CN103349699A - Chinese herbal preparation capable of preventing and curing piglet's yellow-white dysentery and preparation method and application thereof - Google Patents
Chinese herbal preparation capable of preventing and curing piglet's yellow-white dysentery and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herbal preparation capable of preventing and curing piglet's yellow-white dysentery and a preparation method and application thereof, and belongs to the technical field of Chinese herbal preparation. The preparation method comprises the following steps: respectively crushing 30-60 g Chinese pulsatilla root, 20-30 g dianthus superbus, 20-30 g cortex phellodendri, 16-18 g gentian, 20-30 g evodia lepta, 16-18 g kuh-seng, 8-12 g agastache rugosus, 16-18 g costustoot, and 16-20 g ash bark; sieving by a 120-mesh sieve, and uniformly mixing so as to obtain the Chinese herbal preparation. By mass percent, 0.5-1 percent of Chinese herbal preparation prepared is added into fodder for feeding piglets after the two are uniformly mixed, so as to prevent and cure piglet's yellow-white dysentery. Besides, being capable of effectively killing and suppressing pathogenic microorganisms, the Chinese herbal preparation also can stimulate organism immunity, and enhance phagocytic ability of white blood cell and liver reticuloendothelial system so as to suppress devastating reaction for organisms.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, particularly a kind of Chinese medicine preparation and preparation method and application that prevents and treats yellow and white dysentery of piglet.
Background technology
Yellow and white dysentery of piglet is the abbreviation of yellow scour of piglet and Hakuri.Yellow and white dysentery of piglet is a kind of acute infectious intestinal disease that is caused by enterotoxigenic escherichia coli (ETEC).Yellow scour of piglet is to discharge yellow or yellow-white watery stools and rapidly dehydration with violent diarrhoea, contains curdled milk fritter, stench, severe patient defecation incontinence in the excrement, and anus and vaginal orifice take on a red color and be feature, and 1 age in week is multiple with interior pig, and 1～3 age in days is the most common.Brood piglet sickness rate is very high, is everlasting more than 90%, and mortality rate can reach 100%.Piglet pujos blancos clinical manifestation dysentery is discharged the milky that stench flavor is arranged, and canescence medicated porridge sample feces or pasty state feces are feature, sick pig performance appetite weakens, and becomes thin gradually, and body temperature is no more than 39 ℃, normal tired contracting is and sleeping or assemble in heapsly, and 10～30 age in days piglets are multiple, 2～3d that the course of disease is short, about 1 long week, the sick pig multipotency spontaneous recovery that 15 ages in days are above, sickness rate is high, mortality rate is low, but the growth that can affect piglet is educated, and sickness rate is more than 30%, and mortality rate is generally about 50%.No matter be the large scale of pig farm field, or traditional-family's cultivation, all yellow and white dysentery of piglet can occur, be one of principal disease that affects the pig industry economic benefit.
The main cause that yellow and white dysentery of piglet occurs and the resistance of piglet is poor and the paathogenic factor of external environment condition (such as feedstuff, climate change etc.) relevant, for the control of this disease except strengthening feeding and management, add at present the method for antibiotic or chemosynthesis antibacterials in the main employing feedstuff, although antibiotic or chemosynthesis antibacterials have been brought into play effective effect in the control of this disease, but its drawback is also appeared suddenly day by day, it can cause the normal flora imbalance in the animal body, bacterial drug resistance strengthens, drug residue, some drugs also can cause immunosuppressant and the food safety of pig, the problems such as public health security.Because e. coli serotype is more, for this sick vaccine control has brought very large difficulty.
Summary of the invention
The shortcoming that primary and foremost purpose of the present invention is to overcome prior art provides a kind of Chinese medicine preparation of preventing and treating yellow and white dysentery of piglet with not enough.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of described control yellow and white dysentery of piglet.
A further object of the present invention is to provide the application of the Chinese medicine preparation of described control yellow and white dysentery of piglet.
