CN101342273A - Medicament for preventing and controlling botryomycosis of chicken - Google Patents
Medicament for preventing and controlling botryomycosis of chicken Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine which is used for preventing and treating staphylococcus of chicken. The ingredients of the medicine has the following weight portions: 5 to 20 portions of bark of boxthorn root, 5 to 20 portions of Chinese pulsatilla, 5 to 20 portions of Shikonin, 5 to 20 portions of cineole, 5 to 20 portions of corktree, 5 to 20 portions of Jin Qiao Mai (Fagopyrum cymosum (Trey.) Meisn.) , 3 to 12 portions of radix scutellariae, 3 to 12 portions of gentiana scabra bge, 3 to 12 portions of Chinese violet, 3 to 12 portions of diluteyellow crotalaria herb, 3 to 12 portions of madder, 2 to 6 portions of fructus schizandrae, 2 to 6 portions of bark of pomegranate, 2 to 6 portions of Asiatic plantain seed, 2 to 6 portions of alum, 2 to 6 portions of coked rhubarb, and 2 to 6 portions of licorice. The herbs are insolated, weighed, crushed, filtered by a sieve with 60 to 80 meshes, and mixed well, so as to prepare the medicine. When in clinical use, the medicine is dipped for 30 to 60 minutes in boiling water, so that the effective ingredients can be fully dissolved and separated to facilitate the absorption in the body of the sick chicken. Simultaneously, a small amount of sugar and Vc are added to improve the medicinal effects. The medicine has high cure rate, no adverse reaction, no drug-resistance, and no potential of drug residues in the body. The production of the medicine has the advantages of easily accessible raw materials, simple preparation, convenient use, and capability of wide promotion and application in the chicken breeding industry.
Description
Technical field:
The invention belongs to medicine and engineering in medicine technical field, particularly a kind of medicine of preventing and treating chicken staphylococcosis that relates to.
Background technology:
Chicken staphylococcosis is a kind of acute or chronic deteriorated blood sexually transmitted disease of chicken, and Clinical symptoms is the acute sepsis symptom, arthritis, omphalitis, cutaneous necrosis and synovitis, and the case fatality rate of chickling and growing chickens is higher.The pathogen of primary disease is a staphylococcus aureus, claims the suppuration staphylococcus again.This bacterium is very wide in distributed in nature, and is ubiquitous, can produce multiple toxin and enzyme, and any season and kind all primary disease can take place, and rainy wet season is many slightly.Primary disease all has generation in countries in the world, and China is the fast development along with poultry husbandry in nearly 20 years, and feeding manner is then raised in cages by raising scattered to change into, and primary disease happens occasionally in some chicken farms, causes heavy economic losses often for the family of raising chickens.Wound is the main route of transmission of primary disease, but also can and peck wound, the net thorn through contact and air borne, stab, sprain, thorn is planted, disconnected beak, band wing number and fowlpox takes place caused advantage all for the traumatic infection of primary disease, generally raise in cages to put down and support the sickness rate height, be called " disease of raising in cages " outside the native land, some other factor such as chicken group are excessive, crowded, improper ventilation, the air dirt, feedstuff is single, be deficient in vitamin and mineral, illumination is strong excessively, and not disconnected beak and some eqpidemic disease exist, and all can promote the generation of primary disease and increase case fatality rate.The disclosed drug main that is used to prevent and treat chicken staphylococcosis will comprise vaccine, Western medicine and Chinese medicine three major types in the prior art, though the three all has certain prevention effect, also has such or such technical problem.As use staphylococcus inactivated vaccine immunity inoculation, certain preventive effect is arranged, but, fail so far in production practices, to apply because of its immune protective rate is not high; Medicines such as commercially available Western medicine such as gentamycin, kanamycin, chloromycetin, oxytetracycline, streptomycin and sulfonamides all have good prevention effect to the control primary disease when beginning to use, but these medicines differ to establish a capital and are applicable to all chicken houses at present, general in recent years, the lasting antibiotic of using of cause, cause some chicken house to have the staphylococcus Resistant strain to form, these antibacterials of reuse are removed control, curative effect extreme difference even do not have prevention effect.In addition, the residual property of the medicine of Western medicine constitutes a threat to the safety of food such as egg, meat, and some Western medicine such as chloromycetin are by national Ministry of Agriculture explicit order forbidding; Other commercially available herbal medicine such as QIUJUNKE, though killing, coccus waits the drawback of not having above-mentioned Western medicine, but on prescription formation and methods for using them, also there is some technological deficiency, not rigorous curative effect is not good enough because of filling a prescription, on application process, often the direct spice of drug powder is fed, delayed the absorption rate of sick chicken, prevented that effect is also unsatisfactory the medicine active ingredient.Therefore, on the basis of existing technology, necessary to preventing that chicken staphylococcosis from carrying out technological innovation.
