CN104840591A - Traditional Chinese medicine composition with effect of preventing and treating Newcastle disease - Google Patents
Traditional Chinese medicine composition with effect of preventing and treating Newcastle disease Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition with an effect of preventing and treating the Newcastle disease. The traditional Chinese medicine composition is prepared from the following ingredients in parts by weight: 13 to 18 parts of cordate houttuynia, 5 to 7 parts of coptis chinensis, 1 to 2 parts of centipedes, 13 to 15 parts of common cnidium fruits, 5 to 8 parts of humifuse euphorbia herbs, 2 to 4 parts of platycodon grandiflorum, 1 to 3 parts of asarum, 13 to 15 parts of Chinese pulsatilla roots, 5 to 7 parts of Tuckahoe, 7 to 9 parts of perilla frutescens and 3 to 5 parts of peppers. The traditional Chinese medicine composition with the effect of preventing and treating the Newcastle disease has the advantages that the traditional Chinese medicine development theory is combined, the occurrence and development features of the disease condition of the Newcastle disease are integrally considered, various natural traditional Chinese medicine ingredients are selected, and the traditional Chinese medicine composition is precisely prepared through repeated tests, is natural, non-toxic and harmless and conforms to the development requirements of the modern culture industry.
Description
Technical field:
The invention belongs to field of fodder, be specifically related to a kind of Chinese medicine composition with control newcastle effect.
Background technology:
Newcastle (newcastle disease, ND) is that the one caused by Avian pneumo-encephalitis virus is acute, hot, septic and high degree in contact sexually transmitted disease, it is characterized in that high heat, dyspnea, dysentery and occurs nervous symptoms.Main infringement chicken and turkey, other birdss and people also can be subject to viral infection.Avian pneumo-encephalitis virus is the avian paramyxovirus I type (APMV-1) of paramyxovirus section fowl Rubulavirus (Avulavirus).Virus is present in all histoorgans of disease fowl, body fluid, secretions and excretion, the highest with brain, spleen, lung toxic amount, the longest with the bone marrow toxic time.Resistance is strong under cryogenic, can survive 1 ~ 2 year at 4 DEG C, when-20 DEG C more than energy Survival for 10 Years; Vacuum freeze-drying virus can preserve 30 days at 30 DEG C, can preserve 230 days for 15 DEG C; The stability of different strains to heat has larger difference.Due to virus infraction cardiovascular system, cause blood circulation height barrier and cause that Systemic Inflammatory is hemorrhage, edema.In the later stage of disease, Virus entry central nervous system, often causes apyetous encephalitis to change, causes nervous symptoms.Avian pneumo-encephalitis virus can be passed through digestive tract or respiratory tract, also can invade body through eye conjunctiva, injured skin and cloaca mucosa, and virus is very fast in infestation position breeding in 24h, enters blood subsequently and is diffused into whole body, cause viremia.Now viruses adsorption is on cell, makes red cell agglutination, expands, then haemolysis occurs.Virus also makes heart, vascular system generation grievous injury simultaneously, causes muscular degeneration of heart and heart failure occurs, thus causing blood circulation height barrier.Due to capillary permeability gangrenous inflammation, thus face and examine the serious gastricism of performance and dysentery.Then mainly there is catarrhal inflammation and hemorrhage at respiratory tract, make trachea by the mucus plugging of oozing out, cause height dyspnea.Newcastle is classified as the maximum category-A infectious disease of animal injury by World Organization for Animal Health.In China, oneself is for many years popular, is also one of most important deadly infectious disease of harm China's aviculture, is that the focus that veterinary circle shows great attention to is sick.Newcastle is one of epidemic disease that harm chicken and turkey feeding industry are the most serious.Susceptible chicken group is once import the speed property sent out into addicted to visceroatonia type newcastle, and propagate very fast, involve full group within a couple of days, cause crushing popular, M & M can reach more than 90%.In recent years, newcastle there occurs new change, and oneself is rare for typical newcastle.Account for 10 ~ 30% with sickness rate, clinical symptoms is not obvious, and pathological change is not true to type, mortality rate 15 ~ 45%, and laying hen mainly laying rate declines, and is that the atypical newcastle disease of feature is then of common occurrence with respiratory symptom.
