CN105343306A - Naosaitong pill and preparation method thereof - Google Patents

Naosaitong pill and preparation method thereof Download PDF

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Publication number
CN105343306A
CN105343306A CN201510879043.6A CN201510879043A CN105343306A CN 105343306 A CN105343306 A CN 105343306A CN 201510879043 A CN201510879043 A CN 201510879043A CN 105343306 A CN105343306 A CN 105343306A
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Prior art keywords
pill
semen
powder
radix
root
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不公告发明人
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
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    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a Naosaitong pill and a preparation method thereof. The preparation method is characterized by comprising the following steps: taking 21.5 g of piper kadsura, 43 g of xanthium sibiricum fruit, 10.75 g of litsea cubeba fruit, 35 g of apocynum venetum leaf, 10.75 g of nelumbo nucifera seed, 17.15 g of astragalus membranaceus root, 21.75 g of achyranthes bidentata root, 30 g of trichosanthes kirilowii root, 16 g of paeonia suffruticosa bark, 21.5 g of prunus persica seed, 14.25 g of sodium sulfate powder, 10.75 g of ligusticum chuanriong root, 14.25 g of lepidium apetalum seed, 18.75 g of pheretima aspergillum (fried), 64.5 g of rehmannia glutinosa root, 10.75 g of hirudo nipponica (boiled), 7 g of cinnamomum cassia bark and 28.55 g of poria cocos for crushing into coarse powder, putting the coarse powder into a circulating ultrasonic extractor, adding water, germanium powder and Tween 60, conducting ultrasonic extraction, conducting jet flow spray drying, preparing nanometer extract powder, and preparing the pill with refine honey so as to obtain the Naosaitong pill. The Naosaitong pill is used for treating cerebral thrombosis, cerebral heamorrhage sequelae, paralytic limbs, deadlimb and aphasis, has an obviously better curative effect than the commercially available Naosaitong pill, and achieves good effects.

