CN103007199B - A kind of preparation method of zedoary volatile oil clathrate - Google Patents
A kind of preparation method of zedoary volatile oil clathrate Download PDFInfo
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- CN103007199B CN103007199B CN201210580713.0A CN201210580713A CN103007199B CN 103007199 B CN103007199 B CN 103007199B CN 201210580713 A CN201210580713 A CN 201210580713A CN 103007199 B CN103007199 B CN 103007199B
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- 240000009138 Curcuma zedoaria Species 0.000 title claims abstract description 70
- 235000003405 Curcuma zedoaria Nutrition 0.000 title claims abstract description 61
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 title claims abstract description 61
- 235000019509 white turmeric Nutrition 0.000 title claims abstract description 61
- 239000000341 volatile oil Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 67
- 239000003921 oil Substances 0.000 claims abstract description 64
- 235000003392 Curcuma domestica Nutrition 0.000 claims abstract description 49
- 235000003373 curcuma longa Nutrition 0.000 claims abstract description 49
- 235000013976 turmeric Nutrition 0.000 claims abstract description 49
- 239000000084 colloidal system Substances 0.000 claims abstract description 45
- 238000000034 method Methods 0.000 claims abstract description 35
- 235000019441 ethanol Nutrition 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 20
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 17
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 14
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 11
- 229960004853 betadex Drugs 0.000 claims abstract description 11
- 239000008213 purified water Substances 0.000 claims abstract description 10
- 239000000706 filtrate Substances 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 6
- 238000001556 precipitation Methods 0.000 claims abstract description 6
- 239000002002 slurry Substances 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- 244000163122 Curcuma domestica Species 0.000 claims description 46
- 239000006166 lysate Substances 0.000 claims description 15
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 5
- 239000000839 emulsion Substances 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 239000000047 product Substances 0.000 abstract description 6
- 238000011017 operating method Methods 0.000 abstract description 2
- 244000008991 Curcuma longa Species 0.000 abstract 3
- 238000004945 emulsification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 6
- 241000407170 Curcuma Species 0.000 description 5
- 235000014375 Curcuma Nutrition 0.000 description 5
- 239000010692 aromatic oil Substances 0.000 description 5
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 238000005498 polishing Methods 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940030999 antipsoriatics Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000010681 turmeric oil Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Abstract
The present invention relates to a kind of preparation methods of zedoary volatile oil clathrate.Specifically：Take the purified water a of 10 times of amounts；Oil of zedoary turmeric is taken, the ethyl alcohol of 1/5 times of amount of oil of zedoary turmeric is added, obtains b；First colloid mill is sterilized with 75% ethyl alcohol, controls 1500~3500rpm of rotating speed, then b is entered in colloid mill, slurries in colloid mill is rinsed with a, until water outlet is in colourless, obtains c；The beta-cyclodextrin for taking 6 times of amounts of oil of zedoary turmeric, adds a remainder amounts, after being mixed into heating for dissolving, is cooled to 40 DEG C~50 DEG C, obtains d；C is added slowly in d, stirring while adding, 1000~2000rpm of mixing speed, continues to stir 30min~45min after adding, then is placed in 0 DEG C~4 DEG C environment and refrigerate, stands 12h；Then it filters to dry, then precipitation is washed with a small amount of ethyl alcohol, filtrate discards, and obtains volatile oil clathrate compound；It is dried at 50 ± 5 DEG C, fine powder is made,.It is first used in the method operating procedure through colloid mill emulsification, the preparation method for again including emulsion and β-CD with saturated water solution method, the inclusion time is obviously shortened, and the utilization rate and inclusion rate of volatile oil significantly improve, and have the advantages that production efficiency height, product quality are stablized.
Description
Technical field
The present invention relates to the inclusion processing technique fields of Chinese medicine effective ingredient volatile extract, specifically a kind of
The preparation method of zedoary volatile oil clathrate.
