CN101433517A - Compound oxytetracycline injection - Google Patents
Compound oxytetracycline injection Download PDFInfo
- Publication number
- CN101433517A CN101433517A CNA2007101501695A CN200710150169A CN101433517A CN 101433517 A CN101433517 A CN 101433517A CN A2007101501695 A CNA2007101501695 A CN A2007101501695A CN 200710150169 A CN200710150169 A CN 200710150169A CN 101433517 A CN101433517 A CN 101433517A
- Authority
- CN
- China
- Prior art keywords
- injection
- oxytetracycline
- kilograms
- liters
- stir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses compound oxytetracycline injection, and belongs to medicine preparation containing organic effective components, or anti-infective medicament for livestock. The injection of each 1, 000 liters is prepared by the following raw materials: 60 to 150 kilograms of aminopyrine, 100 to 250 liters of 95 percent ethanol, 10 to 50 liters of water for injection, 10 to 50 kilograms of magnesium chloride, 100 to 250 kilograms of dimethyl acetamide, 1 to 10 liters of ethanolamine, 50 to 250 kilograms of oxytetracycline, and the balance being propylene glycol. The injection adopts united compound preparation of the oxytetracycline and the aminopyrine, has efficiency and high efficiency for hyperpyrexia caused by pig bacterial infection, treats both symptoms and root causes, has quick effect, does not relapse, and relieves stress reaction of sick livestock body.
Description
Technical field
The present invention relates to contain the pharmaceutical product of organic principle, or the infection veterinary drug, particularly a kind of compound oxytetracycline injection.
Background technology
Hyperpyrexia due to pig bacterial infects is a kind of commonly encountered diseases of pig, can cause that temperature of pig body raises, quantity of food and growth performance etc. are adopted in influence, can cause pig undergrowth and weightening finish, immune function to descend, and marketing period is prolonged.
The main malignant bacteria of pig hyperpyrexia has pasteurellosis bacillus, streptococcus etc., and these antibacterials often present universality on one's body pig and exist, and generally do not cause infection, but under certain conditions, these antibacterials might become pathogenic bacterium and cause that pig infects.
Veterinary clinic is listed the treatment pig bacterial in and is infected the choice drug of the hyperpyrexia that causes usually oxytetracycline (Terramycinum) or aminophenazone medicines such as (Aminopyrinum).
Oxytetracycline belongs to the Tetracyclines broad-spectrum antibiotic, except that being that the positive and negative bacterium have the bacteriostastis to removing from office orchid, chlamydia, mycoplasma (as mycoplasma hyopneumoniae), various rickettsia, spirillum, actinomycetes and some protozoon also have inhibitory action to a certain degree.2.5% tetramycin hydrochloride injection can supply intramuscular injection, is the veterinary drug commonly used of pig infectious disease.
Aminophenazone belongs to the pyrazolone antipyretic analgesic, has rheumatism and antiinflammation, is mainly used in horse, cattle, dog, pig etc. and makes antipyretic and antirheumatic.Its injection is for subcutaneous or intramuscular injection.
Because these antibiotic of prolonged and repeated use and analgesic analgesic drug, make pathogenic microorganism produce tangible Drug resistance, or be easy to have a rebound said medicine, reduced curative effect of medication, and drug residue occurred and exceed standard.
Chinese patent 1843427 discloses " a kind of animal medicinal composition for the treatment of diarrhea ", and it is made by following raw medicaments in portion by weight: Herba Leonuri 15-35 part, Radix Glycyrrhizae 6-26 part, Herba Polygoni Avicularis 20-40 part, Radix Gentianae 15-35 part, Radix Scutellariae 8-28 part, Rhizoma Coptidis 1-8 part, foxtail millet shell 20-40 part, Cortex Phellodendri 20-40 part, Fructus Aurantii 10-30 part, Cortex Fraxini 20-40 part and the 12.5 ten thousand oxytetracycline 1-30 of unit parts.More than each crude drug by the preparation of described weight portion, be milled into and Powderedly mix in pig feed with it, give the pig feeding, after sow is taken, female, piglet dysentery are got the anti-effect of epidemic disease, female, the anti-dysentery ability of piglet strengthens; Have therapeutical effect simultaneously, every day is sooner or later respectively once to the pig feeding during use.
