CN100428946C - Medicine for preventing and controlling chicken infectious fabricius bursa disease - Google Patents

Medicine for preventing and controlling chicken infectious fabricius bursa disease Download PDF

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Publication number
CN100428946C
CN100428946C CNB2006100129075A CN200610012907A CN100428946C CN 100428946 C CN100428946 C CN 100428946C CN B2006100129075 A CNB2006100129075 A CN B2006100129075A CN 200610012907 A CN200610012907 A CN 200610012907A CN 100428946 C CN100428946 C CN 100428946C
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radix
medicine
herba
isatidis
preventing
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CN1899498A (en
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鹿瑞麟
刘丽娟
刘富强
张书存
王海萍
李正楠
刘茂华
候英慧
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Hebei Agricultural University
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Hebei Agricultural University
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Abstract

The medicine for preventing and controlling chicken's infectious Fabricius bursa disease is prepared with isatis root, isatis leaf, dandelion, andrographis herb, honeysuckle and other 12 kinds of Chinese medicinal materials in certain weight proportion, and through crushing, grinding and mixing. Before application, the medicine is soaked in boiled water for 30-60 min for the effective medicine components to be dissolved and leached fully and to be absorbed easily in chickens' bodies. At the same time, small amount of sugar and vitamin C as auxiliary medicines are added for raised curative effect. The medicine has high curative rate, no adverse reaction, no medicine residue, no drug resistance and other advantages.

