CN106236721A - A kind of preparation method of Guishaoliujun Pill - Google Patents
A kind of preparation method of Guishaoliujun Pill Download PDFInfo
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses the preparation method of a kind of Guishaoliujun Pill, it is made up as crude drug of Radix Angelicae Sinensis 100 parts, Rhizoma Atractylodis Macrocephalae (parched) 100 parts, Radix Codonopsis 100 parts, the Radix Paeoniae Alba 100 parts, 100 parts of Poria, Radix Glycyrrhizae Preparata 50 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts using weight portion number scale, comprises the following steps: (1) crude drug is pulverized；(2) supersound extraction；(3) prepared by capping powder；(4) prepared by concentrated solution；(5) general ball.The Guishaoliujun Pill prepared by the preparation method of this Guishaoliujun Pill is to incoordination between the liver and spleen, stomachache that gastral cavity is swollen, lack of appetite body is tired, the patient with sympotoms such as vomiting have stronger curative effect, clinical trial proves, the total effective rate of patient up to more than 95%, can effectively be reduced the cacogeusia of pill, it is simple to patient takes by the Guishaoliujun Pill prepared by the method simultaneously.
Description
Technical field
The present invention relates to Chinese patent medicine secondary exploitation technology field, be specifically related to the preparation method of a kind of Guishaoliujun Pill.
Background technology
Guishaoliujun Pill is recorded in Ministry of Public Health standard WS3-B-0242-90, prescription is Radix Angelicae Sinensis 100g, Rhizoma Atractylodis Macrocephalae (parched) 100g, party
Ginseng 100g, Radix Paeoniae Alba 100g, Poria 100g, Radix Glycyrrhizae Preparata 50g, Pericarpium Citri Reticulatae 50g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50g, above eight tastes, it is ground into fine powder, mistake
Sieve, mixing, separately take Rhizoma Zingiberis Recens 30g and Fructus Jujubae 30g and smash to pieces, decoct juice, general ball, be dried, to obtain final product.Can benefiting QI and nourishing blood.For incoordination between the liver and spleen,
Stomachache that gastral cavity is swollen, lack of appetite body is tired, vomiting.
After pulverizing medicinal materials is directly become fine powder by existing technique, fine powder is made pellet so that pellet pharmaceutical active composition
Content is low, and active constituents of medicine and medical material impurity mix and is unfavorable for that human body the intestines and stomach absorbs simultaneously, ultimately result in this medicine
Clinical therapeutic efficacy poor.
Summary of the invention
The deficiency existed for prior art, it is an object of the invention to provide the preparation method of a kind of Guishaoliujun Pill, should
Method can be effectively improved the clinical therapeutic efficacy of this medicine.
The above-mentioned technical purpose of the present invention has the technical scheme that
The preparation method of a kind of Guishaoliujun Pill, with weight portion number scale by Radix Angelicae Sinensis 100 parts, Rhizoma Atractylodis Macrocephalae (parched) 100 parts, Radix Codonopsis 100 parts, white
Chinese herbaceous peony 100 parts, 100 parts of Poria, Radix Glycyrrhizae Preparata 50 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts are made as crude drug, comprise the following steps:
(1) crude drug is pulverized, and is rinsed by above-mentioned raw materials medicine, is dried, mixes, is then placed in super micron mill carrying out micropowder
Broken, crude drug is crushed to particle diameter in 6-10 μm, then by microwave sterilizating machine, medicated powder is carried out microwave sterilizating, sterilization time is 2-
4 hours；
(2) supersound extraction, puts in circulating ultrasonic extractor by the medicated powder of step (1) gained, adds 6500 parts of distilled water, selects super
Frequency of sound wave is 35-45KHz, temperature 45-50 DEG C, extracts 20-25 minute, obtains filtrate with filter-cloth filtering；
(3) prepared by capping powder, the filtrate of step (2) gained is placed in jet spray dryer, controls inlet temperature 70-80
DEG C, pressure 0.02-0.03MPa, flow velocity is 450-500m/s, obtains nanoscale capping powder；
(4) prepared by concentrated solution, takes 30 parts of Rhizoma Zingiberis Recens and smashs to pieces with 30 parts of Fructus Jujubae, decocts into 300 portions of juice, adds 300 parts of refined honey mixings
Both；
(5) general ball, makees molding powder with the capping powder prepared in step (3), is placed in oscillating granulator by part capping powder,
The concentrated solution adding appropriate step (4) prepared makes soft material, by oscillating granulator, soft material is made 12 mesh wet granulars, then
Move in general ball machine, rotate general ball machine, make granule become round, and be sequentially added into concentrated solution, capping powder, make pill continue to increase, take
Go out 8-10 mesh sieve, prepare ball mould；
Ball mould is put in general ball machine, adds concentrated solution and the general ball of medicated powder successively, pill is taken out in good time, sieve and grade, by little ball
Grain stepping is placed in general ball machine and strengthens with general ball after concentrated solution and capping powder, weighs 1.6g/10 to ball after making pill in the same size
Grain takes out, points 12 times less than 60 DEG C be dried, be dried 40-55 minute, control moisture less than 5.0% every time；
Mixing, dry ball mixer mixes 15 minutes, contains by cleaner, and the sealing that closes the lid both obtained.