Background technology
Contain volatile oil in several kinds of Chinese medicinal materials, but volatile oil itself is unstable, it is added without processing, Direct spraying
Its active ingredient is readily volatilized in product made of particle method, aoxidizes, and the loss amount of volatile oil is larger, and manufactured product can be direct
The effect of influencing pharmaceutically-active performance, leading to drug declines；Due to differing for storage requirement, different batches production is also resulted in
Quality is inhomogenous.It is using β-ring paste to increase stability of volatile oil at present and cover the common method of volatile oil penetrating odor
Smart (β-cyclodextrin, β-CD) is included, and makes liquid medicine powdered, convenient for a variety of different dosage forms are made.Volatilization
Oil can reduce the volatilization of volatile ingredient after inclusion, reduce the irritation of drug, the disadvantage for overcoming dosage not easy to control, effectively
The stability for improving product quality, to improve the stability and curative effect of drug.
Oil of zedoary turmeric is the volatile oil extracted through steam distillation in Traditional Chinese medicine Rhizoma curcumae, has antitumor, antibacterial, disease-resistant
The multiple pharmacological effects such as poison, antithrombotic, liver protection, anti-psoriasis and enhancing immune function.A variety of aromatic turmeric oil preparations are successful
Applied to clinic.Oil of zedoary turmeric has the shortcomings of not soluble in water, poor bioavailability, bitter, is directly added into particle and is made
Solid pharmaceutical preparation such as capsule, granule when, volatile oil highly volatile and Odor stimulation are big, are not easy to take orally, this is just limited
The application of oil of zedoary turmeric.And smelly flavoring can be rectified by forming inclusion compound with cyclodextrin, prevented the volatilization of oil of zedoary turmeric, enhanced oil of zedoary turmeric
Stability increases its water solubility, improves its bioavilability.
The method of inclusion essential oil mainly has polishing, saturated water solution method, ultrasonic method etc., the volatilization of saturated water solution method
Oily inclusion degree and utilization rate are relatively high, are better than other two methods, therefore generally use saturated water solution method in actual production.
The production method of oil of zedoary turmeric inclusion complex has saturated water solution method, also there is polishing, can form stable inclusion compound.
Saturated water solution method is after preferably：β-CD：Oil (g：Ml it is) 8：1, inclusion temperature be 40 DEG C, the inclusion time for 90min~
120min, refrigeration 20 hours or more filter and obtain inclusion compound, and it is shady and cool dry to place ventilation, obtains oil of zedoary turmeric inclusion compound.It presses《China
People's republic's pharmacopeia》One Ⅹ D determination of volatile oil methods of annex detection, inclusion essential oil rate are 90.90%, volatile oil utilization rate
It is 66.67%.Hebei Yi Ling Pharmaceutical Groups prepare the oil of zedoary turmeric supported in positive capsule using polishing, by β-CD：Oil of zedoary turmeric (g：
m1)： 8：1, add 5 times of water, continuously grinding 100min obtains inclusion compound, filters to dry, then with a small amount of petroleum ether, 50 DEG C
~55 DEG C are dried in vacuo 4 hours, obtain volatile oil clathrate compound.Inclusion rate is between 62.2%~63.7%, average inclusion rate 62.9%.
Invention content：
That the object of the present invention is to provide a kind of volatile oil utilization rates is high, inclusion rate is high and includes time short Curcuma Aromatic Oil
The preparation method of inclusion compound.
A kind of preparation method of zedoary volatile oil clathrate of the present invention, setting inclusion control condition are：Oil of zedoary turmeric and β-ring
Dextrin（Weight/volume）The ratio between be 1: 6,40 DEG C~50 DEG C of temperature of inclusion, the min of inclusion time 30min~45, detailed process and
Steps are as follows：
（1）The purified water a of 10 times of oil of zedoary turmeric (volume) amount is weighed, it is spare；
（2）It takes oil of zedoary turmeric, the ethyl alcohol dissolving of 1/5 times of amount of curcuma zedoary oil volume is added, obtain oil of zedoary turmeric ethyl alcohol lysate b, it is spare；
（3）It with reference to colloid mill specification, is first carried out disinfection to colloid mill with appropriate 75% ethyl alcohol, controls colloid mill rotating speed
1500~3500rpm, then b is passed through in colloid mill, the slurries in colloid mill are rinsed with a, until the water outlet for rinsing colloid mill is in nothing
Color, it is c that this oil of zedoary turmeric ethyl alcohol lysate for crossing colloid mill acquisition, which is in emulsion form,；
（4）The beta-cyclodextrins (g/ml) for taking 6 times of oil of zedoary turmeric amount, add remaining purified water in a, after heating for dissolving, are cooled to
40 DEG C~50 DEG C, obtain the saturated aqueous solution d of beta-cyclodextrin；
（5）C is added slowly in d, stirring while adding, mixing speed is 1000~2000rpm, continues to stir after adding
The min of 30min~45, then be placed in 0 DEG C~4 DEG C environment and refrigerate, stand 12 hours；
（6）Then it filters to dry, then precipitation is washed with a small amount of ethyl alcohol, filtrate discards, and obtains volatile oil clathrate compound；
（7）Volatile oil inclusion complex is dried at 50 ± 5 DEG C, is ground into fine powder,.
