CN101606941A - Be used for the treatment of injection of dog Nocard's bacillus infection and preparation method thereof - Google Patents
Be used for the treatment of injection of dog Nocard's bacillus infection and preparation method thereof Download PDFInfo
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- CN101606941A CN101606941A CNA200910304748XA CN200910304748A CN101606941A CN 101606941 A CN101606941 A CN 101606941A CN A200910304748X A CNA200910304748X A CN A200910304748XA CN 200910304748 A CN200910304748 A CN 200910304748A CN 101606941 A CN101606941 A CN 101606941A
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Abstract
The invention discloses a kind of dog Nocard's bacillus that is used for the treatment of and infect injection and preparation method thereof, aim to provide a kind of instant effect that the dog Nocard's bacillus infects for the treatment of, treating both the principal and secondary aspects of a disease reduces injection of medication number of times and preparation method thereof.Every 100L injection comprises: sulfameter sodium 2～15kg, trimethoprim 0.4～3kg, aminophenazone 2～15kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.It is antibacterial that injection of the present invention adopts sulfameter sodium, the glucocorticoid dexamethasone sodium phosphate that cooperates the agent of sulfonamides special synergistic, antipyretic aminophenazone, promotion digestive tract power carbamylcholine chloride, anti inflammatory detoxication, the clinical symptoms of killing pathogenic bacteria, the performance of the sick dog of treatment fast, recovery is searched for food, help rehabilitation, easy to use.
Description
Technical field
The present invention relates to a kind of compound sulfonamide of dog Nocard's bacillus infection that is used for the treatment of to Sulfamonomethoxine sodium injection and preparation method thereof.
Background technology
It is the dog commonly encountered diseases that Nocard's bacillus infects, and sick dog mainly shows as fervescence, and inappetence or anorexia and performance have respiratory symptom, goes back exhibit tissue suppuration, necrosis.Sick dog is difficult for curing, and often causes death because of other diseases appear in side reaction.
At present, the medicine that treatment dog Nocard's bacillus infects usually can not be omnibearing at disease, a lot of formulation products can only be at a kind of symptom, support medication and treatment occurs and postpone or can not treat fully comprehensively of dog person or veterinary Chang Yin, and the several formulations product uses inconvenient, and provisions dog person or veterinary make troubles.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provides a kind of dog Nocard's bacillus of can treating to infect instant effect, and medication is convenient, the dog for the treatment of both the principal and secondary aspects of a disease with compound sulfonamide to the Sulfamonomethoxine sodium injection.
It is simple that another object of the present invention provides a kind of technology, and easily the above-mentioned dog of realizing is with the preparation method of compound sulfonamide to the Sulfamonomethoxine sodium injection.
The present invention is achieved through the following technical solutions:
A kind of injection that is used for the treatment of the infection of dog Nocard's bacillus, it is characterized in that the consisting of of every 100L injection: the consisting of of every 100L injection: sulfameter sodium 2～15kg, trimethoprim 0.4～3kg, aminophenazone 2～15kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
A kind of preparation method that is used for the treatment of the injection of dog Nocard's bacillus infection is characterized in that, comprises the steps:
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 2～15kg, be stirred to whole dissolvings.
(2) get dimethyl acetylamide 20kg and be heated to 60～80 ℃ of dissolving trimethoprim 0.4～3kg, after the trimethoprim dissolving, add aminophenazone 2～15kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir.
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg.
(4) combining step (1), step (2) and the prepared solution of step (3), replenishing water for injection to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.0～11.0 and promptly got the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
The preferable of wherein every 100L injection consists of: sulfameter sodium 5～12kg, trimethoprim 1～2.4kg, aminophenazone 5～10kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
The best group of every 100L injection becomes: sulfameter sodium 10kg, trimethoprim 2kg, aminophenazone 7kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
The present invention has following technique effect:
Injection of the present invention is a compound preparation, adopting sulfameter sodium is antimicrobial component, cooperate sulfonamides special synergistic agent trimethoprim, its antibacterial effect is strengthened greatly, cooperate antipyretic aminophenazone, the carbamylcholine chloride that promotes digestive tract power, the glucocorticoid dexamethasone sodium phosphate of anti inflammatory detoxication, the clinical symptoms of killing pathogenic bacteria, the sick dog performance of treatment is recovered to search for food fast, improve condition, help rehabilitation.Treatment dog Nocard's bacillus infects instant effect, treating both the principal and secondary aspects of a disease, and also compound preparation of the present invention is an injection, medication is convenient.
Dog of the present invention is simple to the preparation method technology of Sulfamonomethoxine sodium injection with compound sulfonamide, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 2kg, be stirred to whole dissolvings.
(2) get dimethyl acetylamide 20kg, be heated to 60～80 ℃ of dissolving trimethoprim 0.4kg, after the trimethoprim dissolving, add aminophenazone 15kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir.
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.25 and promptly get the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
Embodiment 2
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 15kg, be stirred to whole dissolvings.
(2) get dimethyl acetylamide 20kg, be heated to 60～80 ℃ of dissolving trimethoprim 3kg, after the trimethoprim dissolving, add aminophenazone 2kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir.
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.32 and promptly get the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
Embodiment 3
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 5kg, be stirred to whole dissolvings.
(2) get dimethyl acetylamide 20kg, be heated to 60～80 ℃ of dissolving trimethoprim 1kg, after the trimethoprim dissolving, add aminophenazone 10kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir.
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.55 and promptly get the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
Embodiment 4
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 12kg, be stirred to whole dissolvings.
(2) get dimethyl acetylamide 20kg, be heated to 60～80 ℃ of dissolving trimethoprim 2.4kg, after the trimethoprim dissolving, add aminophenazone 5kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir.
