CN105343677A - Embolism eliminating and collateral dredging capsules and preparing method thereof - Google Patents
Embolism eliminating and collateral dredging capsules and preparing method thereof Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 12
- 208000005189 Embolism Diseases 0.000 title abstract 4
- 239000002775 capsule Substances 0.000 title abstract 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 15
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 15
- 239000009636 Huang Qi Substances 0.000 claims abstract description 10
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 8
- 238000000227 grinding Methods 0.000 claims abstract description 8
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 8
- 239000008727 tongluo Substances 0.000 claims description 29
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- 238000001035 drying Methods 0.000 claims description 17
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 241000628997 Flos Species 0.000 claims description 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 241000180649 Panax notoginseng Species 0.000 claims description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 206010008190 Cerebrovascular accident Diseases 0.000 claims description 5
- 208000006011 Stroke Diseases 0.000 claims description 5
- 208000003028 Stuttering Diseases 0.000 claims description 5
- 206010008118 cerebral infarction Diseases 0.000 claims description 5
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 201000005577 familial hyperlipidemia Diseases 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 240000002505 Pogostemon cablin Species 0.000 abstract description 2
- 235000011751 Pogostemon cablin Nutrition 0.000 abstract description 2
- 244000046101 Sophora japonica Species 0.000 abstract description 2
- 235000010586 Sophora japonica Nutrition 0.000 abstract description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 241000045403 Astragalus propinquus Species 0.000 description 2
- 235000006533 astragalus Nutrition 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000004345 fruit ripening Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 241000219991 Lythraceae Species 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 241000758706 Piperaceae Species 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000035613 defoliation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses embolism eliminating and collateral dredging capsules and a preparing method thereof. The preparing method is characterized in that 15.6 g of pogostemon cablin, 78 g of pericarpium granati, 104 g of semen coicis, 156 g of fructus piperis longi, 287 g of ligusticum wallichii, 215 g of salvia miltiorrhiza, 412 g of radix astragali, 128 g of rhizoma alismatis, 144 g of pseudo-ginseng, 78 g of sophora japonica and 156 g of cassia twig are taken and extracted through a carbon dioxide supercritical extraction method, the extract is dried under reduced pressure and smashed into nanometer dry paste through high-energy nanometer impact grinding, and a functional auxiliary material is added to prepare the embolism eliminating and collateral dredging capsules. The disintegration time is remarkably shortened, the treatment effect is remarkably better than commercially available embolism eliminating and collateral dredging capsules, and a positive effect is achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of XIAOSHUAN TONGLUO JIAONANG and preparation method thereof.
Background technology
XIAOSHUAN TONGLUO JIAONANG blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.For the apoplexy caused by obstruction of collaterals by blood stasis, disease sees dull expression, speech stuttering puckery, hands and feet coolness, limbs pain; Cerebral infarction and hyperlipemia are shown in above-mentioned patient.Commercially available XIAOSHUAN TONGLUO JIAONANG is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides XIAOSHUAN TONGLUO JIAONANG that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Herba Pogostemonis 15.6g, Pericarpium Granati 78g, Semen Coicis 104g, Fructus Piperis Longi 156g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Astragali 412g, Rhizoma Alismatis 128g, Radix Notoginseng 144g, Flos Sophorae 78g, Ramulus Cinnamomi 156g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 19 ~ 44Mpa, extraction temperature 24 ~ 37 DEG C, separator pressure 11 ~ 20Mpa, separator temperature 41 ~ 51 DEG C, disengaging time 2.6 ~ 3.9 hours, carbon dioxide flow 21 ~ 32L per hour, obtains extracting solution; Get extracting solution 62 ~ 76 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained XIAOSHUAN TONGLUO JIAONANG 1100.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Herba Pogostemonis: China's coastal port one ministerial standard.This product is that labiate extensively stores fragrant Pogostemoncablin(Blanco) dry aerial parts of Benth..Tap when branch and leaf are luxuriant, Exposure to Sunlight is vexed for night, repeatedly to dry.
Pericarpium Granati: China's coastal port one ministerial standard.This product is the dry peel of Punicaceae plant Punica granatum L. PunicagranatumL..Autumn collects peel after fruit maturation, dries.
Semen Coicis: China's coastal port one ministerial standard.This product is grass Semen Coicis Coixlacryma-jobiL.var.ma-yuen(ROman.) dry mature kernal of Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, except decapsidate, yellowish-brown seed coat and impurity, collect kernel.
Fructus Piperis Longi: Chinese Pharmacopoeia version one ministerial standard in 2010.This product is the nearly ripe or mature fruit cluster of the drying of Piperaceae plant Fructus Piperis Longi PiperlongumL..Fruit ear is gathered by during green blackening, and removing impurity, dries.
Rhizoma Chuanxiong: China's coastal port one ministerial standard.This product is the dry rhizome of samphire Rhizoma Chuanxiong LigusticumchuanriongHort..The joint dish that summer works as on stem is significantly outstanding, and excavates during purplish, and removing silt, shines post-drying, then remove fibrous root.
Radix Salviae Miltiorrhizae: China's coastal port one ministerial standard.This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Spring, Qiu Erji excavate, removing silt, dry.
The Radix Astragali: China's coastal port one ministerial standard.This product is leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) Bge, dry root.Spring, autumn two, Lee excavated, and removing fibrous root and root head, dry.
Rhizoma Alismatis: China's coastal port one ministerial standard.This product is Notes On Alism At Aceae Rhizoma Alismatis Alismaorientalis(Sam.) dry tuber of Juzep..Excavate when winter, stem and leaf started withered, cleaning, drying, removing fibrous root and rough bark.
