CN105434977A - Huoxiang Zhengqi capsule and preparation method thereof - Google Patents

Huoxiang Zhengqi capsule and preparation method thereof Download PDF

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Publication number
CN105434977A
CN105434977A CN201510898768.XA CN201510898768A CN105434977A CN 105434977 A CN105434977 A CN 105434977A CN 201510898768 A CN201510898768 A CN 201510898768A CN 105434977 A CN105434977 A CN 105434977A
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huoxiang zhengqi
carbon dioxide
dry
ground
capsule
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不公告发明人
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/284—Atractylodes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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Abstract

The invention discloses a Huoxiang Zhengqi capsule and a preparation method thereof. The Huoxiang Zhengqi capsule is characterized in that 146 g of coix seeds, 73 g of gorgon euryale seeds, 36.5 g of small centipeda herb, 195 g of pogostemon cablin, 73 g of perilla leaf, 73 g of radix angelicae dahuricae, 146 g of atractylodes macrocephala koidz (stir-fried), 146 g of tangerine peel, 130 g of rhizoma pinelliae preparatum, 130 g of mangnolia officinalis (ginger mix frying), 60 g of poria cocos and 146 g of platycodon grandiflorum are taken and extracted by adopting a carbon dioxide supercritical extraction method, the extract is dried under reduced pressure and is smashed through a high energy nanometer impacting grinding into nanometer dry paste, functional accessories are added, and the Huoxiang Zhengqi capsule is prepared. The disintegration time is remarkably shortened, the treatment effect is remarkably better than that of a Huoxiang Zhengqi capsule sold in the market, and the positive effect is achieved.

