CN101966231A - Compound pink plumepoppy herb injection for treating calf diarrhea and preparation method thereof - Google Patents
Compound pink plumepoppy herb injection for treating calf diarrhea and preparation method thereof Download PDFInfo
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- CN101966231A CN101966231A CN2010102363961A CN201010236396A CN101966231A CN 101966231 A CN101966231 A CN 101966231A CN 2010102363961 A CN2010102363961 A CN 2010102363961A CN 201010236396 A CN201010236396 A CN 201010236396A CN 101966231 A CN101966231 A CN 101966231A
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- macleayae cordatae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention discloses compound pink plumepoppy herb injection for treating diarrhea of calves and a preparation method thereof. The invention aims to provide quick-response compound pink plumepoppy herb injection for treating diarrhea of the calves infected with one or more of Escherichia coli, clostridium welchii, salmonella, mycoplasma and the like and a simple-process and easily-implemented preparation method thereof. 100 liters of the injection comprises 0.2 to 3 kilograms of pink plumepoppy herb extract, 2 to 8 kilograms of mequindox, 1 to 7 kilograms of ofloxacin, 6 to 24 kilograms of sodium salicylate, 20 liters of dimethylformamide, 20 liters of 95 percent ethanol, 5 liters of hydrochloric acid and the balance of injection water. In the compound pink plumepoppy herb injection, the medicaments are reasonably proportioned; an antibacterial spectrum is expanded as big as possible; pathogenic microorganisms are killed pertinently; medicament resistance is effectively reduced; the response is quick; clinical symptoms can be remitted in the occurrence of the diarrhea of the calves; and the conditions of death of the calves, dysontogenesis after the calves are cured and the like are avoided.
Description
Technical field
The present invention relates to a kind of compound Macleaya cordata injection that is used for the treatment of calf diarrhea and preparation method thereof.
Background technology
Calf diarrhea is the important diseases that causes calf death, and cause of disease has a kind of or several infection such as escherichia coli, clostridieum welchii, Salmonella, mycoplasma, and main clinic symptoms is that calf is acutely suffered from diarrhoea, be with blood in the excrement or be not with blood, be mixed with bubble, color has yellow, yellow green or canescence etc., and sick cattle is bended over and exerts duty, incontinence, the one-tenth that has sprays the sample defecation, pollutes around the anus sick cattle dyspepsia, angor often causes that dehydration dies of exhaustion and dies.
Because this type of disease generally takes place recently, can not accurately judge cause of disease and cause of disease ubiquity, cause infection complicated, diversified, the state of an illness is very fast, and mortality rate is higher, often take the simple treatment of general conventional means, medicine, substantially can not treat, even after judging disease, because drug regimen, collocation problem and drug resistance problem bring inconvenience for numerous culturists, disease can not better controlled, and treatment time is untimely.In therapeutic process,, medicine long because of treatment time insensitive, change medication midway and cause dehydration, or overlong time causes weak, resistance seriously to descend, secondary causes the generation of situations such as other infection, acid alkali poisoning, and cause calf dead or cure the generation of situations such as back dysplasia, be easy to cause very big loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provide a kind of and can treat the calf diarrhea that calf is a kind of by escherichia coli, clostridieum welchii, Salmonella, mycoplasma etc. or several infection cause, widen disease-resistant scope greatly, reduce bacterial drug resistance, it is fast to respond well to treatment, and can alleviate the compound Macleaya cordata injection of using of the clinical symptoms of calf diarrhea when ill.
It is simple that another object of the present invention provides a kind of technology, easily the above-mentioned preparation method that is used for the treatment of the compound Macleaya cordata injection of calf diarrhea that realizes.
The present invention is achieved through the following technical solutions:
A kind of calf diarrhea compound Macleaya cordata injection, it is characterized in that, consisting of of every 100L injection: Herba Macleayae Cordatae extract 0.2～3kg, Mequindox 2～8kg, ofloxacin 1～7kg, sodium salicylate 6～24kg, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, surplus is a water for injection.Wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
A kind of preparation method that is used for the treatment of the compound Macleaya cordata injection of calf diarrhea is characterized in that, comprises the steps:
(1) gets water for injection 30L, add sodium salicylate 6～24kg, after the stirring and dissolving, add ofloxacin 1～7kg, Mequindox 2～8kg more successively, be stirred to whole dissolvings.
