CN107184785A - A kind of medicine for preventing and treating rabbit E.coli disease - Google Patents
A kind of medicine for preventing and treating rabbit E.coli disease Download PDFInfo
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Abstract
Title of the present invention is：A kind of medicine for preventing and treating rabbit E.coli disease, category medicine and engineering in medicine technical field, its composition are expressed as with mass fraction：5 15 parts of the coptis, 5 15 parts of the Chinese bulbul, 5 15 parts of golden cypress, 5 15 parts of folium eucalypti, 4 12 parts of the root bark of tree peony, 4 12 parts of the wind-weed, 4 12 parts of garden burnet, 4 12 parts of sophora flower, 39 parts of Radix Angelicae Sinensis, 39 parts of the root of herbaceous peony, 39 parts of the red sage root, 39 parts of the banksia rose, 26 parts of rheum officinale, 26 parts of cape jasmine, 26 parts of radix glycyrrhizae, 26 parts of jujube.Said herbal medicine is dried, weighed, 100 mesh sieves were crushed to, puddled uniform.Soaked 30 60 minutes using boiling water during clinical practice, effective ingredient is fully dissolved and is separated out, in favor of the body absorption of sick rabbit, while adding a small amount of carbohydrate and Vc, drug effect can be improved.The clinical drug cure rate is higher, has no adverse reaction, and is not likely to produce drug residue free in the resistance to the action of a drug, rabbit meat.Required raw material is easy to get, and prepares simply, easy to use, can be in large, medium and small warren wide popularization and application.
Description
Technical field：
The invention belongs to medicine and engineering in medicine technical field, particularly a kind of medicine for being related to preventing and treating rabbit E.coli disease.
Background technology：
The rabbit keeping of China is with a long history, is one of traditional household sideline production in the vast rural area of China.Particularly opened from reform
Since putting, under the guide of party and state's rich peasant's policy, rabbit keeping is developed rapidly.Raising scale constantly expands, cultivation side
Formula is also supported to intensive, batch production development from fragmentary free-ranging, cave, and some places that turn into having allow the pillar of peasant programme
One of type industry.As rabbit group is intensive, contacts are frequent, rabbit also increasingly increases, in multiple situation occurred frequently, and rabbit turns into supports rabbit
The important restriction factor of industry healthy and sustainable development.Such as rabbit E.coli disease, also known as mucoenteritis, are by the cause of certain serotype
Fulminant enteric infectious disease caused by characteristic of disease Escherichia coli and its toxin.It, which is mainly characterized by suffering from rabbit, there is glue sample or watery diarrhea
And serious dehydration, death rate height.The factors such as this sick generation and raising, weather are closely related, and spring, autumn are multiple；The various ages
Rabbit can occur this disease, but young rabbit is susceptible, occurs mainly in the young rabbit at 1-4 monthly ages, young rabbit invasion rate before and after wean and dead
Rate highest is died, often provisions rabbit person brings heavy economic losses.It is disclosed in the prior art to be used to prevent and treat rabbit E.coli disease
Medicine mainly has vaccine, Western medicine and herbal medicine three major types.Although three has different degrees of prevention effect, there is also so
Or such technical problem, await technological innovation, such as domestic rabbit E.coli inactivated vaccine, curative effect is relatively low so far can not because preventing
It is widely applied, in view of this disease has this particularity of various serotype pathogenic bacteria, extremely indivedual homemade bacterium in warren are gone out
Live seedling is also only limitted to self-control and used by oneself, so as to cause a kind of common disease, the frequently-occurring disease that this disease is still rabbit keeping at present；Commercially available Western medicine
Such as antibioticses, sulfamido and nitrofurans have preferable prevention effect, however as prolonged application for many years, or even disorderly
With abuse, its curative effect is reduced year by year, and consumption then increases year by year, and the continuous formation of endurance strain has been undisputable fact, and tool
There is the potential risk of medicament residue, rabbit meat is constituted a threat to safely.29 kinds of Western medicine of the national disabling of explicit order, such as chloramphenicol,
Furazolidone (being commonly called as furazolidone) etc.；Though the drawback without above-mentioned Western medicine such as other commercially available herbal medicines such as spirit of rabbit bar, rabbit bar be clear, with
Side constitute and application method on there is also some technological deficiencies, or it is not rigorous and curative effect is not good enough because being formulated, or in application process
It is upper often to feed the direct spice of drug powder, delay sick rabbit to the absorption rate of effective ingredient, it is difficult to ensure internal effective
Drug concentration, prevention effect is also unsatisfactory.Therefore, the medicine progress technological innovation to preventing and treating rabbit E.coli is necessary.
