CN103494905B - A kind of pharmaceutical composition preventing and treating piglet diarrhea and its preparation method and application - Google Patents
A kind of pharmaceutical composition preventing and treating piglet diarrhea and its preparation method and application Download PDFInfo
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- CN103494905B CN103494905B CN201310448771.2A CN201310448771A CN103494905B CN 103494905 B CN103494905 B CN 103494905B CN 201310448771 A CN201310448771 A CN 201310448771A CN 103494905 B CN103494905 B CN 103494905B
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Abstract
The invention discloses a kind of pharmaceutical composition preventing and treating piglet diarrhea, described pharmaceutical composition comprises following component: be Polygonum viviparum L. 40 parts, Radix Berberidis 20 parts, Radix Sophorae Flavescentis 20 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Atractylodis 10 parts, Fructus Crataegi (parched to brown) 5 parts according to parts by weight; And provide its methods for making and using same.Beneficial effect of the present invention is: the invention provides a kind of pharmaceutical composition preventing and treating piglet diarrhea, and provide its methods for making and using same, this pharmaceutical composition not only has the effects such as good clearing away heat and eliminating dampness, astringing to arrest diarrhea, strengthening the spleen to promote digestion, but also have that clinical efficacy is obvious, side effect is low, noresidue, not easily produce drug resistance, the feature such as with low cost, easy to use, for piglet diarrhea, there is good prevention and therapy effect.Meet intensive large scale of pig farm need of production, can effectively reduce or reduce antibiotic, the use amount of chemical synthetic drug in control piglet diarrhea.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, be specifically related to a kind of pharmaceutical composition preventing and treating piglet diarrhea and its preparation method and application.
Background technology
Piglet diarrhea is the one multifactor property disease that during intensive large scale of pig farm is produced, piglet is common, multiple, mortality rate is higher; according to investigations; piglet accounts for 39.8% of the dead sum of piglet because of death of suffering from diarrhoea; the piglet of below 30kg; average of the whole year sickness rate is 46.5%; mortality rate is 10.30%, has a strong impact on the sound development of pig industry.Piglet diarrhea can cause that the price of deed is low, piglet survival ratio declines, Piglet Development slowly or stagnate, even dead.Owing to causing the cause of disease of this disease complicated, prevention and therapy difficulty is comparatively large, causes piglet mortality, carrys out tremendous economic loss to industrial belt of raising pigs.At present, antibiotic is the common drug of this disease for the treatment of, but long-term a large amount of antibiotic that uses causes pathogenic bacterium drug resistance to produce, and quantity is more and more large, and curative effect is more and more poor.Meanwhile, the very disruptive balance of piglet gastrointestinal bacterial flora, affect the growth promoter of piglet, drug residue also threatens to public health and food safety.Therefore, development is efficient, generation drug resistance and low-residual medicine have become the problem that control piglet diarrhea needs solution badly safely, not easily.
Summary of the invention
Object of the present invention is exactly for above-mentioned defect of the prior art, provides a kind of pharmaceutical composition effectively can preventing and treating piglet diarrhea.
To achieve these goals, technical scheme provided by the invention is: a kind of pharmaceutical composition preventing and treating piglet diarrhea, and described pharmaceutical composition comprises following component: be Polygonum viviparum L. 40 parts, Radix Berberidis 20 parts, Radix Sophorae Flavescentis 20 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Atractylodis 10 parts, Fructus Crataegi (parched to brown) 5 parts according to parts by weight.
Second object of the present invention there is provided a kind of preparation method of preventing and treating the pharmaceutical composition of piglet diarrhea, comprises the following steps:
1) each drug component is taken according to above-mentioned quality proportioning;
2) after each medicine material pulverizing, excessively 150 mesh sieves that step 1) are taken, or
Each medicine step 1) taken, decocts with water twice, merges the medicinal liquid of twice decoction, sterilizing after thickening filtration.