Use such scheme, crude drug be crushed to particle diameter and crude drug cell sporoderm-broken rate can be made to reach more than 90% in 6-10 μm,
The antibacterial ensconced in crude drug cell can be fully killed, it is ensured that the safety of medical material, microwave is going out simultaneously when it is carried out microwave sterilizating
Medical material temperature can be made during bacterium to rise to about 80 DEG C, can will not destroy medical material while playing the desiccation to medical material
Point；
Simultaneously because crude drug cell wall is broken so that the active component in crude drug cell directly comes out, then it is entered
Active component in medical material can the most just can be extracted by row ultrasonic extraction completely, reduces production cost, then will
After active component extracts, a reserved filtrate, give up filtering residue, compare and directly take with the general ball of medical material powder after in small, broken bits, can reduce and take
Person, to remaining in the absorption of heavy metal, residual pesticide etc. in Chinese crude drug, avoids medical material impurity and active component to be blended in one simultaneously
Rise, affect human body the intestines and stomach and absorb；
Filtrate made nano level capping powder again and carries out general ball, the active component of various medical materials can be mixed rapidly, can protect
The active component of card Chinese medicine will not be destroyed during preparation and preservation, and in pill, active component content is higher, works as human body
Rapidly human body the intestines and stomach can be absorbed after taking, play drug effect；
In addition the use of concentrated solution, can reduce the cacogeusia of pill, it is simple to clothes for patients is used.
As preferably, in described step (2) supersound extraction, the ultrasonic frequency of circulating ultrasonic extractor is set as 35KHz,
Temperature 50 C, extracts 20 minutes.
Use such scheme, find through test of many times, the ultrasonic frequency of supersonic extractors is set as 35KHz,
Temperature 50 C extracts and can be extracted completely by the active component of medical material for 20 minutes, plays optimal curative effect.
In preparing as preferred described step (3) capping powder, the inlet temperature of spray dryer is set as 70 DEG C, and pressure is
0.03MPa, flow velocity is 450 m/s.
Using such scheme, through repeatedly attempting discovery, when the inlet temperature of spray dryer is set as 70 DEG C, pressure is
0.03MPa, flow velocity is 450 m/s, and prepared capping powder is the most uniform, thus the pill prepared can play optimal treatment effect
Really.
