CN1246003C - Medicine for treating piglet yellow dysentery or white dysentery and its preparation method - Google Patents
Medicine for treating piglet yellow dysentery or white dysentery and its preparation method Download PDFInfo
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- CN1246003C CN1246003C CN 200310104036 CN200310104036A CN1246003C CN 1246003 C CN1246003 C CN 1246003C CN 200310104036 CN200310104036 CN 200310104036 CN 200310104036 A CN200310104036 A CN 200310104036A CN 1246003 C CN1246003 C CN 1246003C
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Abstract
The present invention discloses medicine for treating piglet yellow dysentery and white dysentery, which is mainly prepared from ash bark and pink herb according to a certain proportion by weight. The present invention can be prepared into a usual orally taking dose form. The medicine of the present invention has the effects of resisting bacteria, relieving inflammation, stopping pain, clearing heat and dampness, cooling blood for hemostasis, seeping dampness, promoting diuresis, etc. When the present invention is used for treating piglet yellow dysentery and white dysentery, the present invention has significant effect and high healing rate.
Description
Affiliated technical field
The present invention relates to a kind of medicine for the treatment of yellow scour of piglet, Hakuri and preparation method thereof, belong to Chinese veterinarian's field of medicaments.
Background technology
Yellow scour of piglet, piglet pujos blancos, promptly colibacillosis of piglet is the modal a kind of acute infectious disease of suckling pig, particularly the piglet morbidity in 1～2 age in week is maximum, the mortality rate height, the provisions swine rearing already brings serious harm.The medicine of this disease of treatment has two classes at present, and a class is a broad-spectrum antibiotic, as chloromycetin, furans or sulfa drugs; Another kind of is Chinese medicines such as Radix Pulsatillae Decoction, oral Bulbus Allii tincture.Above-mentioned two class medicines all have certain curative effect to yellow scour of piglet, Hakuri.
Have with broad-spectrum antiseptic extract for treating yellow scour of piglet, Hakuri existing questions, one is to use the improper dysbacteriosis that very easily forms; The 2nd, chloromycetin, furans and sulfa drugs all have toxic and side effects, seriously disorderly as chloromycetin drug use amount and the bad treatment back piglet hematopoietic function that will cause of administration time grasp, with having found to cause piglet hemopoietic system functional disorder after the sulfa drugs treatment, sulfamethoxypyridazine as 300～500mg/kg dosage can produce poisoning symptom in short-term, the urinary tract obstacle after using, some sulfonamides can take place (as crystalluria, hematuria, urinary tract obstruction etc.) secondary disease, can vomit after the furans injection, stomachache, gastrointestinal hemorrhage, have a liking for Yihong hematocytosis, and the vision disorder, peripheral neuritis, untoward reaction such as sensitization; The 2nd, generally higher with the broad-spectrum antibiotic drug price for numerous peasants and herdsmen, treat yellow scour of piglet, Hakuri cost height with it, be difficult to apply.
With Radix Pulsatillae Decoction commonly used, oral Bulbus Allii tincture treatment yellow scour of piglet, Hakuri certain curative effect is arranged, but cure rate is lower, only is 60～70%.In addition, treat yellow scour of piglet with Chinese medicine preparation, Hakuri also has many pieces of research reports, these reports sporadically appear in " Chinese veterinarian's medicine " magazine that Chinese Veterinarian Inst., Chinese Academy of Sciences publishes more, as " folk prescription treatment piglet pujos blancos " (" Chinese veterinarian's medicine " magazine, 1993, (1): 24), " loose eucalyptus globulus liquid treatment piglet pujos blancos " (" Chinese veterinarian's medicine " magazine, 1990, (4): 7), " yellow and white dysentery of piglet curative effect " (" Chinese veterinarian's medicine " magazine, 1993, (1): 11), " clinical observation of 654-2 treatment yellow scour of piglet disease " (" Chinese veterinarian's medicine " magazine, 1991, (2): 32) etc., but all have the lower defective of cure rate.
Summary of the invention
Therefore, people need be with a kind of Chinese medicine preparation treatment yellow scour of piglet, Hakuri disease with high curative rate more.Up to now, also do not find the report of any relevant pharmaceutical composition of the present invention.The present inventor is through research repeatedly, and the checking repeatedly by the treatment of animal experiment and piglet, found Chinese veterinarian's medicine endo-medicine that the treatment of better curative effect yellow scour of piglet, Hakuri are arranged finally, thereby finished the present invention.