Description

A kind of HUOXIANG ZHENGQI JIAONANG and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of HUOXIANG ZHENGQI JIAONANG and preparation method thereof.
Background technology
HUOXIANG ZHENGQI JIAONANG is induced sweat removing dampness, regulating the flow of Qi and the middle Jiao.For affection of exogenous wind-cold, internal injury humidity hysteresis, headache dusk is heavy, and chest and diaphragm painful abdominal mass is vexed, abdominal distention, and vomiting is had loose bowels.Commercially available HUOXIANG ZHENGQI JIAONANG is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides HUOXIANG ZHENGQI JIAONANG that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Semen Coicis 146g, Semen Euryales 73g, Herba Centipedae 36.5g, Herba Pogostemonis 195g, Folium Perillae 73g, Radix Angelicae Dahuricae 73g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 146g, Pericarpium Citri Reticulatae 146g, Rhizoma Pinelliae Preparatum 130g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 130g, Poria 60g, Radix Platycodonis 146g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 17 ~ 37 DEG C, separator pressure 11 ~ 20Mpa, separator temperature 36 ~ 59 DEG C, disengaging time 2.2 ~ 3.7 hours, carbon dioxide flow 25 ~ 33L per hour, obtains extracting solution; Get extracting solution 61 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained HUOXIANG ZHENGQI JIAONANG 1600.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Semen Coicis: China's coastal port one ministerial standard.This product is grass Semen Coicis Coixlacryma-jobiL.var.ma-yuen(ROman.) dry mature kernal of Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, except decapsidate, yellowish-brown seed coat and impurity, collect kernel.
Semen Euryales: China's coastal port one ministerial standard.This product is the dry mature kernal of nymphaeaceae plant Gorgon euryale EuryaleferoxSalisb..Time of the year when autumn changes into winter gathers mature fruit, and removing peel, takes out seed, cleans, then removes duricrust (episperm), dry.
Herba Centipedae: China's coastal port one ministerial standard.This product is feverfew Herba Centipedae Centipedaminima(L.) the dry herb of A.Br.etAschers..Summer, autumn two gather when season, the flowers are in blossom, wash away silt, dry.
Herba Pogostemonis: China's coastal port one ministerial standard.This product is that labiate extensively stores fragrant Pogostemoncablin(Blanco) dry aerial parts of Benth..Tap when branch and leaf are luxuriant, Exposure to Sunlight is vexed for night, repeatedly to dry.
Folium Perillae: China's coastal port one ministerial standard.This product is labiate Folium Perillae Perillafrutescens(L.) dried leaves of Britt. (or band twig).Gather when summer, branch and leaf were luxuriant, removing impurity, dries.
The Radix Angelicae Dahuricae: China's coastal port one ministerial standard.This product is samphire Radix Angelicae Dahuricae Angelicadahurica(Fisch.exHOffm.) Benth.etHook.f. or Radix angelicae dahuricae Angelicadahurica(Fisch.exHoffm.) Benth.etHook.f.var.formosana(Boiss.) dry root of ShanetYuan.Excavate when between summer, autumn, leaf is yellow, removing must be reported and silt, dries or cold drying.
The Rhizoma Atractylodis Macrocephalae: China's coastal port one ministerial standard.This product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoldz..Excavate when withered and yellow, the upper leaf of inferior leads in winter becomes fragile, removing silt, dries or dries, then remove fibrous root.
Pericarpium Citri Reticulatae: China's coastal port one ministerial standard.This product is the dry mature skin of rutaceae orange CitrusreticulataBlanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying.
Rhizoma Pinelliae Preparatum: China's coastal port one ministerial standard.This product is the Preparation process product of the Rhizoma Pinelliae.
Cortex Magnoliae Officinalis: China's coastal port one ministerial standard.This product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis MignoliaofficinalisRehd.etWils. or magnolia officinalis rehd.et wils.var.biloba rehd.et wils. MignoliaofficinalisRehd.etWils.var.bilobaRehdetWils., root bark and branch skin.The 4-6 month strips, root bark and branch skin Directly Dried in Shadow; In skin put in boiling water micro-boil after, dark and damp place of banking up, when " diaphoresis " is to inner surface purpling brown or sepia, steams soft, takes out, is rolled into tubular, dry.
Poria: China's coastal port one ministerial standard.This product is On Polyporaceae Poria Poriacocos(Schw.) dry sclerotia of Wolf.Excavate more than the 7-9 month, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and " Poria block ".
Radix Platycodonis: China's coastal port one ministerial standard.This product is Campanulaceae Radix Platycodonis Platycodongrandiflorum(Jacq.) dry root of ADC..Spring, Qiu Erji excavate, and clean, and removing fibrous root, takes advantage of and freshly peel off crust or do not remove crust, dry.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Magnesium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above HUOXIANG ZHENGQI JIAONANG all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression ", " processed with Rhizoma Zingiberis Recens " etc. all defer to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Semen Coicis 146g, Semen Euryales 73g, Herba Centipedae 36.5g, Herba Pogostemonis 195g, Folium Perillae 73g, Radix Angelicae Dahuricae 73g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 146g, Pericarpium Citri Reticulatae 146g, Rhizoma Pinelliae Preparatum 130g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 130g, Poria 60g, Radix Platycodonis 146g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20Mpa, extraction temperature 17 DEG C, separator pressure 11Mpa, separator temperature 36 DEG C, disengaging time 2.2 hours, carbon dioxide flow 25L per hour, obtains extracting solution; Get extracting solution 61 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, incapsulates, obtained HUOXIANG ZHENGQI JIAONANG 1600.
Specific embodiments of the invention 2
Get Semen Coicis 146g, Semen Euryales 73g, Herba Centipedae 36.5g, Herba Pogostemonis 195g, Folium Perillae 73g, Radix Angelicae Dahuricae 73g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 146g, Pericarpium Citri Reticulatae 146g, Rhizoma Pinelliae Preparatum 130g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 130g, Poria 60g, Radix Platycodonis 146g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, extraction temperature 37 DEG C, separator pressure 20Mpa, separator temperature 59 DEG C, disengaging time 3.7 hours, carbon dioxide flow 33L per hour, obtains extracting solution; Get extracting solution 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, incapsulates, obtained HUOXIANG ZHENGQI JIAONANG 1600.
Specific embodiments of the invention 3
Get Semen Coicis 146g, Semen Euryales 73g, Herba Centipedae 36.5g, Herba Pogostemonis 195g, Folium Perillae 73g, Radix Angelicae Dahuricae 73g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 146g, Pericarpium Citri Reticulatae 146g, Rhizoma Pinelliae Preparatum 130g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 130g, Poria 60g, Radix Platycodonis 146g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 27 DEG C, separator pressure 16Mpa, separator temperature 48 DEG C, disengaging time 3 hours, carbon dioxide flow 29L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained HUOXIANG ZHENGQI JIAONANG 1600.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make HUOXIANG ZHENGQI JIAONANG.Actual effect of the present invention is investigated below with the HUOXIANG ZHENGQI JIAONANG that embodiment 3 is obtained:
(1) embodiment 3 HUOXIANG ZHENGQI JIAONANG and contrast disintegration of commercially available HUOXIANG ZHENGQI JIAONANG
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 HUOXIANG ZHENGQI JIAONANG and commercially available HUOXIANG ZHENGQI JIAONANG contrast table disintegration
The above results shows, HUOXIANG ZHENGQI JIAONANG prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available HUOXIANG ZHENGQI JIAONANG.
(2) embodiment 3 HUOXIANG ZHENGQI JIAONANG and commercially available HUOXIANG ZHENGQI JIAONANG treatment affection of exogenous wind-cold, internal injury humidity hysteresis, headache dusk is heavy, and chest and diaphragm painful abdominal mass is vexed, abdominal distention, vomits clinical observation on the therapeutic effect of having loose bowels
1 case scenario
Statistics outpatient service and inpatient, observe affection of exogenous wind-cold, internal injury humidity hysteresis altogether, and headache dusk is heavy, and chest and diaphragm painful abdominal mass is vexed, abdominal distention, vomits case 139 example of having loose bowels, 39 years old mean age.Patient is divided into two groups, test group takes embodiment 3 HUOXIANG ZHENGQI JIAONANG, and matched group takes commercially available HUOXIANG ZHENGQI JIAONANG.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 HUOXIANG ZHENGQI JIAONANG and commercially available HUOXIANG ZHENGQI JIAONANG clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, HUOXIANG ZHENGQI JIAONANG prepared by the present invention is treating affection of exogenous wind-cold, internal injury humidity hysteresis, headache dusk is heavy, and chest and diaphragm painful abdominal mass is vexed, abdominal distention, during vomiting diarrhea, evident in efficacy higher than commercially available HUOXIANG ZHENGQI JIAONANG, p < 0.05.

