CN105614888A - Method for preparing hydrophilic edible nutrient materials for coating curcumin and improving water solubility thereof - Google Patents
Method for preparing hydrophilic edible nutrient materials for coating curcumin and improving water solubility thereof Download PDFInfo
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- CN105614888A CN105614888A CN201610063169.0A CN201610063169A CN105614888A CN 105614888 A CN105614888 A CN 105614888A CN 201610063169 A CN201610063169 A CN 201610063169A CN 105614888 A CN105614888 A CN 105614888A
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- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title claims abstract description 88
- 239000004148 curcumin Substances 0.000 title claims abstract description 44
- 235000012754 curcumin Nutrition 0.000 title claims abstract description 44
- 229940109262 curcumin Drugs 0.000 title claims abstract description 44
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims abstract description 12
- 239000000463 material Substances 0.000 title claims abstract description 10
- 239000011248 coating agent Substances 0.000 title abstract 2
- 238000000576 coating method Methods 0.000 title abstract 2
- 239000000843 powder Substances 0.000 claims abstract description 53
- 108010010803 Gelatin Proteins 0.000 claims abstract description 33
- 229920000159 gelatin Polymers 0.000 claims abstract description 33
- 239000008273 gelatin Substances 0.000 claims abstract description 33
- 235000019322 gelatine Nutrition 0.000 claims abstract description 33
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 33
- 238000002156 mixing Methods 0.000 claims abstract description 22
- 240000000588 Hericium erinaceus Species 0.000 claims abstract description 16
- 235000007328 Hericium erinaceus Nutrition 0.000 claims abstract description 16
- 240000001417 Vigna umbellata Species 0.000 claims abstract description 10
- 235000011453 Vigna umbellata Nutrition 0.000 claims abstract description 10
- 235000021307 Triticum Nutrition 0.000 claims abstract description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 36
- 239000007788 liquid Substances 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- 238000000227 grinding Methods 0.000 claims description 22
- 210000000582 semen Anatomy 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 18
- 239000006228 supernatant Substances 0.000 claims description 18
- 244000309464 bull Species 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000013019 agitation Methods 0.000 claims description 12
- 238000005119 centrifugation Methods 0.000 claims description 12
- 238000002425 crystallisation Methods 0.000 claims description 12
- 230000008025 crystallization Effects 0.000 claims description 12
- 210000002966 serum Anatomy 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 11
- 244000157072 Hylocereus undatus Species 0.000 claims description 10
- 235000016709 nutrition Nutrition 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 7
- 239000004382 Amylase Substances 0.000 claims description 6
- 102000013142 Amylases Human genes 0.000 claims description 6
- 108010065511 Amylases Proteins 0.000 claims description 6
- 108010059892 Cellulase Proteins 0.000 claims description 6
- 235000018481 Hylocereus undatus Nutrition 0.000 claims description 6
- 241000209140 Triticum Species 0.000 claims description 6
- 235000019418 amylase Nutrition 0.000 claims description 6
- 229940106157 cellulase Drugs 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000000151 deposition Methods 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 238000001976 enzyme digestion Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000011812 mixed powder Substances 0.000 claims description 6
- 235000006408 oxalic acid Nutrition 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 229920002545 silicone oil Polymers 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 238000005253 cladding Methods 0.000 claims description 4
- 235000010837 Echinocereus enneacanthus subsp brevispinus Nutrition 0.000 abstract description 7
- 235000006850 Echinocereus enneacanthus var dubius Nutrition 0.000 abstract description 7
- 239000012530 fluid Substances 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 4
- 244000144725 Amygdalus communis Species 0.000 abstract 3
- 240000008086 Echinocereus enneacanthus Species 0.000 abstract 3
- 235000020224 almond Nutrition 0.000 abstract 3