Purpose of the present invention just provides Chinese veterinarian's medical composition of the high treatment yellow scour of piglet of a kind of instant effect cure rate, Hakuri.
Another object of the present invention has provided the preparation method of this Chinese veterinarian's medical composition.
Medicine of the present invention selects Cortex Fraxini, Herba Dianthi to make up, and makes each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat yellow scour of piglet, Hakuri.Wherein selecting Cortex Fraxini for use is because of Cortex Fraxini nature and flavor bitter cold, heat clearing and damp drying, and main hematodiarrhoea is heavy down.Selecting Herba Dianthi for use is because of Herba Dianthi nature and flavor bitter cold, clearing away heat and promoting diuresis, and removing blood stasis stimulates the menstrual flow, and sharp small intestinal cures mainly edema, urinates hot puckery pain, stranguria with blood.
The consumption of drug component of the present invention is also summed up through inventor's long-felt and is drawn, and each amounts of components is for all to have curative effect preferably in the following weight parts scope:
10～25 parts of Cortex Fraxinis, 4～12 parts of Herba Dianthis.
Be preferably: 20 parts of Cortex Fraxinis, 8 parts of Herba Dianthis.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.For example these crude drug can be ground into the powder mix homogeneously and make powder, directly admix feedstuff and feed; These crude drug decocting together can be become decoction, gavage or directly admix feedstuff and feed; Also these crude drug can be soaked, get its supernatant distillation and make oral liquid, gavage or directly admix feedstuff and feed.But these can not be used to limit protection scope of the present invention.
Medicine of the present invention can be made into decoction, powder or oral liquid, and its preparation method is as follows:
It comprises the steps: a) to take by weighing each crude drug Cortex Fraxini, Herba Dianthi decoction, and is standby; B) Cortex Fraxini, the Herba Dianthi of described weight proportion are soaked, decocted, filter, make the decoction of medicine of the present invention.
It comprises the steps: a) to take by weighing each crude drug Cortex Fraxini, Herba Dianthi powder, and is standby; B) Cortex Fraxini, the Herba Dianthi with described weight proportion is ground into the powder shape, sterilizes, and promptly makes the powder of medicine of the present invention.
It comprises the steps: a) to take by weighing each crude drug Cortex Fraxini, Herba Dianthi oral liquid, and is standby; B) Cortex Fraxini, the Herba Dianthi of described weight proportion are soaked 10～24h, get its supernatant, distillation is sterilized, and promptly makes the oral liquid of medicine of the present invention.
Medicine of the present invention has functions such as anti-inflammation, analgesia, eliminating damp-heat, cooling blood for hemostasis, eliminating dampness and diuresis, treatment yellow scour of piglet, Hakuri instant effect cure rate height.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by testing example, these experimental examples have comprised that the pharmacodynamics test of medicine of the present invention and clinical observation on the therapeutic effect test.
Test material: medicine of the present invention is equivalent to described crude drug 1g for every milliliter, through 1.5 pounds, 30min autoclaving; Swine escherichia coli K88 is provided by the Sichuan institute of raising pigs; Experimental animal Kunming kind white mice, wistsar kind rat are provided by the West China Experimental Animal Center; Dual-trace recorder.
The clinical efficacy test of (test example 1) medicine of the present invention
The clinical efficacy standard: the clinical symptom disappearance in three days of fully recovering, character such as stool colour and appetite are normal; Clinical symptom disappearance in effective three days, feces character etc. are normal, and it is relatively poor that appetite is recovered; Clinical symptoms does not disappear in invalid three days, and appetite is poor, and the state of an illness continues development and dead.
Clinical treatment method: yellow scour of piglet treatment piglet (1～7 age in days) row's allusion quotation or yellow-white loose stool, wherein contain the curdling piece, examine and be yellow scour of piglet (treatment refers to disease), divide two kinds of method dispensings, first method is given the sow dispensing of sick pig, every sow total amount 500ml (every ml is equivalent to crude drug 1g) divides clothes 3～5 times, every day 2 times.Piglet pujos blancos is treated the white or canescence loose stool of piglet (in the monthly age) milk ejection, examines to be piglet pujos blancos, and medication administration method is treated with yellow scour of piglet.