Zedoary volatile oil clathrate made from the above method is pressed《Pharmacopoeia of People's Republic of China》2010 editions annex Ⅹ
D determination of volatile oil methods detect, and for volatile oil oil utilization rate up to 85% or more, inclusion rate is 95% or more.
It tests and investigates through influence factor, the oil of zedoary turmeric inclusion compound of the oil of zedoary turmeric preparation method acquisition of patent of the present invention does not have
It degrades.
The preparation method of the zedoary volatile oil clathrate of the present invention, setting control condition are：Oil of zedoary turmeric and beta-cyclodextrin body
The ratio between product is 1: 6,40 DEG C~50 DEG C of temperature of inclusion, the min of inclusion time 30min~45, first using passing through colloid in operating procedure
The preparation method that mill is emulsified, again included emulsion and β-CD with saturated water solution method, inclusion time are obviously shortened, and volatilize
The utilization rate and inclusion rate of oil significantly improve, and have the advantages that production efficiency height, product quality are stablized, and are suitble to extensive raw
Production.
Specific implementation mode
Below by following embodiment, the invention will be further described, it will be helpful to understand the present invention, but and unlimited
Present disclosure processed.
Embodiment 1
With a kind of preparation method of zedoary volatile oil clathrate of the present invention, for the 2kg/ that feeds intake batches of Curcuma Aromatic Oils,
Operating process and steps are as follows：
（1）The purified water a of the i.e. 20L of 10 times of curcuma zedoary oil volume amount is weighed, it is spare；
（2）Oil of zedoary turmeric is taken, the ethyl alcohol dissolving that 1/5 times of amount of curcuma zedoary oil volume is 0.4L is added, obtains oil of zedoary turmeric ethyl alcohol lysate
B, it is spare；
（3）It with reference to colloid mill specification, is first carried out disinfection to colloid mill with appropriate 75% ethyl alcohol, controls colloid mill rotating speed
1500rpm, then by b, that is, oil of zedoary turmeric ethyl alcohol lysate input colloid mill, the slurries in colloid mill are rinsed with 2L-3L a, until punching
The water outlet for washing colloid mill is in colourless, and it is c that this oil of zedoary turmeric ethyl alcohol lysate for crossing colloid mill acquisition, which is in emulsion form,；
（4）Take the beta-cyclodextrin (g of 6 times of i.e. 12L of amount of oil of zedoary turmeric：Ml), remaining purified water a is added, mixes, is heated to 55
DEG C dissolving after, be cooled to 50 DEG C, obtain the saturated aqueous solution d of beta-cyclodextrin；
（5）It was that the oil of zedoary turmeric ethyl alcohol lysate that colloid mill obtains is added slowly in d by c, stirring while adding, mixing speed
For 1000rpm, continue to stir 36 min after adding, then is placed in 0 DEG C~4 DEG C environment and refrigerates, stands 12 hours；
（6）Then it filters to dry, then precipitation is washed with a small amount of ethyl alcohol, filtrate discards, and obtains volatile oil clathrate compound；
（7）Volatile oil inclusion complex is dried at 50 ± 5 DEG C, is ground into fine powder, crosses 80 mesh sieve,.
The method that colloid mill emulsification-saturated water solution method in the present embodiment is combined prepares obtained oil of zedoary turmeric inclusion
Object is pressed《Pharmacopoeia of People's Republic of China》2010 editions Ⅹ D determination of volatile oil methods of annex detections, volatile oil oil utilization rate are
88.9%, inclusion rate 97.0%.And examined through thin-layer chromatography, it was demonstrated that oil of zedoary turmeric principal component after inclusion is basically unchanged, through oxygen
The factors influencings such as change, illumination thermal stability, inclusion compound property are stablized, and are verified through technique reproducibility, and reproducibility is good.
