CN107648184A - Atropine sulfate is scattered and preparation method thereof again - Google Patents
Atropine sulfate is scattered and preparation method thereof again Download PDFInfo
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- CN107648184A CN107648184A CN201711181246.3A CN201711181246A CN107648184A CN 107648184 A CN107648184 A CN 107648184A CN 201711181246 A CN201711181246 A CN 201711181246A CN 107648184 A CN107648184 A CN 107648184A
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- atropine sulfate
- softwood
- lactose
- food
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Dissipated again the invention discloses atropine sulfate and preparation method thereof, it is included by weight：10 20 parts of atropine sulfates, 40 50 parts of amylum pregelatinisatums, 100 120 parts of lactose, 20 30 parts of 80wt% ethanol, 46 parts of food-level titanium dioxides and 30 40 parts of deionized waters.The beneficial effects of the invention are as follows using amylum pregelatinisatum as coating, using food-level titanium dioxide as filler, its toxic side effect to human body is reduced, improves the tolerance to environment, humidity-proof ability is strong, reduces storage cost.
Description
Technical field
The present invention relates to pharmaceutical field, more particularly to atropine sulfate are scattered and preparation method thereof again.
Background technology
Powder refers to medicine and dry powdered preparation of the suitable auxiliary material through crushing, being uniformly mixed, and is divided into oral
Powder and topical powder.
The preparation technology of powder generally comprises the processes such as crushing, sieving, mixing, divided dose, quality examination and packaging.It is conventional
Crushing apparatus have fluid energy mill, ball mill, pulverizer, mortar etc., it is a small amount of to crush conventional mortars.The fineness requirement and medicine of medicine
Property and administering mode etc. are relevant, and general insoluble drug, the insoluble drugs for treating gastric ulcer and external pulvis require to crush
Degree is thin, and the medicine of bitter taste and should not crush meticulous in the unstable medicine of enteron aisle.
Atropine sulfate is anticholinergic agent, and for intestines and stomach, cholecystalgia, mydriasis checks optometry, keratitis, organophosphorus pesticide
The treatment of the syndromes such as poisoning, infectious shock.But because it has toxicity, it usually needs be diluted with diluent to subtract
The danger of few human body poisoning.Typically first taking a small amount of lactose to add grinding in mortar makes mortar inwall saturation, adds recipe quantity
Atropine sulfate ground well with carmine lactose, then add isometric lactose and grind well, by being incremented by facing-up method in equal volume to whole
Untill lactose adds, mix untill color and luster is consistent.Wherein carmine lactose is formulated as follows：Famille rose is taken to be placed in mortar,
Add the grinding of 90% ethanol to make dissolving, add a small amount of lactose digestion and grind well, then added simultaneously by facing-up method to whole lactose are incremented by equal volume
Untill color is uniform, in 60 DEG C of dryings, 100 mesh sieves are crossed, both obtain 1% carmine lactose.It functions as diluent and is made again
Dissipate.But the famille rose that this method uses inherently has certain toxicity, and potential safety hazard is brought to human body, in addition obtained sulfuric acid Ah
Tropine dissipates easy moisture absorption, it is necessary to be stored at 0-8 DEG C again, and storage condition is high, brings the lifting of storage cost.
The content of the invention
The technical problem to be solved in the present invention is that scattered toxicity is higher again for existing atropine sulfate, storage unfavorable to human body
Condition is harsh, and storage cost is high, and it is scattered and preparation method thereof again that a kind of atropine sulfate is provided for this.
The technical scheme is that：Atropine sulfate dissipates again, and it is included by weight：10-20 parts atropine sulfate,
40-50 parts amylum pregelatinisatum, 100-120 parts lactose, 20-30 part 80wt% ethanol, 4-6 parts food-level titanium dioxide and 30-40 parts
Deionized water.
The preparation method that atropine sulfate dissipates again, it comprises the following steps：By 40-50 parts amylum pregelatinisatum and 20-30 parts
80wt% ethanol is heated to 40-50 DEG C after mixing, and is concentrated into the 1/3-1/5 of original volume softwood；By the softwood after concentration with
100-120 part lactose is put into centrifuge and centrifuges 10-20min with 100-120r/min rotating speed, with 2-4 during centrifugation
DEG C/min speed is warming up to 60-70 DEG C；Softwood after centrifugation and 10-20 parts atropine sulfate are mixed and stir evenly precipitation mixing
Thing, add 4-6 parts food-level titanium dioxide and ultrasonic disperse 10-20min, supersonic frequency 20-30KHz；After ultrasonic disperse
Mixture and the mixing of 30-40 parts deionized waters stir evenly and dried 3-5min both at 60-70 DEG C.
