CN103349699B - Chinese herbal preparation capable of preventing and curing piglet's yellow-white dysentery and preparation method and application thereof - Google Patents
Chinese herbal preparation capable of preventing and curing piglet's yellow-white dysentery and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herbal preparation capable of preventing and curing piglet's yellow-white dysentery and a preparation method and application thereof, and belongs to the technical field of Chinese herbal preparation. The preparation method comprises the following steps: respectively crushing 30-60 g Chinese pulsatilla root, 20-30 g dianthus superbus, 20-30 g cortex phellodendri, 16-18 g gentian, 20-30 g evodia lepta, 16-18 g kuh-seng, 8-12 g agastache rugosus, 16-18 g costustoot, and 16-20 g ash bark; sieving by a 120-mesh sieve, and uniformly mixing so as to obtain the Chinese herbal preparation. By mass percent, 0.5-1 percent of Chinese herbal preparation prepared is added into fodder for feeding piglets after the two are uniformly mixed, so as to prevent and cure piglet's yellow-white dysentery. Besides, being capable of effectively killing and suppressing pathogenic microorganisms, the Chinese herbal preparation also can stimulate organism immunity, and enhance phagocytic ability of white blood cell and liver reticuloendothelial system so as to suppress devastating reaction for organisms.
Description
Technical field
The invention belongs to Chinese medicine preparation technical field, particularly a kind of Chinese medicine preparation and preparation method and application that prevents and treats yellow and white dysentery of piglet.
Background technology
Yellow and white dysentery of piglet is the abbreviation of yellow scour of piglet and Hakuri.Yellow and white dysentery of piglet is a kind of acute infectious intestinal disease being caused by enterotoxigenic escherichia coli (ETEC).Yellow scour of piglet is acutely to suffer from diarrhoea to discharge yellow or yellow-white watery stools and dehydration rapidly, contains curdled milk fritter, stench, severe patient defecation incontinence in excrement, and anus and vaginal orifice take on a red color as feature, and 1 week age is multiple with interior pig, and 1～3 age in days is the most common.Brood piglet sickness rate is very high, is everlasting more than 90%, and mortality rate can reach 100%.Piglet pujos blancos clinical manifestation dysentery, discharges the milky that has stench taste, and canescence medicated porridge sample feces or pasty state feces are feature, sick pig performance appetite weakens, and becomes thin gradually, and body temperature is no more than 39 ℃, normal tired contracting is and sleeping or assemble in heapsly, and 10～30 age in days piglets are multiple, 2～3d that the course of disease is short, long about 1 week, sick pig multipotency spontaneous recovery more than 15 ages in days, sickness rate is high, mortality rate is low, but the growth that can affect piglet is educated, sickness rate is more than 30%, and mortality rate is generally in 50% left and right.No matter be large scale of pig farm field, or traditional-family's cultivation, all can there is yellow and white dysentery of piglet, be one of principal disease affecting pig industry economic benefit.
The main cause that yellow and white dysentery of piglet occurs and the resistance of piglet is poor and the paathogenic factor of external environment condition (as feedstuff, climate change etc.) relevant, for the control of this disease except strengthening feeding and management, in main employing feedstuff, add at present the method for antibiotic or chemosynthesis antibacterials, although antibiotic or chemosynthesis antibacterials have been brought into play effective effect in the control of this disease, but its drawback is also appeared suddenly day by day, it can cause the normal flora imbalance in animal body, bacterial drug resistance strengthens, drug residue, some drugs also can cause immunosuppressant and the food safety of pig, the problems such as public health security.Because e. coli serotype is more, for this sick vaccine control has brought very large difficulty.
Summary of the invention
Primary and foremost purpose of the present invention is that the shortcoming that overcomes prior art, with not enough, provides a kind of Chinese medicine preparation of preventing and treating yellow and white dysentery of piglet.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of described control yellow and white dysentery of piglet.
A further object of the present invention is to provide the application of the Chinese medicine preparation of described control yellow and white dysentery of piglet.