In the peasant household on ground such as stone river township, Rongchang County, Sichuan Province, Wucheng township, Shuan He township, Luding County Tian Ba township, Lip river, Shiqu County Xu Zhen and Shuangliu County He Lin township, consonance township, use medicine of the present invention to treat and observation of curative effect, the results are shown in Table 1.To morbidity in 3 families former years, prevented administration not see that the not statistics of morbidity goes into table on the same day in puerperal then.
Table 1 curative effect of medication statistics of the present invention
| Group | Case (number) | Curative effect (%) | ||||
| Sum | Sow | Piglet | Effective percentage | Cure rate | Inefficiency | |
| The Hakuri group | 348 | 108 | 240 | 100 | 100 | 0 |
| The yellow scours group | 179 | 32 | 147 | 99.44 | 98.88 | 0.56 |
Result of the test shows: medicine of the present invention has very definite and significant clinical efficacy, treatment piglet pujos blancos 348 examples, cure rate 100%, treatment yellow scour of piglet 179 examples, cure rate 98.8%.
The bacteriostatic test of (test example 2) medicine of the present invention
Medicinal liquid adopts serial dilution, the nutrient broth of 9,000 ten thousand swine escherichia coli K88 of every milliliter of bacteria containing amount, continuous culture 24h in 37 ℃, test is provided with medicine I group of the present invention, medicine II of the present invention group, and be provided with feminine gender (not dosing does not add bacterium) and positive (not dosing adds bacterium) contrast.
The results are shown in Table 2, the antibacterial II group of test tube is better than the I group.
Table 2 medicine of the present invention is to the influence of swine escherichia coli K88
| Group | Do not add bacterium | 1/10 | 1/20 | 1/40 | 1/80 | 1/160 | 1/320 | 1/640 | 1/1280 | Not dosing |
| The I group | - | - | - | - | - | - | - | + | + | + |
| The II group | - | - | - | - | - | - | - | - | - | + |
Annotate: "-" be not for having bacterial growth in the test tube in the table;
"+" has bacterial growth in the test tube.
Result of the test shows: medicine of the present invention has inhibition and bactericidal action preferably to the pathogenic bacterium that cause yellow scour of piglet, Hakuri, with 0.3125 * 10
-2The medicine oral liquid of the present invention of concentration is to every milliliter of 9,000 ten thousand swine escherichia coli K
88Suppress fully.
(test example 3) medicine of the present invention is to the influence test of the myenteron that exsomatizes
Successively get 5 rabbit about body weight 1.8kg, get from 15 centimetres of duodenums and do specimen for 2 centimetres with jejunum far away, about 37 ℃ of constant temperature, tyrode's solution pH about 7, with concentration 0.3%,
Other is measured with dual-trace recorder with conventional.
Get on an empty stomach exsomatize 40 sections of myenterons of the healthy rabbits behind the 12h of Different Individual, observing medicine of the present invention influences it, the results are shown in Table 3, table 4.
Table 3 medicine of the present invention is to the influence of the myenteron that exsomatizes
| Group | Before the administration | After the administration | ||||
| Amplitude (mm) | Frequency (inferior/min) | Amplitude (mm) | ↑ or ↓ (%) | Frequency (inferior/min) | Suppress (%) | |
| The I group | 25.66 | 17 | 42.5 | 34.7 | 13 | 23.53 |
| The II group | 31 | 12 | 23.2 | 25.16 | 10 | 16.68 |
Annotate: 1. each numerical value is 20 averages of measuring number in the table; 2. amplitude refers to shrinkage amplitude, and frequency refers to contraction frequency; 3. " ↑ " refers to increase or is excited; " ↓ " refers to reduce or suppress.