- 210000004911 serous fluid Anatomy 0.000 abstract 2
- 244000163122 Curcuma domestica Species 0.000 abstract 1
- 235000003392 Curcuma domestica Nutrition 0.000 abstract 1
- 244000098338 Triticum aestivum Species 0.000 abstract 1
- 235000003373 curcuma longa Nutrition 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 235000013976 turmeric Nutrition 0.000 abstract 1
- 235000013361 beverage Nutrition 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 238000010579 first pass effect Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000010224 hepatic metabolism Effects 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000562 conjugate Substances 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a method for preparing hydrophilic edible nutrient materials for coating curcumin and improving the water solubility thereof, and belongs to the field of curcumin. The method includes selecting red beans, almonds, pitaya peel, tiegun rhizoma dioscoreae and hericium erinaceus powder, adding the red beans, the almonds, the pitaya peel, the tiegun rhizoma dioscoreae and the hericium erinaceus powder into water and mixing the red beans, the almonds, the pitaya peel, the tiegun rhizoma dioscoreae, the hericium erinaceus powder and the water with one another to obtain serous fluid; digesting hydrophilic components from the serous fluid by the aid of fat in wheat germ; mixing extracted nutrient fluid and gelatin with each other to obtain gelatin nutrient fluid; extracting the high-purity curcumin from turmeric; spraying the gelatin nutrient fluid on the curcumin; freezing and drying the curcumin. The method has the advantages that the curcumin is coated by the hydrophilic gelatin nutrient fluid prepared by the aid of the method, accordingly, the curcumin can be easily dissolved in water and is difficult to hydrolyze and oxidize, and the stability of the curcumin can be improved; hydrophilic effective nutrient substances are extracted from substances such as the red beans, accordingly, nutrient elements in the curcumin can be enriched, the curcumin is high in efficacy and free of toxic and side effect and can be eaten safely, and the hydrophilic edible nutrient materials are easy to prepare and low in cost.
Description
Technical field
The invention discloses a kind of hydrophilic edible nutrient material cladding curcumin and improve its water miscible preparation method, belong to curcumin field.
Background technology
Curcumin is primarily present the how cruel material of yellow in plant turmeric lotus, is natural antioxidant, and this external antiinflammatory, antibacterial, antitumor, blood fat reducing and prevention parkinson disease aspect also have the drug effect of uniqueness. Still the exploitation of anticancer preparation it is in that at present about the main research of curcumin, and curcumin is difficult to water-soluble, normal oral administration does not absorb, and there is serious liver first-pass effect, namely after gastrointestinal administration, not yet it is being absorbed into namely by liver metabolism before blood circulation, and is making the dose of entrance blood circulation extremely reduce; And curcumin metabolism in vivo and clearance rate are very fast, so under general administration, the bioavailability of curcumin is very low, it is thus desirable to prepare suitable drug delivery system to solve the problems referred to above: be effectively improved curcumin water miscible while, also to prevent medicine from entering after organism and be hydrolyzed, aoxidize and inactivate. In the research of forefathers, existing a lot of nanometer formulation Conventional nano drug delivery system being combined with curcumin and prepare good result, including liposome, polymer nanoparticle, micelle, cyclodextrin and solid lipid particles etc., also there are curcumin conjugate, solid dispersion and emulsion preparations etc. Wherein liposome because of its stability not good, easy allergy, the preparation shortcoming such as poor reproducibility, seriously limit its application in drug delivery system; And the drug loading of nano-particle is relatively low, coupling agent used by dendritic generally has toxicity, it is difficult to is used safely in the problems such as human body and limits it too for clinical treatment. Polymer micelle, since exploitation, has not had good solution route in, finishing difficulty low at carrying drug ratio is bigger etc. yet.