Goal of the invention：
The purpose of the present invention be that a kind of determined curative effect of offer, cure rate is higher, have no toxic side effect, drug residue free,
It is not likely to produce drug resistance, is easy to the sick pure Chinese herbal medicine medicine of the preventing and treating rabbit E.coli of application.
The content of the invention：
To realize the purpose of the present invention, inventor has carried out experimental study for many years and verified repeatedly, has paid substantial amounts of difficult
Hard work is dynamic, constantly explores and filters out multiple Chinese herbal medicine formulas, and optimized design and repetition are put into practice, and are finally determined the present invention's
Formula, its composition is expressed as with mass fraction：5-15 parts of the coptis, 5-15 parts of the Chinese bulbul, 5-15 parts of golden cypress, 5-15 parts of folium eucalypti, pellet
4-12 parts of skin, 4-12 parts of the wind-weed, 4-12 parts of garden burnet, 4-12 parts of sophora flower, 3-9 parts of Radix Angelicae Sinensis, 3-9 parts of the root of herbaceous peony, 3-9 parts of the red sage root, the banksia rose
3-9 parts, 2-6 parts of rheum officinale, 2-6 parts of cape jasmine, 2-6 parts of radix glycyrrhizae, 2-6 parts of jujube.Said herbal medicine is dried, weigh, was crushed to
100 mesh sieves, finished product of the present invention can uniformly be obtained by puddling.
The usage and dosage of medicine of the present invention is as follows：
A. usage：Claim medicinal powder to pour into Porcelain Jar or other ceramic vessels according to rabbit group quantity, the state of an illness, consumption (to avoid with iron, aluminium
Deng canister, reaction is to avoid, is affected the treatment), 5-10 times of boiling water of medicinal powder amount is added, the leaching of lid mouth is stewing 30-60 minutes, this
Sample can make the active ingredient of medicine fully dissolve and separate out.10% is added when fluid temperature is down to 20-25 DEG C, then by boiling water amount
The former powder of the Vc of white sugar or glucose and 200ppm；Purpose is the body fluid and physical efficiency of the sick rabbit of timely supplement, and has certain removing toxic substances
Effect.The decoction so prepared once throws clothes before at dusk, and severe one is gavaged, is used in conjunction 3-5 days.
B. consumption：Therapeutic dose 1-2g/ days, preventive dose 0.5-1g/ days, even served 3-5 days.
Prescription is parsed：
The present invention is theoretical according to the traditional traditional Chinese veterinary medicine of motherland, with reference to the feature of rabbit E.coli disease and clinical for many years real
Trample what is designed through dialectical.Chinese veterinarian thinks：This disease is a kind of more complicated infectious disease, this sick generation and feeding management
The factors such as (fine fodder changes unexpected before and after such as young rabbit wean), climate change (cold and hot indefinite etc.) are closely related, thus this disease the spring,
Autumn is multiple.Escherichia coli are widely present in nature, are a kind of condition pathogens, when rabbit body is stressed, then body resists
Sick power declines, and triggers the pathogenic bacteria amount reproduction in Healthy Rabbits enteron aisle, produces a large amount of endotoxins, and virulence strengthens that this can be triggered
Disease.Invaded in epidemic disease poison, gas physiologic barrier is defended in breakthrough, and epidemic disease heresy is fade-in ying blood, causes stomach and intestine excess heat, stagnation of QI and blood, the rabbit therefore cut open inspection is died of illness
See that intestines and stomach hydrops expands, the lesion such as gastrointestinal mucosa hyperemia, bleeding, oedema.This disease belongs to the warm disease category of traditional Chinese veterinary medicine.Therefore,
Clearing heat and detoxicating, promoting blood circulation to remove blood stasis is preferably established to this disease for the rules for the treatment of.Therefore the coptis, the Chinese bulbul, golden cypress, folium eucalypti 4 are established in this formula first
Taste medicine combination among the strong ones composition main force square formation is monarch drug in a prescription, the effect of to ensure of the invention clearing heat and detoxicating, and modern pharmacological research is proved