Object of the present invention is achieved through the following technical solutions: a kind of Chinese medicine preparation of preventing and treating yellow and white dysentery of piglet, by following constituent: 30～60 grams of the Radix Pulsatillaes, 20～30 grams of Herba Dianthis, 20～30 grams of Cortex Phellodendris, 16～18 grams of Radix Gentianaes, 20～30 grams of Foliumet Ramulus Evodiae, 16～18 grams of Radix Sophorae Flavescentiss, 8～12 grams of Herba Pogostemoniss, 16～18 grams of the Radix Aucklandiae, 16～20 grams of Cortex Fraxinis;
The preparation method of the Chinese medicine preparation of described control yellow and white dysentery of piglet, comprise the steps: 30～60 grams of the Radix Pulsatillaes, 20～30 grams of Herba Dianthis, 20～30 grams of Cortex Phellodendris, 16～18 grams of Radix Gentianaes, 20～30 grams of Foliumet Ramulus Evodiae, 16～18 grams of Radix Sophorae Flavescentiss, 8～12 grams of Herba Pogostemoniss, 16～18 grams of the Radix Aucklandiae and 16～20 grams of pulverizing respectively of Cortex Fraxini, cross mix homogeneously after 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet;
The Chinese medicine preparation of described control yellow and white dysentery of piglet can be applicable to prevent and treat yellow and white dysentery of piglet disease; During use, it 0.5%～1% is made an addition in feedstuff by mass percentage, stir, get final product feeding piglet;
Invention mechanism of the present invention is: yellow and white dysentery of piglet is to accumulate in the dampheat diarrhea of traditional Chinese veterinary medicine category, damp and hot malicious heresy.Damp and hot criminal's spleen, loss of appetite, damp and hot tenesmus, intestine and small intestine secrete not Shi Zhi, water is wet can not divide profit, therefore excrement is rare, stench, controlling should heat-clearing and toxic substances removing, removing dampness antidiarrheal.
Chinese medicine in we and effective ingredient thereof have respectively following effect, and the Radix Pulsatillae, Cortex Phellodendri, Radix Gentianae, Foliumet Ramulus Evodiae have heat-clearing and toxic substances removing, antibacterial and anti-inflammation functions, cure mainly pyretic toxicity dysentery; Cortex Fraxini, Radix Sophorae Flavescentis heat clearing and damp drying, cure mainly damp-heat dysentery; Herba Dianthi bitter in the mouth, have tonneau water channel, control dysentery and not diuresis, the non-merit that it is controlled also; The Herba Pogostemonis removing dampness of inducing sweat, regulating the flow of Qi and the middle Jiao; Radix Aucklandiae energy promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion intestinal stasis relieving.All medicines share, and reach the function of effective control yellow and white dysentery of piglet.
Research shows, Chinese medicine is except containing many effective ingredient, also contain poultry essential enrich the nutritional labelings such as aminoacid, various trace elements and multivitamin, can improve immunity, endocrine regulation, appetite stimulator, growth encourage digestion, the improvement of poultry body and sleep, strengthen resistance against diseases etc., comprehensive our all medicine effects, have good therapeutic effect to yellow and white dysentery of piglet.This test shows, this can effectively be killed and suppress outside pathogenic microorganism, can also excitating organism immunity, strengthen the phagocytic activity of leukocyte and liver reticuloendothelial system, and suppress body to produce destructive reaction.Also explanation of test, it is perfect that the Chinese medicine of heat-clearing and toxic substances removing can make the permeability of inflammation part blood capillary be able to, inflammation-inhibiting oozes out and limits the development of inflammation, can detoxify again, ease pain and repair damaged tissues, can also promote hypophysis cerebri adrenal cortex function to strengthen simultaneously, enhancing body anti-stress ability, thus the resistance against diseases of piglet to Other diseases improved.
The present invention has following advantage and effect with respect to prior art:
In recent years, violation additive, the drug residue events such as pork product " clenbuterol hydrochloride " and antibiotic happen occasionally, and cause showing great attention to of people.The safety problem of pork product rises to the major issue that is related to people's livelihood safety gradually.And, along with the raising of people's living standard, wish that the hope of purchase safety, health, high quality food is day by day strong.For this reason, under the alarming situation of present food security, with the theory of " preventive treatment of disease ", research and development have herbal medicine product, feed additive and the feed product etc. of health care, not only apply to prevent and treat yellow and white dysentery of piglet disease, simultaneously also for improving resistance against diseases and the reproductive performance of live pig.The most important thing is to use the diseases such as herbal medicine control yellow and white dysentery of piglet disease, its Chinese medicine can be not residual in Carnis Sus domestica, is safety, healthy and efficient animal health-care product, contributes to produce the pork product of healthy high-quality, ensures that consumer is physically and mentally healthy.This has also realized the quality safety of controlling pork product from source, for stopping Carnis Sus domestica drug residue, ensureing consumer's food safety establish a firm foundation.
Along with the fast development of China's animal husbandry, the chemicals of take is that main veterinary drug application is increasingly extensive, for ensure animal husbandry sound development, meet people the demand of animal food made a great contribution, but also brought series of problems simultaneously.Because most of veterinary drugs belong to chemosynthesis class medicine, as hormone, antibiotics etc., when improving poultry output, livestock products medicine residual increases, the health that is directly endangering the mankind.Antibiotic, chemical synthetic drug are limited to use even disabled gradually.In animal husbandry is produced, it is with a long history that Chinese medicine preparation is used for preventing and treating livestock and poultry, and clinical effectiveness is obvious.