The beneficial effects of the invention are as follows using amylum pregelatinisatum as coating, using food-level titanium dioxide as filler, drop
Its low toxic side effect to human body, improves the tolerance to environment, and humidity-proof ability is strong, reduces storage cost.
Embodiment
The atropine sulfate of the present invention dissipates again, and it is included by weight：10-20 parts atropine sulfate, 40-50 parts can be pressed
Property starch, 100-120 parts lactose, 20-30 part 80wt% ethanol, 4-6 parts food-level titanium dioxide and 30-40 part deionized waters.
The preparation method that atropine sulfate dissipates again, it comprises the following steps：By 40-50 parts amylum pregelatinisatum and 20-30 parts
80wt% ethanol is heated to 40-50 DEG C after mixing, and is concentrated into the 1/3-1/5 of original volume softwood；By the softwood after concentration with
100-120 part lactose is put into centrifuge and centrifuges 10-20min with 100-120r/min rotating speed, with 2-4 during centrifugation
DEG C/min speed is warming up to 60-70 DEG C；Softwood after centrifugation and 10-20 parts atropine sulfate are mixed and stir evenly precipitation mixing
Thing, add 4-6 parts food-level titanium dioxide and ultrasonic disperse 10-20min, supersonic frequency 20-30KHz；After ultrasonic disperse
Mixture and the mixing of 30-40 parts deionized waters stir evenly and dried 3-5min both at 60-70 DEG C.
With reference to embodiment, the present invention will be further described.
Embodiment 1：Atropine sulfate dissipates again, and it is included by weight：10 parts of atropine sulfates, 40 parts of compressibility are formed sediment
Powder, 100 parts of lactose, 20 parts of 80wt% ethanol, 4 parts of food-level titanium dioxides and 30-40 part deionized waters.
The preparation method that atropine sulfate dissipates again, it comprises the following steps：By 40 parts of amylum pregelatinisatums and 20-30 parts
80wt% ethanol is heated to 40 DEG C after mixing, and is concentrated into 1/3 softwood of original volume；By the softwood after concentration and 100 parts of lactose
It is put into centrifuge and 10min is centrifuged with 100r/min rotating speed, 60 DEG C is warming up to 2 DEG C/min speed during centrifugation；
Softwood after centrifugation and 10 parts of atropine sulfates are mixed and stir evenly precipitation mixture, adds 4 parts of food-level titanium dioxides and ultrasound
Scattered 10min, supersonic frequency 20KHz；Mixture after ultrasonic disperse and 30 parts of deionized waters are mixed and stirred evenly and at 60 DEG C
Lower dry 3min was both obtained.
Embodiment:2：Atropine sulfate dissipates again, and it is included by weight：15 parts of atropine sulfates, 45 parts of compressibility are formed sediment
Powder, 110 parts of lactose, 25 parts of 80wt% ethanol, 5 parts of food-level titanium dioxides and 35 parts of deionized waters.
The preparation method that atropine sulfate dissipates again, it comprises the following steps：By 45 parts of amylum pregelatinisatums and 25 parts of 80wt% second
Alcohol is heated to 45 DEG C after mixing, and is concentrated into 1/4 softwood of original volume；By the softwood after concentration and 110 parts of lactose be put into from
15min is centrifuged with 110r/min rotating speed in scheming, 65 DEG C are warming up to 3 DEG C/min speed during centrifugation；Will centrifugation
Softwood and 15 parts of atropine sulfate mixing afterwards stirs evenly precipitation mixture, adds 5 parts of food-level titanium dioxides and ultrasonic disperse
15min, supersonic frequency 25KHz；Mixture after ultrasonic disperse and 35 parts of deionized waters are mixed and stirs evenly and is done at 65 DEG C
Dry 4min was both obtained.
Embodiment 3：Atropine sulfate dissipates again, and it is included by weight：20 parts of atropine sulfates, 50 parts of compressibility are formed sediment
Powder, 120 parts of lactose, 30 parts of 80wt% ethanol, 6 parts of food-level titanium dioxides and 40 parts of deionized waters.
