CN101342299B - Medicament for preventing and controlling white diarrhea disease - Google Patents
Medicament for preventing and controlling white diarrhea disease Download PDFInfo
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- CN101342299B CN101342299B CN2008100792594A CN200810079259A CN101342299B CN 101342299 B CN101342299 B CN 101342299B CN 2008100792594 A CN2008100792594 A CN 2008100792594A CN 200810079259 A CN200810079259 A CN 200810079259A CN 101342299 B CN101342299 B CN 101342299B
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Abstract
The present invention discloses a medicine which is used for preventing and treating pullorum. The medicine comprises the ingredients of the following weight portions: 5 to 20 portions of Chinese pulsatilla, 5 to 20 portions of cortex moutan, 5 to 20 portions of bark of Chinese ash, 5 to 20 portions of purslane, 5 to 20 portions of myrobalan, 3 to 12 portions of radix geutianae, 3 to 12 portions of corktree, 3 to 12 portions of realgar, 3 to 12 portions of ageratum, 2 to 6 portions of garlic, 2 to 6 portions of banksian rose, 2 to 6 portions of rhubarb, 2 to 6 portions of talc and 2 to 6 portions of licorice. The herbs are insolated (excepting that the fresh garlic can be used), weighed, crushed, filtered by a sieve with 60 to 80 meshes, and mixed well, so as to prepare the medicine. When in clinical use, the medicine is dipped for 30 to 60 minutes in boiling water, so that the effective ingredients can be fully dissolved and separated to facilitate the absorption in the body of the sick chicken. Simultaneously, a small amount of sugar and Vc are added to improve the medicinal effects. The medicine has high cure rate, no adverse reaction, no drug residues in the body, and nearly no drug resistance. The production of the medicine has the advantages of easily acquirable raw materials, simple preparation, convenient use, and capability of wide promotion and application in the chicken breeding industry.
Description
Technical field:
The invention belongs to medicine and engineering in medicine technical field, particularly a kind of medicine of preventing and treating white diarrhea disease that relates to.
Background technology:
China has been the world big country of raising chickens, and poultry husbandry is still in continuous development.Yet fowl disease is still harm chicken group health, influences the principal element of the sustainable stable development of poultry husbandry.(comprise Pullorum Disease, three kinds of different diseases of antigenic structure of avian typhoid and avian paratyphoid as the fowl salmonellosis, but the control medicine is identical), primary disease is all over sending out in all over the world, development to aviculture brings serious threat, nearly 25000 of the separators of primary disease, many types of primary disease can make the people infect and take place alimentary toxicosis, can't neglect.The chicken of various kinds all has infectibility to Pullorum Disease, characteristics of incidence in years is the highest with the chickling M ﹠ M of 2-3 in age in week, and be popular, young chicken takes second place, the chicken that grows up infects and then is chronic and recessive process, but the egg that carries disease germs that it produced is again a new important polluter, if plant hen vertical transmission takes place then, during the microbiological contamination egg incubation or form dead Embryo Gallus domesticus, or hatch the disease chickling, infect healthy chick again with the group, if untimely treatment or treatment improper measures, a then big death, and the anti-chicken that crosses primary disease carries disease germs for a long time, produce the egg that carries disease germs after growing up again, so go round and begin again, be handed down from age to age, cause serious economy loss to aviculture.The morbidity chickling is the most acute person, asymptomatic rapid death.That slow slightly person shows is stupefied, hair disorderly, the wing that hangs down, close one's eyes, necking down, happiness crouch, squeeze heap, few food or do not eat, suffer from diarrhoea, the pasty state loose stool often pollutes fine hair around the anus, and people are commonly called as " sticking with paste the hip disease ", anus inflammation and pain, usually emit a shrill cry, dead because of dyspnea and heart failure at last.Blind and limping symptom appear in the sick young bird that has.Existing laying rate of the chicken multilist of growing up and rate of fertilization are low, many hyperpyrexia and lethargy behind the human infection.Cut open inspection pathological changes visible hepatomegaly, congested or to be striated hemorrhage, absorption of yolk at its is bad, and necrosis region or tuberosity are arranged in cardiac muscle, liver, lung, caecum, large intestine, muscular stomach and muscle, and caecum has cheesy thing or is mixed with blood, and intestinal wall thickens, with peritonitis.Adult chicken then produces distortion, variable color