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 0.2～3kg, stirring and dissolving.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
The preferable content of each component is in wherein every 100L injection: Herba Macleayae Cordatae extract 0.5～1.5kg, Mequindox 3～6kg, ofloxacin 3～6kg, sodium salicylate 9～18kg, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, and surplus is a water for injection.Wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
The optimum content of each component is in every 100L injection: Herba Macleayae Cordatae extract 1kg, Mequindox 5kg, ofloxacin 4kg, sodium salicylate 15kg, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, and surplus is a water for injection.Wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
The present invention has following technique effect:
Injection of the present invention is a compound preparation, adopt Chinese medicine ingredients Herba Macleayae Cordatae anti-inflammation, western medicine composition Mequindox and ofloxacin are compound, greatly enlarged antimicrobial spectrum, thereby widened disease-resistant scope greatly, pathogenic microbe killing is treated the diarrhoea that calf is a kind of by escherichia coli, clostridieum welchii, Salmonella, mycoplasma etc. or several infection cause targetedly.The Chinese medicine and western medicine compound recipe combination that injection of the present invention adopts, can effectively reduce chemical sproof generation, it is fast to respond well to treatment, can alleviate the clinical symptoms of calf diarrhea when ill, avoid, medicine long because of treatment time insensitive, change the dehydration that medication causes midway, weak, the resistance that simultaneously can avoid overlong time to cause seriously descend, and secondary causes the generation of situations such as other infection, acid alkali poisoning, and cause the generation of situations such as calf death or healing back dysplasia.And the preparation method technology of the compound Macleaya cordata injection that is used for the treatment of calf diarrhea of the present invention is simple, realizes easily.
The specific embodiment
The present invention is described in detail below in conjunction with specific embodiment.
Employed Herba Macleayae Cordatae extract is the alkaloid sulfate that the Herba Macleayae Cordatae fruit is made through extraction separation according to a conventional method in following examples, is the total alkaloids of Herba Macleayae Cordatae, and total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
Embodiment 1
(1) gets water for injection 30L, add sodium salicylate 6kg, after the stirring and dissolving, add ofloxacin 1kg, Mequindox 2kg more successively, be stirred to whole dissolvings.
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 3kg, stirring and dissolving.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 20L, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
Embodiment 2
(1) gets water for injection 30L, add sodium salicylate 24kg, after the stirring and dissolving, add ofloxacin 7kg, Mequindox 8kg more successively, be stirred to whole dissolvings.
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 0.2kg, stirring and dissolving.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 20L, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
Embodiment 3
(1) gets water for injection 30L, add sodium salicylate 9kg, after the stirring and dissolving, add ofloxacin 3kg, Mequindox 3kg more successively, stirring and dissolving.
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 1.5kg, stirring and dissolving;
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 20L, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
Embodiment 4
(1) gets water for injection 30L, add sodium salicylate 18kg, after the stirring and dissolving, add ofloxacin 6kg, Mequindox 6kg more successively, stirring and dissolving.
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 0.5kg, stirring and dissolving;
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 20L, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
Embodiment 5
(1) gets water for injection 30L, add sodium salicylate 12kg, after the stirring and dissolving, add ofloxacin 5kg, Mequindox 4kg more successively, stirring and dissolving.
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 1.2kg, stirring and dissolving;
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 20L, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
Embodiment 6
(1) gets water for injection 30L, add sodium salicylate 15kg, after the stirring and dissolving, add ofloxacin 4kg, Mequindox 5kg more successively, stirring and dissolving.
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 1kg, stirring and dissolving;
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 20L, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
Clinical experiment:
1. laboratory animal:
Picked at random is suffered from 100 of diarrhoea calves.
2. experiment medicine
The compound Macleaya cordata injection our unit development that is used for the treatment of calf diarrhea of the embodiment of the invention 6 preparations;
1% Macleaya cordata injection our unit prepared in laboratory;
5% mequindox injection our unit prepared in laboratory.
3 experimental techniques:
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 1% Macleaya cordata injection: intramuscular injection, every 1kg body weight 0.1ml, 2 times on the one, logotype 3 days.
The C group is treated usage with 5% mequindox injection: intramuscular injection, every 1kg body weight 0.1ml, 2 times on the one, logotype 3 days.
The D group is treated usage with the compound Macleaya cordata injection that is used for the treatment of calf diarrhea of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.1ml, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, the distribution of calf diarrhea health situation of change suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the calf diarrhea symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the calf diarrhea symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from calf diarrhea and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from calf diarrhea and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from calf diarrhea and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the compound Macleaya cordata injection treatment group that is used for the treatment of calf diarrhea, 1% Macleaya cordata injection treatment group and 5% Mequindox side's injection group of the embodiment of the invention 6 preparations and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | A symptom number is arranged during end | A dead number | Effect on the 2nd | Effect on the 4th |
| A | Matched group | 25 | 0 | 0 | 2 | 23 | Dead 18 | Dead 22 |
| B | The treatment of 1% Macleaya cordata injection | 14 | 11 | 6 | 9 | 10 | Dead 7,3 rehabilitations | Dead 9,6 rehabilitations, remaining has symptom |
| C | The treatment of 5% mequindox injection | 12 | 13 | 7 | 6 | 12 | Dead 9,5 of rehabilitations | Dead 11,6 rehabilitations, remaining has symptom |
| D | The compound Macleaya cordata injection treatment of embodiment 6 preparations | 3 | 22 | 18 | 5 | 2 | Dead 2,12 of rehabilitations | Dead 2,16 of rehabilitations, remaining has symptom |
Annotate: contained the 2nd day quantity on 4th, overall death toll is the result after the 7th day.