Summary of the invention
The technical problem that present invention mainly solves: be difficult to water-soluble for current curcumin, normal oral administration does not absorb, and there is serious liver first-pass effect, namely after gastrointestinal administration, not yet it is being absorbed into before blood circulation namely by liver metabolism, hydrolysis, the problem aoxidized and inactivate, provide a kind of hydrophilic edible nutrient material cladding curcumin and improve its water miscible preparation method, the present invention first chooses Semen Phaseoli, Semen Armeniacae Amarum, pitaya peel, Rhizoma Dioscoreae, Hericium erinaceus (Bull. Ex Fr.) Pers., fat in recycling Fructus Tritici aestivi adjusts the polarity of acid soil, obtain mixture hydrophilic phase component is extracted, the composite nutrient-fluid and the gelatin that obtain extraction are mixed to get gelatin nutritional liquid, the curcumin that purity is high is extracted from Rhizoma Curcumae Longae, and gelatin solution is sprayed at above, lyophilization, the present invention prepares hydrophilic mixing gelatin nutritional liquid and curcumin is coated with, curcumin can be made soluble in water, and not easily it is hydrolyzed, oxidation, enhance its stability, the effective nutrient substance of hydrophilic is extracted from the materials such as Semen Phaseoli, the nutrient of abundant curcumin, make the higher edible safety of its drug effect, have no side effect, and prepare simple, cost is low.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is:
(1) count by weight, choose 15��20 parts of Semen Phaseolis, 15��20 parts of Semen Armeniacae Amarums, 20��30 parts of HUOLONG respectively
1. peel, 8��15 parts of Rhizoma Dioscoreae, 10��15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers. and 10��15 portions of Fructus Tritici aestivis, be dried respectively, then is broken into 60��80 order powder under-5��0 DEG C of condition, by red bean powder, Semen Armeniacae Amarum powder, Hylocereus undatus corium farinosum, Rhizoma Dioscoreae powder, Hericium erinaceus (Bull. Ex Fr.) Pers. powder mixes, and adds deionized water by solid-to-liquid ratio 1:8��1:10 in mixed powder, it is uniformly mixed, obtains mixed serum;
(2) above-mentioned mixed serum is sent in grinding pot, be-5��0 DEG C and 20��30r/min rotating speed bar in temperature
2. under, grind 10��12h, grinding adds wheat germ powder after completing, again at 5��10 DEG C, continue grinding 3��5h under 15��20r/min, mixture after grinding is at room temperature stood centrifugation after depositing 2��3 days, takes supernatant, it is added thereto to gross mass 4��6% gelatin, at 0��5 DEG C, carry out magnetic agitation make gelatin perfect solution, obtain gelatin nutritional liquid, standby;
(3) take 200��300g Rhizoma Curcumae Longae, dried, pulverize and sieve to obtain 80��100 order powder, by solid-to-liquid ratio 1:4��
3.1:6 adds distilled water and mixing and stirring obtains Rhizoma Curcumae Longae serosity, put in 60��70min water-bath after stirring, gross mass 2��4% cellulase and 5��8% amylase are added in serosity, regulating pH value of solution with mass fraction 25% oxalic acid again is 4.5��5.0, enzyme digestion reaction 3��5h when stirring, obtains Rhizoma Curcumae Longae enzymolysis solution;
(4) in Rhizoma Curcumae Longae enzymolysis solution, 1:5��1:8 adds ethylene glycol by volume, puts into Vltrasonic device after mixing
4. in, carry out supersound process 15��20min, centrifugation under 5000��7000r/min rotating speed again after ultrasonic, take supernatant, supernatant pressurization is concentrated into the 50��60% of original volume, and reclaim ethylene glycol, gross mass 50��100% silicone oil is added in concentrated solution, stand to being layered completely after stirring mixing, take subnatant, put into standing 10��12h in-5��0 DEG C of environment, have crystallization, sucking filtration, obtain crystallization, and with washes of absolute alcohol 2��3 times, carry out after cleaning vacuum drying curcumin;
5.(5) in the gelatin solution of step (2), by volume 5:1 mixes with glycerol, with magnetic agitation uniformly after, be sprayed on above-mentioned curcumin solid, spray after uniformly and carry out lyophilization 2��5h.
