CN103142824B - Medicine for controlling swine erysipelas - Google Patents
Medicine for controlling swine erysipelas Download PDFInfo
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- CN103142824B CN103142824B CN201310111814.8A CN201310111814A CN103142824B CN 103142824 B CN103142824 B CN 103142824B CN 201310111814 A CN201310111814 A CN 201310111814A CN 103142824 B CN103142824 B CN 103142824B
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Abstract
The invention provides a medicine for controlling swine erysipelas, belonging to the technical field of pharmaceutical and medical engineering. The medicine comprises the following components in parts by weight: 5-15 parts of honeysuckle, 5-15 parts of dyers woad leaf, 5-15 parts of Tokyo violet herb, 5-15 parts of radix arnebiae, 4-12 parts of cyrtomium rhizome, 4-12 parts of gypsum rubrum, 4-12 parts of tree peony root bark, 4-12 parts of common anemarrhena rhizome, 3-10 parts of figwort root, 3-10 parts of spikemoss, 3-10 parts of red peony root, 3-10 parts of platycodon root, 2-6 parts of rhubarb, 2-6 parts of cape jasmine fruit and 2-6 parts of liquorice. The medicine is prepared by drying the above Chinese herbal medicines in the sun, weighing the dried medicines, grinding the weighed medicines, sieving the powder with a 60-80-mesh sieve and mixing the powder uniformly. During clinical application, the medicine is soaked in boiling water for 30-60 minutes so that the active ingredients of the medicine are fully dissolved and precipitated to be beneficial to internal absorption of sick swine, and at the same time, the medicine efficacy can be improved by adding a few sugars and Vc. The medicine has higher clinical cure rate, does not have adverse reactions, does not generate medicine resistance easily, avoids medicine residues in pork, has easily obtained needed raw materials, is simple to prepare and convenient to use and can be widely applied in the swine industry.
Description
Technical field:
The invention belongs to medicine and engineering in medicine technical field, particularly a kind of medicine of preventing and treating swine erysipelas that relates to.
Background technology:
Since reform and opening-up, the pig industry of China is developed rapidly.The scale of raising pigs constantly expands, and breeding way, to batch production, intensive future development, has met the market demand of people to Carnis Sus domestica substantially.Yet swine diseases remains the key factor of harm and the sound development of restriction pig industry.Particularly the harm of some infectious disease more very, as pig erysipelas etc.This disease is that a kind of urgency being caused by bacillus rhusiopathiae suis is hot, infectious diseases common to human beings and animals.Its feature main manifestations is acute sepsis and sub-hot rash piece type, shows as individually chronic polyarthritis and endocarditis.This disease is widely current in all over the world, and also there is generation in the many areas of China, thereby bring huge economic loss to pig industry.Primary disease all can occur throughout the year, but at burning hot and rainy seasonal prevalence, especially with feeder pig susceptible the most.Its clinical symptoms can be divided into three kinds of acute, acute and chronic types.Acute is clinical more rare, performance sudden onset, sudden death, mortality rate is often 100%, acute presents septicemia more to be changed, clinical common with this kind of, and performance body temperature rises to suddenly 43 ℃, eat less or go on a hunger strike, stare blankly, instability of gait, happiness lying mat grass, two are rubescent, upper eyelid swelling, urinate red constipation, vomiting sometimes.Subsequently the basal part of the ear, neck side, breast abdomen, strand in etc. skin thin location, there is kermesinus rash piece (being commonly called as diamond-skin disease) irregular, not of uniform size, finger presses rash speckle disappears, hands restores from rash color, and chronic type main manifestations is extremities joint swelling, be off one's feed, walks lamely, cough, mao unrest, day by day become thin etc.In prior art, the medicine of disclosed control pig erysipelas mainly contains vaccine, Western medicine and herbal medicine three major types, although three all has prevention effect in various degree, also has such or such technical problem.As though domestic swine erysipelas vaccine has good prevention curative effect, but find in practice, some person of raising pigs is at immune programme for children, inoculation time, there are problems and cause the undesirable even immuning failure of immune effect in the aspects such as dosage of inoculation, What is more does not do immunity and cause primary disease to occur; Western medicine all has good prevention effect as antibiotics (penicillin, streptomycin, tetracycline, oxytetracycline etc.), sulfa drugs etc., yet, along with prolonged application for many years, even abuse abuse, its curative effect reduced year by year, consumption increases year by year, and the continuous formation of endurance strain has been undisputable fact, and there is the residual hidden danger of potential medicine, charcuterie is constituted a threat to safely; Though other commercially available herbal medicine is as the drawback without above-mentioned Western medicine such as erysipelas health, erysipelas spirit, but form on and methods for using them and also have some technological deficiency at formula, because filling a prescription, not rigorous curative effect is not good enough, on application process, often the direct spice of drug powder is fed, delayed the absorption rate of sick pig to effective ingredient, prevention effect is also unsatisfactory.Therefore, the necessary medicine to control swine erysipelas carries out technological innovation.