Table 4 medicine is to the pharmaceutically-active influence of the present invention
| Before the administration | Order of administration | The result | ||||
| Amplitude (mm) | Frequency (inferior/min) | Amplitude (mm) | ↑ or ↓ (%) | Frequency (inferior/min) | ↑ or ↓ (%) | |
| 21 | 15 | The Qin → Ah → Ah | 2325 | ↑8 * | 1415 | ↓6 * |
| 32 | 17.5 | The Qin → ACh | 39 | ↑21.875 | 13 | ↓25.7 |
| 38 | 13 | ACh → Qin | 16 | ↑57.89 | 13 | 0 |
| 32 | 16 | The Qin → benzene | 17 | ↑46.875 | 14 | ↓12.5 |
| 33 | 15 | Benzene → Qin | 16 | ↑51.51 | 13 | ↓13.3 |
Annotate: before 1. showing in the medicine order behind first medicine second medicine before the administration; Except that " * " P＞0.05, be P＜0.05;
2. each number is the average of 10 numbers in the table, and other illustrates with table 3;
3. in the table, " Qin " represents medicine of the present invention; " Ah " represents atropine; " benzene " represents diphenhydramine; " Ach " represents acetylcholine.
Result of the test shows: 3% medicine oral liquid of the present invention has certain influence to the isolated rabbit myenteron, myenteron under the excitatory state there is the obvious suppression effect, its shrinkage amplitude suppression ratio 25.16%, its frequency suppression ratio 16.86%, to the myenteron under the inhibitory state, occur after the administration producing contractility enhancing 10%～60% after the of short duration inhibition, frequency but slows down about 23.6%, and acetylcholine and atropine are very weak to its function influence.
The animal toleration and the toxic reaction test of (test example 4) medicine of the present invention
Carry out LD50 mensuration with white mice (1m1 contains the medicinal liquid of crude drug 2g) and do not see death, then measure toleration and the toxic reaction of animal.Adopt 10 of Kunming kind white mice, male and female half and half are irritated stomach 7.6 * 10 every day
4Mg/kgbw adopts 10 of wistsar kind rat, and is male, irritates stomach 1.5 * 10 every day
4Mg/kgbw, successive administration 7 days.
Continuous use 7 days only occurring calm phenomenon after the administration first time about 0.5h, recovers about 20min, and all the other do not see toxic reaction and death, but sees the phenomenon that dispensing back appetite strengthens, feed intake increases.
Above-mentioned result of the test shows that medicine of the present invention has very definite and significant clinical efficacy, treatment piglet pujos blancos 348 examples, cure rate 100%, treatment yellow scour of piglet 179 examples, cure rate 98.8%, and do not see drug resistance and toxicity, the pathogenic bacterium that cause yellow scour of piglet, Hakuri there are inhibition and bactericidal action, effect is better than externally in the medicine I wherein of the present invention group body, and this medicine galactopoiesis still has bacteriostasis, and is more valuable to yellow scour of piglet treatment and prevention yellow, Hakuri.After medicine of the present invention made myenteron present earlier slightly inhibition in short-term, it is complete that it shrinks reinforcement diastole, the rhythm and pace of moving things arranged and frequency deceleration.Its shrinks the effect of myenteron, be subjected to atropinic influence very weak, but can be cloudy disconnected by diphenhydramine, formerly add acetylcholine and add this medicine again, myenteron presents obvious suppression.Disclose these effects and be its composition such as several bark glycosides that contain tannin, Coumarins direct effect and may the indirect action receptor due to.Finding that in its tolerance test it can also appetite stimulator, improve feed intake, is very favourable for therapeutical effect.
Come further to set forth medicine of the present invention and preparation method thereof by the following examples.
The preparation of (embodiment 1) medicine decoction of the present invention
A) take by weighing each crude drug Cortex Fraxini 100g, Herba Dianthi 120g, standby;
B) above-mentioned Cortex Fraxini, Herba Dianthi were soaked 5～8 minutes, decoct with water twice, each amount of water was not advisable to have powder, merged decocting liquid twice, filtered, and made the decoction of medicine of the present invention.The decoction container, is avoided and is used ironware for well with marmite, enamel ware, uses low baking temperature instead after boiling, in order to avoid too fast boiling dry.
Prepared decoction is equivalent to crude drug 1 gram for every milliliter.
During treatment, by gavaging or admix the indirect administration of sow of feeding behind the feedstuff.As directly gavaging piglet, every day twice, every each 3～6ml of piglet must use balling iron when gavaging piglet, and must guard against the medicine meter is poured in the trachea, avoids causing easy rerum natura pneumonia.