Description

A kind of medicine of preventing and treating infectious bursal disease
Technical field:
The invention belongs to medicine and engineering in medicine technical field, particularly relate to a kind of medicine of preventing and treating infectious bursal disease.
Background technology:
Poultry husbandry almost spreads all over countries in the world, and China is first big country of raising chickens.The particularly viral fowl disease of fowl disease is particularly serious to the harm of poultry husbandry, is exactly that a kind of whole world takes place as infectious bursal disease, endangers serious viral acute infectious disease.Disclosedly in the prior art be used to prevent this sick medicine that domestic and imported class vaccine is arranged; Prevent and treat this sick drug main and will comprise biological product (as hyper-immune serum, high-immunity yolk liquid), Western medicine (as moroxydine, virazole etc.) and Chinese medicine (, capsule sick clear sick disappear etc.) as capsule.But see that from the clinical practice in more than 10 years all there is such or such problem and shortage in above-mentioned various kinds of drug, prevention protective rate as all kinds of vaccines only is 10-70%, the name of the game is that this virus has open-air changeableness and presents the biological characteristics of different serotypes clinically, cause ideal vaccine to be difficult to so far come out, raise chickens produce in epidemic prevention every year, Fa Bing phenomenon takes place repeatedly every year; Though some biological preparation has higher specificity curative effect, the national standard that can't decide still is in the preliminary examination stage so far, fails large scale application; Commercially available antiviral Western medicine is not good enough to this disease curative effect, and develops immunity to drugs and potential sequel such as drug residue; Though other commercially available Chinese medicine does not have the fraud of Western medicine, but constitute some defectives of existence on the and methods for using them at prescription, or because of not rigorous the affecting the treatment of prescription, or on application process, simply the direct spice of Chinese powder medicine is fed, delayed the absorption of sick chicken to the medicine active ingredient, prevention effect is unsatisfactory.
Summary of the invention:
The object of the present invention is to provide a kind of determined curative effect, cure rate height, have no side effect, drug residue free, the medicine of the control infectious bursal disease that is difficult for developing immunity to drugs after chicken is taken.
The medicine of control infectious bursal disease provided by the invention is a kind of pure Chinese medicine composition powder, and the prescription composition is expressed as by weight: Radix Isatidis 6-12, Folium Isatidis 6-12, Herba Taraxaci 6-12, Herba Andrographis 6-12, Flos Lonicerae 5-10, Radix Scutellariae 5-10, Fructus Forsythiae 5-10, Cortex Phellodendri 5-10, Gypsum Fibrosum 5-20, Rhizoma Anemarrhenae 1-5, Radix Rehmanniae 4-8, Radix Astragali 4-8, Radix Scrophulariae 4-8, Herba Agrimoniae 3-8, Radix Et Rhizoma Rhei 2-5, Fructus Gardeniae 2-5, Radix Glycyrrhizae 2-5.The 60-80 mesh sieve is dried, weighs, pulverized to said medicine, and stirring gets final product.
Drug use method of the present invention is such:
A, method: claim medicated powder to pour (canisters such as forbidding ferrum, aluminum in Porcelain Jar or the porcelain urn into according to chicken group quantity, the state of an illness, consumption, to avoid reaction, affect the treatment), the 5-10 times of boiling water that adds the medicated powder amount again, cover mouth rapidly, soaked stewing 30-60 minute, can make the active ingredient of medicine fully dissolve and separate out like this, when treating that fluid temperature is reduced to 20-25 ℃, again by boiling water amount or amount of liquid medicine, the saccharide (glucose or white sugar) of adding 10% and 0.02% vitamin C, purpose are additional chicken energy i (in vivo), have certain Detoxication concurrently.The medicinal liquid for preparing once threw clothes, logotype 3-5 days for the chicken group before the dusk.
B, consumption: therapeutic dose 1.0-1.5g/ is the sky only, and preventive dose 0.5-0.75g/ is the sky only, logotype 3-5 days.
Prescription is understood: medicament composing prescription of the present invention is according to motherland's traditional medical theory, designs in conjunction with the state of an illness characteristic determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of infectious bursal disease.Primary disease belongs to the epidemic febrile disease category, be that failure of defensive QI to protect the body against pathogen, heresy are gone into edema caused by disorder of QI, battalion and directly go into blood system thoroughly goes into that blood is given birth to wind, wind is contained and dry, the dry utmost point is lit a fire, contain on the pathogenic heat top, the absurd row of forcing blood, so occur slow-witted refreshing, the greedy drink of chicken group, disease such as hemorrhage clinically, be the pyretic toxicity disease of typical vital QI being weakened and pathogen being violent.Establish the rule of treatment of eliminating pathogenic factor for supporting vital QI in view of the above, promptly based on heat-clearing and toxic substances removing, boosting qi and nourishing yin is auxilliary.So try hard to recommend famous medicine Radix Isatidis, Folium Isatidis, Herba Taraxaci, Herba Andrographis, the Flos Lonicerae of heat-clearing and toxic substances removing is that monarch drug is formed the powerful antiviral main force, thereby guarantees effective efficacy of a drug of the present invention; Alternative Radix Scutellariae, Fructus Forsythiae, Cortex Phellodendri, Gypsum Fibrosum, the Rhizoma Anemarrhenae are ministerial drug, and the effect of performance pathogenic fire purging detumescence, the cool three warmers of elimination interior-heat is with the efficacy of a drug of principal