The application process of the present invention: the present invention is prepared product and can be made into solid preparation such as tablet, powder, granule, capsule and liquid preparation such as water or oil-suspending agent or other liquid preparation of routine; The preparation obtained is used directly in functional health-care food, it is possible to be directly applied in nourishing beverage.
The invention has the beneficial effects as follows:
(1) present invention prepare hydrophilic mixing gelatin nutritional liquid curcumin is coated with, it is possible to make curcumin soluble in water, and be not easily hydrolyzed, aoxidize, enhance its stability;
(2) present invention extracts from the materials such as Semen Phaseoli and has hydrophilic effective nutrient substance, the nutrient of abundant curcumin, strengthens its drug effect, edible safety, has no side effect, and prepares simple, and cost is low.
Detailed description of the invention
First count by weight, choose 15��20 parts of Semen Phaseolis, 15��20 parts of Semen Armeniacae Amarums, 20��30 parts of HUOLONG respectively
7. peel, 8��15 parts of Rhizoma Dioscoreae powder, 10��15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers. and 10��15 portions of Fructus Tritici aestivis, be dried respectively, then is broken into 60��80 order powder under-5��0 DEG C of condition, by red bean powder, Semen Armeniacae Amarum powder, Hylocereus undatus corium farinosum, Rhizoma Dioscoreae powder, Hericium erinaceus (Bull. Ex Fr.) Pers. powder mixes, and adds deionized water by solid-to-liquid ratio 1:8��1:10 in mixed powder, it is uniformly mixed, obtains mixed serum, mixed serum is sent in grinding pot, it is grinding 10��12h under-5��0 DEG C and 20��30r/min speed conditions in temperature, grinding adds wheat germ powder after completing, then at 5��10 DEG C, continues grinding 3��5h under 15��20r/min, mixture after grinding is at room temperature stood centrifugation after depositing 2��3 days, take supernatant, be added thereto to gross mass 4��6% gelatin, at 0��5 DEG C, carry out magnetic agitation make gelatin perfect solution, gelatin nutritional liquid, standby, take 200��300g Rhizoma Curcumae Longae, dried, pulverized and sieved to obtain 80��100 order powder, add distilled water by solid-to-liquid ratio 1:4��1:6 and mixing and stirring obtains Rhizoma Curcumae Longae serosity, put in 60��70min water-bath after stirring, gross mass 2��4% cellulase and 5��8% amylase are added in serosity, regulating pH value of solution with mass fraction 25% oxalic acid again is 4.5��5.0, enzyme digestion reaction 3��5h when stirring, obtains Rhizoma Curcumae Longae enzymolysis solution, in Rhizoma Curcumae Longae enzymolysis solution, 1:5��1:8 adds ethylene glycol by volume, put into after mixing and Vltrasonic device carries out supersound process 15��20min, centrifugation under 5000��7000r/min rotating speed again after ultrasonic, take supernatant, supernatant pressurization is concentrated into the 50��60% of original volume, and reclaim ethylene glycol, gross mass 50��100% silicone oil is added in concentrated solution, stand to being layered completely after stirring mixing, take subnatant, put into standing 10��12h in-5��0 DEG C of environment, there is crystallization, sucking filtration, obtain crystallization, and with washes of absolute alcohol 2��3 times, carry out after cleaning vacuum drying curcumin, in gelatin solution, by volume 5:1 mixes with glycerol, with magnetic agitation uniformly after, be sprayed on above-mentioned curcumin solid, spray after uniformly and carry out lyophilization 2��5h.