Summary of the invention
The objective of the invention is in order to enlarge the range of choice of pig hyperpyrexia medicine, solve pig bacterial and infect the discomfort that the hyperpyrexia that causes causes, and a kind of compound oxytetracycline injection that can treating both the principal and secondary aspects of a disease is provided.
The present invention realizes by following technical scheme:
A kind of compound oxytetracycline injection, every 1000L injection is made according to the following steps,
A. aminophenazone 60-150kg is put into 95% ethanol, 100-250L, stir 10-25min to clarification;
B. get water for injection 10～50L dissolving magnesium chloride 10～50kg;
C. merge the solution that a, b make, stir, add dimethyl acetylamide 100～250L, ethanolamine 1～10kg successively, oxytetracycline 50-250kg stirs, keep 15-20min, treat that adding propylene glycol to total capacity after the medicinal liquid clarification is that 1000L promptly makes.
Described compound oxytetracycline injection, every 1000L injection is made by following raw material:
Oxytetracycline 50-240kg, aminophenazone 60-140kg, it is 1000L that 95% ethanol, 100-240L, magnesium chloride 10～45kg, ethanolamine 1～9L, dimethyl acetylamide 100～240L, water for injection 10～45L, propylene glycol add to total capacity.
Described compound oxytetracycline injection, every 1000L injection is made by following raw material:
Oxytetracycline 200kg, aminophenazone 100kg, it is 1000L that 95% ethanol 300L, magnesium chloride 30kg, ethanolamine 8L, dimethyl acetylamide 250L, water for injection 30L, propylene glycol add to total capacity.
Advantage of the present invention is: the compound preparation that adopts oxytetracycline, aminophenazone, the hyperpyrexia that infection causes to pig bacterial is effectively also efficient, can alleviate and suffer from poultry health stress, experiment showed, the use of uniting of oxytetracycline and aminophenazone, clinical result of use is strengthened, the energy treating both the principal and secondary aspects of a disease, clinical practice is extensive, can be widely used in pig bacterial and infect the hyperpyrexia that causes, the pig rehabilitation is accelerated.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1:
A. aminophenazone 150kg is put into 95% ethanol 250L, stir 10-25min to clarification.
B. get water for injection 30L dissolving magnesium chloride 50kg;
C. merge the solution that a and b make, stir, add dimethyl acetylamide 300L, ethanolamine 5L, oxytetracycline 80kg stirring and dissolving successively, keep 15-20min, treat that adding propylene glycol to total capacity after medicinal liquid is clarified is 1000L, stir, promptly make a kind of compound oxytetracycline injection.
Embodiment 2:
A. aminophenazone 130kg is put into 95% ethanol 250L, stir 10-25min to clarification.
B. get water for injection 25L dissolving magnesium chloride 40kg;
C. merge the solution that a and b make, stir, add dimethyl acetylamide 250L, ethanolamine 6L, oxytetracycline 100kg stirring and dissolving successively, keep 15-20min, treat that adding propylene glycol to total capacity after medicinal liquid is clarified is 1000L, stir, promptly make a kind of compound oxytetracycline injection.
Embodiment 3:
A. aminophenazone 120kg is put into 95% ethanol 250L, stir 10-25min to clarification.
B. get water for injection 25L dissolving magnesium chloride 35kg;
C. merge the solution that a and b make, stir, add dimethyl acetylamide 220L, ethanolamine 6.5L, oxytetracycline 150kg stirring and dissolving successively, keep 15-20min, treat that adding propylene glycol to total capacity after medicinal liquid is clarified is 1000L, stir, promptly make a kind of compound oxytetracycline injection.
Embodiment 4:
A. take by weighing the 110kg aminophenazone and put into 95% ethanol 200L, stir 10-25min and clarify to solution;
B. get water for injection 20L dissolving magnesium chloride 30kg;
C. merge the solution that a and b make, stir, add dimethyl acetylamide 200L, ethanolamine 7L, oxytetracycline 180kg stirring and dissolving successively, keep 15-20min, treat that adding propylene glycol to total capacity after medicinal liquid is clarified is 1000L, stir, promptly make a kind of compound oxytetracycline injection.