At present in order to prevent the generation of newcastle and the popular existing method adopting vaccination more, but along with the evolution of biotic population, the continuous hypertrophy of new Virus Type, variation strain, superpower Strain occur in succession, the impact of the many factors such as vaccine Fruit variety is improper, immune programme for children is improper, the effect of the good vaccine prevention of original effect is weakened greatly, even changes into atypical newcastle disease.After newcastle morbidity, antibiotics does not have therapeutical effect for Avian pneumo-encephalitis virus; Although application hyper-immune serum, yolk antibody treatment newcastle curative effect are fine, because cost is too high, absorb the infectious disease slowly, easily causing some to propagate through egg, often not by the Therapeutic Method as first-selection.The present invention in order to overcome deficiency of the prior art, for aviculture provides a kind of Chinese medicine composition effectively can treating newcastle.
Summary of the invention:
In order to solve newcastle control Problems existing in prior art, the invention provides a kind of Chinese medicine composition with control newcastle effect, it is in conjunction with Chinese medicine theory of development, generation and the developing characteristics of the newcastle state of an illness are considered, select multiple natural Chinese medicine composition, precisely configure through repetition test and form, natural, nonhazardous, meet the growth requirement of modern farming.
For solving above technical problem, the present invention adopts following technological means:
There is the Chinese medicine composition of control newcastle effect, it is characterized in that, be made up of the raw material of following weight portion: Herba Houttuyniae 13-18 part, Rhizoma Coptidis 5-7 part, Scolopendra 1-2 part, Fructus Cnidii 13-15 part, Herba Euphorbiae Humifusae 5-8 part, Radix Platycodonis 2-4 part, Herba Asari 1-3 part, Radix Pulsatillae 13-15 part, Poria 5-7 part, Folium Perillae 7-9 part, Pericarpium Zanthoxyli 3-5 part.
Preferably, the Chinese medicine composition with control newcastle effect of the present invention, is made up of the raw material of following weight portion: Herba Houttuyniae 13 parts, Rhizoma Coptidis 7 parts, Scolopendra 1 part, Fructus Cnidii 13 parts, Herba Euphorbiae Humifusae 5 parts, Radix Platycodonis 2 parts, Herba Asari 1 part, the Radix Pulsatillae 13 parts, 5 parts, Poria, Folium Perillae 7 parts, 3 parts, Pericarpium Zanthoxyli.
Preferably, the Chinese medicine composition with control newcastle effect of the present invention, is made up of the raw material of following weight portion: Herba Houttuyniae 15 parts, Rhizoma Coptidis 6 parts, Scolopendra 2 parts, Fructus Cnidii 14 parts, Herba Euphorbiae Humifusae 6 parts, Radix Platycodonis 3 parts, Herba Asari 2 parts, the Radix Pulsatillae 14 parts, 6 parts, Poria, Folium Perillae 8 parts, 4 parts, Pericarpium Zanthoxyli.
Preferably, the Chinese medicine composition with control newcastle effect of the present invention, is made up of the raw material of following weight portion: Herba Houttuyniae 18 parts, Rhizoma Coptidis 5 parts, Scolopendra 2 parts, Fructus Cnidii 15 parts, Herba Euphorbiae Humifusae 8 parts, Radix Platycodonis 4 parts, Herba Asari 3 parts, the Radix Pulsatillae 15 parts, 7 parts, Poria, Folium Perillae 9 parts, 5 parts, Pericarpium Zanthoxyli.
The Chinese medicine composition with control newcastle effect of the present invention adopts following methods to obtain:
The first step, takes each raw material according to weight portion;
Second step, adds mixture weight 3-5 pure water doubly by after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boils and extract 20-30 minute, filter, obtain Aqueous extracts;
3rd step, adding mixture weight 2-3 volumetric concentration doubly after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 30-40 DEG C of condition, leaves standstill soak extraction 5-8 hour, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 60-80 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, dried is carried out at 50-60 DEG C, be dried to water content lower than 8%, be ground into 50-70 object powder again, namely obtain the Chinese medicine composition with control newcastle effect of the present invention.