Example 1
8. first count by weight, choose 15 parts of Semen Phaseolis, 20 parts of Semen Armeniacae Amarums, 20 parts of pitaya peels, 15 parts of Rhizoma Dioscoreae powder, 15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers. and 15 portions of Fructus Tritici aestivis respectively, it is dried respectively, 60 order powder it are broken into again, by red bean powder, Semen Armeniacae Amarum powder, Hylocereus undatus corium farinosum, Rhizoma Dioscoreae powder under-5 DEG C of conditions, Hericium erinaceus (Bull. Ex Fr.) Pers. powder mixes, in mixed powder, add deionized water by solid-to-liquid ratio 1:8, be uniformly mixed, obtain mixed serum; Mixed serum is sent in grinding pot, it is under-5 DEG C and 20r/min speed conditions, grind 10h in temperature, grinding adds wheat germ powder after completing, then at 5 DEG C, continues to grind 3h under 15r/min, mixture after grinding is at room temperature stood centrifugation after depositing 2 days, take supernatant, be added thereto to gross mass 4% gelatin, at 0 DEG C, carry out magnetic agitation make gelatin perfect solution, gelatin nutritional liquid, standby; Take 200g Rhizoma Curcumae Longae, dried, pulverized and sieved to obtain 80 order powder, add distilled water by solid-to-liquid ratio 1:4 and mixing and stirring obtains Rhizoma Curcumae Longae serosity, put in 60min water-bath after stirring, gross mass 2% cellulase and 5% amylase is added in serosity, regulating pH value of solution with mass fraction 25% oxalic acid again is 4.5, the enzyme digestion reaction 3h when stirring, obtains Rhizoma Curcumae Longae enzymolysis solution; In Rhizoma Curcumae Longae enzymolysis solution, 1:5 adds ethylene glycol by volume, put into after mixing and Vltrasonic device carries out supersound process 15min, centrifugation under 5000r/min rotating speed again after ultrasonic, take supernatant, supernatant pressurization is concentrated into the 50% of original volume, and reclaims ethylene glycol, in concentrated solution, add gross mass 50% silicone oil, stand to being layered completely after stirring mixing, take subnatant, put into standing 10h in-5 DEG C of environment, have crystallization, sucking filtration, obtain crystallization, and with washes of absolute alcohol 2 times, carry out after cleaning vacuum drying curcumin; In gelatin solution, by volume 5:1 mixes with glycerol, with magnetic agitation uniformly after, be sprayed on above-mentioned curcumin solid, spray after uniformly and carry out lyophilization 2h.
The present invention is prepared product and can be made into solid preparation such as tablet, powder, granule, capsule and liquid preparation such as water or oil-suspending agent or other liquid preparation of routine; The preparation obtained is used directly in functional health-care food, it is possible to be directly applied in nourishing beverage.
Example 2
9. first count by weight, choose 17 parts of Semen Phaseolis, 17 parts of Semen Armeniacae Amarums, 25 parts of pitaya peels, 15 parts of Rhizoma Dioscoreae powder, 13 parts of Hericium erinaceus (Bull. Ex Fr.) Pers. and 13 portions of Fructus Tritici aestivis respectively, it is dried respectively, 70 order powder it are broken into again, by red bean powder, Semen Armeniacae Amarum powder, Hylocereus undatus corium farinosum, Rhizoma Dioscoreae powder under-3 DEG C of conditions, Hericium erinaceus (Bull. Ex Fr.) Pers. powder mixes, in mixed powder, add deionized water by solid-to-liquid ratio 1:9, be uniformly mixed, obtain mixed serum; Mixed serum is sent in grinding pot, it is under-3 DEG C and 25r/min speed conditions, grind 11h in temperature, grinding adds wheat germ powder after completing, then at 8 DEG C, continues to grind 4h under 17r/min, mixture after grinding is at room temperature stood centrifugation after depositing 2.5 days, take supernatant, be added thereto to gross mass 5% gelatin, at 3 DEG C, carry out magnetic agitation make gelatin perfect solution, gelatin nutritional liquid, standby; Take 250g Rhizoma Curcumae Longae, dried, pulverized and sieved to obtain 90 order powder, add distilled water by solid-to-liquid ratio 1:5 and mixing and stirring obtains Rhizoma Curcumae Longae serosity, put in 65min water-bath after stirring, gross mass 3% cellulase and 6% amylase is added in serosity, regulating pH value of solution with mass fraction 25% oxalic acid again is 4.7, the enzyme digestion reaction 4h when stirring, obtains Rhizoma Curcumae Longae enzymolysis solution; In Rhizoma Curcumae Longae enzymolysis solution, 1:6 adds ethylene glycol by volume, put into after mixing and Vltrasonic device carries out supersound process 17min, centrifugation under 6000r/min rotating speed again after ultrasonic, take supernatant, supernatant pressurization is concentrated into the 55% of original volume, and reclaims ethylene glycol, in concentrated solution, add gross mass 75% silicone oil, stand to being layered completely after stirring mixing, take subnatant, put into standing 11h in-3 DEG C of environment, have crystallization, sucking filtration, obtain crystallization, and with washes of absolute alcohol 2 times, carry out after cleaning vacuum drying curcumin; In gelatin solution, by volume 5:1 mixes with glycerol, with magnetic agitation uniformly after, be sprayed on above-mentioned curcumin solid, spray after uniformly and carry out lyophilization 3h.