drug assistance heat-clearing and toxic substances removing; Transfer the Radix Rehmanniae, the Radix Astragali, Radix Scrophulariae, Herba Agrimoniae for assistant again, be intended to removing heat from blood pathogenic fire purging, YIN nourishing and the production of body fluid promoting, tonifying Qi and lifting yang, astringing to arrest bleeding, make blood return, help the monarch and his subjects' a helping hand through to set upright; Send Radix Et Rhizoma Rhei, Fructus Gardeniae, Radix Glycyrrhizae for making again, Radix Glycyrrhizae is apt to coordinating the actions of various ingredients in a prescription, makes the monarch and his subjects help coordination linkage, and Radix Et Rhizoma Rhei is apt to make the poison heresy to excrete from digestive tract, and the kind poison heresy that makes of Fructus Gardeniae excretes through urinary tract, gives malicious evil two outlets, exempts from the trouble of " close door and stay the bandit ".So it is rigorous that the present invention fills a prescription, monarch, minister, help, make the division of labor clear and definite, Each performs its own functions, raises respectively that it is long, brings out the best in each other.When clinical practice, increased by two foreign aid's medicines of saccharide and Vc again, more strengthened eliminating pathogenic factor for supporting vital QI effect of the present invention.Therefore.Originally bright have higher clinical cure rate than other related drugs.
The specific embodiment:
Following examples are in order to explanation the present invention.
Embodiment 1:
The medicine of control infectious bursal disease, the prescription composition is expressed as by weight:
Radix Isatidis 10, Folium Isatidis 10, Herba Taraxaci 10, Herba Andrographis 10, Flos Lonicerae 8, Radix Scutellariae 8, Fructus Forsythiae 8, Cortex Phellodendri 8, Gypsum Fibrosum 16, the Rhizoma Anemarrhenae 4, the Radix Rehmanniae 6, the Radix Astragali 6, Radix Scrophulariae 6, Herba Agrimoniae 6, Radix Et Rhizoma Rhei 4, Fructus Gardeniae 4, Radix Glycyrrhizae 4.
With said medicine weigh, pulverized 80 mesh sieves respectively, stirring gets final product.
The inventor utilizes this prescription medicine to be used for clinical treatment, has obtained better curative effect, and concrete grammar is as follows:
For trying the place: the wide chicken house of Handan City, Hebei flood.
For trying the chicken group: 4000 parts in Beijing opera spoken in Beijing dialect 939 commodity are for chickling, and 32 ages in days are suffered from infectious bursal disease, and the group is with giving up together.
Test group: 2000, use Drug therapy of the present invention.
Matched group: 2000, with Western medicine moroxydine (moroxydine hydrochloride) treatment.The test group step is as follows:
1. claim medicine: every chicken medication of test group 1.0g, nominal is got the above-mentioned Chinese medicine powder of 2000g and is poured in the cylinder.
2. soak: in cylinder, add boiling water 10kg, add a cover and soak stewing 30 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 1kg white sugar and 2gVc powder, stir evenly and get final product.
4. throw clothes: before the feeding, once drop into this medicinal liquid (containing medicinal residues) for the chicken group between the lights, appoint the free drink-service of chicken group.
5. course of treatment; 1 dose of every day, logotype 3 days.
Matched group: throw clothes Western medicine moroxydine for 2000 sick chickens, consumption is 0.02g/, and 40g is dissolved in the 4000g drinking-water altogether, and concentration is 1%, freely drinks for the chicken group.Every day 1 time, logotype 3 days.
Therapeutic outcome is listed in the table below: (unit: only, %)
Figure C20061001290700051
Test group exceeds 25.8 percentage points than the cure rate of matched group.
Embodiment 2:
The medicine of control infectious bursal disease, the prescription composition is expressed as by weight:
Radix Isatidis 6, Folium Isatidis 6, Herba Taraxaci 6, Herba Andrographis 6, Flos Lonicerae 5, Radix Scutellariae 5, Fructus Forsythiae 5, Cortex Phellodendri 5, Gypsum Fibrosum 5, the Rhizoma Anemarrhenae 1.25, the Radix Rehmanniae 4, the Radix Astragali 4, Radix Scrophulariae 4, Herba Agrimoniae 3, Radix Et Rhizoma Rhei 2, Fructus Gardeniae 2, Radix Glycyrrhizae 2..
60 mesh sieves are weighed, pulverized to said medicine respectively, and stirring gets final product.
The inventor has carried out clinical practice with this prescription medicine to suffering from infectious bursal disease chicken group, has obtained better curative effect, and the detailed results record is as follows:
For trying the place: the Hebei Hengshui City is known towering chicken house.
For trying the chicken group: 6000 Ai Wei mattress commodity are for broiler, and 18 ages in days are suffered from infectious bursal disease, and the group is with giving up together.
Test group: 3000, with above-mentioned Drug therapy of the present invention.
Matched group: 3000, with the treatment that disappears of commercially available herbal medicine capsule disease.The test group concrete steps are:
1. claim medicine: every chicken medication of test group 1.5g, nominal is got the above-mentioned Chinese medicine powder of 4500g and is poured in the cylinder.
2. soak: in cylinder, add boiling water 45kg, add a cover and soak stewing 60 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 4.5kg white sugar and 9gVc powder, stir evenly and get final product.
4. throw clothes: before the feeding, once drop into this medicinal liquid (containing medicinal residues) for the chicken group between the lights, appoint the free drink-service of chicken group.
5. course of treatment; 1 dose of every day, logotype 5 days.
Matched group: take by weighing NANGBINGXIAO ZHONGSHOUYAO for 3000 sick chickens, consumption be 1.5g/ only, this medicine of 4500g was admixed feedstuff and once threw clothes before the dusk altogether, connected and fed 5 days.
Therapeutic outcome is listed in the table below: unit: only, %
Test group exceeds 8.47 percentage points than the cure rate of matched group.