In sum, the method have the advantages that
To incoordination between the liver and spleen, stomachache that gastral cavity is swollen, the patient with sympotoms such as lack of appetite body is tired, vomiting have stronger curative effect, and clinical trial proves, use
The total effective rate of patient up to more than 95%, can effectively be reduced the cacogeusia of pill, just by the Guishaoliujun Pill that the method prepares simultaneously
Take in patient.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
The preparation method of a kind of Guishaoliujun Pill, with weight portion number scale by Radix Angelicae Sinensis 100 parts, Rhizoma Atractylodis Macrocephalae (parched) 100 parts, Radix Codonopsis 100 parts, white
Chinese herbaceous peony 100 parts, 100 parts of Poria, Radix Glycyrrhizae Preparata 50 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts are made as crude drug, comprise the following steps:
(1) crude drug is pulverized, and is rinsed by above-mentioned raw materials medicine, is dried, mixes, is then placed in super micron mill carrying out micropowder
Broken, crude drug is crushed to particle diameter in 6-10 μm, then by microwave sterilizating machine, medicated powder is carried out microwave sterilizating, sterilization time is 2-
4 hours；
(2) supersound extraction, puts in circulating ultrasonic extractor by the medicated powder of step (1) gained, adds 6500 parts of distilled water, selects super
Frequency of sound wave is 35KHz, temperature 50 C, extracts 20 minutes, obtains filtrate with filter-cloth filtering；
(3) prepared by capping powder, the filtrate of step (2) gained is placed in jet spray dryer, controls inlet temperature 70 DEG C, pressure
Power 0.03MPa, flow velocity is 450m/s, obtains nanoscale capping powder；
(4) prepared by concentrated solution, takes 30 parts of Rhizoma Zingiberis Recens and smashs to pieces with 30 parts of Fructus Jujubae, decocts into 300 portions of juice, adds 300 parts of refined honey mixings
Both；
(5) general ball, makees molding powder with the capping powder prepared in step (3), is placed in oscillating granulator by part capping powder,
The concentrated solution adding appropriate step (4) prepared makes soft material, by oscillating granulator, soft material is made 12 mesh wet granulars, then
Move in general ball machine, rotate general ball machine, make granule become round, and be sequentially added into concentrated solution, capping powder, make pill continue to increase, take
Go out 8-10 mesh sieve, prepare ball mould；
Ball mould is put in general ball machine, adds concentrated solution and the general ball of medicated powder successively, pill is taken out in good time, sieve and grade, by little ball
Grain stepping is placed in general ball machine and strengthens with general ball after concentrated solution and capping powder, weighs 1.6g/10 to ball after making pill in the same size
Grain takes out, points 12 times less than 60 DEG C be dried, be dried 40-55 minute, control moisture less than 5.0% every time；
Mixing, dry ball mixer mixes 15 minutes, contains by cleaner, and the sealing that closes the lid both obtained.
Embodiment 2
The preparation method of a kind of Guishaoliujun Pill, with weight portion number scale by Radix Angelicae Sinensis 100 parts, Rhizoma Atractylodis Macrocephalae (parched) 100 parts, Radix Codonopsis 100 parts, white
Chinese herbaceous peony 100 parts, 100 parts of Poria, Radix Glycyrrhizae Preparata 50 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts are made as crude drug, comprise the following steps:
(1) crude drug is pulverized, and is rinsed by above-mentioned raw materials medicine, is dried, mixes, is then placed in super micron mill carrying out micropowder
Broken, crude drug is crushed to particle diameter in 6-10 μm, then by microwave sterilizating machine, medicated powder is carried out microwave sterilizating, sterilization time is 2-
4 hours；
(2) supersound extraction, puts in circulating ultrasonic extractor by the medicated powder of step (1) gained, adds 6500 parts of distilled water, selects super
Frequency of sound wave is 45KHz, temperature 45 C, extracts 25 minutes, obtains filtrate with filter-cloth filtering；
(3) prepared by capping powder, the filtrate of step (2) gained is placed in jet spray dryer, controls inlet temperature 80 DEG C, pressure
Power 0.02MPa, flow velocity is 500m/s, obtains nanoscale capping powder；
(4) prepared by concentrated solution, takes 30 parts of Rhizoma Zingiberis Recens and smashs to pieces with 30 parts of Fructus Jujubae, decocts into 300 portions of juice, adds 300 parts of refined honey mixings
Both；
(5) general ball, makees molding powder with the capping powder prepared in step (3), is placed in oscillating granulator by part capping powder,
The concentrated solution adding appropriate step (4) prepared makes soft material, by oscillating granulator, soft material is made 12 mesh wet granulars, then
Move in general ball machine, rotate general ball machine, make granule become round, and be sequentially added into concentrated solution, capping powder, make pill continue to increase, take
Go out 8-10 mesh sieve, prepare ball mould；
Ball mould is put in general ball machine, adds concentrated solution and the general ball of medicated powder successively, pill is taken out in good time, sieve and grade, by little ball
Grain stepping is placed in general ball machine and strengthens with general ball after concentrated solution and capping powder, weighs 1.6g/10 to ball after making pill in the same size
Grain takes out, points 12 times less than 60 DEG C be dried, be dried 40-55 minute, control moisture less than 5.0% every time；
Mixing, dry ball mixer mixes 15 minutes, contains by cleaner, and the sealing that closes the lid both obtained.