Preferably, the Chinese medicine composition with control newcastle effect of the present invention adopts following methods to obtain:
The first step, takes each raw material according to weight portion;
Second step, by adding the pure water of mixture weight 4 times after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boiling extraction 25 minutes, filtering, obtain Aqueous extracts;
3rd step, the volumetric concentration adding mixture weight 3 times after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 35 DEG C of conditions, leaves standstill soak extraction 7 hours, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 70 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, dried is carried out at 55 DEG C, be dried to water content lower than 8%, be ground into 60 object powder again, namely obtain the Chinese medicine composition with control newcastle effect of the present invention.
The using method with the Chinese medicine composition of control newcastle effect of the present invention is drunk feeding after itself and feed-mixing or being added on during birds drinks water for birds, the addition recommended is that 0.08-0.25g/ (kg body weight * every day) is (namely according to birds body weight, every day uses according to the addition of 0.08-0.25g/kg body weight, and concrete consumption can take the circumstances into consideration to select according to PD situation within the scope of this).
Based on above technical scheme, tool of the present invention has the following advantages and beneficial effect:
First, the present invention is based on the theory of herbal medicine, combine the feature that newcastle occurs and develops, combine the applicant's cultivation experience for many years, in compatibility materials, implement the principle of the monarch of Chinese medicine, complemented each other between each herbal medicine selected, acted on and mutually working in coordination with.Wherein selected Herba Houttuyniae, has heat-clearing and toxic substances removing, effect of inducing diuresis to remove edema; Rhizoma Coptidis, has eliminating fire and detoxication, effect of heat clearing and damp drying; Scolopendra, has detoxicating and resolving stagnation of pathogens, effect of dispeling the wind of calming the frightened; Fructus Cnidii, has effect of warming the kidney to activate YANG, removing dampness and killing parasites; Herba Euphorbiae Humifusae, have invigorate blood circulation, effect of heat-clearing and toxic substances removing; Radix Platycodonis, has lung qi dispersing, eliminates the phlegm, effect of evacuation of pus; Herba Asari, has lung qi dispersing, eliminates the phlegm, effect of expelling wind and cold; The Radix Pulsatillae is the root of the ranunculaceae plant Radix Pulsatillae, has effect that clearing away heat and cooling blood, removing food stagnancy are stagnant; Poria, has effect of mind tranquilizing and the heart calming, strengthening the spleen stomach function regulating, eliminating dampness and diuresis; Folium Perillae, has dispersing wind-cold, an effect that circulation of qi promoting is amusing; Pericarpium Zanthoxyli, has warming spleen and stomach for dispelling cold, helps digestion insecticidal action.Herba Houttuyniae, champac, Scolopendra and Pericarpium Zanthoxyli major embodiment are the development suppressing the state of an illness in the present invention, Fructus Cnidii, Herba Euphorbiae Humifusae, Radix Platycodonis and Folium Perillae mainly concentrate the health status for improving focus, and the cooperation of Herba Asari, the Radix Pulsatillae and Poria has positive meaning for the immunity improving birds.
Secondly, in compatibility process of the present invention, the consumption of each raw material and preparation method are must be observant, it is that applicant is through exploring the optimum proportioning obtained in a large number, the effect adopting other proportionings obviously can not reach pharmaceutical composition of the present invention to reach, particularly have employed different processing modes to each herbal medicine, it can make the drug effect of each herbal medicine obtain maximum performance.
In sum, the Chinese medicine composition that the present invention obtains has good preventive and therapeutic effect for newcastle, and adopt All Pure Nature Chinese medicine to obtain, do not add any antibiotic and chemokine class material, natural, green, healthy, noresidue, meet the development trend of modern farming, there is wide market prospect.