Description

A kind of brain plug leads to ball and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of brain plug and lead to ball and preparation method thereof.
Background technology
Brain plug leads to ball blood circulation promoting and blood stasis dispelling, dredge the meridian passage, supplementing QI and nourishing YIN, for cerebral thrombosis, and cerebral blood stasis sequela, hemiplegia of limb, numb hand and foot, aphasis etc.Commercially available brain plug leads to ball due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.
Summary of the invention
The present invention is for overcoming above-mentioned deficiency, and the brain plug providing a kind of curative effect high leads to ball and preparation method thereof.
Invention embodiment is as follows:
Get Caulis Piperis Kadsurae 21.5g, Fructus Xanthii 43g, Fructus Litseae 10.75g, Folium Apocyni Veneti 35g, Semen Nelumbinis 10.75g, Radix Astragali 17.15g, Radix Achyranthis Bidentatae 21.75g, Radix Trichosanthis 30g, Cortex Moutan 16g, Semen Persicae 21.5g, Matrii Sulfas Exsiccatus 14.25g, Rhizoma Chuanxiong 10.75g, Semen Lepidii (Semen Descurainiae) 14.25g, Pheretima (stir-fry) 18.75g, Radix Rehmanniae 64.5g, Hirudo (scalding) 10.75g, Cortex Cinnamomi 7g, Poria 28.55g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 4052g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, and obtained brain plug leads to ball.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Caulis Piperis Kadsurae: Chinese Pharmacopoeia version one ministerial standard in 2010.This product is the dry rattan of Piperaceae plant Radix seu Caulis fici Martinii Piperkadsura (Choisy) OhWi.Summer, Qiu Erji tap, and removing root, leaf, dry.
Fructus Xanthii: China's coastal port one ministerial standard.This product is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii XanthiumsibiricumPatr..Gather during fruit maturation in autumn, dry, except impurity such as destemming, leaves.
Fructus Litseae: China's coastal port one ministerial standard.This product is canella cubeb litsen tree Litseacubeba(Lour.) dry mature fruit of Pers..Gather during fruit maturation in autumn, removing impurity dries.
Folium Apocyni Veneti: China's coastal port one ministerial standard.This product is the dried leaves of apocynaceae plant Herba Apocyni veneti ApocynumvenetumL..Summer gathers, removing impurity, dry.
Semen Nelumbinis: China's coastal port one ministerial standard.This product is the dry mature seed of nymphaeaceae plant lotus NelumbonuciferaGaertn..Tap Receptaculum Nelumbinis during fruit maturation in autumn, take out fruit, removing peel, dry.
The Radix Astragali: China's coastal port one ministerial standard.This product is leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) Bge, dry root.Spring, autumn two, Lee excavated, and removing fibrous root and root head, dry.
Radix Achyranthis Bidentatae: China's coastal port one ministerial standard.This product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae AchyranthesbidentataBl..Excavate when winter, stem and leaf was withered, removing fibrous root and silt, be bundled into wisp, shines as after wrinkle, trimmed on top, dry.
Radix Trichosanthis: China's coastal port one ministerial standard.This product is the dry root of cucurbitaceous plant Fructus Trichosanthis TrichosantheskirilowiiMaxim. or trichosanthes rosthornii Harms TrichosanthesrosthorniiHarms.Autumn, season in winter two excavate, and clean, removing crust, and cutting or vertical profile become lobe, dry.
Cortex Moutan: China's coastal port one ministerial standard.This product is the dry root bark of ranunculaceae peony PaeoniasuffruticosaAndr..Autumn excavates root, and removing radicula and silt, strip root bark, dry.
Semen Persicae: China's coastal port one ministerial standard.This product is rosaceous plant Fructus Persicae Prunuspersica(L.) Batsch or Prunus davidiana Prunusdavidiana(Cars.) dry mature seed of Franch..Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.
Matrii Sulfas Exsiccatus: China's coastal port one ministerial standard.This product is that Natrii Sulfas is obtained through air slaking drying.Main contains sodium sulfate (Na2SO4).
Rhizoma Chuanxiong: China's coastal port one ministerial standard.This product is the dry rhizome of samphire Rhizoma Chuanxiong LigusticumchuanriongHort..The joint dish that summer works as on stem is significantly outstanding, and excavates during purplish, and removing silt, shines post-drying, then remove fibrous root.
Semen Lepidii (Semen Descurainiae): China's coastal port one ministerial standard.This product is crucifer Lepidium sativum L. LepidiumapetalumWilld. or descurainia sophia (l.) webb ex prantl Descurainiasophia(L.) dry mature seed of WebbexPrantl.The former practises title " lepidii,semen ", and the latter practises title " Semen Descurainiae ".Tap plant during fruit maturation in summer, dry, rub seed, removing impurity.Pheretima: China's coastal port one ministerial standard.This product is Ju Yin section animal Pheretima aspergillum Pheretimaaspergillum(E.Perrier), popular Pheretimatschiliensis PheretimavulgarisChen, power simulation Pheretimaguillelmi(Michaelsen) or the dry body of the blind Pheretimatschiliensis PheretimaPectiniferaMichaelsen of comb.Front one is practised and is claimed " LUMBRICUS ", practises title " Shanghai Pheretima " for latter three kinds.LUMBRICUS catches to autumn spring, and Shanghai Pheretima catches summer, cuts abdominal part open in time, and removing internal organs and silt are cleaned, dried or cold drying.