Summary of the invention:
Purpose of the present invention to provide exactly a kind of determined curative effect, cure rate higher, have no side effect, drug residue free, chicken be difficult for developing immunity to drugs the pure Chinese herbal medicine of the control chicken staphylococcosis of being convenient to use after taking.
For realizing purpose of the present invention, the inventor has carried out experimentation and checking repeatedly for many years, paid hard work, filter out a plurality of Chinese herbal medicine formulas, finally determined prescription of the present invention through optimal design, its composition is expressed as with mass fraction: Cortex Lycii 5-20 part, Radix Pulsatillae 5-20 part, Radix Arnebiae (Radix Lithospermi) 5-20 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 5-20 part, Cortex Phellodendri 5-20 part, Rhizoma Fagopyri Dibotryis 5-20 part, Radix Scutellariae 3-12 part, Radix Gentianae 3-12 part, Herba Violae 3-12 part, Herba crotalariae albidae 3-12 part, Radix Rubiae 3-12 part, Fructus Schisandrae Chinensis 2-6 part, Pericarpium Granati 2-6 part, Semen Plantaginis 2-6 part, Alumen 2-6 part, Radix et Rhizoma Rhei (parched to brown) 2-6 part, Radix Glycyrrhizae 2-6 part.The 60-80 mesh sieve is dried, weighs, was crushed to said herbal medicine, puddle evenly get final product finished product of the present invention.
Usage and dosage of the present invention is as follows:
A. method: claim medicated powder of the present invention to pour in Porcelain Jar or the porcelain urn according to chicken group quantity, the state of an illness, consumption and (avoid with canisters such as ferrum, aluminum, to avoid reaction, affect the treatment), the 5-10 times of boiling water that adds the medicated powder amount again, cover mouth rapidly, soaked stewing 30-60 minute, can make the active ingredient of medicine fully dissolve and separate out like this, when treating that fluid temperature is reduced to 20-25 ℃, press the white sugar of boiling water amount or amount of liquid medicine adding 10% or the former powder of Vc of glucose and 0.02% again, purpose is in time to replenish sick chicken energy i (in vivo), increases certain detoxicating adhesive again.The medicinal liquid that so prepares once threw clothes, logotype 3-5 days for the chicken group before the dusk.
B. consumption: therapeutic dose 1-2g/ only day, preventive dose 0.5-1g/ only day, logotype 3-5 days.
Prescription is resolved:
The present invention is the traditional traditional Chinese veterinary medicine theory according to motherland, in conjunction with the feature of chicken staphylococcosis through dialectical and design.Chinese veterinarian thinks: primary disease is many to descend chicken body premunition because of stresses such as hen house humidity, sultry, wounds, and failure of defensive QI to protect the body against pathogen is felt the epidemic disease poison again, and its damp, pyretic toxicity, epidemic disease are tied invasion and attack chicken body mutually and fallen ill.The evil dispelling the stagnated QI of poison divides and is fade-in nutrient blood, excessive noxious heat, invade and harass the internal organs organ, be whole body deteriorated blood process, so General Symptoms appears in sick chicken, fervescence, spirit is depressed, and appetite reduces or is useless exhausted, and two wings are sagging, slow-witted upright or squat, the feather pine is random, two semi-closures, the dysentery that has, discharge canescence or green loose stool, comparatively the pathological changes of feature is a breast subcutaneous abdomen edema, is purplish red or atropurpureus, and the skin table has differ in size hemorrhage, arthritis type, omphalitis type (being commonly called as " big tripe chicken ") are arranged in addition, ocular form and pulmonary type case etc.Therefore, should establish heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, promoting blood circulation to remove blood stasis are the rule of treatment.To form main force's square formations be monarch drug so establish the 6 flavor medicine combinations among the strong ones of Cortex Lycii, the Radix Pulsatillae, Radix Arnebiae (Radix Lithospermi), Folium eucalypti globueli (Eucalyptus globulus Labill.), Cortex Phellodendri, Rhizoma Fagopyri Dibotryis in the prescription, to guarantee heat-clearing and toxic substances removing of the present invention, to press down the effect of killing staphylococcus; Catching and can solve under the prerequisite of this principal contradiction, alternative Radix Scutellariae, Radix Gentianae, Herba Violae, Herba crotalariae albidae, Radix Rubiae are ministerial drug, are intended to the merit of the clear wet heat extraction of performance, eliminating pathogen in the liver detumescence, cooling blood for hemostasis, assist monarch drug, strengthen the efficacy of a drug; Transfer Fructus Schisandrae Chinensis again, Pericarpium Granati, Semen Plantaginis, Alumen is an adjuvant drug, brings into play its relieving diarrhea with astringents, the length of diuretic antiinflammatory helps the monarch and his subjects' a helping hand altogether; Sending Radix et Rhizoma Rhei (parched to brown), Radix Glycyrrhizae again is messenger drug, brings into play its coordinating the actions of various ingredients in a prescription, and the characteristic that cathartic heals is put down the virus killing heresy with the monarch and his subjects' adjuvant drug, to strengthen drug effect.