Embodiment 5:
.a. take by weighing the 90kg aminophenazone and put into 95% ethanol 200L, stir 10-25min and clarify to solution;
B. get water for injection 20L dissolving magnesium chloride 25kg;
C. merge the solution that a and b make, stir, add dimethyl acetylamide 180L, ethanolamine 7.5L, oxytetracycline 220kg stirring and dissolving successively, keep 15-20min, treat that adding propylene glycol to total capacity after medicinal liquid is clarified is 1000L, stir, promptly make a kind of compound oxytetracycline injection.
Embodiment 6:
A. take by weighing the 100kg aminophenazone and put into 95% ethanol 200L, stir 10-25min and clarify to solution;
B. get water for injection 20L dissolving magnesium chloride 30kg;
C. merge the solution that a and b make, stir, add dimethyl acetylamide 250L, ethanolamine 8L, oxytetracycline 200kg stirring and dissolving successively, keep 15-20min, treat that adding propylene glycol to total capacity after medicinal liquid is clarified is 1000L, stir, promptly make a kind of compound oxytetracycline injection.
Clinical trial:
1. laboratory animal:
Only 100 of the ill one-tenth of picked at random pigs, body weight is at 40～80kg.
2. experiment medicine:
Compound oxytetracycline injection, our unit's development;
Ursocycline injection, our unit's prepared in laboratory;
Antondin injection (main component is an aminophenazone), our unit's prepared in laboratory.
3 experimental techniques:
Suffer from pig with 100 and be divided into four groups at random by body weight.Wherein one group is the blank group, does not give the medicine treatment; One group for treating with the compound oxytetracycline injection of the embodiment of the invention 6 prescriptions;
Usage: every 1kg body weight is with 0.1～0.15ml, 1 time on the one, logotype 3 days.
Treat with existing medicine, treat every 1kg body weight 10mg, 2 times on the one, logotype 3 days for one group with Ursocycline injection for other two groups; Another group is treated with the antondin injection, every body weight 10ml, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, record trouble poultry health situation of change and dead animal distributed, and treated and added up therapeutic effect after 10 days.
The treatment standard:
Invalid: as after referring to 10 days, to suffer from the poultry symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 10 days, suffer from the poultry symptom and change, the effect before symptom is better than treating.
Cure: after referring to 10 days, transference cure is suffered from poultry and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 10 days, suffer from poultry and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from poultry and does not cure.Its numeral has been included in the invalid and effective numeral.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.See attached list.
Subordinate list
| Numbering | Group | A dead number | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end | The relative weight gain rate % |
| A | Matched group | 20 | — | — | — | — | — |
| B | Ursocycline injection treatment group | 2 | 5 | 20 | 17 | 6 | 52.3 |
| C | Antondin injection for treating group | 10 | 14 | 11 | 2 | 13 | 22.5 |
| D | Treatment group of the present invention | 0 | 1 | 24 | 23 | 2 | 80.0 |
4. conclusion:
This result of the test is analyzed by statistics, and treatment group of the present invention, Ursocycline injection treatment group and antondin injection group and matched group difference is (P＜0.01) extremely significantly.The result shows that curative effect of the present invention is better than existing two kinds of common drugs.
Claims (3)
1. compound oxytetracycline injection is characterized in that every 1000L injection makes according to the following steps,
A. aminophenazone 60-150kg is put into 95% ethanol, 100-250L, stir 10-25min to clarification;
B. get water for injection 10～50L dissolving magnesium chloride 10～50kg;
C. merge the solution that a, b make, stir, add dimethyl acetylamide 100～250kg, ethanolamine 1～10L successively, oxytetracycline 50-250kg stirs, keep 15-20min, treat that adding propylene glycol to total capacity after the medicinal liquid clarification is that 1000L promptly makes.
2. compound oxytetracycline injection according to claim 1 is characterized in that every 1000L injection made by following raw material:
Oxytetracycline 50-240kg, aminophenazone 60-140kg, 95% ethanol, 100-240L,
Magnesium chloride 10～45kg, ethanolamine 1～9L, dimethyl acetylamide 100～240L,
It is 1000L that water for injection 10～45L, propylene glycol add to total capacity.