Detailed description of the invention:
Embodiment 1: a kind of Chinese medicine composition with control newcastle effect, is made up of the raw material of following weight portion: Herba Houttuyniae 13 parts, Rhizoma Coptidis 7 parts, Scolopendra 1 part, Fructus Cnidii 13 parts, Herba Euphorbiae Humifusae 5 parts, Radix Platycodonis 2 parts, Herba Asari 1 part, the Radix Pulsatillae 13 parts, 5 parts, Poria, Folium Perillae 7 parts, 3 parts, Pericarpium Zanthoxyli.
The described Chinese medicine composition with control newcastle effect adopts following methods to obtain:
The first step, takes each raw material according to weight portion;
Second step, by adding the pure water of mixture weight 4 times after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boiling extraction 25 minutes, filtering, obtain Aqueous extracts;
3rd step, the volumetric concentration adding mixture weight 3 times after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 35 DEG C of conditions, leaves standstill soak extraction 7 hours, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 70 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, dried is carried out at 55 DEG C, be dried to water content lower than 8%, be ground into 60 object powder again, namely obtain the Chinese medicine composition with control newcastle effect of the present invention.
Embodiment 2: a kind of Chinese medicine composition with control newcastle effect, is made up of the raw material of following weight portion: Herba Houttuyniae 15 parts, Rhizoma Coptidis 6 parts, Scolopendra 2 parts, Fructus Cnidii 14 parts, Herba Euphorbiae Humifusae 6 parts, Radix Platycodonis 3 parts, Herba Asari 2 parts, the Radix Pulsatillae 14 parts, 6 parts, Poria, Folium Perillae 8 parts, 4 parts, Pericarpium Zanthoxyli.
The described Chinese medicine composition with control newcastle effect adopts following methods to obtain:
The first step, takes each raw material according to weight portion;
Second step, by adding the pure water of mixture weight 3 times after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boiling extraction 20 minutes, filtering, obtain Aqueous extracts;
3rd step, the volumetric concentration adding mixture weight 2 times after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 30 DEG C of conditions, leaves standstill soak extraction 5 hours, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 60 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, dried is carried out at 50 DEG C, be dried to water content lower than 8%, be ground into 50 object powder again, namely obtain the Chinese medicine composition with control newcastle effect of the present invention.
Embodiment 3: a kind of Chinese medicine composition with control newcastle effect, is made up of the raw material of following weight portion: Herba Houttuyniae 18 parts, Rhizoma Coptidis 5 parts, Scolopendra 2 parts, Fructus Cnidii 15 parts, Herba Euphorbiae Humifusae 8 parts, Radix Platycodonis 4 parts, Herba Asari 3 parts, the Radix Pulsatillae 15 parts, 7 parts, Poria, Folium Perillae 9 parts, 5 parts, Pericarpium Zanthoxyli.
The described Chinese medicine composition with control newcastle effect adopts following methods to obtain:
The first step, takes each raw material according to weight portion;
Second step, by adding the pure water of mixture weight 5 times after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boiling extraction 30 minutes, filtering, obtain Aqueous extracts;
3rd step, the volumetric concentration adding mixture weight 3 times after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 40 DEG C of conditions, leaves standstill soak extraction 8 hours, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 80 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, dried is carried out at 60 DEG C, be dried to water content lower than 8%, be ground into 70 object powder again, namely obtain the Chinese medicine composition with control newcastle effect of the present invention.
Embodiment 4: safety testing
(1) acute toxicity test in mice: mice of feeding after adopting the preparation of embodiment of the present invention 1-3 and feedstuff to carry out mix (use amount is 2.5g/ (kg body weight * every day)), Continuous Observation 15 days, duration of test has no dead and undue toxicity's reaction, off-test, Dissection test mice, observe liver,kidney,spleen, stomach, the heart, lung and intestinal, be showed no abnormal change.By standard of acute toxicity, this feed additive belongs to nontoxic level.
