CN101422476A - Animal compound sodium closantel injection - Google Patents
Animal compound sodium closantel injection Download PDFInfo
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- CN101422476A CN101422476A CNA2007101500086A CN200710150008A CN101422476A CN 101422476 A CN101422476 A CN 101422476A CN A2007101500086 A CNA2007101500086 A CN A2007101500086A CN 200710150008 A CN200710150008 A CN 200710150008A CN 101422476 A CN101422476 A CN 101422476A
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- injection
- closantel
- sodium
- ivermectin
- sheep
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Abstract
The invention discloses a veterinary compound sodium closantel injection which reduces poisoning probability generated when killing the parasites of cows and sheep. The invention belongs to a medical product which contains organic effective components. The preparation method thereof is as follows: 30 to 100kg of sodium closantel is added into 50 to 200L of propanediol, heated to the temperature of 50 to 60 DEG C and stirred for 10 to 25min until the mixture is clear; 1 to 20kg of ivermectin is added into 200L of glycerol formal and stirred for 15 to 20min until the liquid is clear; after the two obtained liquids are combined, the glycerol formal is added to 1000L, stirred uniformly and maintained for 15 to 20min; and after the medicine liquid is clear, the veterinary compound sodium closantel injection is obtained. The invention adopts a compound preparation, is highly effective to the parasites of cows and sheep, can be broadly applied to the parasites of cows and sheep, reduce the infection rate of the parasites and increase the weights of cows and sheep.
Description
Technical field
The present invention relates to a kind of pharmaceutical products that contains organic effective ingredient, as antiparasitic, particularly a kind of animal compound sodium closantel injection.
Background technology
It is the disease that cattle, sheep very easily infect that cattle, sheep parasite infect, and can cause degradation under cattle, sheep undergrowth, the increase of food consumption rate, the resistance.
Cattle, sheep parasite by endoparasites such as, trematodiasis, ascarid, ancylostome, cestode and some vermins as: louse, torsalo maggot, acarid etc. are formed, traditional parasite medicine such as sodium closantel injection and ivermectin injection killed, kill parasite certain limitation is arranged
As closantel sodium (Closantel Sodium) anthelmintic, effectively sick to cattle, Hepar Caprae seu ovis sheet trematodiasis, gastrointestinal tract nematicide and Oestrus ovis, invalid to acarid.
Ivermectin (Streptomyces Avermitilis) anthelmintic is killed effect to gastrointestinal tract nematicide (except the cestode), external arthropod (as louse, acarid etc.), and is invalid to cestode and trematodiasis and protozoacide.
Like this in the body, externally kill parasite need to distinguish medication cumbersome, and the ectoparasite insects medicine of antibody, generally with organophosphor or other insecticides, dosage is grasped and is not with great difficulty caused poisoning, perhaps animal licks health and also can cause poisoning.The antibody endoparasite insecticide also can cause poisoning, and the phenomenon of organophosphate poisoning is also arranged with the ill domestic animal of antibody endoparasite treatment in much carrying out.
Chinese patent 200610014380.X discloses the patent of a kind of " animal compound sodium closantel-abamectin injection and preparation method thereof ", its major technique characteristics are to be raw material with closantel sodium, avilamycin, glycerol formal, phenethanol, propylene glycol, and mix homogeneously is promptly made animal compound sodium closantel-abamectin injection by a certain percentage under certain condition.This compound preparation curative effect is powerful, distoma hepaticum, gastrointestinal tract nematicide and arthropodan larval stage had kill activity fast, clinical practice is extensive, can be in treatment, control cattle, sheep and aspect extensive uses such as other animal liver sheet trematodiasiss, gastrointestinal tract nematicide and sheep magenta.
Summary of the invention
The objective of the invention is in order to enlarge the pest-resistant scope of medicine, reduce the medication number of times, provide a kind of and reduce cattle, take place when sheep is killed parasite the animal compound sodium closantel injection of poisoning probability.