egg, and peritonitis and pericarditis are arranged.In view of the popularity and the seriousness of primary disease, the someone attempts according to immunology principle, utilizes the generation of dead bacterium or live vaccine control primary disease, does not succeed so far.The medicine of disclosed control white diarrhea disease mainly contains Western medicine and Chinese medicine two big classes in the prior art, though the two all has prevention effect in various degree, also has such or such technical problem, awaits further technological innovation.Commercially available Western medicine, all effective in cure as sulfonamides, furans and some antibiotic to primary disease, even when just beginning to use, have good curative effect, perform meritorious deeds never to be obliterated.But As time goes on, its drawback also day by day highlights in clinical practice, can suppress chick growth as sulfa drugs and grow, and becomes laying rate of chicken significantly to reduce, and is difficult to recover, and disturbs the picked-up of chicken to feedstuff and drinking-water; Nitrofurans with furazolidone (claim again " furazolidone ") for well, but this concentration can not excessive (≦ 0.066%), drinking-water will dissolve fully, and spice is wanted evenly, otherwise easily causes chicken to be poisoned to death, to this, the author knows from experience quite dark, and the clinical practice in year surplus in the of 20 the chickling furazolidone takes place is poisoned to death, even the phenomenon that full group is annihilated is of common occurrence, and lesson is painful; Tri-Biocin is better with chloromycetin and oxytetracycline effect.But, along with prolonged application decades, even abuse abuse, the curative effect of Western medicine worse and worse, Drug resistance is more and more stronger, and drug residue constitutes a threat to meat, egg food safety again, becomes big public hazards, therefore, China Ministry of Agriculture has issued that relevant decree forbids part Western medicine such as chloromycetin, furazolidone in edible animal; And other commercially available herbal medicine such as BAILIJING, though Hakuri peace etc. does not have the drawback of above-mentioned Western medicine, but on prescription formation and methods for using them, also there is some technological deficiency, not rigorous curative effect is not good enough because of filling a prescription, on application process, often the direct spice of drug powder is fed, delayed the absorption rate of sick fowl to the medicine active ingredient, its curative effect is barely satisfactory.Therefore, it is necessary the medicine of preventing and treating white diarrhea disease to be carried out technological innovation.
Summary of the invention:
Purpose of the present invention be exactly to provide a kind of determined curative effect, cure rate higher, have no side effect, pure Chinese herbal medicine that drug residue free, chicken group are difficult for the control white diarrhea disease that develops immunity to drugs, be convenient to use after taking.
For realizing purpose of the present invention, the inventor has carried out experimentation and checking repeatedly for many years, paid hard work, filter out a plurality of Chinese herbal medicine formulas, seek assiduously, unremitting effort, finally determined prescription of the present invention through optimal design, its composition is expressed as with mass fraction: Radix Pulsatillae 5-20 part, Cortex Moutan 5-20 part, Cortex Fraxini 5-20 part, Herba Portulacae 5-20 part, Fructus Chebulae 5-20 part, Radix Gentianae 3-12 part, Cortex Phellodendri 3-12 part, Realgar 3-12 part, Herba Pogostemonis 3-12 part, Bulbus Allii 2-6 part, Radix Aucklandiae 2-6 part, Radix Et Rhizoma Rhei 2-6 part, Talcum 2-6 part, Radix Glycyrrhizae 2-6 part.Said herbal medicine dried (except the Bulbus Allii, but using fresh herb), weigh, be crushed to the 60-80 mesh sieve, puddle evenly get final product finished product of the present invention.
Usage and dosage of the present invention is as follows:
A. method: claim medicated powder of the present invention to pour in Porcelain Jar or the porcelain urn according to chicken group quantity, the state of an illness, consumption and (avoid with canisters such as ferrum, aluminum, to avoid reaction, affect the treatment), the 5-10 times of boiling water that adds the medicated powder amount again, cover mouth rapidly, soaked stewing 30-60 minute, can make the active ingredient of medicine fully dissolve and separate out like this, when treating that fluid temperature is reduced to 20-25 ℃, press the white sugar of boiling water amount or amount of liquid medicine adding 10% or the former powder of Vc of glucose and 0.02% again, purpose is in time to replenish sick chicken energy i (in vivo), has certain detoxicating adhesive concurrently.The medicinal liquid that so prepares once threw clothes for the chicken group before the dusk, logotype 3-5 days is a course of treatment.