Embodiment 2
With a kind of preparation method of zedoary volatile oil clathrate of the present invention, for the 3kg/ that feeds intake batches of Curcuma Aromatic Oils,
Operating process and steps are as follows：
（1）The purified water a of the i.e. 30L of 10 times of curcuma zedoary oil volume amount is weighed, it is spare；
（2）Oil of zedoary turmeric is taken, the ethyl alcohol dissolving that 1/5 times of amount of curcuma zedoary oil volume is 0.6L is added, obtains oil of zedoary turmeric ethyl alcohol lysate
B, it is spare；
（3）It with reference to colloid mill specification, is first carried out disinfection to colloid mill with appropriate 75% ethyl alcohol, controls colloid mill rotating speed
2900rpm, then by b, that is, oil of zedoary turmeric ethyl alcohol lysate input colloid mill, the slurries in colloid mill are rinsed with 2L-3L a, until punching
The water outlet for washing colloid mill is in colourless, and it is c that this oil of zedoary turmeric ethyl alcohol lysate for crossing colloid mill acquisition, which is in emulsion form,；
（4）Take the beta-cyclodextrin (g of 6 times of i.e. 18L of amount of oil of zedoary turmeric：Ml), remaining purified water a is added, mixes, is heated to 45
DEG C dissolving after, be cooled to 40 DEG C, obtain the saturated aqueous solution d of beta-cyclodextrin；
（5）It was that the oil of zedoary turmeric ethyl alcohol lysate that colloid mill obtains is added slowly in d by c, stirring while adding, mixing speed
For 1500rpm, continue to stir 30 min after adding, then is placed in 2 DEG C~4 DEG C environment and refrigerates, stands 12 hours；
（6）Then it filters to dry, then precipitation is washed with a small amount of ethyl alcohol, filtrate discards, and obtains volatile oil clathrate compound；
（7）Volatile oil inclusion complex is dried at 50 ± 5 DEG C, is ground into fine powder, crosses 80 mesh sieve,.
The method that colloid mill emulsification-saturated water solution method in this implementation is combined prepares oil of zedoary turmeric inclusion compound, presses《China
People's republic's pharmacopeia》2010 editions Ⅹ D determination of volatile oil methods of annex detections, volatile oil oil utilization rate are 85.3%, inclusion
Rate is 95.2%.And examined through thin-layer chromatography, it was demonstrated that oil of zedoary turmeric principal component after inclusion is basically unchanged, and oxidized, illumination is hot steady
The factors influencings such as qualitative, inclusion compound property are stablized, and are verified through technique reproducibility, and reproducibility is good.
Embodiment 3
With a kind of preparation method of zedoary volatile oil clathrate of the present invention, for the 1kg/ that feeds intake batches of Curcuma Aromatic Oils,
Operating process and steps are as follows：
（1）The purified water a of the i.e. 10L of 10 times of curcuma zedoary oil volume amount is weighed, it is spare；
（2）Oil of zedoary turmeric is taken, the ethyl alcohol dissolving that 1/5 times of amount of curcuma zedoary oil volume is 0.2L is added, obtains oil of zedoary turmeric ethyl alcohol lysate
B, it is spare；
（3）It with reference to colloid mill specification, is first carried out disinfection to colloid mill with appropriate 75% ethyl alcohol, controls colloid mill rotating speed
3500rpm, then by b, that is, oil of zedoary turmeric ethyl alcohol lysate input colloid mill, the slurries in colloid mill are rinsed with 1L-1.5L a, until
The water outlet for rinsing colloid mill is in colourless, and it is c that this oil of zedoary turmeric ethyl alcohol lysate for crossing colloid mill acquisition, which is in emulsion form,；
（4）Take the beta-cyclodextrin (g of 6 times of i.e. 6L of amount of oil of zedoary turmeric：Ml), remaining purified water a is added, mixes, is heated to 50
DEG C dissolving after, be cooled to 45 DEG C, obtain the saturated aqueous solution d of beta-cyclodextrin；
（5）The saturated aqueous solution liquid for the β-CD that the oil of zedoary turmeric ethyl alcohol that c was colloid mill acquisition dissolves 45 DEG C is added slowly to d
（The saturated aqueous solution of i.e. 45 DEG C of β-CD）In, stirring while adding, mixing speed 2000rpm continues stirring 45 after adding
Min, then be placed in 1 DEG C~3 DEG C environment and refrigerate, stand 12 hours；
（6）Then it filters to dry, then precipitation is washed with a small amount of ethyl alcohol, filtrate discards, and obtains volatile oil clathrate compound；
（7）Volatile oil inclusion complex is dried at 50 ± 5 DEG C, is ground into fine powder, crosses 80 mesh sieve,.