The preparation of (embodiment 2) drug powder of the present invention
A) take by weighing each crude drug Cortex Fraxini 200g, Herba Dianthi 80g, standby;
B) above-mentioned Cortex Fraxini, Herba Dianthi are ground into the powder shape, granularity is 300 orders, sterilizes, and promptly makes the powder of medicine of the present invention.
During treatment,, every day 2 times, admix feedstuff by every each 3～6g of piglet by admixing the indirect administration of sow of feeding behind the feedstuff.
The preparation of (embodiment 3) medicine oral liquid of the present invention
A) take by weighing each crude drug Cortex Fraxini 250g, Herba Dianthi 40g, standby;
B) above-mentioned Cortex Fraxini, Herba Dianthi are added twice water logging bubble 15h, get its supernatant, distillation is sterilized, and promptly makes the oral liquid of medicine of the present invention.
Prepared oral liquid is equivalent to crude drug 1 gram for every milliliter.
During treatment, by gavaging or admix the indirect administration of sow of feeding behind the feedstuff.As directly gavaging piglet, every day twice, every each 3～6ml of piglet must use balling iron when gavaging piglet, and must guard against the medicine meter is poured in the trachea, avoids causing easy rerum natura pneumonia; As by admixing the indirect administration of sow of feeding behind the feedstuff, every day 2 times, admix feedstuff by every each 3～6ml of piglet.
Claims (9)
1, a kind of medicine for the treatment of yellow scour of piglet, Hakuri, it is characterized in that: it is made by following bulk drugs: 10～25 parts of Cortex Fraxinis, 4～12 parts of Herba Dianthis.
2, medicine according to claim 1 is characterized in that: it is made by following bulk drugs: 20 parts of Cortex Fraxinis, 8 parts of Herba Dianthis.
3, the preparation method of claim 1 or 2 described medicines, it comprises the steps:
A) take by weighing each crude drug Cortex Fraxini, Herba Dianthi, standby;
B) Cortex Fraxini, the Herba Dianthi of described weight proportion are soaked, decocted, filter, make the decoction of medicine of the present invention.
4, preparation method according to claim 3 is characterized in that: the decoction in the described step b) is for decocting with water twice, and each amount of water was not advisable to have powder, and merged decocting liquid twice.
5, according to claim 3 or 4 described preparation methoies, it is characterized in that: prepared decoction is equivalent to described crude drug 1 gram for every milliliter.
6, the preparation method of claim 1 or 2 described medicines, it comprises the steps:
A) take by weighing each crude drug Cortex Fraxini, Herba Dianthi, standby;
B) Cortex Fraxini, the Herba Dianthi with described weight proportion is ground into the powder shape, sterilizes, and promptly makes the powder of medicine of the present invention.
7, preparation method according to claim 6 is characterized in that: the granularity that Cortex Fraxini, Herba Dianthi are pulverized in the described step b) is 200～400 orders.
8, the preparation method of claim 1 or 2 described medicines, it comprises the steps:
A) take by weighing each crude drug Cortex Fraxini, Herba Dianthi, standby;
B) Cortex Fraxini, the Herba Dianthi of described weight proportion are soaked 10～24h, get its supernatant, distillation is sterilized, and promptly makes the oral liquid of medicine of the present invention.
9, preparation method according to claim 8 is characterized in that: prepared oral liquid is equivalent to described crude drug 1 gram for every milliliter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310104036 CN1246003C (en) | 2003-12-17 | 2003-12-17 | Medicine for treating piglet yellow dysentery or white dysentery and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310104036 CN1246003C (en) | 2003-12-17 | 2003-12-17 | Medicine for treating piglet yellow dysentery or white dysentery and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1546071A CN1546071A (en) | 2004-11-17 |
| CN1246003C true CN1246003C (en) | 2006-03-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310104036 Expired - Fee Related CN1246003C (en) | 2003-12-17 | 2003-12-17 | Medicine for treating piglet yellow dysentery or white dysentery and its preparation method |
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| CN (1) | CN1246003C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142755B (en) * | 2013-03-28 | 2014-05-07 | 重庆市畜牧科学院 | Synbiotic traditional Chinese medicine composite for preventing and treating yellow scour of piglets as well as preparation method of composite |
| CN105030913B (en) * | 2015-07-24 | 2018-06-29 | 成都乾坤动物药业股份有限公司 | A kind of composition for treating piglet yellow-white dysentery and preparation, preparation method, application |
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