B. consumption: therapeutic dose 1-2g/ only day, preventive dose 0.5-1g/ only day, logotype 3-5 days.
Prescription is resolved:
The present invention is the traditional Chinese veterinary medicine theory traditional according to motherland, in conjunction with the feature of white diarrhea disease through dialectical and design.Chinese veterinarian thinks: the fowl Salmonella spreads all over all over the world, poultry is the Salmonella reservoir of nature maximum, when the chicken body is healthy, do not fall ill with popular, and when the decline of chicken body premunition, in the body during failure of defensive QI to protect the body against pathogen, the Pullorum Disease Salmonella by digestive tract, respiratory tract or eye conjunctiva break through a first line of defence infect, popular.This bacterium is invaded gas, battalion, blood system, breeding, virulence crescendo rapidly immediately, soaks into each internal organs organ in the body, interior intrinsic heat poison, and the absurd row of forcing blood is general deteriorated blood process.So in visible cardiac muscle, liver, lung, caecum, large intestine, muscular stomach and the muscle necrosis region or link are arranged, intestinal wall inflammation swelling has a strong impact on the absorption to moisture, presents the diarrhoea dysentery.Therefore, should establish heat-clearing and toxic substances removing to primary disease, eliminating pathogenic heat from blood to cure dysentery, inducing diuresis to remove edema, promoting the circulation of QI to relieve pain are the rule of treatment.So establishing the Radix Pulsatillae, Cortex Moutan, Cortex Fraxini, Herba Portulacae, Fructus Chebulae, 5 flavor medicine combinations among the strong ones in the prescription, to form main force's square formations be monarch drug, to guarantee heat-clearing and toxic substances removing of the present invention, the effect of eliminating pathogenic heat from blood to cure dysentery, when catching and solving this principal contradiction, alternative Radix Gentianae, Cortex Phellodendri, Realgar, Herba Pogostemonis are ministerial drug, the effect of performance heat clearing and damp drying, pathogenic fire purging sterilization, principal drug assistance is strengthened the efficacy of a drug; Transferring Bulbus Allii, the Radix Aucklandiae again is adjuvant drug, and the performance promoting the circulation of QI to relieve pain press down the effect of killing pathogenic bacteria, help the monarch and his subjects' a helping hand altogether; Sending Radix Et Rhizoma Rhei, Talcum, Radix Glycyrrhizae again is messenger drug, is intended to supplementing QI to induce diuresis, concocts all medicines, residual poison in the body is evicted from from digestive tract and urinary tract respectively external, in order to avoid future trouble.
Take a broad view of full side, the present invention fills a prescription rigorous, and Each performs its own functions for monarch, and coordination linkage is played the medicine merit altogether.In addition, when clinical practice, increased by two foreign aid's medicines of saccharide and Vc again, can fast supply support, dispersed virulence, more strengthened the centralizing function of getting rid of evils of the present invention, therefore, the present invention has higher clinical cure rate than other related drugs.
The specific embodiment: following examples are in order to explanation the present invention.
Embodiment 1:
Supply the examination time: in April, 2000.
For trying the place: beautiful precious chicken farm of Guanyao County, Hebei province summer.
For trying the chicken group: 11 ages in days, 3000 assorted 579 commodity of stars are for laying hen, and because of the sometimes cold and sometimes hot DISEASE IN FLOCKS of breaking out of the room temperature of brooding, the group is with giving up together.
Supply the reagent thing: pure Chinese medicinal preparation promptly of the present invention, each crude drug of distinguishing the flavor of is all available from oriental drug city, Anguo City, Hebei province, and its composition is expressed as by mass fraction: 5 parts of the Radix Pulsatillaes, 5 parts of Cortex Moutans, 5 parts of Cortex Fraxinis, 5 parts of Herba Portulacaes, 5 parts of Fructus Chebulaes, 3 parts of Radix Gentianaes, 3 parts of Cortex Phellodendris, 3 parts of Realgars, 3 parts of Herba Pogostemoniss, 2 parts in Bulbus Allii, 2 parts of the Radix Aucklandiae, 2 parts of Radix Et Rhizoma Rhei, 2 parts in Talcum, 2 parts in Radix Glycyrrhizae.Said herbal medicine is dried (except the Bulbus Allii, but using fresh herb, down with), weigh, be crushed to 80 mesh sieves, stir get final product finished product of the present invention.
Test group: 1500, use Drug therapy of the present invention.
Matched group: 1500, with the treatment of Western medicine sulfamethazine.
The test group step is as follows:
1. claim medicine: every chicken medication 1g, nominal is got 1500g medicine of the present invention and is poured in the Porcelain Jar.
2. soak: in cylinder, add boiling water 7.5Kg, add a cover and soak stewing 30 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 750g white sugar and the former powder of 1.5gVc, stir.
