the Chinese herbal medicine compatibility: the windproof 25g Cortex Magnoliae Officinalis of Rhizoma Coptidis 50g Folium Isatidis 40g Rhizoma Atractylodis Macrocephalae 30g Fructus Chebulae 50g Herba Violae 30g Rhizoma Osmundae 30g Herba Agrimoniae 25g Cortex Magnoliae Officinalis 30g Bulbus Allii 60g 25g.

2. adopt solvent low temperature leach extraction method, extract effective ingredient, can adjust drug level as required, produce then to meet and culture clinical needs packing specification product.

3. concrete technological process is following:

The oral liquid preparation method:

Raw material screening → compatibility raw material measures → soaks → decoct → filter → precipitate → refilter → sterilizes → fill

The injection preparation method:

Raw material screening → compatibility raw material measures → soaks → decoct → filter → evaporation and concentration → add ethanol → deposition → filtration → recovery ethanol → cold preservation → add benzyl alcohol, tween 80, injection water → mixing filtration → embedding → sterilization.