(2) chronic toxicity test: mice of feeding after adopting the preparation of embodiment of the present invention 1-3 and feedstuff to carry out mix (use amount is 1.0g/kg body weight * every day), feed continuously 98 days, result shows: the mice fur of invention formulation of feeding is smooth, behavioral activity is normal, drinking-water of ingesting is normal, Normal-weight increases, blood parameters and hematology are all fluctuated within normal range, routine urinalysis and bone marrow index all fluctuate within normal range, organize internal organs no abnormality seen, generally speaking have no toxicity reaction.
(3) chicken group feeding trial: choose each 500 of chickling, duckling, the Chinese medicine composition (use amount is 0.5g/ (kg body weight * every day)) with control newcastle effect described in the embodiment of the present invention 1,2 or 3 is added in its feedstuff, feed 200 days according to normal feeding and management method, between this feed period, death is there is not in this chickling, the whole growth course of duckling, also not there is poisoning abnormal symptom of Denging, healthy growth; And after eliminating after its laying period, slaughtering, its internal organs, organize also no abnormality seen.Therefore, it is also safety non-toxic for the birdss such as chicken and duck.
Embodiment 5: feeding experiment
Following two comparative experimental example are set:
Comparative experimental example 1: commercially available newcastle medicine (minced by Radix Scutellariae ground product, Radix Isatidis powder, Folium Isatidis powder minces, Bulbus Allii powder minces, astragalus membranaceus powder minces, powder of Folium Mori minces, Herba Menthae powder minces and Radix Glycyrrhizae powder minces etc. make)
Comparative experimental example 2: a kind of Chinese medicine preparation, is made up of the raw material of following weight portion: Herba Houttuyniae 13 parts, Rhizoma Coptidis 7 parts, Scolopendra 1 part, Fructus Cnidii 13 parts, Herba Asari 1 part, the Radix Pulsatillae 13 parts, 5 parts, Poria, 3 parts, Pericarpium Zanthoxyli.Preparation method is with the embodiment of the present application 1.
1. test objective: what checking the present invention produced has the Chinese medicine composition of control newcastle effect treating newcastle disease, chicken group being resisted to newcastle epidemic situation, suppressing epidemic situation diffusion, improves the effect of chicken group survival rate.
2. test site: the plant that Haishu District newcastle breaks out
3. experimental animal: newcastle epidemic situation develops the chicken group (chicken group mortality rate reaches about 20%-30%) in mid-term
4. test:
Sick chicken stochastic averagina in chicken group is divided into five groups, 1-3 group is test group, adopt the Chinese medicine composition with control newcastle effect of embodiment 1-3 and feedstuff to carry out mix respectively, according to Feed consumption, use according to the consumption of 0.1g medicine/(kg body weight * every day); 4th group is contrast 1, abides by veterinary's doctor's advice and uses; 5th group is matched group 2, uses the Chinese medicine preparation of comparative experimental example 2, carries out mix, according to Feed consumption, use according to the consumption of 0.1g medicine/(kg body weight * every day) with feedstuff.Observe the development of epidemic situation and the mortality rate of record chicken group.Concrete condition is as follows:
Group 1: newcastle epidemic situation was controlled through 5 days, did not occur the phenomenon that chicken is died of illness again afterwards.In process of the test dead 25, mortality rate is 6.25%.After recovering, chicken group in condition, and food ration recovers fast.
Group 2: newcastle epidemic situation was controlled through 4 days, did not occur the phenomenon that chicken is died of illness again afterwards.In process of the test dead 28, mortality rate is 7%.After recovering, chicken group in condition, and food ration recovers fast.
Group 3: newcastle epidemic situation was controlled through 2 days, did not occur the phenomenon that chicken is died of illness again afterwards.In process of the test dead 15, mortality rate is 3.75%.After recovering, chicken group in condition, and food ration recovers fast.
Group 4: newcastle epidemic situation was controlled through 10 days, did not occur the phenomenon that chicken is died of illness again afterwards.In process of the test dead 95, mortality rate is 23.75%.After recovering, chicken group health status is general, and food ration recovers slow.