4. throw clothes: before the feeding, give this medicinal liquid of the disposable input of chicken group between the lights, appoint the free drink-service of chicken.
5. course of treatment: continuous use 5 days.
Matched group: take by weighing sulfamethazine powder 150g, evenly admix the 30Kg powder, concentration is 0.5%, and every day is disposable throwing clothes 6Kg at dusk, appoints the chicken free choice feeding, continuous use 5 days.
Result of the test is listed in the table below: unit: only, %
The result shows: test group exceeds 6.34 percentage points than the cure rate of matched group.
Embodiment 2:
Supply the examination time: in November, 2002.
For trying the place: Li Limin chicken farm, Neiqiu County, Hebei province.
For trying the chicken group: 17 ages in days, 2200 blue brown commodity in sea are for laying hen, and on the low side because of the room temperature of brooding, the chicken group catches a cold and breaks out DISEASE IN FLOCKS, with group's house together.
Supply the reagent thing: i.e. the present invention, the purchasing of raw materials is with embodiment 1, and its composition is expressed as by mass fraction: 10 parts of the Radix Pulsatillaes, 10 parts of Cortex Moutans, 10 parts of Cortex Fraxinis, 10 parts of Herba Portulacaes, 10 parts of Fructus Chebulaes, 6 parts of Radix Gentianaes, 6 parts of Cortex Phellodendris, 6 parts of Realgars, 6 parts of Herba Pogostemoniss, 4 parts in Bulbus Allii, 4 parts of the Radix Aucklandiae, 4 parts of Radix Et Rhizoma Rhei, 4 parts in Talcum, 4 parts in Radix Glycyrrhizae.Processing method is with embodiment 1.
Test group: 1100, use Drug therapy of the present invention.
Matched group: 1100, with the treatment of Western medicine furazolidone.
The test group step is as follows:
1. claim medicine: every chicken medication 1.5g, nominal is got 1650g medicine of the present invention and is poured in the Porcelain Jar.
2. soak: in cylinder, add boiling water 13.2Kg, add a cover and soak stewing 45 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 1.32Kg soft plantation white sugar and the former powder of 2.64gVc, stir.
4. throw clothes: with embodiment 1.
5. course of treatment: continuous use 4 days.
Matched group: take by weighing furazolidone 6.6g, add in the 13.2Kg boiling water, stir, treat abundant dissolving, when temperature is reduced to 20-25 ℃, throw clothes, the same test group of method, continuous use 4 days to chicken.
Result of the test is listed in the table below: unit: only, %
The result shows: test group exceeds 6.73 percentage points than the cure rate of matched group.
Embodiment 3:
Supply the examination time: in August, 2003.
For trying the place: Yanshan County, Hebei province poplar state chapter chicken farm.
For trying the chicken group: 15 ages in days, 4000 great river AA commodity are for broiler, because of the bad DISEASE IN FLOCKS of breaking out of the chamber sanitary condition of brooding, with group's house together.
Supply the reagent thing: i.e. the present invention, the purchasing of raw materials are with embodiment 1, and its composition is expressed as by mass fraction; 20 parts of the Radix Pulsatillaes, 20 parts of Cortex Moutans, 20 parts of Cortex Fraxinis, 20 parts of Herba Portulacaes, 20 parts of Fructus Chebulaes, 12 parts of Radix Gentianaes, 12 parts of Cortex Phellodendris, 12 parts of Realgars, 12 parts of Herba Pogostemoniss, 6 parts in Bulbus Allii, 6 parts of the Radix Aucklandiae, 6 parts of Radix Et Rhizoma Rhei, 6 parts in Talcum, 6 parts in Radix Glycyrrhizae.Processing method is with embodiment 1.
Test group: 2000, use Drug therapy of the present invention.
Matched group: 2000, with commercially available herbal medicine BAILIJING treatment.
The test group step is as follows:
1. claim medicine: every chicken medication 2g, nominal is got 4000g medicine of the present invention and is poured in the Porcelain Jar.
2. soak: in cylinder, add boiling water 40Kg, add a cover and soak stewing 60 minutes.
3. dosing: when treating that the medicine juice temperature is reduced to 20-25 ℃, add 4Kg glucose powder and the former powder of 8gVc, stir.
4. throw clothes: with embodiment 1.
5. course of treatment: continuous use 3 days.
Matched group; Take by weighing BAILIJING 4000g, every same test group of chicken consumption, directly continuous use 3 days is obeyed in the disposable throwing of spice.