Purpose of the present invention is achieved through the following technical solutions: a kind of Chinese medicine preparation of preventing and treating yellow and white dysentery of piglet, by following constituent: the Radix Pulsatillae 30～60 grams, Herba Dianthi 20～30 grams, Cortex Phellodendri 20～30 grams, Radix Gentianae 16～18 grams, Foliumet Ramulus Evodiae 20～30 grams, Radix Sophorae Flavescentis 16～18 grams, Herba Pogostemonis 8～12 grams, the Radix Aucklandiae 16～18 grams, Cortex Fraxini 16～20 grams;
The preparation method of the Chinese medicine preparation of described control yellow and white dysentery of piglet, comprise the steps: the Radix Pulsatillae 30～60 grams, Herba Dianthi 20～30 grams, Cortex Phellodendri 20～30 grams, Radix Gentianae 16～18 grams, Foliumet Ramulus Evodiae 20～30 grams, Radix Sophorae Flavescentis 16～18 grams, Herba Pogostemonis 8～12 grams, the Radix Aucklandiae 16～18 grams and Cortex Fraxini 16～20 grams are pulverized respectively, cross mix homogeneously behind 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet;
The Chinese medicine preparation of described control yellow and white dysentery of piglet can be applicable to prevent and treat yellow and white dysentery of piglet disease; During use, it 0.5%～1% is made an addition in the feedstuff by mass percentage, stir, get final product the feeding piglet;
Invention mechanism of the present invention is: yellow and white dysentery of piglet is to accumulate in the dampheat diarrhea of traditional Chinese veterinary medicine category, the damp and hot malicious heresy.Damp and hot criminal's spleen, loss of appetite, damp and hot tenesmus, intestine and small intestine secrete not Shi Zhi, water is wet can not to divide profit, so excrement is rare, stench, controlling should heat-clearing and toxic substances removing, removing dampness antidiarrheal.
Chinese medicine among the we and effective ingredient thereof have respectively following effect, and the Radix Pulsatillae, Cortex Phellodendri, Radix Gentianae, Foliumet Ramulus Evodiae have heat-clearing and toxic substances removing, antibacterial and anti-inflammation functions, cure mainly the pyretic toxicity dysentery; Cortex Fraxini, Radix Sophorae Flavescentis heat clearing and damp drying cure mainly damp-heat dysentery; The Herba Dianthi bitter in the mouth, the tonneau water channel is arranged, control dysentery and not diuresis, the non-merit that it is controlled also; The Herba Pogostemonis removing dampness of inducing sweat, regulating the flow of Qi and the middle Jiao; Radix Aucklandiae energy promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion intestinal stasis relieving.All medicines share, and reach the function of effective control yellow and white dysentery of piglet.
Studies show that, Chinese medicine is except containing many effective ingredient, also contain poultry essential enrich the nutritional labelings such as aminoacid, various trace elements and multivitamin, can improve immunity, endocrine regulation, appetite stimulator, growth encourage digestion, the improvement of poultry body and sleep, strengthen resistance against diseases etc., comprehensive our all medicine effects have good therapeutic effect to yellow and white dysentery of piglet.This test shows, this can effectively be killed and suppress outside the pathogenic microorganism, can also excitating organism immunity, strengthen the phagocytic activity of leukocyte and liver reticuloendothelial system, and suppress body is produced destructive reaction.Also explanation of test, it is perfect that the Chinese medicine of heat-clearing and toxic substances removing can make the permeability of inflammation part blood capillary be able to, inflammation-inhibiting oozes out and limits the development of inflammation, can detoxify again, ease pain and repair damaged tissues, can also promote simultaneously the hypophysis cerebri adrenal cortex function to strengthen, the enhancing body anti-stress ability, thus piglet improved to the resistance against diseases of Other diseases.
The present invention has following advantage and effect with respect to prior art:
In recent years, violation additive, the drug residue events such as pork product " clenbuterol hydrochloride " and antibiotic happen occasionally, and cause showing great attention to of people.The safety problem of pork product rises to the major issue that is related to people's livelihood safety gradually.And, along with the raising of people's living standard, wish that the hope of purchase safety, health, high quality food is day by day strong.For this reason, under the alarming situation of present food security, with the theory of " preventive treatment of disease ", research and development have herbal medicine product, feed additive and the feed product etc. of health care, not only apply to prevent and treat yellow and white dysentery of piglet disease, also be used for improving simultaneously resistance against diseases and the reproductive performance of live pig.The most important thing is to use the diseases such as herbal medicine control yellow and white dysentery of piglet disease, its Chinese medicine can be not residual in Carnis Sus domestica, is safety, healthy and efficient animal health-care product, helps to produce the pork product of healthy high-quality, ensures that consumer is physically and mentally healthy.This has also realized from the quality safety of source control pork product, for stopping the Carnis Sus domestica drug residue, ensureing consumer's food safety establish a firm foundation.
Along with the fast development of China's animal husbandry, use increasingly extensively take chemicals as main veterinary drug, for the sound development that ensures animal husbandry, satisfy people the demand of animal food is made a great contribution, but also brought series of problems simultaneously.Because most of veterinary drugs belong to chemosynthesis class medicine, such as hormone, antibiotics etc., when improving poultry output, livestock products medicine residual increases, and is directly endangering human health.Antibiotic, chemical synthetic drug are limited gradually to use even are disabled.In animal husbandry was produced, it is with a long history that Chinese medicine preparation is used for the control livestock and poultry, and clinical effectiveness is obvious.