Claims (6)
1. compound Macleaya cordata injection that is used for the treatment of calf diarrhea, it is characterized in that, consisting of of every 100L injection: Herba Macleayae Cordatae extract 0.2～3kg, Mequindox 2～8kg, ofloxacin 1～7kg, sodium salicylate 6～24kg, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, surplus is a water for injection, and wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
2. the compound Macleaya cordata injection that is used for the treatment of calf diarrhea according to claim 1, it is characterized in that, consisting of of every 100L injection: Herba Macleayae Cordatae extract 0.5～1.5kg, Mequindox 3～6kg, ofloxacin 3～6kg, sodium salicylate 9～18kg, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, and surplus is a water for injection, and wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
3. the compound Macleaya cordata injection that is used for the treatment of calf diarrhea according to claim 1, it is characterized in that, consisting of of every 100L injection: Herba Macleayae Cordatae extract 1kg, Mequindox 5kg, ofloxacin 4kg, sodium salicylate 15kg, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, and surplus is a water for injection, and wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
4. the described preparation method that is used for the treatment of the compound Macleaya cordata injection of calf diarrhea of claim 1 is characterized in that, comprises the steps:
(1) gets water for injection 30L, add sodium salicylate 6～24kg, after the stirring and dissolving, add ofloxacin 1～7kg, Mequindox 2～8kg more successively, be stirred to whole dissolvings;
(2) get dimethyl formamide 20L, add Herba Macleayae Cordatae extract 0.2～3kg, stirring and dissolving; Total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract;
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol, stir, the adding mass percent is 37% analytical pure hydrochloric acid 5L, after stirring, add the injection water, stir to 100L, keep 15-20min, treat that medicinal liquid promptly makes the compound Macleaya cordata injection that is used for the treatment of calf diarrhea after clear and bright.
5. the preparation method that is used for the treatment of the compound Macleaya cordata injection of calf diarrhea according to claim 4, it is characterized in that, Herba Macleayae Cordatae extract 0.5～1.5kg in every 100L injection, Mequindox 3～6kg, ofloxacin 3～6kg, sodium salicylate 9～18kg,, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, and surplus is a water for injection, and wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
6. the preparation method that is used for the treatment of the compound Macleaya cordata injection of calf diarrhea according to claim 4, it is characterized in that, Herba Macleayae Cordatae extract 1kg in every 100L injection, Mequindox 5kg, ofloxacin 4kg, sodium salicylate 15kg, dimethyl formamide 20L, 95% ethanol 20L, mass percent is 37% analytical pure hydrochloric acid 5L, and surplus is a water for injection, and wherein total alkaloid contents is 0.5g in the 1g Herba Macleayae Cordatae extract.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102363961A CN101966231A (en) | 2010-07-26 | 2010-07-26 | Compound pink plumepoppy herb injection for treating calf diarrhea and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102363961A CN101966231A (en) | 2010-07-26 | 2010-07-26 | Compound pink plumepoppy herb injection for treating calf diarrhea and preparation method thereof |
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| CN101966231A true CN101966231A (en) | 2011-02-09 |
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| CN2010102363961A Pending CN101966231A (en) | 2010-07-26 | 2010-07-26 | Compound pink plumepoppy herb injection for treating calf diarrhea and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690538A (en) * | 2013-12-03 | 2014-04-02 | 深圳松乐生物科技有限公司 | Traditional Chinese medicine extract and traditional Chinese medicine composition having poultry and livestock mycoplasma resistant activity |
-
2010
- 2010-07-26 CN CN2010102363961A patent/CN101966231A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690538A (en) * | 2013-12-03 | 2014-04-02 | 深圳松乐生物科技有限公司 | Traditional Chinese medicine extract and traditional Chinese medicine composition having poultry and livestock mycoplasma resistant activity |
| CN103690538B (en) * | 2013-12-03 | 2018-07-13 | 深圳松乐生物科技有限公司 | With the active Chinese medical extract of anti-poultry mycoplasma, Chinese medicine composition |
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Application publication date: 20110209 |