Embodiment 3
The preparation method of a kind of Guishaoliujun Pill, with weight portion number scale by Radix Angelicae Sinensis 100 parts, Rhizoma Atractylodis Macrocephalae (parched) 100 parts, Radix Codonopsis 100 parts, white
Chinese herbaceous peony 100 parts, 100 parts of Poria, Radix Glycyrrhizae Preparata 50 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts are made as crude drug, comprise the following steps:
(1) crude drug is pulverized, and is rinsed by above-mentioned raw materials medicine, is dried, mixes, is then placed in super micron mill carrying out micropowder
Broken, crude drug is crushed to particle diameter in 6-10 μm, then by microwave sterilizating machine, medicated powder is carried out microwave sterilizating, sterilization time is 2-
4 hours；
(2) supersound extraction, puts in circulating ultrasonic extractor by the medicated powder of step (1) gained, adds 6500 parts of distilled water, selects super
Frequency of sound wave is 40KHz, temperature 48 DEG C, extracts 23 minutes, obtains filtrate with filter-cloth filtering；
(3) prepared by capping powder, the filtrate of step (2) gained is placed in jet spray dryer, controls inlet temperature 75 DEG C, pressure
Power 0.025MPa, flow velocity is 480m/s, obtains nanoscale capping powder；
(4) prepared by concentrated solution, takes 30 parts of Rhizoma Zingiberis Recens and smashs to pieces with 30 parts of Fructus Jujubae, decocts into 300 portions of juice, adds 300 parts of refined honey mixings
Both；
(5) general ball, makees molding powder with the capping powder prepared in step (3), is placed in oscillating granulator by part capping powder,
The concentrated solution adding appropriate step (4) prepared makes soft material, by oscillating granulator, soft material is made 12 mesh wet granulars, then
Move in general ball machine, rotate general ball machine, make granule become round, and be sequentially added into concentrated solution, capping powder, make pill continue to increase, take
Go out 8-10 mesh sieve, prepare ball mould；
Ball mould is put in general ball machine, adds concentrated solution and the general ball of medicated powder successively, pill is taken out in good time, sieve and grade, by little ball
Grain stepping is placed in general ball machine and strengthens with general ball after concentrated solution and capping powder, weighs 1.6g/10 to ball after making pill in the same size
Grain takes out, points 12 times less than 60 DEG C be dried, be dried 40-55 minute, control moisture less than 5.0% every time；
Mixing, dry ball mixer mixes 15 minutes, contains by cleaner, and the sealing that closes the lid both obtained.
Embodiment 4:
The Guishaoliujun Pill that Example 1-3 prepares treats incoordination between the liver and spleen, stomachache that gastral cavity is swollen, lack of appetite body with commercially available Guishaoliujun Pill
Tired, the clinical observation on the therapeutic effect such as vomiting:
1. case scenario
Statistics outpatient service and inpatient, observe incoordination between the liver and spleen altogether, stomachache that gastral cavity is swollen, case 400 examples such as lack of appetite body is tired, vomiting, the age
In 20-60 year.Patient is divided into four groups, and test group takes the Guishaoliujun Pill of embodiment 1-3, and matched group takes tradition GUISHAO six
Monarch's ball.
2. instructions of taking and curative effect are shown in Table 1:
Table 1 embodiment 1-3 and matched group instructions of taking and curative effect
| Group | Number/people | Day/time | Each serving consumption/gram | Take natural law/sky | Total effective rate |
| Embodiment 1 | 100 | 2 | 9 | 7 | 99% |
| Embodiment 2 | 100 | 2 | 9 | 7 | 96% |
| Embodiment 3 | 100 | 2 | 9 | 7 | 96% |
| Matched group | 100 | 2 | 9 | 7 | 79% |
Wherein total effective rate calculates according to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard.