(similarly hereinafter), the coptis, golden cypress and the taste main ingredient of folium eucalypti 3 have stronger inhibitory action to Escherichia coli；Select again the root bark of tree peony, the wind-weed, garden burnet,
Sophora flower altogether be ministerial drug, wherein the root bark of tree peony, the wind-weed, garden burnet have the effect of suppress Escherichia coli, with assist monarch drug in a prescription enhancing it is clearing heat and detoxicating,
The drug effect of hemostasis stasis；It is another to adjust Radix Angelicae Sinensis, the root of herbaceous peony, the red sage root, the banksia rose to be adjutant altogether, it is intended that to increase the promoting flow of qi and blood circulation, the work(of slow contraction analgesic
Effect, wherein Radix Angelicae Sinensis, the root of herbaceous peony, the red sage root have the effect of to suppress Escherichia coli, and the monarch and his subjects' drug effect is helped altogether；Send again rheum officinale, cape jasmine, radix glycyrrhizae,
Jujube is to make medicine altogether, it is intended that adjust all medicines, the slow property of medicine, attacks evil without hindering just, and from alimentary canal and the remaining evil poison of the urinary tract drive with body
Outside, wherein rheum officinale has inhibitory action to the germ, exempts the secret worry of " close door and stay bandit ".
Full side is taken a broad view of, inventive formulation is rigorous, link closely the rules for the treatment of, monarch, minister, help, make that Each performs its own functions, show its length fully, and coordinate connection
Move, play medicine work(altogether.In addition, in clinical practice, two foreign aid's medicines of carbohydrate and Vc are added again, it fast can feed and support and disperse poison
Power, more enhances the centralizing function of getting rid of evils of the present invention.Therefore, the present invention has higher clinical cure rate than other related drugs.
Embodiment：Following examples are to illustrate the present invention.
Embodiment 1：
For the examination time：In October, 2011.
For examination place：The plump county king pillar rabbit warren in Hebei province.
For examination rabbit group：35-85 ages in days, 210 commercial generation beaver rabbits, because of concentrated feed suddenly change and the sometimes hot and sometimes cold grade of weather
Generation rabbit E.coli disease.
For reagent thing：That is pure Chinese medicinal preparation of the invention, each taste bulk drug is purchased from Tangshan, Hebei Province Chinese medicine company,
Its composition is expressed as by mass fraction：5 parts of the coptis, 5 parts of the Chinese bulbul, 5 parts of golden cypress, 5 parts of folium eucalypti, 4 parts of the root bark of tree peony, 4 parts of the wind-weed, garden burnet
4 parts, 4 parts of sophora flower, 3 parts of Radix Angelicae Sinensis, 3 parts of the root of herbaceous peony, 3 parts of the red sage root, 3 parts of the banksia rose, 2 parts of rheum officinale, 2 parts of cape jasmine, 2 parts of radix glycyrrhizae, 2 parts of jujube.
Said herbal medicine is dried, weighed, 100 mesh sieves were crushed to, stirs and produces finished product of the present invention.
Test group：105, use drug therapy of the present invention.
Control group：105, with Western medicine strepto- extract for treating.
Test group step is as follows：
1. medicine is claimed：The daily medication 1g of every rabbit, nominal takes 105g medicines of the present invention to pour into Porcelain Jar.
2. soak：Add boiling water 525g in toward cylinder, capping leaching is stewing 30 minutes.
3. dosing：When concoction temperature is down to 20-25 DEG C, 52.5g white sugar and the former powder of 0.105gVc are added.
4. clothes are thrown：Before dusk feeding, the decoction (containing the dregs of a decoction) is disposably put into rabbit group, appoints the free drink-service of rabbit group, weight
Person gavages.
5. the course for the treatment of：Continuous use 3 days.
Control group：Streptomycin sulphate intramuscular injection is used, every rabbit is per kg body weight 20-30mg, and 2 times a day, even note 3 days.
Result of the test is listed in the table below unit：.%
As a result show：Test group is higher by 9.52 percentage points than the cure rate of control group.