Further, the preparation method of the pharmaceutical composition of above-mentioned control piglet diarrhea, be specially: take Polygonum viviparum L. 40 parts, Radix Berberidis 20 parts, Radix Sophorae Flavescentis 20 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Atractylodis 10 parts, Fructus Crataegi (parched to brown) 5 parts, be placed in stainless steel cask, add deionized water 500ml, decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid; Add deionized water 400ml again, continue to decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid, merge the medicinal liquid of twice decoction, be diluted to 1000ml, filter, stir evenly, subpackage, sterilizing, both obtained oral liquid.
3rd object of the present invention there is provided a kind of application of pharmaceutical composition in the medicine for the preparation for the treatment of or prevention of diarrhea in piglets of above-mentioned control piglet diarrhea.
Beneficial effect of the present invention is: the invention provides a kind of pharmaceutical composition preventing and treating piglet diarrhea, and provide its methods for making and using same, this pharmaceutical composition is the pathogenic factor according to piglet diarrhea, pathogeny and clinical symptoms, theoretical according to Traditional Chinese Medicine veterinary, in clearing away heat and eliminating dampness, astringing to arrest diarrhea, prepare under the prescription foundation of strengthening the spleen to promote digestion and control principle, it not only has good clearing away heat and eliminating dampness, astringing to arrest diarrhea, the effects such as strengthening the spleen to promote digestion, but also it is obvious to have clinical efficacy, side effect is low, noresidue, not easily produce drug resistance, with low cost, the feature such as easy to use, for piglet diarrhea, there is good prevention and therapy effect.Simultaneously; owing to have employed the form of Chinese medicine composition; in process of production; more meet intensive large scale of pig farm need of production; can effectively reduce or reduce antibiotic, the use amount of chemical synthetic drug in control piglet diarrhea; eliminate drug residue to food safety and sanitarian threat, meet the requirement of agricultural product quality and safety System Construction and environmental type countryside tax system product, meet the social need that safety, pollution-free animal-derived food and human health are provided.
Detailed description of the invention
embodiment 1:
Accurately take Polygonum viviparum L. 40 parts, Radix Berberidis 20 parts, Radix Sophorae Flavescentis 20 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Atractylodis 10 parts, Fructus Crataegi (parched to brown) 5 parts respectively, pulverize, cross 150 mesh sieves, subpackage, both obtain powder.
embodiment 2:
Accurately take Polygonum viviparum L. 40 parts, Radix Berberidis 20 parts, Radix Sophorae Flavescentis 20 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Atractylodis 10 parts, Fructus Crataegi (parched to brown) 5 parts respectively, be placed in stainless steel cask, add deionized water 500ml, decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid; Add deionized water 400ml again, continue to decoct, after boiling, continue decoction 1 hour, incline and medicinal liquid, merge the medicinal liquid of twice decoction, be diluted to 1000ml, filter, stir evenly, subpackage, sterilizing, both obtained oral liquid.
the application of the embodiment of the present invention 1 Chinese medicine composition:
1 materials and methods:
1.1 laboratory animals:
The piglet 120 suffering from diarrhoea is selected on pig farm, Lanzhou City, Gansu Province.
1.2 experimental drugs:
Contrast medicine: ciprofloxacin injection (production of pharmaceutical factory, Hunan);
Test drug; Use medicine of the present invention.
2. experimental design:
Suffer from diarrhoea piglet, be divided into three groups at random, often organize 40 for 120, use preparation embodiment 1 and embodiment 2 and control drug to treat respectively.Preparation embodiment 1 medicine, adds in 1g medicine that 10ml is boiled to be put in the water of temperature, after stirring evenly, gavages, every day 2 times, is used in conjunction 2 days.Preparation embodiment 2 medicine, each 10ml, every day 2 times, is used in conjunction 2 days.Matched group is ciprofloxacin injection, 5mg, intramuscular injection, every day 1 time, is used in conjunction 2 days.