The present invention is prepared product and can be made into solid preparation such as tablet, powder, granule, capsule and liquid preparation such as water or oil-suspending agent or other liquid preparation of routine; The preparation obtained is used directly in functional health-care food, it is possible to be directly applied in nourishing beverage.
Example 3
10. first count by weight, choose 20 parts of Semen Phaseolis, 15 parts of Semen Armeniacae Amarums, 30 parts of pitaya peels, 8 parts of Rhizoma Dioscoreae powder, 14 parts of Hericium erinaceus (Bull. Ex Fr.) Pers. and 13 portions of Fructus Tritici aestivis respectively, it is dried respectively, 80 order powder it are broken into again, by red bean powder, Semen Armeniacae Amarum powder, Hylocereus undatus corium farinosum, Rhizoma Dioscoreae powder under 0 DEG C of condition, Hericium erinaceus (Bull. Ex Fr.) Pers. powder mixes, in mixed powder, add deionized water by solid-to-liquid ratio 1:10, be uniformly mixed, obtain mixed serum; Mixed serum is sent in grinding pot, it is under 0 DEG C and 30r/min speed conditions, grind 12h in temperature, grinding adds wheat germ powder after completing, then at 10 DEG C, continues to grind 5h under 20r/min, mixture after grinding is at room temperature stood centrifugation after depositing 3 days, take supernatant, be added thereto to gross mass 6% gelatin, at 5 DEG C, carry out magnetic agitation make gelatin perfect solution, gelatin nutritional liquid, standby; Take 300g Rhizoma Curcumae Longae, dried, pulverized and sieved to obtain 100 order powder, add distilled water by solid-to-liquid ratio 1:6 and mixing and stirring obtains Rhizoma Curcumae Longae serosity, put in 70min water-bath after stirring, gross mass 4% cellulase and 8% amylase is added in serosity, regulating pH value of solution with mass fraction 25% oxalic acid again is 5.0, the enzyme digestion reaction 5h when stirring, obtains Rhizoma Curcumae Longae enzymolysis solution; In Rhizoma Curcumae Longae enzymolysis solution, 1:8 adds ethylene glycol by volume, put into after mixing and Vltrasonic device carries out supersound process 20min, centrifugation under 7000r/min rotating speed again after ultrasonic, take supernatant, supernatant pressurization is concentrated into the 60% of original volume, and reclaims ethylene glycol, in concentrated solution, add gross mass 100% silicone oil, stand to being layered completely after stirring mixing, take subnatant, put into standing 12h in 0 DEG C of environment, have crystallization, sucking filtration, obtain crystallization, and with washes of absolute alcohol 3 times, carry out after cleaning vacuum drying curcumin; In gelatin solution, by volume 5:1 mixes with glycerol, with magnetic agitation uniformly after, be sprayed on above-mentioned curcumin solid, spray after uniformly and carry out lyophilization 5h.