Group 5: newcastle epidemic situation was controlled through 3 days, did not occur the phenomenon that chicken is died of illness again afterwards.In process of the test dead 88, mortality rate is 22%.After recovering, chicken group health status is general, and food ration recovers slower.
From above result of the test, the Chinese medicine composition with control newcastle effect of embodiment of the present invention 1-3 is adopted to carry out the chicken group fed, its survival rate is apparently higher than marketed drugs and other contrast test group, and after recovering the recovery of chicken group also significantly better than matched group, namely medicine of the present invention achieves effective treatment of newcastle, its survival rate relative comparison group improves about 15%, for raiser has retrieved great economic loss.And chicken group resume speed is fast, is conducive to the speed of growth improving chicken group, improves culture benefit, also have great importance for raiser.More known by what test above, just because of formula composition and the proportion relation of uniqueness of the present invention, make the present invention achieve unforeseeable technique effect.
Embodiment 6: culture experiment
Culture experiment is carried out in extra large daybreak somewhere, use to by the medicament Free distribution of the embodiment of the present invention 1 poultry cooperative society, use 5 months, during this period, this village do not use the raiser of medicament of the present invention all there occurs in 7-9 month scale not wait newcastle, be not chickling yet, mortality rate reaches more than 25%, but the raiser employing this product newcastle does not occur substantially, avoid the economic loss that newcastle brings, obtain the consistent favorable comment of test peasant household.
Raw material of the present invention all can be commercially.Be only specific embodiments of the invention above, but the present invention is not limited thereto, the changes that any person skilled in the art can think of, all should drops within protection scope of the present invention.
Claims (7)
1. there is the Chinese medicine composition of control newcastle effect, it is characterized in that, be made up of the raw material of following weight portion: Herba Houttuyniae 13-18 part, Rhizoma Coptidis 5-7 part, Scolopendra 1-2 part, Fructus Cnidii 13-15 part, Herba Euphorbiae Humifusae 5-8 part, Radix Platycodonis 2-4 part, Herba Asari 1-3 part, Radix Pulsatillae 13-15 part, Poria 5-7 part, Folium Perillae 7-9 part, Pericarpium Zanthoxyli 3-5 part.
2. the Chinese medicine composition with control newcastle effect according to claim 1, is made up of the raw material of following weight portion: Herba Houttuyniae 13 parts, Rhizoma Coptidis 7 parts, Scolopendra 1 part, Fructus Cnidii 13 parts, Herba Euphorbiae Humifusae 5 parts, Radix Platycodonis 2 parts, Herba Asari 1 part, the Radix Pulsatillae 13 parts, 5 parts, Poria, Folium Perillae 7 parts, 3 parts, Pericarpium Zanthoxyli.
3. the Chinese medicine composition with control newcastle effect according to claim 1, is made up of the raw material of following weight portion: Herba Houttuyniae 15 parts, Rhizoma Coptidis 6 parts, Scolopendra 2 parts, Fructus Cnidii 14 parts, Herba Euphorbiae Humifusae 6 parts, Radix Platycodonis 3 parts, Herba Asari 2 parts, the Radix Pulsatillae 14 parts, 6 parts, Poria, Folium Perillae 8 parts, 4 parts, Pericarpium Zanthoxyli.
4. the Chinese medicine composition with control newcastle effect according to claim 1, is made up of the raw material of following weight portion: Herba Houttuyniae 18 parts, Rhizoma Coptidis 5 parts, Scolopendra 2 parts, Fructus Cnidii 15 parts, Herba Euphorbiae Humifusae 8 parts, Radix Platycodonis 4 parts, Herba Asari 3 parts, the Radix Pulsatillae 15 parts, 7 parts, Poria, Folium Perillae 9 parts, 5 parts, Pericarpium Zanthoxyli.