Chinese herbal medicine advantage is pure natural property, multifunctionality, have no side effect, without Drug resistance.Can promote animal digestion to absorb, improve food conversion ratio and fertility performance, disease preventing and treating, improves animal health condition, regulates body non-specific immunity etc.In addition, Chinese herbal medicine itself is rich in the multiple nutritional components such as aminoacid, tannin, polysaccharide, trace element, pigment, not only can supplement animal feed nutrient substance, and can improve color, palatability of meat product etc., thus Integral lifting livestock products quality.Therefore, strengthen Chinese medicine preparation R&D intensity, development high, refined, peak products, make it to traceization development, improve manufacturing process and equipment, accelerate compound compatibility research, accelerate the construction that standardization and baseization are produced.Can reduce crude drug dosage, reduce costs, enhancement effect, reduces the wasting of resources, thereby improves animal derived food quality comprehensively, improves the quality of life of China urban and rural residents, and assurance consumers in general's is healthy.
In this patent, relate to for preventing and treating the pure Chinese medicinal preparation of yellow and white dysentery of piglet disease, through studying and draw in clinical trial for a long time, this Chinese medicine preparation is effectively treated yellow and white dysentery of piglet disease (cure rate surpasses 90.0%, and total effective rate surpasses 95.0%); Can also obviously promote piglet growth, result of the test shows uses Chinese medicine test group weight ratio by Chinese drug-treated group, not weigh 8.8%, uses Chinese medicine test group survival rate more than 95%, and does not use Chinese drug-treated group lower than 90% simultaneously.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1
16 grams of 30 grams of the Radix Pulsatillaes, 20 grams of Herba Dianthis, 20 grams of Cortex Phellodendris, 16 grams of Radix Gentianaes, 20 grams of Foliumet Ramulus Evodiae, 16 grams of Radix Sophorae Flavescentiss, 8 grams of Herba Pogostemoniss, 16 grams of the Radix Aucklandiae and Cortex Fraxinis are pulverized respectively to (Guangzhou large auspicious electric mechanical equipment company limited, DXF-20C), cross mix homogeneously after 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
3-4 month in 2011, on Tang Jia pig farm, Sanshui District, Foshan City, carry out the clinical trial of Chinese medicine preparation control yellow and white dysentery of piglet.By above-mentioned formula, prepare the Chinese medicine preparation of control yellow and white dysentery of piglet, by 120 of clinical treatments, suffer from HUANGBAI(sic) dysentery piglets, test group is added by mass percentage 0.5% above-mentioned Chinese medicine preparation in feedstuff, allows pig free choice feeding.Matched group is injection LIJUNJING injection (production of Tian Bao, Guangdong Province Biology Pharmacy Co., Ltd), intramuscular injection, 5mg of every pig.Result of the test demonstration, test group is compared with matched group, therapeutic effect significant difference (P<0.05).Cure rate and total effective rate are 91.7% and 98.3%, exceed 15.0% and 18.3% respectively than matched group.Average every the piglet medical expense of test group reduces by 0.56 yuan than matched group.Test group piglet is after the loose healing of Hakuri, and development condition is good, without rebound phenomenon; And after matched group piglet cures by LIJUNJING, still there is dysentery in indivedual piglets.
Embodiment 2
20 grams of 60 grams of the Radix Pulsatillaes, 30 grams of Herba Dianthis, 30 grams of Cortex Phellodendris, 18 grams of Radix Gentianaes, 30 grams of Foliumet Ramulus Evodiae, 18 grams of Radix Sophorae Flavescentiss, 12 grams of Herba Pogostemoniss, 18 grams of the Radix Aucklandiae and Cortex Fraxinis are pulverized respectively to (Guangzhou large auspicious electric mechanical equipment company limited, DXF-20C), cross mix homogeneously after 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
11-12 month in 2011, in benevolent moral integrity cultivation base, Sihui City, carry out the clinical trial of Chinese medicine preparation control yellow and white dysentery of piglet.By above-mentioned formula, prepare the Chinese medicine preparation of control yellow and white dysentery of piglet, by 160 of clinical treatments, suffer from HUANGBAI(sic) dysentery piglets, test group is added by mass percentage 1% above-mentioned Chinese medicine preparation in feedstuff, allows pig free choice feeding.Matched group is injection LIJUNJING injection (production of Tian Bao, Guangdong Province Biology Pharmacy Co., Ltd), intramuscular injection, 5mg of every pig.Result of the test demonstration, test group is compared with matched group, therapeutic effect significant difference (P<0.05).Cure rate and total effective rate are 90.0% and 97.5%, exceed 21.25% and 22.5% respectively than matched group.Average every the piglet medical expense of test group reduces by 0.68 yuan than matched group.Test group piglet is after the loose healing of Hakuri, and development condition is good, without rebound phenomenon; And after matched group piglet cures by LIJUNJING, still there is dysentery in indivedual piglets.