Goal of the invention:
Object of the present invention be just to provide a kind of determined curative effect, cure rate higher, have no side effect, drug residue free, the pure Chinese herbal medicine that is difficult for producing drug resistance and is convenient to the control swine erysipelas of application.
Summary of the invention:
For realizing object of the present invention, inventor has carried out experimental study for many years and checking repeatedly, paid a large amount of hardships work, constantly explore and filter out a plurality of Chinese herbal medicine formulas, through optimal design, put into practice with repeating, finally established formula of the present invention, its composition is expressed as with mass fraction: Flos Lonicerae 5-15 part, Folium Isatidis 5-15 part, Herba Violae 5-15 part, Radix Arnebiae (Radix Lithospermi) 5-15 part, Rhizoma Osmundae 4-12 part, Mirabilitum crystallina 4-12 part, Cortex Moutan 4-12 part, Rhizoma Anemarrhenae 4-12 part, Radix Scrophulariae 3-10 part, Herba Selaginellae 3-10 part, Radix Paeoniae Rubra 3-10 part, Radix Platycodonis 3-10 part, Radix Et Rhizoma Rhei 2-6 part, Fructus Gardeniae 2-6 part, Radix Glycyrrhizae 2-6 part.60-80 mesh sieve is dried, weighs, was crushed to said herbal medicine, puddle and evenly get final product to obtain finished product of the present invention.
The usage and dosage of medicine of the present invention is as follows:
A, usage: according to swinery quantity, the state of an illness, consumption, claim medicine of the present invention to pour in Porcelain Jar and (avoid with canisters such as ferrum, aluminum, to avoid reaction, affect the treatment), the 5-10 times of boiling water that adds again medicated powder amount, cover rapidly mouth, soak stewing 30-60 minute, can make like this effective ingredient of medicine dissolve and separate out, when medicine temperature is down to 20-25 ℃, by boiling water amount or amount of liquid medicine, add 10% white sugar or the former powder of Vc of glucose and 200ppm again, object is to supplement in time sick pig energy i (in vivo), and has certain detoxicating adhesive.The medicinal liquid so preparing was once thrown clothes before the dusk to swinery, being used in conjunction 3-5 days is a course for the treatment of.
B, consumption: therapeutic dose 50-100g/ head. day, preventive dose 25-50g/ head. day, serve on 3-5 days.
Prescription is resolved:
The present invention is theoretical according to motherland tradition traditional Chinese veterinary medicine, in conjunction with the feature of swine erysipelas through dialectical and design.Chinese veterinarian thinks: cause that this sick pathogenic microorganism is erysipelothrix ruhsiopathiae, be commonly called as bacillus rhusiopathiae suis, this pathogenic bacteria extensively distributes at nature, belongs to gram positive bacteria, has 24 serotypes, and the health pig that carries disease germs accounts for 24.3-70.5%.Once improper because of feeding and management, climate change is variable, pig house is moist, particularly, in burning hot and rainy season, pig is experienced epidemic disease heresy (pathogenic bacteria), and self resists physically-draining, cause failure of defensive QI to protect the body against pathogen, the natural physiologic barrier of first is damaged, and epidemic disease heresy is taken advantage of in void enters, reach nutrient blood, rapid hypertrophy, pathogen is gradually prosperous, the absurd row of forcing blood, therefore sick just visible macule is indistinct, evil poison enters lung, can cause cough with asthma, evil poison enters constipation or have loose bowels of the intestines and stomach, thereupon causing whole body clinical symptom, falls ill.Facts have proved, with the easy infection of the feeder pig of about 25-50kg, morbidity is swift and violent, infects fast the existing acute sepsis of multilist especially.This disease belongs to the epidemic febrile disease category on traditional Chinese veterinary medicine.Therefore, to primary disease should establish heat-clearing and toxic substances removing, removing heat from blood rash is the rule for the treatment of.Therefore first establish the 4 taste famous medicine power-power cooperations of Flos Lonicerae, Folium Isatidis, Herba Violae, Radix Arnebiae (Radix Lithospermi) in this formula, to form main force's square formations be monarch drug, to guarantee the effect of clearing away heat and cooling blood of the present invention, removing toxic substances rash; Next selects Rhizoma Osmundae, Mirabilitum crystallina, Cortex Moutan, the Rhizoma Anemarrhenae is ministerial drug, strengthens the effect of clearing away heat-fire, cool the blood dissipate blood stasis, antibacterial anti-inflammatory, assists monarch drug with the strengthening efficacy of a drug; Adjusting Radix Scrophulariae, Herba Selaginellae, Radix Paeoniae Rubra, Radix Platycodonis is adjuvant drug again, is intended to nourishing YIN to lower pathogenic fire, hemostasis removing heat from blood, rash detumescence, helps altogether the monarch and his subjects' a helping hand; Send again Radix Et Rhizoma Rhei, Fructus Gardeniae, Radix Glycyrrhizae for making medicine, be intended to coordinating the actions of various ingredients in a prescription, invigorating the spleen and replenishing QI, puts down pathogenic toxin killing and residual hazard is driven in external through digestive tract and urinary tract, can be without the suffering of " close door and stay bandit ".
