CN101422464A - Compound fubennikao injection - Google Patents
Compound fubennikao injection Download PDFInfo
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- CN101422464A CN101422464A CNA2007101500067A CN200710150006A CN101422464A CN 101422464 A CN101422464 A CN 101422464A CN A2007101500067 A CNA2007101500067 A CN A2007101500067A CN 200710150006 A CN200710150006 A CN 200710150006A CN 101422464 A CN101422464 A CN 101422464A
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- injection
- florfenicol
- doxofylline
- compound
- propylene glycol
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Abstract
The invention discloses a compound florfenicol injection for curing porcine mycoplasmas infection, which belongs to a medical preparation containing effective components, or an anti-infection animal medicament. Every 100L of injection is prepared by the following materials: 5 to 20kg of florfenicol, 10 to 30L of dimethylformamide, 0.5 to 5kg of doxofylline and the rest is propanediol. The invention adopts a compound preparation of florfenicol and doxofylline, which is highly effective to the mycoplasmal pneumonia of swine, reduces the medicament use times, treats both principal and secondary aspects of diseases and eases the stress response of the body of an affected animal. The injection for curing porcine mycoplasmas infection can be broadly applied to the porcine mycoplasmas diseases, relieve the clinical symptoms caused by the infection of the porcine mycoplasmas and increase the weight of the pig.
Description
Technical field
The present invention relates to contain the pharmaceutical product of organic effective ingredient, or the infection veterinary drug, particularly a kind of veterinary compound florfenicol injection.
Background technology
The porcine mycoplasmal pneumonia is a kind of commonly encountered diseases of pig, can cause typicality Respiratory symptoms such as pig cough, asthma, can cause pig undergrowth and rate of body weight gain to descend, and marketing period is prolonged.The porcine mycoplasmal pneumonia is mainly caused by mycoplasma, claims mycoplasma pneumoniae of swine again, and it is popular to be acute fulminant in new epidemic-stricken area, sees chronic or recessive outbreak in old epidemic-stricken area more.Various stressors can impel the generation of porcine mycoplasmal pneumonia or the state of an illness to increase the weight of, and popular extensive.In recent years, often use Macrolide or quinolones as this sick drug of first choice.
Clinical florfenicol commonly used (Florfenicol) claims fluorine first sulfone enzyme element or fluorinated chloramphenicol again, belongs to amide alcohols antibiotic.It has been widely used in veterinary clinic as broad-spectrum antibiotic, is mainly used in intestinal, respiratory tract and urinary tract infection, and stronger anti-mycoplasma effect is arranged.
Doxofylline (Doxofylline) is a kind of bronchodilator, can directly act on bronchus, lax bronchial smooth muscle, thus reach the effect that suppresses asthma.It belongs to theophylline class medicine, is the derivant of methylxanthine.The clinical indication of doxofylline: bronchial asthma, asthmatic bronchitis reach the dyspnea that other bronchitiies cause.
But prolonged and repeated independent use said medicine makes pathogenic microorganism produce Drug resistance to medicine, has reduced curative effect, and drug residue occurs and exceed standard.
Chinese patent 1582909 discloses a kind of " animal-used compound preparation that contains florfenicol ", and other contained in preparation medicine comprises: tylosin class antibiotic, polymyxin class antibiotic, taimulin class antibiotic, nonsteroidal anti-inflammatory drug.But this compound preparation oral administration, also injectable administration, the method administration that also can adopt interior injection of breast or intrauterine to inject; Preparation of the present invention is used to prevent and treat the caused disease of animal gram positive bacterial infection or gram-negative bacterial infections or mycoplasma infection, and preparation of the present invention is especially outstanding to respiratory tract, infection of digestive canal disease and disease effects such as mastitis or metritis.
Summary of the invention
The objective of the invention is to alleviate porcine mycoplasmal and infect cough and the asthma that causes, a kind of compound florfenicol injection of energy treating both the principal and secondary aspects of a disease is provided in order to treat the porcine mycoplasmal pneumonia.