Take a broad view of full side, the present invention fills a prescription rigorous, and Each performs its own functions for monarch, and coordination linkage is played the medicine merit altogether.In addition, when clinical practice, increase by two foreign aid's medicines of saccharide and Vc again, can fast supply support, can disperse virulence again, more strengthened the centralizing function of getting rid of evils of the present invention.Therefore, the present invention has higher clinical cure rate than other related drugs.
The specific embodiment:
Following examples are in order to explanation the present invention.
Embodiment 1:
Supply the examination time: in July, 1998.
For trying the place: the beautiful post of peak-to-peak mining area, Hebei province bavin chicken farm.
For examination chicken group: 52 ages in days, 2200 commodity Dai Babu cock-B300 laying hens, because of having a humid climate, it is former thereby break out the chicken staphylococcosis disease that disconnected beak is improper etc., with the group with giving up.
Supply the reagent thing: pure Chinese medicinal preparation promptly of the present invention, each crude drug of distinguishing the flavor of is all available from oriental drug city, Anguo City, Hebei province, and its composition is expressed as by mass fraction: 5 parts of Cortex Lycii, 5 parts of the Radix Pulsatillaes, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 5 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Fagopyri Dibotryiss, 3 parts of Radix Scutellariaes, 3 parts of Radix Gentianaes, 3 parts of Herba Violaes, 3 parts of Herba crotalariae albidaes, 3 parts in Radix Rubiae, 2 parts of Fructus Schisandrae Chinensis, 2 parts of Pericarpium Granatis, 2 parts of Semen Plantaginiss, 2 parts of Alumens, 2 parts of Radix et Rhizoma Rhei (parched to brown), 2 parts in Radix Glycyrrhizae.The 60-80 mesh sieve is dried, weighs, was crushed to said herbal medicine, stand-by after stirring.
Test group: 1100, use Drug therapy of the present invention.
Matched group: 1100, with commercially available chloromycetin of western medicine treatment.
The test group step is as follows:
1. claim medicine: every chicken medication 1g, nominal is got 1100g medicine of the present invention and is poured in the Porcelain Jar.
2. soak: in cylinder, add boiling water 5.5Kg, add a cover and soak stewing 30 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 550g white sugar and the former powder of 1.1gVc, stir.
4. throw clothes: before the feeding, give this medicinal liquid of the disposable input of chicken group between the lights, appoint the free drink-service of chicken group.
5. course of treatment: continuous use 5 days.
Matched group: take by weighing chloromycetin 5.5g and pour in the 5.5Kg drinking-water, concentration is 0.1%, and clothes are thrown in the back that stirs, the method and the course of treatment same test group.
Result of the test is listed in the table below: unit: only, %
The result shows: test group exceeds 7.54 percentage points than the cure rate of matched group.
Embodiment 2:
Supply the examination time: in JIUYUE, 2000.
For trying the place: the Yan of Gaocheng City, Hebei province the last two chicken farm.
For examination chicken group: 43 ages in days, 3600 brown commodity of Yi Sha are for laying hen, and are excessive because of the chicken group, air is dirty, thorn kind of a fowlpox is broken out chicken staphylococcosis, with the group with house.
Supply the reagent thing: i.e. the present invention, the purchasing of raw materials is with embodiment 1, and its composition is expressed as by mass fraction: 10 parts of Cortex Lycii, 10 parts of the Radix Pulsatillaes, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 10 parts of Cortex Phellodendris, 10 parts of Rhizoma Fagopyri Dibotryiss, 6 parts of Radix Scutellariaes, 6 parts of Radix Gentianaes, 6 parts of Herba Violaes, 6 parts of Herba crotalariae albidaes, 6 parts in Radix Rubiae, 4 parts of Fructus Schisandrae Chinensis, 4 parts of Pericarpium Granatis, 4 parts of Semen Plantaginiss, 4 parts of Alumens, 4 parts of Radix et Rhizoma Rhei (parched to brown), 4 parts in Radix Glycyrrhizae.Processing method is identical with embodiment 1.