Radix Rehmanniae: China's coastal port one ministerial standard.This product is the fresh of scrophulariaceae rehmannia glutinosa plant RehmanniaglutinosaLibosch. or dried root.Autumn excavates, except removing LU, fibrous root and silt, and using fresh herb; Or Radix Rehmanniae is slowly cured to about most probably dry.The former practises title " Radix Rehmanniae ", and the latter practises title " Radix Rehmanniae ".
Hirudo: China's coastal port one ministerial standard.This product is that the drying of Hirudinidae animal whitmania WbitmaniapigraWhitman, Hylarana guentheri HirudonipponicaWhitman or Folium Salicis Babylonicae Hirudo Wbitmaniaac-ranulataWhitman is all.Summer, Qiu Erji catch, and scald dead, dry or cold drying with boiling water.
Cortex Cinnamomi: China's coastal port one ministerial standard.This product is the dry bark of canella Cortex Cinnamomi CiNNamomumcassiaPresl.Strip more than autumn, dry in the shade.
Poria: China's coastal port one ministerial standard.This product is On Polyporaceae Poria Poriacocos(Schw.) dry sclerotia of Wolf.Excavate more than the 7-9 month, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and " Poria block ".
Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;
Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;
The above brain plug raw material led to used by ball all can be bought from pharmaceuticals and obtain, and is not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.
The key equipment that foregoing invention embodiment is mentioned is as follows:
Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,
(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)
Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;
(typical production producer: Nai Nuo bio tech ltd, Beijing)
The above brain plug raw material led to used by ball all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression ", " scalding " etc. all defer to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Detailed description of the invention
Specific embodiments of the invention 1
Get Caulis Piperis Kadsurae 21.5g, Fructus Xanthii 43g, Fructus Litseae 10.75g, Folium Apocyni Veneti 35g, Semen Nelumbinis 10.75g, Radix Astragali 17.15g, Radix Achyranthis Bidentatae 21.75g, Radix Trichosanthis 30g, Cortex Moutan 16g, Semen Persicae 21.5g, Matrii Sulfas Exsiccatus 14.25g, Rhizoma Chuanxiong 10.75g, Semen Lepidii (Semen Descurainiae) 14.25g, Pheretima (stir-fry) 18.75g, Radix Rehmanniae 64.5g, Hirudo (scalding) 10.75g, Cortex Cinnamomi 7g, Poria 28.55g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 4052g water, 4g germanium powder, 6g polysorbate60, select supersonic frequency 50KHz, pressure 0.3Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 20g adds appropriate water pill, dry, makes water-honeyed pill, and obtained brain plug leads to ball.
Specific embodiments of the invention 2
Get Caulis Piperis Kadsurae 21.5g, Fructus Xanthii 43g, Fructus Litseae 10.75g, Folium Apocyni Veneti 35g, Semen Nelumbinis 10.75g, Radix Astragali 17.15g, Radix Achyranthis Bidentatae 21.75g, Radix Trichosanthis 30g, Cortex Moutan 16g, Semen Persicae 21.5g, Matrii Sulfas Exsiccatus 14.25g, Rhizoma Chuanxiong 10.75g, Semen Lepidii (Semen Descurainiae) 14.25g, Pheretima (stir-fry) 18.75g, Radix Rehmanniae 64.5g, Hirudo (scalding) 10.75g, Cortex Cinnamomi 7g, Poria 28.55g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 4052g water, 6g germanium powder, 8g polysorbate60, select supersonic frequency 60KHz, pressure 0.5Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 50 DEG C, pressure 0.04Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 30g adds appropriate water pill, dry, makes water-honeyed pill, and obtained brain plug leads to ball.
Specific embodiments of the invention 3
Get Caulis Piperis Kadsurae 21.5g, Fructus Xanthii 43g, Fructus Litseae 10.75g, Folium Apocyni Veneti 35g, Semen Nelumbinis 10.75g, Radix Astragali 17.15g, Radix Achyranthis Bidentatae 21.75g, Radix Trichosanthis 30g, Cortex Moutan 16g, Semen Persicae 21.5g, Matrii Sulfas Exsiccatus 14.25g, Rhizoma Chuanxiong 10.75g, Semen Lepidii (Semen Descurainiae) 14.25g, Pheretima (stir-fry) 18.75g, Radix Rehmanniae 64.5g, Hirudo (scalding) 10.75g, Cortex Cinnamomi 7g, Poria 28.55g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 4052g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, and obtained brain plug leads to ball.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make brain plug and leads to ball.Lead to ball with the brain plug that embodiment 3 is obtained below and investigate actual effect of the present invention:
(1) embodiment 3 brain plug leads to ball and commercially available brain plug leads to pill for curing cerebral thrombosis, cerebral blood stasis sequela, hemiplegia of limb, numb hand and foot, aphasis clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe cerebral thrombosis, cerebral blood stasis sequela, hemiplegia of limb, numb hand and foot altogether, the cases such as aphasis 118 example, 55 years old mean age.Patient is divided into two groups, test group is taken embodiment 3 brain plug and is led to ball, and matched group is taken traditional brain plug and led to ball.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Cure: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 1 embodiment 3 brain plug leads to ball and commercially available brain plug leads to the contrast of ball clinical efficacy
Above-mentioned clinical observation on the therapeutic effect result shows, brain plug prepared by the present invention leads to ball at treatment cerebral thrombosis, cerebral blood stasis sequela, hemiplegia of limb, numb hand and foot, during aphasis etc., evident in efficacyly leads to ball higher than commercially available brain plug, p < 0.05.