The present invention is prepared product and can be made into solid preparation such as tablet, powder, granule, capsule and liquid preparation such as water or oil-suspending agent or other liquid preparation of routine; The preparation obtained is used directly in functional health-care food, it is possible to be directly applied in nourishing beverage.
Claims (1)
1. a hydrophilic edible nutrient material cladding curcumin improves its water miscible preparation method, it is characterised in that
Concrete preparation process is:
(1) count by weight, choose 15��20 parts of Semen Phaseolis, 15��20 parts of Semen Armeniacae Amarums, 20��30 parts of HUOLONG respectively
Peel, 8��15 parts of Rhizoma Dioscoreae, 10��15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers. and 10��15 portions of Fructus Tritici aestivis, be dried respectively, then is broken into 60��80 order powder under-5��0 DEG C of condition, by red bean powder, Semen Armeniacae Amarum powder, Hylocereus undatus corium farinosum, Rhizoma Dioscoreae powder, Hericium erinaceus (Bull. Ex Fr.) Pers. powder mixes, and adds deionized water by solid-to-liquid ratio 1:8��1:10 in mixed powder, it is uniformly mixed, obtains mixed serum;
(2) above-mentioned mixed serum is sent in grinding pot, be-5��0 DEG C and 20��30r/min rotating speed bar in temperature
10��12h is ground under part, grinding adds wheat germ powder after completing, again at 5��10 DEG C, continue grinding 3��5h under 15��20r/min, mixture after grinding is at room temperature stood centrifugation after depositing 2��3 days, takes supernatant, it is added thereto to gross mass 4��6% gelatin, at 0��5 DEG C, carry out magnetic agitation make gelatin perfect solution, obtain gelatin nutritional liquid, standby;
(3) take 200��300g Rhizoma Curcumae Longae, dried, pulverize and sieve to obtain 80��100 order powder, by solid-to-liquid ratio 1:4��
1:6 adds distilled water and mixing and stirring obtains Rhizoma Curcumae Longae serosity, put in 60��70min water-bath after stirring, gross mass 2��4% cellulase and 5��8% amylase are added in serosity, regulating pH value of solution with mass fraction 25% oxalic acid again is 4.5��5.0, enzyme digestion reaction 3��5h when stirring, obtains Rhizoma Curcumae Longae enzymolysis solution;
(4) in Rhizoma Curcumae Longae enzymolysis solution, 1:5��1:8 adds ethylene glycol by volume, puts into Vltrasonic device after mixing
In carry out supersound process 15��20min, after ultrasonic, centrifugation under 5000��7000r/min rotating speed again, takes supernatant, supernatant pressurization is concentrated into the 50��60% of original volume, and reclaims ethylene glycol, in concentrated solution, add gross mass 50��100% silicone oil, stand to being layered completely after stirring mixing, take subnatant, put into standing 10��12h in-5��0 DEG C of environment, have crystallization, sucking filtration, obtain crystallization, and with washes of absolute alcohol 2��3 times, carry out after cleaning vacuum drying curcumin;
(5) in the gelatin solution of step (2), by volume 5:1 mixes with glycerol, with magnetic agitation uniformly after, be sprayed on above-mentioned curcumin solid, spray after uniformly and carry out lyophilization 2��5h.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108719970A (en) * | 2018-04-24 | 2018-11-02 | 海南久惠生物科技有限公司 | A kind of composition, health products and preparation method thereof comprising it increasing bone density |
| CN108935848A (en) * | 2018-08-01 | 2018-12-07 | 上海应用技术大学 | A kind of bag tea and preparation method thereof containing dendrobium leaf with reduction postprandial blood sugar function |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108719970A (en) * | 2018-04-24 | 2018-11-02 | 海南久惠生物科技有限公司 | A kind of composition, health products and preparation method thereof comprising it increasing bone density |
| CN108935848A (en) * | 2018-08-01 | 2018-12-07 | 上海应用技术大学 | A kind of bag tea and preparation method thereof containing dendrobium leaf with reduction postprandial blood sugar function |
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