Take a broad view of full side, the present invention fills a prescription rigorous, monarch, minister, helps, makes that Each performs its own functions, and coordination linkage, plays medicine merit altogether.In addition, when clinical practice, increased again saccharide and Vc two taste foreign aid medicines, can fast supply support, disperse virulence, more strengthened the centralizing function of getting rid of evils of the present invention, therefore, medicine of the present invention is compared other related drugs and is had higher clinical cure rate.
The specific embodiment: following examples are in order to illustrate the present invention.
Embodiment 1:
Supply the examination time: in August, 2010.
For trying place: San Cheng pig farm, Shen, Chengan County, Hebei province.
For trying swinery: 80-105 age in days, body weight 25-50kg, 116 Yorkshire commercial generation pigs, do not break out swine erysipelas because doing the reasons such as immunity, hot climate, pig house humidity, with the same group of house.
Supply reagent thing: pure Chinese herbal and crude drugs preparations of the present invention, each taste crude drug is all purchased from oriental drug city, Anguo City, Hebei province, and its composition is expressed as by mass fraction: 5 parts of Flos Loniceraes, 5 parts of Folium Isatidiss, 5 parts of Herba Violaes, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 4 parts of Rhizoma Osmundae, 4 parts of Mirabilitum crystallinas, 4 parts of Cortex Moutans, 4 parts of the Rhizoma Anemarrhenaes, 3 parts of Radix Scrophulariaes, 3 parts of Herba Selaginellaes, 3 parts of Radix Paeoniae Rubra, 3 parts of Radix Platycodoniss, 2 parts of Radix Et Rhizoma Rhei, 2 parts of Fructus Gardeniaes, 2 parts, Radix Glycyrrhizae.60 mesh sieves are dried, weigh, were crushed to said herbal medicine, stir and get final product to obtain finished product of the present invention.
Test group: 58, use Drug therapy of the present invention.
Matched group: 58, with the treatment of Western medicine sulfa drugs.
Test group step is as follows:
1. claim medicine: 50 grams of every pig medications, nominal is got 2900 grams of medicines of the present invention and poured in Porcelain Jar.
2. soak: in cylinder, add boiling water 14.5kg, add a cover and soak stewing 30 minutes.
3. dosing: when medicine juice temperature is down to 20-25 ℃, add the former powder of 1.45kg white sugar and 2.9gVc, stir.
4. throw clothes: between the lights, give this medicinal liquid of the disposable input of swinery (containing medicinal residues), appoint the free drink-service of pig, search for food.
5. course for the treatment of: continuous use 3 days.
Matched group: with 20% soluble sulphathiazole liquid intramuscular injection 10-20ml, doubled amount, every injection in 5-6 hour once, connects note 3 days first
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 12.07 percentage points than the cure rate of matched group.
Embodiment 2:
Supply the examination time: in July, 2011.
For trying place: Li Zhiguo pig farm, Wei County, Hebei province.
For trying swinery: 73-112 age in days, body weight 23-52kg, 98 long white commercial generation pigs, do not break out swine erysipelas because doing the reasons such as immunity, weather is sultry, pig house is unclean, with the same house of group.