The present invention realizes by following technical scheme:
A kind of compound florfenicol injection, every 100L injection is made by following raw material: florfenicol 5-20kg, dimethyl formamide 10-30L, doxofylline 0.5-5kg, all the other are propylene glycol, during preparation,
A. take by weighing florfenicol 5-20kg and put into dimethyl formamide 10-30L, stir 10-25min to clear and bright;
B. doxofylline 0.5-5kg is put into propylene glycol 10-30L, be heated to 50～60 ℃ and stir 10-25min to clear and bright;
C. merge the solution that a, b make, add propylene glycol again, stir, keep 15-20min, treat promptly to make behind medicinal liquid clear and bright to 100L.
Described compound florfenicol injection, the injection of every 100L is made by following raw material: florfenicol 7-12kg, doxofylline 0.5-2kg, dimethyl formamide 10-25L, propylene glycol add to 100L.
Described compound florfenicol injection, the injection of every 100L is made by following raw material: florfenicol 10kg, doxofylline 1kg, dimethyl formamide 20L, propylene glycol adds to 100L.
Advantage of the present invention is: the compound preparation that adopts antimicrobial drug and bronchodilator to share, effectively also efficient to porcine mycoplasmal, and can obviously alleviate the clinical symptoms that the porcine mycoplasmal infection causes, experimental results show that, the uniting use and can reach satisfactory therapeutic effects of florfenicol and doxofylline, clinical practice is extensive.Improved curative effect, and reduced and drug residue to occur and exceed standard.
The present invention can be widely used in the porcine mycoplasmal disease, reduces porcine mycoplasmal and infects the discomfort that causes, increases the weightening finish of pig.
The specific embodiment
Embodiment 1:
A. take by weighing florfenicol 1.5kg and put into dimethyl formamide 2.5L, stir 10-25min to clear and bright;
B. take by weighing doxofylline 0.2kg and put into the 3L propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clear and bright;
C. merge the solution that a, b make, add propylene glycol again, stir, keep 15-20min, treat that medicinal liquid promptly makes a kind of compound florfenicol injection after clear and bright to 10L.
Embodiment 2:
A. the 1.2kg florfenicol is put into dimethyl formamide 2.2L, stir 10-25min to clarification;
B. get propylene glycol 3L, add the 0.15kg doxofylline, be heated to 50～60 ℃ of stirring and dissolving after;
C. merge the solution that a, b make, add propylene glycol again, stir, keep 15-20min, treat promptly to make a kind of compound florfenicol injection after the clarification of medicinal liquid to 10L.
Embodiment 3:
A. 1.1kg part florfenicol is put into dimethyl formamide 2L, stir 10-25min to clarification;
B. get propylene glycol 3L, add the 0.12kg doxofylline, be heated to 50～60 ℃ of stirring and dissolving after;
C. merge the solution that a, b make, add propylene glycol again, stir, keep 15-20min, treat promptly to make a kind of compound florfenicol injection after the clarification of medicinal liquid to 10L.
Embodiment 4:
A. 0.9kg part florfenicol is put into dimethyl formamide 1.5L, stir 10-25min to clarification;
B. get propylene glycol 3L part, add the 0.08kg doxofylline, be heated to 50～60 ℃ of stirring and dissolving after;
C. merge the solution that a, b make, add propylene glycol again, stir, keep 15-20min, treat promptly to make a kind of compound florfenicol injection after the clarification of medicinal liquid to 10L.
Embodiment 5:
A. the 0.8kg florfenicol is put into dimethyl formamide 1.5L, stir 10-25min to clarification;
B. get propylene glycol 3L, add the 0.15kg doxofylline, be heated to 50～60 ℃ of stirring and dissolving after;
C. merge the solution that a, b make, add propylene glycol again, stir, keep 15-20min, treat promptly to make a kind of compound florfenicol injection after the clarification of medicinal liquid to 10L.
Embodiment 6:
A. the 1kg florfenicol is put into dimethyl formamide 2L, stir 10-25min to clarification;
B. get propylene glycol 3L, add the 0.1kg doxofylline, be heated to 50～60 ℃ of stirring and dissolving after;
C. merge the solution that a, b make, add propylene glycol again, stir, keep 15-20min, treat promptly to make a kind of compound florfenicol injection after the clarification of medicinal liquid to 10L.
Clinical trial:
1. laboratory animal:
Only 100 of the ill one-tenth of picked at random pigs, body weight is at 40～80kg.