Result of the test is listed in the table below: unit: only, %
The result shows: test group exceeds 6.7 percentage points than the cure rate of matched group.
Claims (3)
1. medicine of preventing and treating white diarrhea disease is characterized in that its composition is expressed as with mass fraction:
Radix Pulsatillae 5-20 part, Cortex Moutan 5-20 part, Cortex Fraxini 5-20 part, Herba Portulacae 5-20 part, Fructus Chebulae 5-20 part, Radix Gentianae 3-12 part, Cortex Phellodendri 3-12 part, Realgar 3-12 part, Herba Pogostemonis 3-12 part, Bulbus Allii 2-6 part, Radix Aucklandiae 2-6 part, Radix Et Rhizoma Rhei 2-6 part, Talcum 2-6 part, Radix Glycyrrhizae 2-6 part.
2. by the medicine of the described control white diarrhea disease of claim 1, it is characterized in that its composition is expressed as with mass fraction:
5 parts of the Radix Pulsatillaes, 5 parts of Cortex Moutans, 5 parts of Cortex Fraxinis, 5 parts of Herba Portulacaes, 5 parts of Fructus Chebulaes, 3 parts of Radix Gentianaes, 3 parts of Cortex Phellodendris, 3 parts of Realgars, 3 parts of Herba Pogostemoniss, 2 parts in Bulbus Allii, 2 parts of the Radix Aucklandiae, 2 parts of Radix Et Rhizoma Rhei, 2 parts in Talcum, 2 parts in Radix Glycyrrhizae.
3. by the medicine of the described control white diarrhea disease of claim 1, it is characterized in that its composition is expressed as with mass fraction:
20 parts of the Radix Pulsatillaes, 20 parts of Cortex Moutans, 20 parts of Cortex Fraxinis, 20 parts of Herba Portulacaes, 20 parts of Fructus Chebulaes, 12 parts of Radix Gentianaes, 12 parts of Cortex Phellodendris, 12 parts of Realgars, 12 parts of Herba Pogostemoniss, 6 parts in Bulbus Allii, 6 parts of the Radix Aucklandiae, 6 parts of Radix Et Rhizoma Rhei, 6 parts in Talcum, 6 parts in Radix Glycyrrhizae.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100792594A CN101342299B (en) | 2008-08-25 | 2008-08-25 | Medicament for preventing and controlling white diarrhea disease |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100792594A CN101342299B (en) | 2008-08-25 | 2008-08-25 | Medicament for preventing and controlling white diarrhea disease |
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| CN101342299A CN101342299A (en) | 2009-01-14 |
| CN101342299B true CN101342299B (en) | 2010-11-10 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102397446A (en) * | 2010-12-08 | 2012-04-04 | 王有成 | Chinese herbal medicine used for treating bird and beast enteritis |
| CN102885927A (en) * | 2011-07-20 | 2013-01-23 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition for treating pullorum disease and preparation method thereof |
| CN103041005A (en) * | 2011-10-14 | 2013-04-17 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition with effect of astringing intestine to stop diarrhea, and preparation method thereof |
| CN103372086A (en) * | 2012-04-23 | 2013-10-30 | 德州和膳生态农业有限公司 | Traditional Chinese medicine-based health care and epidemic prevention method for laying hen breeding |
| CN103349699B (en) * | 2013-07-26 | 2014-12-17 | 华南农业大学 | Chinese herbal preparation capable of preventing and curing piglet's yellow-white dysentery and preparation method and application thereof |
| CN104258015B (en) * | 2014-09-26 | 2017-07-28 | 河南科技大学 | A kind of Chinese medicine preparation of prevention bamboo silk white diarrhea |
| CN107137537A (en) * | 2017-05-04 | 2017-09-08 | 河北工程大学 | A kind of medicine for preventing and treating rabbit salmonellosis |
| CN107823307A (en) * | 2017-11-30 | 2018-03-23 | 黄桂月 | A kind of herb liquid for preventing and treating broiler chicken dysentery characterized by white mucous stool and preparation method thereof |
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- 2008-08-25 CN CN2008100792594A patent/CN101342299B/en not_active Expired - Fee Related
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Assignee: Shenzhou baoji'ankang Technology Co., Ltd. Assignor: Agricultural University of Hebei Contract record no.: 2011130000058 Denomination of invention: Medicament for preventing and controlling white diarrhea disease Granted publication date: 20101110 License type: Exclusive License Open date: 20090114 Record date: 20110602 |
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Granted publication date: 20101110 Termination date: 20160825 |