Test group: 1800, use Drug therapy of the present invention.
Matched group: 1800, with commercially available Western medicine sulfadiazine sodium treatment.
The test group step is as follows:
1. claim medicine: every chicken medication 1.5g, nominal is got 2700g medicine of the present invention and is poured in the Porcelain Jar.
2. soak: in cylinder, add boiling water 21.6Kg, add a cover and soak stewing 40 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 2.16Kg soft plantation white sugar and the former powder of 4.32gVc, stir.
4. throw clothes: before the feeding, give this medicinal liquid of the disposable input of chicken group between the lights, appoint the free drink-service of chicken.
5. course of treatment: continuous use 4 days.
Matched group: take by weighing the 10.8g sulfadiazine sodium, add in the 21.6Kg drinking-water, concentration is 0.05%, stir evenly the back and throw clothes, the method and the course of treatment same test group.
Result of the test is listed in the table below: unit: only, %
The result shows: test group exceeds 10.88 percentage points than the cure rate of matched group.
Embodiment 3:
Supply the examination time: in August, 2004.
For the examination place: the two English chicken farms of reviving the Raoyang County, Hebei province.
For trying the chicken group: 62 ages in days, 2000 blue grey commodity in sea are for laying hen.Because of weather is sultry, moist rainy, reasons such as commentaries on classics group are broken out the chicken staphylococcosis disease, with group's house together.
Supply the reagent thing: i.e. the present invention, the purchasing of raw materials is with embodiment 1, and its composition is expressed as by mass fraction: 20 parts of Cortex Lycii, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 20 parts of Cortex Phellodendris, 20 parts of Rhizoma Fagopyri Dibotryiss, 12 parts of Radix Scutellariaes, 12 parts of Radix Gentianaes, 12 parts of Herba Violaes, 12 parts of Herba crotalariae albidaes, 12 parts in Radix Rubiae, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Pericarpium Granatis, 6 parts of Semen Plantaginiss, 6 parts of Alumens, 6 parts of Radix et Rhizoma Rhei (parched to brown), 6 parts in Radix Glycyrrhizae.Processing method is with embodiment 1.
Test group: 1000, use Drug therapy of the present invention.
Matched group: 1000, with commercially available herbal medicine QIUJUNKE treatment.
The test group step is as follows:
1. claim medicine: every chicken medication 2g, nominal is got 2000g medicine of the present invention and is poured in the Porcelain Jar.
2. soak: in cylinder, add boiling water 20Kg, add a cover and soak stewing 60 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 2Kg soft plantation white sugar and the former powder of 4gVc, stir.
4. throw clothes: method is with embodiment 1.
5. course of treatment: continuous use 3 days.
Matched group: take by weighing QIUJUNKE 2000g, every same test group of chicken consumption, directly the disposable throwing clothes of spice are appointed the chicken free choice feeding, continuous use 3 days.
Result of the test is listed in the table below: unit: only, %
The result shows: test group exceeds 6.5 percentage points than the cure rate of matched group.
Claims (4)
1. medicine of preventing and treating chicken staphylococcosis is characterized in that its composition is expressed as with mass fraction:
Cortex Lycii 5-20 part, Radix Pulsatillae 5-20 part, Radix Arnebiae (Radix Lithospermi) 5-20 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 5-20 part, Cortex Phellodendri 5-20 part, Rhizoma Fagopyri Dibotryis 5-20 part, Radix Scutellariae 3-12 part, Radix Gentianae 3-12 part, Herba Violae 3-12 part, Herba crotalariae albidae 3-12 part, Radix Rubiae 3-12 part, Fructus Schisandrae Chinensis 2-6 part, Pericarpium Granati 2-6 part, Semen Plantaginis 2-6 part, Alumen 2-6 part, Radix et Rhizoma Rhei (parched to brown) 2-6 part, Radix Glycyrrhizae 2-6 part.