2. experiment medicine:
Compound florfenicol injection, our unit's development;
Florfenicol injection, our unit's prepared in laboratory
The doxofylline injection, our unit's prepared in laboratory
3 experimental techniques:
Suffer from pig with 100 and be divided into four groups at random by body weight: wherein one group is the blank group, does not give the medicine treatment; One group of compound florfenicol injection with the embodiment of the invention 6 preparations is treated, is observed;
Usage: intramuscular injection, every 1kg body weight is with 0.1～0.15ml, 1 time on the two, logotype 2 times.
Treat with existing medicine, treat intramuscular injection, every 1kg body weight 20mg, 1 time on the two, logotype 2 times for one group with florfenicol injection for other two groups; Another group is treated with the doxofylline injection, every 1kg body weight 2mg, 2 times on the one, logotype 4 days.
After the treatment beginning, every day, record trouble poultry health situation of change and dead animal distributed, and treated and added up therapeutic effect after 10 days, wherein
Invalid: as after referring to 10 days, to suffer from the poultry symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 10 days, suffer from the poultry symptom and change, the effect before symptom is better than treating.
Cure: after referring to 10 days, transference cure is suffered from poultry and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 10 days, suffer from poultry and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from poultry and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.See attached list.
Subordinate list
| Numbering | Group | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end | The relative weight gain rate % |
| A | Matched group | — | — | — | — | — |
| B | Florfenicol injection treatment group | 4 | 21 | 15 | 10 | 73.2 |
| C | Doxofylline injection for treating group | 4 | 21 | 0 | 25 | 20.5 |
| D | Treatment group of the present invention | 1 | 24 | 23 | 2 | 80.0 |
4. conclusion:
This result of the test is analyzed by statistics, and compound florfenicol injection treatment group, florfenicol injection treatment group and doxofylline injection group and matched group difference is (P＜0.01) extremely significantly.
Curative effect of the present invention is better than existing two kinds of medicines.
Claims (2)
1. compound florfenicol injection is characterized in that every 100L injection made by following raw material:
Florfenicol 5-20kg, dimethyl formamide 10-30L, doxofylline 0.5-5kg, all the other are propylene glycol, during preparation,
A. take by weighing florfenicol 5-20kg and put into dimethyl formamide 10-30L, stir 10-25min to clear and bright;
B. doxofylline 0.5-5kg is put into propylene glycol 10-30L, be heated to 50～60 ℃ and stir 10-25min to clear and bright;
C. merge the solution that a. and b make, add propylene glycol again, stir, keep 15-20min, treat promptly to make behind medicinal liquid clear and bright to 100L.
2. compound florfenicol injection according to claim 1, it is characterized in that the injection of every 100L is made by following raw material: florfenicol 7-12kg, doxofylline 0.5-2kg, dimethyl formamide 10-25L, propylene glycol add to 100L.
3. compound florfenicol injection according to claim 1, it is characterized in that the injection of every 100L is made by following raw material: florfenicol 100kg, doxofylline 1kg, dimethyl formamide 200L, propylene glycol adds to 100L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101500067A CN101422464A (en) | 2007-10-31 | 2007-10-31 | Compound fubennikao injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101500067A CN101422464A (en) | 2007-10-31 | 2007-10-31 | Compound fubennikao injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101422464A true CN101422464A (en) | 2009-05-06 |
Family
ID=40613493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101500067A Pending CN101422464A (en) | 2007-10-31 | 2007-10-31 | Compound fubennikao injection |
Country Status (1)
| Country | Link |
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| CN (1) | CN101422464A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488709A (en) * | 2011-12-28 | 2012-06-13 | 广州市和生堂动物药业有限公司 | Florfenicol-zinc chelate injection and preparation method thereof |
| CN102755337A (en) * | 2012-07-31 | 2012-10-31 | 山东中牧兽药有限公司 | Compound florfenicol injection and preparation method thereof |
-
2007
- 2007-10-31 CN CNA2007101500067A patent/CN101422464A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488709A (en) * | 2011-12-28 | 2012-06-13 | 广州市和生堂动物药业有限公司 | Florfenicol-zinc chelate injection and preparation method thereof |
| CN102488709B (en) * | 2011-12-28 | 2013-10-30 | 广州市和生堂动物药业有限公司 | Florfenicol-zinc chelate injection and preparation method thereof |
| CN102755337A (en) * | 2012-07-31 | 2012-10-31 | 山东中牧兽药有限公司 | Compound florfenicol injection and preparation method thereof |
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Open date: 20090506 |