The Chinese herbal medicine advantage is pure natural property, multifunctionality, have no side effect, without Drug resistance.Can promote animal digestion to absorb, improve food conversion ratio and fertility performance that disease preventing and treating is improved animal health condition, regulate body non-specific immunity etc.In addition, Chinese herbal medicine itself is rich in the multiple nutritional components such as aminoacid, tannin, polysaccharide, trace element, pigment, not only can replenish the animal feed nutrient substance, and can improve color, palatability of meat product etc., thus Integral lifting livestock products quality.Therefore, strengthen the Chinese medicine preparation R﹠D intensity, the development high, refined, peak products make it to the trace development, improve manufacturing process and equipment, accelerate compound compatibility research, accelerate the construction of standardization and base production.Can reduce the crude drug dosage, reduce cost, enhancement effect reduces the wasting of resources, thereby improves the animal derived food quality comprehensively, improves the quality of life of China urban and rural residents, and the assurance consumers in general's is healthy.
The pure Chinese medicinal preparation that is used for control yellow and white dysentery of piglet disease that relates in this patent study in clinical trial through for a long time and to be drawn, and this Chinese medicine preparation is effectively treated yellow and white dysentery of piglet disease (cure rate surpasses 90.0%, and total effective rate is above 95.0%); Simultaneously can also obviously promote piglet growth, result of the test shows uses Chinese medicine test group weight ratio not weigh 8.8% with Chinese drug-treated group, uses Chinese medicine test group survival rate more than 95%, and is not lower than 90% with Chinese drug-treated group.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment, but embodiments of the present invention are not limited to this.
Embodiment 1
The Radix Pulsatillae 30 grams, Herba Dianthi 20 grams, Cortex Phellodendri 20 grams, Radix Gentianae 16 grams, Foliumet Ramulus Evodiae 20 grams, Radix Sophorae Flavescentis 16 grams, Herba Pogostemonis 8 grams, the Radix Aucklandiae 16 grams and Cortex Fraxini 16 grams are pulverized respectively (the large auspicious electric mechanical equipment company limited in Guangzhou, DXF-20C), cross mix homogeneously behind 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
3-4 month in 2011, carry out the clinical trial of Chinese medicine preparation control yellow and white dysentery of piglet on Tang Jia pig farm, Sanshui District, Foshan City.Prepare the Chinese medicine preparation of control yellow and white dysentery of piglet by above-mentioned prescription, suffer from HUANGBAI(sic) dysentery piglet by 120 of clinical treatments, test group is added 0.5% above-mentioned Chinese medicine preparation by mass percentage in feedstuff, allows the pig free choice feeding.Matched group is injection LIJUNJING injection (production of Tian Bao, Guangdong Province Biology Pharmacy Co., Ltd), intramuscular injection, 5mg of every pig.Result of the test shows that test group is compared with matched group, therapeutic effect significant difference (P＜0.05).Cure rate and total effective rate are 91.7% and 98.3%, and the contrast group exceeds 15.0% and 18.3% respectively.Average every the piglet medical expense contrast group of test group reduces by 0.56 yuan.The test group piglet is after the loose healing of Hakuri, and development condition is good, without rebound phenomenon; And after the matched group piglet cured with LIJUNJING, dysentery still appearred in indivedual piglets.
Embodiment 2
The Radix Pulsatillae 60 grams, Herba Dianthi 30 grams, Cortex Phellodendri 30 grams, Radix Gentianae 18 grams, Foliumet Ramulus Evodiae 30 grams, Radix Sophorae Flavescentis 18 grams, Herba Pogostemonis 12 grams, the Radix Aucklandiae 18 grams and Cortex Fraxini 20 grams are pulverized respectively (the large auspicious electric mechanical equipment company limited in Guangzhou, DXF-20C), cross mix homogeneously behind 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
11-12 month in 2011, carry out the clinical trial of Chinese medicine preparation control yellow and white dysentery of piglet in benevolent moral integrity cultivation base, Sihui City.Prepare the Chinese medicine preparation of control yellow and white dysentery of piglet by above-mentioned prescription, suffer from HUANGBAI(sic) dysentery piglet by 160 of clinical treatments, test group is added 1% above-mentioned Chinese medicine preparation by mass percentage in feedstuff, allows the pig free choice feeding.Matched group is injection LIJUNJING injection (production of Tian Bao, Guangdong Province Biology Pharmacy Co., Ltd), intramuscular injection, 5mg of every pig.Result of the test shows that test group is compared with matched group, therapeutic effect significant difference (P＜0.05).Cure rate and total effective rate are 90.0% and 97.5%, and the contrast group exceeds 21.25% and 22.5% respectively.Average every the piglet medical expense contrast group of test group reduces by 0.68 yuan.The test group piglet is after the loose healing of Hakuri, and development condition is good, without rebound phenomenon; And after the matched group piglet cured with LIJUNJING, dysentery still appearred in indivedual piglets.