Conclusion: matched group is in treatment incoordination between the liver and spleen, and stomachache that gastral cavity is swollen, lack of appetite body is tired, the total effective rate of the 100 example patients such as vomiting
Be 79%, of the present invention group in incoordination between the liver and spleen, stomachache that gastral cavity is swollen, lack of appetite body is tired, and the average total effective rate of the 300 example patients such as vomiting is
97%, wherein the total effective rate of embodiment 1 treatment is up to 99%, and the total effective rate of of the present invention group compares with matched group total effective rate
There were significant differences.
This specific embodiment is only explanation of the invention, and it is not limitation of the present invention, people in the art
The present embodiment can be made after reading this specification by member as required does not has the amendment of creative contribution, but as long as at this
All protected by Patent Law in the right of invention.
Claims (3)
1. a preparation method for Guishaoliujun Pill, with weight portion number scale by Radix Angelicae Sinensis 100 parts, Rhizoma Atractylodis Macrocephalae (parched) 100 parts, Radix Codonopsis 100 parts,
The Radix Paeoniae Alba 100 parts, 100 parts of Poria, Radix Glycyrrhizae Preparata 50 parts, Pericarpium Citri Reticulatae 50 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts are made as crude drug, it is characterized in that including
Following steps:
(1) crude drug is pulverized, and is rinsed by above-mentioned raw materials medicine, is dried, mixes, is then placed in super micron mill carrying out micropowder
Broken, crude drug is crushed to particle diameter in 6-10 μm, then by microwave sterilizating machine, medicated powder is carried out microwave sterilizating, sterilization time is 2-
4 hours；
(2) supersound extraction, puts in circulating ultrasonic extractor by the medicated powder of step (1) gained, adds 6500 parts of distilled water, selects super
Frequency of sound wave is 35-45KHz, temperature 45-50 DEG C, extracts 20-25 minute, obtains filtrate with filter-cloth filtering；
(3) prepared by capping powder, the filtrate of step (2) gained is placed in jet spray dryer, controls inlet temperature 70-80
DEG C, pressure 0.02-0.03MPa, flow velocity is 450-500m/s, obtains nanoscale capping powder；
(4) prepared by concentrated solution, takes 30 parts of Rhizoma Zingiberis Recens and smashs to pieces with 30 parts of Fructus Jujubae, decocts into 300 portions of juice, adds 300 parts of refined honey mixings
Both；
(5) general ball, makees molding powder with the capping powder prepared in step (3), is placed in oscillating granulator by part capping powder,
The concentrated solution adding appropriate step (4) prepared makes soft material, by oscillating granulator, soft material is made 12 mesh wet granulars, then
Move in general ball machine, rotate general ball machine, make granule become round, and be sequentially added into concentrated solution, capping powder, make pill continue to increase, take
Go out 8-10 mesh sieve, prepare ball mould；
Ball mould is put in general ball machine, adds concentrated solution and the general ball of medicated powder successively, pill is taken out in good time, sieve and grade, by little ball
Grain stepping is placed in general ball machine and strengthens with general ball after concentrated solution and capping powder, weighs 1.6g/10 to ball after making pill in the same size
Grain takes out, points 12 times less than 60 DEG C be dried, be dried 40-55 minute, control moisture less than 5.0% every time；
Mixing, dry ball mixer mixes 15 minutes, contains by cleaner, and the sealing that closes the lid both obtained.
The preparation method of a kind of Guishaoliujun Pill the most according to claim 1, is characterized in that: described step (2) is ultrasonic to be carried
In taking, the ultrasonic frequency of circulating ultrasonic extractor is set as 35KHz, temperature 50 C, extracts 20 minutes.