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.33 and promptly get the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
Embodiment 5
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 8kg, be stirred to whole dissolvings.
(2) get dimethyl acetylamide 20kg, be heated to 60～80 ℃ of dissolving trimethoprim 1.6kg, after the trimethoprim dissolving, add aminophenazone 9kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir.
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.52 and promptly get the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
Embodiment 6
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 10kg, be stirred to whole dissolvings.
(2) get dimethyl acetylamide 20kg, be heated to 60～80 ℃ of dissolving trimethoprim 2kg, after the trimethoprim dissolving, add aminophenazone 7kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir.
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.62 and promptly get the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
Clinical trial:
1. laboratory animal:
100 of the ill one-tenth of picked at random dogs.
2. experiment medicine:
The injection our unit development that is used for the treatment of the infection of dog Nocard's bacillus of the embodiment of the invention 6 preparations;
10% sulfameter sodium injection our unit prepared in laboratory;
7% aminophenazone injection our unit prepared in laboratory.
3. experimental technique:
Suffer from dog with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% sulfameter sodium injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 5 days.
The C group is treated usage with 7% aminophenazone injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 5 days.
The D group is treated usage with the injection that is used for the treatment of the infection of dog Nocard's bacillus of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, the distribution of dog health situation of change suffered from record, and treat after the 7th day and add up therapeutic effect, wherein:
Invalid: as after referring to 7 days, to suffer from the dog symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the dog symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from dog and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from dog and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from dog and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.Wherein, the medicine that C group data representation just takes stopgap measures can be brought down a fever expression effectively, but can not be treated disease itself.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the injection for treating group, 10% sulfameter sodium injection treatment group and the 7% aminophenazone injection group that are used for the treatment of the Nocard's bacillus infection of the embodiment of the invention 6 and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | The symptom number of elements is arranged during end | Dead number of elements |
| ??A | Matched group | ??25 | ??0 | ??0 | ??15 | ??10 |
| ??B | The treatment of 10% sulfameter sodium injection | ??10 | ??15 | ??12 | ??10 | ??3 |
| ??C | 7% aminophenazone injection for treating | ??0 | ??25 | ??0 | ??15 | ??10 |
| ??D | The injection for treating that is used for the treatment of the infection of dog Nocard's bacillus of the embodiment of the invention 6 | ??2 | ??23 | ??21 | ??2 | ??2 |
Claims (6)
1. one kind is used for the treatment of the injection that the dog Nocard's bacillus infects, and it is characterized in that the consisting of of every 100L injection: sulfameter sodium 2～15kg, trimethoprim 0.4～3kg, aminophenazone 2～15kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
2. according to claim 1ly be used for the treatment of the injection that the dog Nocard's bacillus infects, it is characterized in that, the consisting of of every 100L injection: sulfameter sodium 5～12kg, trimethoprim 1～2.4kg, aminophenazone 5～10kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
3. according to claim 1ly be used for the injection that the dog Nocard's bacillus infects, it is characterized in that, the consisting of of every 100L injection: sulfameter sodium 10kg, trimethoprim 2kg, aminophenazone 7kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
4. the described preparation method that is used for the treatment of the compound sulfonamide of dog Nocard's bacillus infection to the Sulfamonomethoxine sodium injection of claim 1 is characterized in that, comprises the steps:
(1) gets water for injection 30L, behind dissolving EDTA-2Na 0.01kg, the sodium sulfite 0.2kg, add sulfameter sodium 2～15kg, be stirred to whole dissolvings;
(2) get dimethyl acetylamide 20kg and be heated to 60～80 ℃ of dissolving trimethoprim 0.4～3kg, after the trimethoprim dissolving, add aminophenazone 2～15kg again, after the aminophenazone dissolving, add propylene glycol 20kg, 95% ethanol 10kg again, stir;
(3) get water for injection 1L, dissolving carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg;
(4) combining step (1), step (2) and the prepared solution of step (3), replenishing water for injection to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 10.0～11.0 and promptly got the injection that is used for the treatment of the infection of dog Nocard's bacillus of the present invention with mass percent concentration.
5. according to claim 4ly be used for the treatment of compound sulfonamide that the dog Nocard's bacillus infects, it is characterized in that, the consisting of of every 100L injection: sulfameter sodium 5～12kg the Sulfamonomethoxine sodium injection, trimethoprim 1～2.4kg, aminophenazone 5～10kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
6. the compound sulfonamide of dog Nocard's bacillus infection that is used for according to claim 4 is to the Sulfamonomethoxine sodium injection, it is characterized in that the consisting of of every 100L injection: sulfameter sodium 10kg, trimethoprim 2kg, aminophenazone 7kg, carbamylcholine chloride 0.05kg, dexamethasone sodium phosphate 0.05kg, EDTA-2Na 0.01kg, sodium sulfite 0.2kg, dimethyl acetylamide 20kg, propylene glycol 20kg, 95% ethanol 10kg, surplus is a water for injection.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200910304748XA CN101606941A (en) | 2009-07-23 | 2009-07-23 | Be used for the treatment of injection of dog Nocard's bacillus infection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200910304748XA CN101606941A (en) | 2009-07-23 | 2009-07-23 | Be used for the treatment of injection of dog Nocard's bacillus infection and preparation method thereof |
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| CN101606941A true CN101606941A (en) | 2009-12-23 |
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| CNA200910304748XA Pending CN101606941A (en) | 2009-07-23 | 2009-07-23 | Be used for the treatment of injection of dog Nocard's bacillus infection and preparation method thereof |
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- 2009-07-23 CN CNA200910304748XA patent/CN101606941A/en active Pending
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Application publication date: 20091223 |