Embodiment 3
The Radix Pulsatillae 40 grams, Herba Dianthi 25 grams, Cortex Phellodendri 25 grams, Radix Gentianae 17 grams, Foliumet Ramulus Evodiae 25 grams, Radix Sophorae Flavescentis 17 grams, Herba Pogostemonis 10 grams, the Radix Aucklandiae 17 grams and Cortex Fraxini 18 grams are pulverized respectively (the large auspicious electric mechanical equipment company limited in Guangzhou, DXF-20C), cross mix homogeneously behind 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
7-9 month in 2011, carry out the clinical trial of Chinese medicine preparation control yellow and white dysentery of piglet at sieve home, Lianzhou City agricultural company limited.Prepare the Chinese medicine preparation of control yellow and white dysentery of piglet by above-mentioned prescription, suffer from HUANGBAI(sic) dysentery piglet by 180 of clinical treatments, test group is added 0.5% above-mentioned Chinese medicine preparation by mass percentage in feedstuff, allows the pig free choice feeding.Matched group is injection LIJUNJING injection (production of Tian Bao, Guangdong Province Biology Pharmacy Co., Ltd), intramuscular injection, 5mg of every pig.Result of the test shows that test group is compared with matched group, therapeutic effect significant difference (P＜0.05).Cure rate and total effective rate are 91.1% and 96.7%, and the contrast group exceeds 15.6% and 13.4% respectively.Average every the piglet medical expense contrast group of test group reduces by 0.63 yuan.The test group piglet is after the loose healing of Hakuri, and development condition is good, without rebound phenomenon; And after the matched group piglet cured with LIJUNJING, dysentery still appearred in indivedual piglets.
Above-described embodiment is the better embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (4)
1. a Chinese medicine preparation of preventing and treating yellow and white dysentery of piglet is characterized in that by following constituent: the Radix Pulsatillae 30～60 grams, Herba Dianthi 20～30 grams, Cortex Phellodendri 20～30 grams, Radix Gentianae 16～18 grams, Foliumet Ramulus Evodiae 20～30 grams, Radix Sophorae Flavescentis 16～18 grams, Herba Pogostemonis 8～12 grams, the Radix Aucklandiae 16～18 grams, Cortex Fraxini 16～20 grams.
2. the preparation method of the Chinese medicine preparation of control yellow and white dysentery of piglet claimed in claim 1, it is characterized in that comprising the steps: the Radix Pulsatillae 30～60 grams, Herba Dianthi 20～30 grams, Cortex Phellodendri 20～30 grams, Radix Gentianae 16～18 grams, Foliumet Ramulus Evodiae 20～30 grams, Radix Sophorae Flavescentis 16～18 grams, Herba Pogostemonis 8～12 grams, the Radix Aucklandiae 16～18 grams and Cortex Fraxini 16～20 grams are pulverized respectively, cross mix homogeneously behind 120 mesh sieves, obtain preventing and treating the Chinese medicine preparation of yellow and white dysentery of piglet.
3. the Chinese medicine preparation of control yellow and white dysentery of piglet claimed in claim 1 is applied to prevent and treat yellow and white dysentery of piglet disease.
4. the Chinese medicine preparation of control yellow and white dysentery of piglet according to claim 3 is applied to prevent and treat yellow and white dysentery of piglet disease, when it is characterized in that using, it 0.5%～1% is made an addition in the feedstuff by mass percentage, stirs the feeding piglet.
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Cited By (2)
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| CN104799003A (en) * | 2015-05-18 | 2015-07-29 | 山东新希望六和集团有限公司 | Compound feed for 10-30-day-old piglets and preparing method thereof |
| CN105250726A (en) * | 2015-11-15 | 2016-01-20 | 衡阳市金凤牲猪养殖专业合作社 | Drug for preventing and treating pig scour and preparation method thereof |
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| CN101259171A (en) * | 2008-04-11 | 2008-09-10 | 福建农林大学 | Chinese medicine preparation for preventing pigling's yellow-white dysentery and improving immunity |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104799003A (en) * | 2015-05-18 | 2015-07-29 | 山东新希望六和集团有限公司 | Compound feed for 10-30-day-old piglets and preparing method thereof |
| CN105250726A (en) * | 2015-11-15 | 2016-01-20 | 衡阳市金凤牲猪养殖专业合作社 | Drug for preventing and treating pig scour and preparation method thereof |
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Effective date of registration: 20180323 Address after: 266000 Shandong Province, Qingdao city Chengyang District Tiankang Road No. 1 building 2019 room A Patentee after: Qingdao seashore Taikang Bio Technology Co., Ltd. Address before: 510642 Tianhe District, Guangdong, No. five road, No. 483, Patentee before: South China Agricultural University |
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