2. press the medicine of claim 1 described control chicken staphylococcosis, it is characterized in that its composition is expressed as with mass fraction:
5 parts of Cortex Lycii, 5 parts of the Radix Pulsatillaes, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 5 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Fagopyri Dibotryiss, 3 parts of Radix Scutellariaes, 3 parts of Radix Gentianaes, 3 parts of Herba Violaes, 3 parts of Herba crotalariae albidaes, 3 parts in Radix Rubiae, 2 parts of Fructus Schisandrae Chinensis, 2 parts of Pericarpium Granatis, 2 parts of Semen Plantaginiss, 2 parts of Alumens, 2 parts of Radix et Rhizoma Rhei (parched to brown), 2 parts in Radix Glycyrrhizae.
3. press the medicine of claim 1 described control chicken staphylococcosis, it is characterized in that its composition is expressed as with mass fraction:
10 parts of Cortex Lycii, 10 parts of the Radix Pulsatillaes, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 10 parts of Cortex Phellodendris, 10 parts of Rhizoma Fagopyri Dibotryiss, 6 parts of Radix Scutellariaes, 6 parts of Radix Gentianaes, 6 parts of Herba Violaes, 6 parts of Herba crotalariae albidaes, 6 parts in Radix Rubiae, 4 parts of Fructus Schisandrae Chinensis, 4 parts of Pericarpium Granatis, 4 parts of Semen Plantaginiss, 4 parts of Alumens, 4 parts of Radix et Rhizoma Rhei (parched to brown), 4 parts in Radix Glycyrrhizae.
4. press the medicine of claim 1 described control chicken staphylococcosis, it is characterized in that its composition is expressed as with mass fraction:
20 parts of Cortex Lycii, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 20 parts of Cortex Phellodendris, 20 parts of Rhizoma Fagopyri Dibotryiss, 12 parts of Radix Scutellariaes, 12 parts of Radix Gentianaes, 12 parts of Herba Violaes, 12 parts of Herba crotalariae albidaes, 12 parts in Radix Rubiae, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Pericarpium Granatis, 6 parts of Semen Plantaginiss, 6 parts of Alumens, 6 parts of Radix et Rhizoma Rhei (parched to brown), 6 parts in Radix Glycyrrhizae.
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| CN2008100792607A CN101342273B (en) | 2008-08-25 | 2008-08-25 | Medicament for preventing and controlling botryomycosis of chicken |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100792607A CN101342273B (en) | 2008-08-25 | 2008-08-25 | Medicament for preventing and controlling botryomycosis of chicken |
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| CN101342273B CN101342273B (en) | 2012-05-30 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547572A (en) * | 2014-12-29 | 2015-04-29 | 河南天纳图生物科技有限公司 | Compound fermented traditional Chinese medicine for preventing and treating staphylococcosis in chickens and preparation method of compound fermented traditional Chinese medicine |
| CN106563053A (en) * | 2015-10-13 | 2017-04-19 | 黄旺 | Drug for treating chicken staphylococcosis |
| CN107007771A (en) * | 2017-05-04 | 2017-08-04 | 河北工程大学 | A kind of medicine for preventing and treating rabbit staphylococosis |
| CN107184785A (en) * | 2017-05-04 | 2017-09-22 | 河北工程大学 | A kind of medicine for preventing and treating rabbit E.coli disease |
| CN107198744A (en) * | 2017-05-04 | 2017-09-26 | 河北工程大学 | A kind of medicine for preventing and treating rabbit hemorrhage |
| CN107927425A (en) * | 2017-12-14 | 2018-04-20 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing the infection of chick Staphylococcus gallinarum and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
-
2008
- 2008-08-25 CN CN2008100792607A patent/CN101342273B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547572A (en) * | 2014-12-29 | 2015-04-29 | 河南天纳图生物科技有限公司 | Compound fermented traditional Chinese medicine for preventing and treating staphylococcosis in chickens and preparation method of compound fermented traditional Chinese medicine |
| CN106563053A (en) * | 2015-10-13 | 2017-04-19 | 黄旺 | Drug for treating chicken staphylococcosis |
| CN107007771A (en) * | 2017-05-04 | 2017-08-04 | 河北工程大学 | A kind of medicine for preventing and treating rabbit staphylococosis |
| CN107184785A (en) * | 2017-05-04 | 2017-09-22 | 河北工程大学 | A kind of medicine for preventing and treating rabbit E.coli disease |
| CN107198744A (en) * | 2017-05-04 | 2017-09-26 | 河北工程大学 | A kind of medicine for preventing and treating rabbit hemorrhage |
| CN107927425A (en) * | 2017-12-14 | 2018-04-20 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing the infection of chick Staphylococcus gallinarum and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101342273B (en) | 2012-05-30 |
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