The technical solution used in the present invention is summarized as follows:
A kind of animal compound sodium closantel injection, every 1000L injection is made up of following raw material: closantel sodium 30-100kg, ivermectin 1-20kg, glycerol formal 800～950L, propylene glycol 50-200L.Its preparation method is as follows: (1). and closantel sodium is put into propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification; (2). get glycerol formal 200L, add the ivermectin stirring and dissolving; (3). the glycerol adding formal stirs to 1000L behind the solution that combining step (1) and (2) make, and keeps 15-20min, treats the medicinal liquid clarification, promptly makes
Described animal compound sodium closantel injection, be made up of following raw material in its every 1000L injection: closantel sodium 30-75kg, ivermectin 5-15kg, propylene glycol 70-120L, all the other are glycerol formal.
Described animal compound sodium closantel injection, be made up of following raw material in its every 1000L injection: closantel sodium 50kg, ivermectin 10kg, propylene glycol 100L, all the other are glycerol formal.
Advantage of the present invention is: the present invention adopts compound preparation, make the deficiency of the complementary pest-resistant scope of closantel sodium and ivermectin, effectively also efficient to killing cattle, sheep parasite, increased the parasiticide scope, experimental results show that, the uniting use and can enlarge pest-resistant scope of closantel sodium and ivermectin, clinical practice is extensive, can be widely used in cattle, sheep parasite, the probability that reduces the medication number of times and take place to poison, easy to use, the body weight of increase cattle, sheep.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
1. the 70kg closantel sodium is put into the 150L propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification;
2. get glycerol formal 200L, add 5kg ivermectin stirring and dissolving;
3. the glycerol adding formal stirs to 1000L behind the solution that makes of combining step 1 and step 2, keeps 15-20min, treats promptly to make after the medicinal liquid clarification.
Embodiment 2
1. the 65kg closantel sodium is put into the 130L propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification;
2. get glycerol formal 200L, add 6kg ivermectin stirring and dissolving;
3. the glycerol adding formal stirs to 1000L behind the solution that makes of combining step 1 and step 2, keeps 15-20min, treats promptly to make after the medicinal liquid clarification.
Embodiment 3
1. the 60kg closantel sodium is put into the 100L propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification;
2. get glycerol formal 200L, add 7kg ivermectin stirring and dissolving;
3. the glycerol adding formal stirs to 1000L behind the solution that makes of combining step 1 and step 2, keeps 15-20min, treats promptly to make after the medicinal liquid clarification.
Embodiment 4
1. the 50kg closantel sodium is put into the 100L propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification;
2. get glycerol formal 200L, add 8kg ivermectin stirring and dissolving;
3. the solution glycerol adding formal that makes of combining step 1 and step 2 stirs to 1000L, keeps 15-20min, treats promptly to make after the medicinal liquid clarification.
Embodiment 5
1. the 40kg closantel sodium is put into the 150L propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification;
2. get glycerol formal 200L, add 9kg ivermectin stirring and dissolving;
3. the glycerol adding formal stirs to 1000L behind the solution that makes of combining step 1 and step 2, keeps 15-20min, treats the medicinal liquid clarification, promptly makes.
Embodiment 6
1. the 50kg closantel sodium is put into the 100L propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification;
2. get glycerol formal 200L, add 10kg ivermectin stirring and dissolving;
3. the solution that makes of combining step 1 and step 2 stirs, and keeps 15-20min, treats that medicinal liquid clarification back glycerol adding formal to 1000L, promptly makes.
Clinical trial:
1. laboratory animal:
100 of the ill one-tenth of picked at random cattle, body weight is at 250-500kg.
2. experiment medicine:
The development of compound sodium closantel injection our unit;
Sodium closantel injection our unit prepared in laboratory
Ivermectin injection our unit prepared in laboratory
3 experimental techniques:
Suffer from cattle with 100 and be divided into four groups at random by body weight.Wherein one group is the blank group, does not give the medicine treatment; One group for to treat with No. 6 prescriptions of compound sodium closantel injection of the present invention; Usage: intramuscular injection: every 1kg body weight is with 0.01～0.015ml, and repeated drug taking once after 7 days.Treat with existing medicine for other two groups, treat with sodium closantel injection for one group, intramuscular injection: every 1kg body weight 5mg, repeated drug taking once after 7 days, another group is treated intramuscular injection with ivermectin injection: every 1kg body weight 0.2mg, and repeated drug taking is once after 7 days, treat and add up therapeutic effect after 10 days, wherein
Invalid: after referring to 10 days, suffer from the poultry symptom and do not have obvious change, number of parasites and faecal egg are counted no change or are increased.