Claims (3)

1. a treatment affection of exogenous wind-cold, internal injury humidity hysteresis, headache dusk is heavy, chest and diaphragm painful abdominal mass is vexed, abdominal distention, vomit the Chinese medicine of having loose bowels, it is characterized in that getting Semen Coicis 146g, Semen Euryales 73g, Herba Centipedae 36.5g, Herba Pogostemonis 195g, Folium Perillae 73g, Radix Angelicae Dahuricae 73g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 146g, Pericarpium Citri Reticulatae 146g, Rhizoma Pinelliae Preparatum 130g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 130g, Poria 60g, Radix Platycodonis 146g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 20 ~ 40Mpa, extraction temperature 17 ~ 37 DEG C, separator pressure 11 ~ 20Mpa, separator temperature 36 ~ 59 DEG C, disengaging time 2.2 ~ 3.7 hours, carbon dioxide flow 25 ~ 33L per hour, obtain extracting solution, get extracting solution 61 ~ 79 DEG C of drying under reduced pressure, get dry extract, get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm, get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained HUOXIANG ZHENGQI JIAONANG.
2. the preparation method of Chinese medicine according to claim 1, it is characterized in that getting Semen Coicis 146g, Semen Euryales 73g, Herba Centipedae 36.5g, Herba Pogostemonis 195g, Folium Perillae 73g, Radix Angelicae Dahuricae 73g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 146g, Pericarpium Citri Reticulatae 146g, Rhizoma Pinelliae Preparatum 130g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 130g, Poria 60g, Radix Platycodonis 146g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 20 ~ 40Mpa, extraction temperature 17 ~ 37 DEG C, separator pressure 11 ~ 20Mpa, separator temperature 36 ~ 59 DEG C, disengaging time 2.2 ~ 3.7 hours, carbon dioxide flow 25 ~ 33L per hour, obtain extracting solution, get extracting solution 61 ~ 79 DEG C of drying under reduced pressure, get dry extract, get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm, get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained HUOXIANG ZHENGQI JIAONANG.
3. the preparation method of Chinese medicine according to claim 1, gets Semen Coicis 146g, Semen Euryales 73g, Herba Centipedae 36.5g, Herba Pogostemonis 195g, Folium Perillae 73g, Radix Angelicae Dahuricae 73g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 146g, Pericarpium Citri Reticulatae 146g, Rhizoma Pinelliae Preparatum 130g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 130g, Poria 60g, Radix Platycodonis 146g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30Mpa, extraction temperature 27 DEG C, separator pressure 16Mpa, separator temperature 48 DEG C, disengaging time 3 hours, carbon dioxide flow 29L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained HUOXIANG ZHENGQI JIAONANG.
CN201510898768.XA 2015-12-08 2015-12-08 Huoxiang Zhengqi capsule and preparation method thereof Pending CN105434977A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106421708A (en) * 2016-10-26 2017-02-22 北京大品种联盟科技咨询有限公司 Traditional Chinese medicine composition and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106421708A (en) * 2016-10-26 2017-02-22 北京大品种联盟科技咨询有限公司 Traditional Chinese medicine composition and preparation method thereof
CN106421708B (en) * 2016-10-26 2018-03-16 北京大品种联盟科技咨询有限公司 A kind of Chinese medicine composition and preparation method thereof

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