Claims (3)

1, a kind of medicine of preventing and treating infectious bursal disease is characterized in that making the raw materials of effective components medicine and is expressed as by weight:
Radix Isatidis 6-12, Folium Isatidis 6-12, Herba Taraxaci 6-12, Herba Andrographis 6-12, Flos Lonicerae 5-10, Radix Scutellariae 5-10, Fructus Forsythiae 5-10, Cortex Phellodendri 5-10, Gypsum Fibrosum 5-20, Rhizoma Anemarrhenae 1-5, Radix Rehmanniae 4-8, Radix Astragali 4-8, Radix Scrophulariae 4-8, Herba Agrimoniae 3-8, Radix Et Rhizoma Rhei 2-5, Fructus Gardeniae 2-5, Radix Glycyrrhizae 2-5.
2, by the medicine of the described treatment infectious bursal disease of claim 1, it is characterized in that making the raw materials of effective components medicine and be expressed as by weight:
Radix Isatidis 10, Folium Isatidis 10, Herba Taraxaci 10, Herba Andrographis 10, Flos Lonicerae 8, Radix Scutellariae 8, Fructus Forsythiae 8, Cortex Phellodendri 8, Gypsum Fibrosum 16, the Rhizoma Anemarrhenae 4, the Radix Rehmanniae 6, the Radix Astragali 6, Radix Scrophulariae 6, Herba Agrimoniae 6, Radix Et Rhizoma Rhei 4, Fructus Gardeniae 4, Radix Glycyrrhizae 4.
3, by the medicine of the described control infectious bursal disease of claim 1, it is characterized in that making the raw materials of effective components medicine and be expressed as by weight:
Radix Isatidis 6, Folium Isatidis 6, Herba Taraxaci 6, Herba Andrographis 6, Flos Lonicerae 5, Radix Scutellariae 5, Fructus Forsythiae 5, Cortex Phellodendri 5, Gypsum Fibrosum 5, the Rhizoma Anemarrhenae 1.25, the Radix Rehmanniae 4, the Radix Astragali 4, Radix Scrophulariae 4, Herba Agrimoniae 3, Radix Et Rhizoma Rhei 2, Fructus Gardeniae 2, Radix Glycyrrhizae 2.
CNB2006100129075A 2006-07-05 2006-07-05 Medicine for preventing and controlling chicken infectious fabricius bursa disease Expired - Fee Related CN100428946C (en)

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101332256B (en) * 2007-06-28 2011-03-16 保定冀中药业有限公司 Traditional Chinese medicine composition for infectious bursal disease and preparation method thereof
CN101569707B (en) * 2009-06-11 2011-06-01 中国农业科学院兰州畜牧与兽药研究所 Drug for controlling bursa of Fabricius in poultry
CN101695339B (en) * 2009-10-29 2012-07-04 镇江天和生物技术有限公司 Pure Chinese medicinal immunopotentiator special for animal
CN101797345B (en) * 2010-04-19 2011-12-21 河南工业大学 Traditional Chinese medicine composition for preventing and treating viral diseases of poultry and preparation method
CN103599448B (en) * 2013-10-23 2016-04-06 青岛华仁技术孵化器有限公司 Be used for the treatment of the Chinese medicine composition of infections chicken cloacal bursa
CN104644962A (en) * 2013-11-21 2015-05-27 天津瑞贝特科技发展有限公司 Traditional Chinese medicine composition for treating infectious bursal disease of chicken and preparation method thereof
CN104288554A (en) * 2014-09-30 2015-01-21 天津瑞贝特科技发展有限公司 Traditional Chinese veterinary medicine injection for treating infectious bursal disease and preparation method thereof
CN104523943A (en) * 2014-12-29 2015-04-22 河南天纳图生物科技有限公司 Compound fermentation type traditional Chinese medicine for preventing and treating multiple seasonal febrile diseases of livestock and poultry
CN106266317A (en) * 2015-05-26 2017-01-04 河北工程大学 A kind of Chinese medicine preparation preventing and treating chickling bursal disease
CN105106581B (en) * 2015-10-15 2018-10-30 保定冀中药业有限公司 It is a kind of to be used to prevent Chinese medicine composition, oral solution of chicken kidney disease and preparation method thereof
CN105833128A (en) * 2016-05-31 2016-08-10 刘三保 Chinese herbal medicine composition for preventing and treating chicken infectious bursal disease and application method of Chinese herbal medicine composition for preventing and treating chicken infectious bursal disease
CN106236946A (en) * 2016-08-29 2016-12-21 旌德县德源农业开发有限公司 A kind of Chinese medicine composition treating a bursa of Fabricius in poultry
CN107549100A (en) * 2017-08-31 2018-01-09 安徽金丰源畜牧科技有限公司 A kind of method with a variety of herbal control chickens disease
CN112022996A (en) * 2020-09-01 2020-12-04 潍坊宇洋药业有限公司 Traditional Chinese medicine formula for relieving spotted kidney of broiler chicken and preparation process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1085092A (en) * 1993-05-19 1994-04-13 刘道鹏 Chicken pest rice
CN1176804A (en) * 1996-11-21 1998-03-25 湖南省常德市兽药厂 Quick action medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1085092A (en) * 1993-05-19 1994-04-13 刘道鹏 Chicken pest rice
CN1176804A (en) * 1996-11-21 1998-03-25 湖南省常德市兽药厂 Quick action medicine

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