Embodiment 2：
For the examination time：In April, 2012.
For examination place：Hebei province Luan County Chen Yu duckweed rabbit warrens.
For examination rabbit group：30-90 ages in days, 262 commercial generation beaver rabbits because of climate change, change not slow transition of concentrated feed etc.
Generation rabbit E.coli disease.
For reagent thing：That is pure Chinese medicinal preparation of the invention, each taste bulk drug purchases be the same as Example 1, and it, which is constituted, presses mass parts
Number is expressed as：15 parts of the coptis, 15 parts of the Chinese bulbul, 15 parts of golden cypress, 15 parts of folium eucalypti, 12 parts of the root bark of tree peony, 12 parts of the wind-weed, 12 parts of garden burnet, Chinese scholartree
Spend 12 parts, 9 parts of Radix Angelicae Sinensis, 9 parts of the root of herbaceous peony, 9 parts of the red sage root, 9 parts of the banksia rose, 6 parts of rheum officinale, 6 parts of cape jasmine, 6 parts of radix glycyrrhizae, 6 parts of jujube.Processing side
Method be the same as Example 1.
Test group：131, use drug therapy of the present invention.
Control group：131, treated clearly with commercially available herbal medicine rabbit bar.
Test group step is as follows：
1. medicine is claimed：The daily medication 2g of every rabbit, nominal takes 262g medicines of the present invention to pour into Porcelain Jar.
2. medicine is soaked：Add boiling water 2620g in toward cylinder, capping leaching is stewing 60 minutes.
3. dosing：When concoction temperature is down to 20-25 DEG C, 262g glucose and the former powder of 0.524gVc are added, is stirred.
4. clothes are thrown：Be the same as Example 1.
5. the course for the treatment of：Continuous use 5 days.
Control group：The clear 262g of rabbit bar is weighed, every same test group of rabbit consumption directly mixes concentrated feed and throws clothes, continuous use 5 days.
Result of the test is listed in the table below unit：.%
As a result show：Test group is higher by 8.47 percentage points than the cure rate of control group.
Claims (3)
1. a kind of medicine for preventing and treating rabbit E.coli disease, it is characterised in that its composition is expressed as with mass fraction：
5-15 parts of the coptis, 5-15 parts of the Chinese bulbul, 5-15 parts of golden cypress, 5-15 parts of folium eucalypti, 4-12 parts of the root bark of tree peony, 4-12 parts of the wind-weed, garden burnet
4-12 parts, 4-12 parts of sophora flower, 3-9 parts of Radix Angelicae Sinensis, 3-9 parts of the root of herbaceous peony, 3-9 parts of the red sage root, 3-9 parts of the banksia rose, 2-6 parts of rheum officinale, cape jasmine 2-6
Part, 2-6 parts of radix glycyrrhizae, 2-6 parts of jujube.
2. the medicine of the preventing and treating rabbit E.coli disease as described in claim 1, it is characterised in that its composition is represented with mass fraction
For：
5 parts of the coptis, 5 parts of the Chinese bulbul, 5 parts of golden cypress, 5 parts of folium eucalypti, 4 parts of the root bark of tree peony, 4 parts of the wind-weed, 4 parts of garden burnet, 4 parts of sophora flower, Radix Angelicae Sinensis 3
Part, 3 parts of the root of herbaceous peony, 3 parts of the red sage root, 3 parts of the banksia rose, 2 parts of rheum officinale, 2 parts of cape jasmine, 2 parts of radix glycyrrhizae, 2 parts of jujube.
3. the medicine of the preventing and treating rabbit E.coli disease as described in claim 1, it is characterised in that its composition is represented with mass fraction
For：
15 parts of the coptis, 15 parts of the Chinese bulbul, 15 parts of golden cypress, 15 parts of folium eucalypti, 12 parts of the root bark of tree peony, 12 parts of the wind-weed, 12 parts of garden burnet, sophora flower 12
Part, 9 parts of Radix Angelicae Sinensis, 9 parts of the root of herbaceous peony, 9 parts of the red sage root, 9 parts of the banksia rose, 6 parts of rheum officinale, 6 parts of cape jasmine, 6 parts of radix glycyrrhizae, 6 parts of jujube.
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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