Claims (3)

1. a treatment cerebral thrombosis, cerebral blood stasis sequela, hemiplegia of limb, numb hand and foot, the Chinese medicine of aphasis, it is characterized in that getting Caulis Piperis Kadsurae 21.5g, Fructus Xanthii 43g, Fructus Litseae 10.75g, Folium Apocyni Veneti 35g, Semen Nelumbinis 10.75g, Radix Astragali 17.15g, Radix Achyranthis Bidentatae 21.75g, Radix Trichosanthis 30g, Cortex Moutan 16g, Semen Persicae 21.5g, Matrii Sulfas Exsiccatus 14.25g, Rhizoma Chuanxiong 10.75g, Semen Lepidii (Semen Descurainiae) 14.25g, Pheretima (stir-fry) 18.75g, Radix Rehmanniae 64.5g, Hirudo (scalding) 10.75g, Cortex Cinnamomi 7g, Poria 28.55g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 4052g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, and obtained brain plug leads to ball.
2. the preparation method of Chinese medicine according to claim 1, it is characterized in that getting Caulis Piperis Kadsurae 21.5g, Fructus Xanthii 43g, Fructus Litseae 10.75g, Folium Apocyni Veneti 35g, Semen Nelumbinis 10.75g, Radix Astragali 17.15g, Radix Achyranthis Bidentatae 21.75g, Radix Trichosanthis 30g, Cortex Moutan 16g, Semen Persicae 21.5g, Matrii Sulfas Exsiccatus 14.25g, Rhizoma Chuanxiong 10.75g, Semen Lepidii (Semen Descurainiae) 14.25g, Pheretima (stir-fry) 18.75g, Radix Rehmanniae 64.5g, Hirudo (scalding) 10.75g, Cortex Cinnamomi 7g, Poria 28.55g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 4052g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, and obtained brain plug leads to ball.
3. get Caulis Piperis Kadsurae 21.5g, Fructus Xanthii 43g, Fructus Litseae 10.75g, Folium Apocyni Veneti 35g, Semen Nelumbinis 10.75g, Radix Astragali 17.15g, Radix Achyranthis Bidentatae 21.75g, Radix Trichosanthis 30g, Cortex Moutan 16g, Semen Persicae 21.5g, Matrii Sulfas Exsiccatus 14.25g, Rhizoma Chuanxiong 10.75g, Semen Lepidii (Semen Descurainiae) 14.25g, Pheretima (stir-fry) 18.75g, Radix Rehmanniae 64.5g, Hirudo (scalding) 10.75g, Cortex Cinnamomi 7g, Poria 28.55g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 4052g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, and obtained brain plug leads to ball.
CN201510879043.6A 2015-12-05 2015-12-05 Naosaitong pill and preparation method thereof Pending CN105343306A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236721A (en) * 2016-08-31 2016-12-21 太极集团浙江东方制药有限公司 A kind of preparation method of Guishaoliujun Pill

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236721A (en) * 2016-08-31 2016-12-21 太极集团浙江东方制药有限公司 A kind of preparation method of Guishaoliujun Pill

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