The preparation method that atropine sulfate dissipates again, it comprises the following steps：By 50 parts of amylum pregelatinisatums and 30 parts of 80wt% second
Alcohol is heated to 50 DEG C after mixing, and is concentrated into 1/5 softwood of original volume；By the softwood after concentration and 120 parts of lactose be put into from
20min is centrifuged with 120r/min rotating speed in scheming, 70 DEG C are warming up to 4 DEG C/min speed during centrifugation；Will centrifugation
Softwood and 20 parts of atropine sulfate mixing afterwards stirs evenly precipitation mixture, adds 6 parts of food-level titanium dioxides and ultrasonic disperse
20min, supersonic frequency 30KHz；Mixture after ultrasonic disperse and 40 parts of deionized waters are mixed and stirs evenly and is done at 70 DEG C
Dry 5min was both obtained.
Amylum pregelatinisatum and ethanol are mixed and heat concentrated type softwood by the invention, using softwood as dilution
Agent, have no toxic side effect, add lactose as composite thinning agent, carry out centrifugation heating and add atropine sulfate, form mixing
Thing, food-level titanium dioxide and ultrasound are added, the weatherability especially moisture resistance of finished product can be improved, can be carried out at normal temperatures
Storage, and then reduce storage cost.
Claims (2)
1. atropine sulfate dissipates again, it is characterized in that it is included by weight：10-20 parts atropine sulfate, 40-50 part compressibility
Starch, 100-120 parts lactose, 20-30 part 80wt% ethanol, 4-6 parts food-level titanium dioxide and 30-40 part deionized waters.
2. the preparation method that atropine sulfate as claimed in claim 1 dissipates again, it is characterized in that it comprises the following steps：By 40-
50 parts of amylum pregelatinisatums and 20-30 part 80wt% ethanol are heated to 40-50 DEG C after mixing, and are concentrated into the 1/3-1/5's of original volume
Softwood；Softwood after concentration and 100-120 part lactose are put into centrifuge 10- is centrifuged with 100-120r/min rotating speed
20min, 60-70 DEG C is warming up to 2-4 DEG C/min speed during centrifugation；By the softwood after centrifugation and 10-20 part sulfuric acid
Atropine mixing stirs evenly precipitation mixture, adds 4-6 parts food-level titanium dioxide and ultrasonic disperse 10-20min, and supersonic frequency is
20-30KHz；Mixture after ultrasonic disperse and 30-40 parts deionized water are mixed and stir evenly and dried at 60-70 DEG C 3-5min
Both.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711181246.3A CN107648184A (en) | 2017-11-23 | 2017-11-23 | Atropine sulfate is scattered and preparation method thereof again |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711181246.3A CN107648184A (en) | 2017-11-23 | 2017-11-23 | Atropine sulfate is scattered and preparation method thereof again |
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| Publication Number | Publication Date |
|---|---|
| CN107648184A true CN107648184A (en) | 2018-02-02 |
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ID=61120344
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711181246.3A Withdrawn CN107648184A (en) | 2017-11-23 | 2017-11-23 | Atropine sulfate is scattered and preparation method thereof again |
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| Country | Link |
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| CN (1) | CN107648184A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698648A (en) * | 2004-05-21 | 2005-11-23 | 山东绿叶制药有限公司 | Montmorillonite dispersed tablet and preparation technique thereof |
| CN101190203A (en) * | 2006-11-29 | 2008-06-04 | 天津市润拓生物技术有限公司 | Atropine sulfate chewable tablets for dog or cat |
| CN106214643A (en) * | 2016-08-30 | 2016-12-14 | 铜陵翔宇商贸有限公司 | Compound recipe sodium citrate dissipates and preparation method thereof |
| CN106265578A (en) * | 2016-08-30 | 2017-01-04 | 铜陵翔宇商贸有限公司 | Theo-Dur and preparation method thereof |
-
2017
- 2017-11-23 CN CN201711181246.3A patent/CN107648184A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698648A (en) * | 2004-05-21 | 2005-11-23 | 山东绿叶制药有限公司 | Montmorillonite dispersed tablet and preparation technique thereof |
| CN101190203A (en) * | 2006-11-29 | 2008-06-04 | 天津市润拓生物技术有限公司 | Atropine sulfate chewable tablets for dog or cat |
| CN106214643A (en) * | 2016-08-30 | 2016-12-14 | 铜陵翔宇商贸有限公司 | Compound recipe sodium citrate dissipates and preparation method thereof |
| CN106265578A (en) * | 2016-08-30 | 2017-01-04 | 铜陵翔宇商贸有限公司 | Theo-Dur and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180202 |
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| WW01 | Invention patent application withdrawn after publication |