CN104474089A - Wuweixianglian pill and preparation method thereof - Google Patents
Wuweixianglian pill and preparation method thereof Download PDFInfo
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- 239000006187 pill Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 9
- 239000009670 cang er zi wan Substances 0.000 claims abstract description 9
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 9
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000012907 honey Nutrition 0.000 claims abstract description 8
- 208000004998 Abdominal Pain Diseases 0.000 claims abstract description 6
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 6
- 206010057071 Rectal tenesmus Diseases 0.000 claims abstract description 6
- 239000008280 blood Substances 0.000 claims abstract description 6
- 208000001848 dysentery Diseases 0.000 claims abstract description 6
- 210000000936 intestine Anatomy 0.000 claims abstract description 6
- 210000002784 stomach Anatomy 0.000 claims abstract description 6
- 208000012271 tenesmus Diseases 0.000 claims abstract description 6
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 8
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 8
- 229940113124 polysorbate 60 Drugs 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 241001078983 Tetradium ruticarpum Species 0.000 abstract description 4
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000007670 refining Methods 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 238000002137 ultrasound extraction Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 244000247747 Coptis groenlandica Species 0.000 description 3
- 235000002991 Coptis groenlandica Nutrition 0.000 description 3
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 241000037803 Coptis deltoidea Species 0.000 description 2
- 241000218201 Ranunculaceae Species 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 244000272264 Saussurea lappa Species 0.000 description 1
- 235000006784 Saussurea lappa Nutrition 0.000 description 1
- 241001251949 Xanthium sibiricum Species 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000004345 fruit ripening Effects 0.000 description 1
- 229940119177 germanium dioxide Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a wuweixianglian pill and a preparation method thereof. The method is characterized by comprising the following steps: taking 24g of fructus xanthii, 192g of costusroot, 576g of coptis chinensis, 75g of evodia, 48g of radix paeoniae alba and 192g of rhizoma corydalis, crushing into crude powder, and putting into a circulating ultrasonic extractor; adding water, germanium powder and tween-60, and carrying out ultrasonic extraction and jet spray drying, so as to prepare a nano extract; and refining the pill with honey, so as to prepare the wuweixianglian pill. The wuweixianglian pill is used for treating abdominal pain and diarrhea caused by damp-heat in the intestines and stomach, pus-blood mixing of red and white dysentery and tenesmus; the curative effect is obviously superior to that of a commercially available wuweixianglian pill; and a good effect is obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Wuweixianglian pills and preparation method thereof.
Background technology
Wuweixianglian pills heat clearing and damp drying, promoting the circulation of QI to relieve pain.For the damp and hot abdominal pain diarrhea caused of the intestines and stomach, red-white dysentery pus and blood is mixed mutually, tenesmus.Commercially available Wuweixianglian pills is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides Wuweixianglian pills that a kind of curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Fructus Xanthii 24g, Radix Aucklandiae 192g, Rhizoma Coptidis 576g, Fructus Evodiae 75g, Radix Paeoniae Alba 48g, Rhizoma Corydalis 192g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, obtained Wuweixianglian pills.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Fructus Xanthii: China's coastal port one ministerial standard.This product is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii Xanthium sibiricum Patr..Gather during fruit maturation in autumn, dry, except impurity such as destemming, leaves.
The Radix Aucklandiae: China's coastal port one ministerial standard.This product is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Autumn, season in winter two excavate, removing silt and fibrous root, cutting.Large vertical profile again becomes lobe, hits rough bark after drying.
Rhizoma Coptidis: China's coastal port one ministerial standard.This product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coplis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Coptisteeta Wall..Practise title " taste connects ", " refined company ", " Coptis Teeta Wall " respectively for above three kinds.Autumn digs, removing fibrous root and silt, dry, hits residual fibrous root.
Fructus Evodiae: China's coastal port one ministerial standard.This product is luxuriant growth savoury herb Fructus Evodiae Evodia rutaecarpa(Juss.) Benth., Shi Hu Evodia rutaecarpa(Juss.) Benth. var.officina-lis(Dode) Huang or thin hair Fructus Evodiae Evodia rutaecarpa(Juss.) Benth.var.bodinieri(Dode) the dry almost ripe fruit of Huang.When the 8-11 month, fruit not yet ftractureed, cut Fruit branch, dry or cold drying. except impurity such as debranching, leaf, carpopodiums.
The Radix Paeoniae Alba: China's coastal port one ministerial standard.This product is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Summer, Qiu Erji dig, clean, removing end to end and radicula, put in boiling water boil rear removing crust or go should after boil again, dry.
Rhizoma Corydalis: China's coastal port one ministerial standard.This product is the dry tuber of papaveraceae plant corydalis Corydalis yanhusno W.T.Wang.Excavate when early summer stem and leaf is withered, removing fibrous root, cleans, and puts in boiling water and boils to during just without the white heart, take out, dry.
Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;
Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;
Raw material used by above Wuweixianglian pills all can be bought from pharmaceuticals and obtain, and is not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.
The key equipment that foregoing invention embodiment is mentioned is as follows:
Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,
(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)
Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;
(typical production producer: Nai Nuo bio tech ltd, Beijing)
Raw material used by above Wuweixianglian pills all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Detailed description of the invention
Specific embodiments of the invention 1
Get Fructus Xanthii 24g, Radix Aucklandiae 192g, Rhizoma Coptidis 576g, Fructus Evodiae 75g, Radix Paeoniae Alba 48g, Rhizoma Corydalis 192g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 4g germanium powder, 6g polysorbate60, select supersonic frequency 50KHz, pressure 0.3Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20g adds appropriate water pill, dry, makes water-honeyed pill, obtained Wuweixianglian pills.
Specific embodiments of the invention 2
Get Fructus Xanthii 24g, Radix Aucklandiae 192g, Rhizoma Coptidis 576g, Fructus Evodiae 75g, Radix Paeoniae Alba 48g, Rhizoma Corydalis 192g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 6g germanium powder, 8g polysorbate60, select supersonic frequency 60KHz, pressure 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 50 DEG C, pressure 0.04 Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 30g adds appropriate water pill, dry, makes water-honeyed pill, obtained Wuweixianglian pills.
Specific embodiments of the invention 3
Get Fructus Xanthii 24g, Radix Aucklandiae 192g, Rhizoma Coptidis 576g, Fructus Evodiae 75g, Radix Paeoniae Alba 48g, Rhizoma Corydalis 192g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, obtained Wuweixianglian pills.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Wuweixianglian pills.Actual effect of the present invention is investigated below with the Wuweixianglian pills that embodiment 3 is obtained:
(1) embodiment 3 Wuweixianglian pills and commercially available Wuweixianglian pills treat the damp and hot abdominal pain diarrhea caused of the intestines and stomach, and red-white dysentery pus and blood is mixed mutually, tenesmus clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe the damp and hot abdominal pain diarrhea caused of the intestines and stomach altogether, red-white dysentery pus and blood is mixed mutually, tenesmus case 104 example, 33 years old mean age.Patient is divided into two groups, test group takes embodiment 3 Wuweixianglian pills, and matched group takes traditional five sapor Xianglian Wan.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Cure: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 1 embodiment 3 Wuweixianglian pills and the contrast of commercially available Wuweixianglian pills clinical efficacy
Above-mentioned clinical observation on the therapeutic effect result shows, Wuweixianglian pills prepared by the present invention is at the damp and hot abdominal pain diarrhea caused for the treatment of the intestines and stomach, and red-white dysentery pus and blood is mixed mutually, during tenesmus, evident in efficacy higher than commercially available Wuweixianglian pills, p < 0.05.
Claims (3)
1. treat the damp and hot abdominal pain diarrhea caused of the intestines and stomach, red-white dysentery pus and blood is mixed mutually, the Chinese medicine of tenesmus disease, it is characterized in that getting Fructus Xanthii 24g, Radix Aucklandiae 192g, Rhizoma Coptidis 576g, Fructus Evodiae 75g, Radix Paeoniae Alba 48g, Rhizoma Corydalis 192g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, selects supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, obtained Wuweixianglian pills.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Fructus Xanthii 24g, Radix Aucklandiae 192g, Rhizoma Coptidis 576g, Fructus Evodiae 75g, Radix Paeoniae Alba 48g, Rhizoma Corydalis 192g, is ground into 40 order coarse powder, puts in circulating ultrasonic extractor, add 7130g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, obtained Wuweixianglian pills.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Fructus Xanthii 24g, Radix Aucklandiae 192g, Rhizoma Coptidis 576g, Fructus Evodiae 75g, Radix Paeoniae Alba 48g, Rhizoma Corydalis 192g, is ground into 40 order coarse powder, puts in circulating ultrasonic extractor, add 7130g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, obtained Wuweixianglian pills.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410716965.0A CN104474089A (en) | 2014-12-03 | 2014-12-03 | Wuweixianglian pill and preparation method thereof |
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| CN201410716965.0A CN104474089A (en) | 2014-12-03 | 2014-12-03 | Wuweixianglian pill and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109833305A (en) * | 2017-11-24 | 2019-06-04 | 珠海天成中药有限公司 | Perfume connects the preparation process of antidiarrheal enteric-coated micro-pill |
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2014
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109833305A (en) * | 2017-11-24 | 2019-06-04 | 珠海天成中药有限公司 | Perfume connects the preparation process of antidiarrheal enteric-coated micro-pill |
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Application publication date: 20150401 |