Efficacy determination: recovery from illness: through treatment, ill piglet spirit is normal, suck the breast or food normal, formed stools, neither too hard, nor too soft, color and abnormal smells from the patient are normal, and clinical symptoms disappears completely, recovers normal.Effective: through treatment, the ill piglet mental status takes a turn for the better, and appetite strengthens, and the improvement of feces character, wherein moisture obviously reduce, clinical symptom remission.Invalid: through treatment, ill piglet spirit, appetite are without improvement, and feces character is without improvement, aggravation or use other drug treatment instead, even dead.
3. experimental result:
The total effective rate of embodiment 1 medicine and experimental example 2 medicine is respectively 95% and 97.5%, and matched group is 95%, and test group compares with matched group, and test group is greater than or equal to matched group.The cure rate of embodiment 1 medicine and embodiment 2 medicine is respectively 87.5% and 90%, matched group is 85%, and test group compares with matched group, and cure rate obviously raises, illustrate that this medicine has good therapeutical effect to diarrhea of pigs, its to the therapeutical effect of piglet diarrhea the results detailed in Table 1.
。
the Application Example 2 of Chinese medicine composition of the present invention:
1 materials and methods:
1.1 laboratory animals:
Select on pig farm, Lanzhou City, Gansu Province to suffer from the brood sodium selenite of piglet diarrhea or the sodium selenite 120 with delivery room.
1.2 experimental drugs:
Contrast medicine: ciprofloxacin injection (production of pharmaceutical factory, Hunan);
Test drug: use medicine of the present invention.
2. experimental design:
Sodium selenite 120, is divided into three groups at random, often organizes 40, uses preparation embodiment 1 and embodiment 2 and control drug to carry out prophylactic respectively.Preparation embodiment 1 medicine, adds in 1g medicine that 10ml is boiled to be put in the water of temperature, after stirring evenly, gavages, every day 1 time, is used in conjunction 2 days.Preparation embodiment 2 medicine, each 10ml, every day 1 time, is used in conjunction 2 days.Ciprofloxacin injection, 2.5mg/kg, intramuscular injection, once a day, is used in conjunction 2 days.
Prevention effective percentage is the percentage rate that the effective head number of prevention accounts for prevention head number, and prophylactic terminates the head number without piglet diarrhea disease symptoms in latter 3 days to prevent effective head number to refer to, morbidity head number refers to that prophylactic terminates the morbidity head number in latter 3 days.
3. experimental result:
The prevention effective percentage of embodiment 1 medicine and embodiment 2 medicine is respectively 97.5% and 100%, matched group is 95%, and test group compares with matched group, and prevention effective percentage obviously raises, illustrate that this medicine has good preventive effect to piglet diarrhea, its to the preventive effect of piglet diarrhea the results detailed in Table 2.
。
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. prevent and treat a pharmaceutical composition for piglet diarrhea, it is characterized in that, described pharmaceutical composition is prepared by following component: be Polygonum viviparum L. 40 parts, Radix Berberidis 20 parts, Radix Sophorae Flavescentis 20 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Atractylodis 10 parts, Fructus Crataegi (parched to brown) 5 parts according to parts by weight.
2. prevent and treat a preparation method for the pharmaceutical composition of piglet diarrhea, it is characterized in that, comprise the following steps:
1) each drug component is taken according to weight according to claim 1;
2) after each medicine material pulverizing, excessively 150 mesh sieves that step 1) are taken, or
Each medicine step 1) taken, decocts with water twice, merges the medicinal liquid of twice decoction, sterilizing after thickening filtration.
3. the application of pharmaceutical composition in the medicine for the preparation for the treatment of or prevention of diarrhea in piglets of a control piglet diarrhea according to claim 1.
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| CN106822890B (en) * | 2017-01-19 | 2021-06-04 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for preventing and treating diarrhea of weaned piglets and preparation method and application thereof |
| CN108938832A (en) * | 2018-08-08 | 2018-12-07 | 江苏农牧科技职业学院 | A kind of traditional Chinese medicine oral liquid and preparation method thereof preventing and treating grice diarrhoea |
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