3. compound oxytetracycline injection according to claim 1 is characterized in that every 1000L injection made by following raw material:
Oxytetracycline 200kg, aminophenazone 100kg, it is 1000L that 95% ethanol 250L, magnesium chloride 30kg, ethanolamine 8L, dimethyl acetylamide 250kg, water for injection 30L, propylene glycol add to total capacity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101501695A CN101433517A (en) | 2007-11-14 | 2007-11-14 | Compound oxytetracycline injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101501695A CN101433517A (en) | 2007-11-14 | 2007-11-14 | Compound oxytetracycline injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101433517A true CN101433517A (en) | 2009-05-20 |
Family
ID=40708259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101501695A Pending CN101433517A (en) | 2007-11-14 | 2007-11-14 | Compound oxytetracycline injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101433517A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653448B (en) * | 2009-09-24 | 2011-07-20 | 陈建波 | Veterinary compound terramycin injection and preparation method thereof |
| CN104667282A (en) * | 2015-02-09 | 2015-06-03 | 华北制药河北华诺有限公司 | Compound oxytetracycline injection and preparation method thereof |
| WO2018070775A1 (en) * | 2016-10-11 | 2018-04-19 | 주식회사 삼양애니팜 | Veterinary composition for suppressing pale soft exudative meat |
| CN108158984A (en) * | 2018-01-24 | 2018-06-15 | 江西博莱大药厂有限公司 | A kind of Terramycin injection for veterinary use and preparation method thereof |
-
2007
- 2007-11-14 CN CNA2007101501695A patent/CN101433517A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653448B (en) * | 2009-09-24 | 2011-07-20 | 陈建波 | Veterinary compound terramycin injection and preparation method thereof |
| CN104667282A (en) * | 2015-02-09 | 2015-06-03 | 华北制药河北华诺有限公司 | Compound oxytetracycline injection and preparation method thereof |
| CN104667282B (en) * | 2015-02-09 | 2017-09-26 | 华北制药集团动物保健品有限责任公司 | A kind of compound oxytetracycline injection and preparation method |
| WO2018070775A1 (en) * | 2016-10-11 | 2018-04-19 | 주식회사 삼양애니팜 | Veterinary composition for suppressing pale soft exudative meat |
| CN108158984A (en) * | 2018-01-24 | 2018-06-15 | 江西博莱大药厂有限公司 | A kind of Terramycin injection for veterinary use and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102524565A (en) | Duck feed | |
| CN101433517A (en) | Compound oxytetracycline injection | |
| CN101543601B (en) | Compound pharmaceutical composition for preventing and curing respiratory diseases in animals and preparation method thereof | |
| CN101698011B (en) | Medicine for treating epidemic diarrhea of livestock and poultry | |
| CN101417018B (en) | Preparation method of animal injection capable of clearing away the heat-evil and expelling superficial evils, cooling blood and relieving dysentery | |
| CN102258635B (en) | Antibacterial Chinese medicine for veterinary use | |
| CN101590019A (en) | Soluble compound doxycycline hyclate powder for animals and preparation method thereof | |
| CN101314016B (en) | Compound andrographis paniculata injection for treating pig hyperpyrexia and preparation method thereof | |
| CN101433518A (en) | Compound ofloxacin injection for animals | |
| CN101297813B (en) | Compound niacin norfloxacin injection for animals and preparation thereof | |
| CN101433543A (en) | Compound mequindox injection | |
| CN101297793A (en) | Injection for curing diarrhea of pig and preparation thereof | |
| CN104523897A (en) | Enteroclysis medicine composition for treating piglet epidemic diarrhea | |
| CN103550226B (en) | Compound sulfamonomethoxine sodium injection as well as preparation method thereof | |
| CN101422477A (en) | Compound apramycin sulfate injection | |
| CN101301274B (en) | Compound mequindox soluble powder for animals and preparation thereof | |
| CN101612118A (en) | Porcine compound astragalus polysaccharide injection and preparation method thereof | |
| CN101297808B (en) | Compound ofloxacin injection for fowl and preparation method thereof | |
| CN101422464A (en) | Compound fubennikao injection | |
| CN101297795B (en) | Compound florfenicol powder for animals and preparation thereof | |
| CN103520699B (en) | A kind of veterinary traditional Chinese medicine antiviral injection and preparation method thereof | |
| CN1246003C (en) | Medicine for treating piglet yellow dysentery or white dysentery and its preparation method | |
| CN101653486A (en) | Compound Bailongsan for treating diarrhoea of nursery pig and preparation method thereof | |
| CN101297794B (en) | Compound kanamycin sulphate injection for dogs and preparation thereof | |
| CN101653597A (en) | Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090520 |