The Curcuma Aromatic Oil inclusion that the method that colloid mill emulsification-saturated water solution method in this implementation is combined prepares
Object is pressed《Pharmacopoeia of People's Republic of China》2010 editions Ⅹ D determination of volatile oil methods of annex detections, volatile oil oil utilization rate are
92.9%, inclusion rate 98.0%.And examined through thin-layer chromatography, it was demonstrated that oil of zedoary turmeric principal component after inclusion is basically unchanged, through oxygen
The factors influencings such as change, light illumination thermal stability, inclusion compound property are stablized, and are verified through technique reproducibility, and reproducibility is good.
Claims (2)
1. a kind of preparation method of zedoary volatile oil clathrate, it is characterised in that including control condition is：Oil of zedoary turmeric is pasted with β-ring
The ratio between smart volume/weight is 1: 6,40 DEG C~50 DEG C of temperature of inclusion, the inclusion min of time 30min~60, detailed process and step
It is as follows：
（1）The purified water a of ten times of curcuma zedoary oil volume amount is weighed, it is spare；
（2）Take oil of zedoary turmeric, the ethyl alcohol that 1/5 amount of volume is added dissolves, and obtains oil of zedoary turmeric ethyl alcohol lysate b, spare；
（3）After first by appropriate 75% ethyl alcohol by colloid mill, colloid mill 1500~3500rpm of rotating speed is controlled, then b is passed through colloid
In mill, the slurries in colloid mill are rinsed with a, until the water outlet for rinsing colloid mill stops in colourless, then obtained the oil of zedoary turmeric second of colloid mill
Alcohol lysate c；
（4）The beta-cyclodextrins (g/ml) for taking 6 times of oil of zedoary turmeric amount, are added remaining a, after heating for dissolving, are cooled to 40 DEG C~50 DEG C,
Obtain the saturated aqueous solution d of beta-cyclodextrin；
（5）C is added slowly in d, stirring while adding, mixing speed is 1000~2000rpm, continues to stir 30min after adding
~45min, then be placed in 0 DEG C~4 DEG C environment and refrigerate, stand 12 hours；
（6）Then it filters to dry, then precipitation is washed with a small amount of ethyl alcohol, filtrate discards, and obtains volatile oil clathrate compound；
（7）Volatile oil clathrate compound is dried at 50 ± 5 DEG C, is ground into fine powder,.
2. the preparation method of zedoary volatile oil clathrate according to claim 1, it is characterised in that：Curcuma zedoary volatilization obtained
Oily inclusion compound is pressed《Pharmacopoeia of People's Republic of China》2010 editions Ⅹ D determination of volatile oil methods of annex detections, volatile oil utilization rate
Up to 85% or more, inclusion rate is 95% or more.
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| CN106237343A (en) * | 2016-08-30 | 2016-12-21 | 铜陵翔宇商贸有限公司 | Rhizoma Curcumae volatile oil beta cyclodextrin is combined clathrate and preparation method thereof |
| CN106860876A (en) * | 2017-03-14 | 2017-06-20 | 胡江宇 | Oil of zedoary turmeric sustained release inclusion compound and preparation method thereof |
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| CN1586604A (en) * | 2004-07-30 | 2005-03-02 | 张正生 | Zedoary injection preparation and its preparing method |
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| 莪术油环糊精包合物的制备工艺研究;王艳等;《天津中医药大学学报》;20120630;第31卷(第2期);101-104页 * |
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