Effectively: after referring to 10 days, suffer from the poultry symptom and change, number of parasites and faecal egg number reduce or disappear.
Cure: after referring to 10 days, parasite and faecal egg number disappear.
Symptom is arranged during end: after referring to 10 days, number of parasites and faecal egg number reduce or no change, suffer from poultry and do not cure.Its numeral has been included in the numeral of invalid number and effective number.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
| Numbering | Group | Invalid number | Effective number | Cure a number | Worm's ovum ox head number is arranged during end | The relative weight gain rate % |
| A | Matched group | — | — | — | — | — |
| B | The sodium closantel injection treatment | 5 | 20 | 15 | 10 | 73.2 |
| C | The ivermectin injection treatment | 4 | 21 | 17 | 8 | 71.5 |
| D | The compound sodium closantel injection treatment | 1 | 24 | 23 | 2 | 80.0 |
4. conclusion:
This result of the test is analyzed by statistics, and compound sodium closantel injection treatment group, sodium closantel injection treatment group and ivermectin injection treatment group and matched group difference is (P＜0.01) extremely significantly.Compound sodium closantel injection curative effect of the present invention is better than existing two kinds of medicines.
Claims (3)
1. an animal compound sodium closantel injection is characterized in that every 1000L injection is made up of following raw material: closantel sodium 30-100kg, ivermectin 1-20kg, glycerol formal 800～950L, propylene glycol 50-200L; Its preparation method is as follows: (1). and closantel sodium is put into propylene glycol, be heated to 50～60 ℃ and stir 10-25min to clarification; (2). get glycerol formal 200L, add the ivermectin stirring and dissolving; (3). the glycerol adding formal stirs to 1000L behind the solution that combining step (1) and step (2) make, and keeps 15-20min, treats the medicinal liquid clarification, promptly makes.
2. animal compound sodium closantel injection according to claim 1 is characterized in that every 1000L injection is made up of following raw material: closantel sodium 30-75kg, ivermectin 5-15kg, propylene glycol 70-120L, all the other are glycerol formal.
3. animal compound sodium closantel injection according to claim 1 and 2 is characterized in that every 1000L injection is made up of following raw material: closantel sodium 50kg, ivermectin 10kg, propylene glycol 100L, all the other are glycerol formal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101500086A CN101422476A (en) | 2007-10-31 | 2007-10-31 | Animal compound sodium closantel injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101500086A CN101422476A (en) | 2007-10-31 | 2007-10-31 | Animal compound sodium closantel injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101422476A true CN101422476A (en) | 2009-05-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101500086A Pending CN101422476A (en) | 2007-10-31 | 2007-10-31 | Animal compound sodium closantel injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101422476A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101693009B (en) * | 2009-10-27 | 2010-12-01 | 纽素乐必佳（天津）药业集团有限公司 | Antiparasitic closantel sodium transdermal solution for ox and sheep and preparation method thereof |
| CN105412135A (en) * | 2015-12-03 | 2016-03-23 | 重庆布尔动物药业有限公司 | Compound closantel sodium ivermectin injection liquid for veterinary use |
-
2007
- 2007-10-31 CN CNA2007101500086A patent/CN101422476A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101693009B (en) * | 2009-10-27 | 2010-12-01 | 纽素乐必佳（天津）药业集团有限公司 | Antiparasitic closantel sodium transdermal solution for ox and sheep and preparation method thereof |
| CN105412135A (en) * | 2015-12-03 | 2016-03-23 | 重庆布尔动物药业有限公司 | Compound closantel sodium ivermectin injection liquid for veterinary use |
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Open date: 20090506 |