The preparation method of a kind of Guishaoliujun Pill the most according to claim 1, is characterized in that: described step (3) capping powder
In preparation, the inlet temperature of spray dryer is set as 70 DEG C, and pressure is 0.03MPa, and flow velocity is 450 m/s.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114377094A (en) * | 2022-01-11 | 2022-04-22 | 广州复大医疗有限公司 | Traditional Chinese medicine composition and preparation as well as preparation method and application thereof |
| CN114699499A (en) * | 2022-04-13 | 2022-07-05 | 浙江三溪堂中药有限公司 | Method for preparing liver-protecting spleen-harmonizing pills |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599292A (en) * | 2013-11-26 | 2014-02-26 | 李强 | Preparation method and application of angelica sinensis and radix paeoniae alba liujun pill |
| CN104383254A (en) * | 2014-12-03 | 2015-03-04 | 黑龙江江恒医药科技有限公司 | Tianwang heart-invigorating pill and preparation method thereof |
| CN105213458A (en) * | 2015-09-21 | 2016-01-06 | 黑龙江江恒医药科技有限公司 | A kind of XIHUANG WAN and preparation method thereof |
| CN105343200A (en) * | 2015-12-08 | 2016-02-24 | 黑龙江江恒医药科技有限公司 | Guanxin suhe pills and preparing method thereof |
| CN105343306A (en) * | 2015-12-05 | 2016-02-24 | 黑龙江江恒医药科技有限公司 | Naosaitong pill and preparation method thereof |
| CN105362766A (en) * | 2015-12-05 | 2016-03-02 | 黑龙江江恒医药科技有限公司 | Miraculous pill of ledebouriella and preparation method of pill |
| CN105362588A (en) * | 2015-12-08 | 2016-03-02 | 黑龙江江恒医药科技有限公司 | Compound leucorrhea treatment pill and preparation method thereof |
| CN105395792A (en) * | 2016-01-12 | 2016-03-16 | 朱焕荣 | Traditional Chinese medicine pill for curing radiculitis and preparation method thereof |
| CN105412536A (en) * | 2015-12-05 | 2016-03-23 | 黑龙江江恒医药科技有限公司 | Rhinitis treating pill and preparation method thereof |
| CN105456599A (en) * | 2015-12-08 | 2016-04-06 | 黑龙江江恒医药科技有限公司 | Xianglian stagnation removing pills and preparing method thereof |
-
2016
- 2016-08-31 CN CN201610778587.8A patent/CN106236721A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599292A (en) * | 2013-11-26 | 2014-02-26 | 李强 | Preparation method and application of angelica sinensis and radix paeoniae alba liujun pill |
| CN104383254A (en) * | 2014-12-03 | 2015-03-04 | 黑龙江江恒医药科技有限公司 | Tianwang heart-invigorating pill and preparation method thereof |
| CN105213458A (en) * | 2015-09-21 | 2016-01-06 | 黑龙江江恒医药科技有限公司 | A kind of XIHUANG WAN and preparation method thereof |
| CN105343306A (en) * | 2015-12-05 | 2016-02-24 | 黑龙江江恒医药科技有限公司 | Naosaitong pill and preparation method thereof |
| CN105362766A (en) * | 2015-12-05 | 2016-03-02 | 黑龙江江恒医药科技有限公司 | Miraculous pill of ledebouriella and preparation method of pill |
| CN105412536A (en) * | 2015-12-05 | 2016-03-23 | 黑龙江江恒医药科技有限公司 | Rhinitis treating pill and preparation method thereof |
| CN105343200A (en) * | 2015-12-08 | 2016-02-24 | 黑龙江江恒医药科技有限公司 | Guanxin suhe pills and preparing method thereof |
| CN105362588A (en) * | 2015-12-08 | 2016-03-02 | 黑龙江江恒医药科技有限公司 | Compound leucorrhea treatment pill and preparation method thereof |
| CN105456599A (en) * | 2015-12-08 | 2016-04-06 | 黑龙江江恒医药科技有限公司 | Xianglian stagnation removing pills and preparing method thereof |
| CN105395792A (en) * | 2016-01-12 | 2016-03-16 | 朱焕荣 | Traditional Chinese medicine pill for curing radiculitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 傅超美等主编: "《中药药剂学》", 31 August 2014, 中国医药科技出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114377094A (en) * | 2022-01-11 | 2022-04-22 | 广州复大医疗有限公司 | Traditional Chinese medicine composition and preparation as well as preparation method and application thereof |
| CN114699499A (en) * | 2022-04-13 | 2022-07-05 | 浙江三溪堂中药有限公司 | Method for preparing liver-protecting spleen-harmonizing pills |
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Application publication date: 20161221 |