5. the Chinese medicine composition with control newcastle effect according to claim 1, is characterized in that, adopts following methods to obtain:
The first step, takes each raw material according to weight portion;
Second step, adds mixture weight 3-5 pure water doubly by after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boils and extract 20-30 minute, filter, obtain Aqueous extracts;
3rd step, adding mixture weight 2-3 volumetric concentration doubly after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 30-40 DEG C of condition, leaves standstill soak extraction 5-8 hour, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 60-80 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, dried is carried out at 50-60 DEG C, be dried to water content lower than 8%, be ground into 50-70 object powder again, namely obtain the described Chinese medicine composition with control newcastle effect.
6. prepare the method with the Chinese medicine composition of control newcastle effect described in any one of claim 1-4, it is characterized in that, comprise the following steps:
The first step, takes each raw material according to weight portion;
Second step, adds mixture weight 3-5 pure water doubly by after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boils and extract 20-30 minute, filter, obtain Aqueous extracts;
3rd step, adding mixture weight 2-3 volumetric concentration doubly after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 30-40 DEG C of condition, leaves standstill soak extraction 5-8 hour, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 60-80 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, dried is carried out at 50-60 DEG C, be dried to water content lower than 8%, be ground into 50-70 object powder again, namely obtain the described Chinese medicine composition with control newcastle effect.
7. method according to claim 6, is characterized in that, comprises the following steps:
The first step, takes each raw material according to weight portion;
Second step, by adding the pure water of mixture weight 4 times after the Herba Houttuyniae taken, Rhizoma Coptidis, Herba Euphorbiae Humifusae, the Radix Pulsatillae and Pericarpium Zanthoxyli mixing, boiling extraction 25 minutes, filtering, obtain Aqueous extracts;
3rd step, the volumetric concentration adding mixture weight 3 times after the Radix Platycodonis taken, Herba Asari and Folium Perillae being mixed is the alcoholic solution of 95%, under 35 DEG C of conditions, leaves standstill soak extraction 7 hours, filters, obtain alcohol extract;
4th step, will take Scolopendra, and Fructus Cnidii and Poria mixing, be crushed to 70 object powder;
5th step, the alcohol extract that the Aqueous extracts obtained by second step, the 3rd step obtain and the powder mix homogeneously that the 4th step obtains, carry out dried, be dried to water content lower than 8% at 55 DEG C, be ground into 60 object powder again, namely obtain the described Chinese medicine composition with control newcastle effect.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105175240A (en) * | 2015-10-28 | 2015-12-23 | 云南中烟工业有限责任公司 | Method for preparing novel nicotianasesterpene H having antiviral activity with supercritical fluid chromatography |
| CN110292594A (en) * | 2019-07-26 | 2019-10-01 | 烟台海研制药有限公司 | A kind of Chinese medicine composition that treating avian paramyxovirus disease, preparation method and application |
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| CN101342266A (en) * | 2008-08-15 | 2009-01-14 | 东北农业大学 | Anti-newcastle disease virus traditional Chinese medicine oral liquid and preparation method thereof |
| CN101757574A (en) * | 2010-02-08 | 2010-06-30 | 寇忠军 | Oral medication for treating chicken virus disease |
| CN102205036A (en) * | 2011-05-10 | 2011-10-05 | 蒋保珍 | Chinese medicinal composition for treating Newcastle disease and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342266A (en) * | 2008-08-15 | 2009-01-14 | 东北农业大学 | Anti-newcastle disease virus traditional Chinese medicine oral liquid and preparation method thereof |
| CN101757574A (en) * | 2010-02-08 | 2010-06-30 | 寇忠军 | Oral medication for treating chicken virus disease |
| CN102205036A (en) * | 2011-05-10 | 2011-10-05 | 蒋保珍 | Chinese medicinal composition for treating Newcastle disease and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105175240A (en) * | 2015-10-28 | 2015-12-23 | 云南中烟工业有限责任公司 | Method for preparing novel nicotianasesterpene H having antiviral activity with supercritical fluid chromatography |
| CN110292594A (en) * | 2019-07-26 | 2019-10-01 | 烟台海研制药有限公司 | A kind of Chinese medicine composition that treating avian paramyxovirus disease, preparation method and application |
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