Supply reagent thing: i.e. the present invention, the purchasing of raw materials is with embodiment 1, and its composition is expressed as by mass fraction: 15 parts of Flos Loniceraes, 15 parts of Folium Isatidiss, 15 parts of Herba Violaes, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Rhizoma Osmundae, 12 parts of Mirabilitum crystallinas, 12 parts of Cortex Moutans, 12 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Scrophulariaes, 10 parts of Herba Selaginellaes, 10 parts of Radix Paeoniae Rubra, 10 parts of Radix Platycodoniss, 6 parts of Radix Et Rhizoma Rhei, 6 parts of Fructus Gardeniaes, 6 parts, Radix Glycyrrhizae.Processing method is with embodiment 1.
Test group: 49, use Drug therapy of the present invention.
Matched group: 49, with commercially available herbal medicine erysipelas health treatment.
Test group step is as follows:
1. claim medicine: 100 grams of every pig medications, nominal is got 4900 grams of medicines of the present invention and poured in Porcelain Jar.
2. soak: in cylinder, add boiling water 49kg, add a cover and soak stewing 60 minutes.
3. dosing: when medicine juice temperature is down to 20-25 ℃, add the former powder of 4.9kg glucose and 9.8gVc, stir.
4. throw clothes: with embodiment 1.
5. course for the treatment of: continuous use 5 days.
Matched group: take erysipelas health 4900g, every same test group of pig consumption, direct spice, disposable throwing clothes before at dusk, continuous use 5 days.
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 8.17 percentage points than the cure rate of matched group.
Claims (3)
1. prevent and treat a medicine for swine erysipelas, it is characterized in that its composition is expressed as with mass fraction:
Flos Lonicerae 5-15 part, Folium Isatidis 5-15 part, Herba Violae 5-15 part, Radix Arnebiae (Radix Lithospermi) 5-15 part, Rhizoma Osmundae 4-12 part, Mirabilitum crystallina 4-12 part, Cortex Moutan 4-12 part, Rhizoma Anemarrhenae 4-12 part, Radix Scrophulariae 3-10 part, Herba Selaginellae 3-10 part, Radix Paeoniae Rubra 3-10 part, Radix Platycodonis 3-10 part, Radix Et Rhizoma Rhei 2-6 part, Fructus Gardeniae 2-6 part, Radix Glycyrrhizae 2-6 part.
2. by the medicine of control swine erysipelas claimed in claim 1, it is characterized in that its composition is expressed as with mass fraction:
5 parts of Flos Loniceraes, 5 parts of Folium Isatidiss, 5 parts of Herba Violaes, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 4 parts of Rhizoma Osmundae, 4 parts of Mirabilitum crystallinas, 4 parts of Cortex Moutans, 4 parts of the Rhizoma Anemarrhenaes, 3 parts of Radix Scrophulariaes, 3 parts of Herba Selaginellaes, 3 parts of Radix Paeoniae Rubra, 3 parts of Radix Platycodoniss, 2 parts of Radix Et Rhizoma Rhei, 2 parts of Fructus Gardeniaes, 2 parts, Radix Glycyrrhizae.
3. by the medicine of control swine erysipelas claimed in claim 1, it is characterized in that its composition is expressed as with mass fraction:
15 parts of Flos Loniceraes, 15 parts of Folium Isatidiss, 15 parts of Herba Violaes, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Rhizoma Osmundae, 12 parts of Mirabilitum crystallinas, 12 parts of Cortex Moutans, 12 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Scrophulariaes, 10 parts of Herba Selaginellaes, 10 parts of Radix Paeoniae Rubra, 10 parts of Radix Platycodoniss, 6 parts of Radix Et Rhizoma Rhei, 6 parts of Fructus Gardeniaes, 6 parts, Radix Glycyrrhizae.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310111814.8A CN103142824B (en) | 2013-04-02 | 2013-04-02 | Medicine for controlling swine erysipelas |
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| CN201310111814.8A CN103142824B (en) | 2013-04-02 | 2013-04-02 | Medicine for controlling swine erysipelas |
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| CN103142824A CN103142824A (en) | 2013-06-12 |
| CN103142824B true CN103142824B (en) | 2014-11-26 |
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| CN103721103B (en) * | 2013-12-30 | 2015-12-02 | 山东新希望六和集团有限公司 | Medicine being used for the treatment of pig erysipelas and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137400A (en) * | 1996-01-15 | 1996-12-11 | 贺力坤 | Method for preparation of drug for curing acute epidemic febrile disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1137400A (en) * | 1996-01-15 | 1996-12-11 | 贺力坤 | Method for preparation of drug for curing acute epidemic febrile disease |
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