Embodiment 3
18 grams of 40 grams of the Radix Pulsatillaes, 25 grams of Herba Dianthis, 25 grams of Cortex Phellodendris, 17 grams of Radix Gentianaes, 25 grams of Foliumet Ramulus Evodiae, 17 grams of Radix Sophorae Flavescentiss, 10 grams of Herba Pogostemoniss, 17 grams of the Radix Aucklandiae and Cortex Fraxinis are pulverized respectively to (Guangzhou large auspicious electric mechanical equipment company limited, DXF-20C), cross mix homogeneously after 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
7-9 month in 2011, in sieve home, Lianzhou City agricultural company limited, carry out the clinical trial of Chinese medicine preparation control yellow and white dysentery of piglet.By above-mentioned formula, prepare the Chinese medicine preparation of control yellow and white dysentery of piglet, by 180 of clinical treatments, suffer from HUANGBAI(sic) dysentery piglets, test group is added by mass percentage 0.5% above-mentioned Chinese medicine preparation in feedstuff, allows pig free choice feeding.Matched group is injection LIJUNJING injection (production of Tian Bao, Guangdong Province Biology Pharmacy Co., Ltd), intramuscular injection, 5mg of every pig.Result of the test demonstration, test group is compared with matched group, therapeutic effect significant difference (P<0.05).Cure rate and total effective rate are 91.1% and 96.7%, exceed 15.6% and 13.4% respectively than matched group.Average every the piglet medical expense of test group reduces by 0.63 yuan than matched group.Test group piglet is after the loose healing of Hakuri, and development condition is good, without rebound phenomenon; And after matched group piglet cures by LIJUNJING, still there is dysentery in indivedual piglets.
Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and principle, substitutes, combination, simplify; all should be equivalent substitute mode, within being included in protection scope of the present invention.
Claims (2)
1. prevent and treat a Chinese medicine preparation for yellow and white dysentery of piglet, it is characterized in that being formed by following constituent: 30～60 grams of the Radix Pulsatillaes, 20～30 grams of Herba Dianthis, 20～30 grams of Cortex Phellodendris, 16～18 grams of Radix Gentianaes, 20～30 grams of Foliumet Ramulus Evodiae, 16～18 grams of Radix Sophorae Flavescentiss, 8～12 grams of Herba Pogostemoniss, 16～18 grams of the Radix Aucklandiae, 16～20 grams of Cortex Fraxinis.
2. the preparation method of the Chinese medicine preparation of control yellow and white dysentery of piglet claimed in claim 1, it is characterized in that comprising the steps: by 30～60 grams of the Radix Pulsatillaes, 20～30 grams of Herba Dianthis, 20～30 grams of Cortex Phellodendris, 16～18 grams of Radix Gentianaes, 20～30 grams of Foliumet Ramulus Evodiae, 16～18 grams of Radix Sophorae Flavescentiss, 8～12 grams of Herba Pogostemoniss, 16～18 grams of the Radix Aucklandiae and 16～20 grams of pulverizing respectively of Cortex Fraxini, cross mix homogeneously after 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
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| CN105250726A (en) * | 2015-11-15 | 2016-01-20 | 衡阳市金凤牲猪养殖专业合作社 | Drug for preventing and treating pig scour and preparation method thereof |
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| CN101259171A (en) * | 2008-04-11 | 2008-09-10 | 福建农林大学 | Chinese medicine preparation for preventing pigling's yellow-white dysentery and improving immunity |
| CN101342299A (en) * | 2008-08-25 | 2009-01-14 | 河北农业大学 | Medicament for preventing and controlling white diarrhea disease |
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| CN101259171A (en) * | 2008-04-11 | 2008-09-10 | 福建农林大学 | Chinese medicine preparation for preventing pigling's yellow-white dysentery and improving immunity |
| CN101342299A (en) * | 2008-08-25 | 2009-01-14 | 河北农业大学 | Medicament for preventing and controlling white diarrhea disease |
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| 翁痢康;石家庄市宇龙动物药业有限公司;《http://www.yulong-yy.cn/products_show.asp?id=126》;20090416;第1页 * |
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Effective date of registration: 20180323 Address after: 266000 Shandong Province, Qingdao city Chengyang District Tiankang Road No. 1 building 2019 room A Patentee after: Qingdao seashore Taikang Bio Technology Co., Ltd. Address before: 510642 Tianhe District, Guangdong, No. five road, No. 483, Patentee before: South China Agricultural University |
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