Radix Notoginseng: China's coastal port one ministerial standard.This product is the dry root and rhizome of panax araliaceae plant Punaxnotoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".
Flos Sophorae: China's coastal port one ministerial standard.This product is the dry flower and alabastrum of leguminous plant Chinese scholartree SophorajaponicaL..Summer, the flowers are in blossom put or alabastrum is formed time gather, dry in time, except debranching, stalk and impurity.The former practises title " Flos Sophorae ", and the latter practises title " Flos Sophorae Immaturus ".
Ramulus Cinnamomi: China's coastal port one ministerial standard.This product is the dry twig of canella Cortex Cinnamomi CinnamomumcassiaPresl.Spring, Xia Erji gather, and except defoliation, dry, or section is dried.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Magnesium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above XIAOSHUAN TONGLUO JIAONANG all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Herba Pogostemonis 15.6g, Pericarpium Granati 78g, Semen Coicis 104g, Fructus Piperis Longi 156g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Astragali 412g, Rhizoma Alismatis 128g, Radix Notoginseng 144g, Flos Sophorae 78g, Ramulus Cinnamomi 156g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 19Mpa, extraction temperature 24 DEG C, separator pressure 11Mpa, separator temperature 41 DEG C, disengaging time 2.6 hours, carbon dioxide flow 21L per hour, obtains extracting solution; Get extracting solution 62 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, incapsulates, obtained XIAOSHUAN TONGLUO JIAONANG 1100.
Specific embodiments of the invention 2
Get Herba Pogostemonis 15.6g, Pericarpium Granati 78g, Semen Coicis 104g, Fructus Piperis Longi 156g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Astragali 412g, Rhizoma Alismatis 128g, Radix Notoginseng 144g, Flos Sophorae 78g, Ramulus Cinnamomi 156g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 19 ~ 44Mpa, extraction temperature 37 DEG C, separator pressure 20Mpa, separator temperature 51 DEG C, disengaging time 3.9 hours, carbon dioxide flow 32L per hour, obtains extracting solution; Get extracting solution 76 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, incapsulates, obtained XIAOSHUAN TONGLUO JIAONANG 1100.
Specific embodiments of the invention 3
Get Herba Pogostemonis 15.6g, Pericarpium Granati 78g, Semen Coicis 104g, Fructus Piperis Longi 156g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Astragali 412g, Rhizoma Alismatis 128g, Radix Notoginseng 144g, Flos Sophorae 78g, Ramulus Cinnamomi 156g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 32Mpa, extraction temperature 31 DEG C, separator pressure 16Mpa, separator temperature 46 DEG C, disengaging time 3.3 hours, carbon dioxide flow 27L per hour, obtains extracting solution; Get extracting solution 69 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained XIAOSHUAN TONGLUO JIAONANG 1100.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make XIAOSHUAN TONGLUO JIAONANG.Actual effect of the present invention is investigated below with the XIAOSHUAN TONGLUO JIAONANG that embodiment 3 is obtained:
(1) embodiment 3 XIAOSHUAN TONGLUO JIAONANG and contrast disintegration of commercially available XIAOSHUAN TONGLUO JIAONANG
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 XIAOSHUAN TONGLUO JIAONANG and commercially available XIAOSHUAN TONGLUO JIAONANG contrast table disintegration
The above results shows, XIAOSHUAN TONGLUO JIAONANG prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available XIAOSHUAN TONGLUO JIAONANG.
(2) embodiment 3 XIAOSHUAN TONGLUO JIAONANG and the apoplexy of commercially available XIAOSHUAN TONGLUO JIAONANG treatment caused by obstruction of collaterals by blood stasis, disease sees dull expression, speech stuttering puckery, hands and feet coolness, limbs pain; Cerebral infarction and hyperlipemia are shown in above-mentioned patient clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe the apoplexy caused by obstruction of collaterals by blood stasis altogether, disease sees dull expression, speech stuttering puckery, hands and feet coolness, limbs pain; Cerebral infarction and hyperlipemia are shown in above-mentioned patient case 122 example, 58 years old mean age.Patient is divided into two groups, test group takes embodiment 3 XIAOSHUAN TONGLUO JIAONANG, and matched group takes commercially available XIAOSHUAN TONGLUO JIAONANG.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 XIAOSHUAN TONGLUO JIAONANG and commercially available XIAOSHUAN TONGLUO JIAONANG clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, XIAOSHUAN TONGLUO JIAONANG prepared by the present invention apoplexy caused by treatment obstruction of collaterals by blood stasis, and disease sees dull expression, speech stuttering puckery, hands and feet coolness, limbs pain; When cerebral infarction and hyperlipemia are shown in above-mentioned patient, evident in efficacy higher than commercially available XIAOSHUAN TONGLUO JIAONANG, p < 0.05.
Claims (3)
1. treat the apoplexy caused by obstruction of collaterals by blood stasis, disease sees dull expression, speech stuttering puckery, hands and feet coolness, limbs pain; Cerebral infarction and hyperlipemia are shown in the Chinese medicine of above-mentioned patient, it is characterized in that getting Herba Pogostemonis 15.6g, Pericarpium Granati 78g, Semen Coicis 104g, Fructus Piperis Longi 156g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Astragali 412g, Rhizoma Alismatis 128g, Radix Notoginseng 144g, Flos Sophorae 78g, Ramulus Cinnamomi 156g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 19 ~ 44Mpa, extraction temperature 24 ~ 37 DEG C, separator pressure 11 ~ 20Mpa, separator temperature 41 ~ 51 DEG C, disengaging time 2.6 ~ 3.9 hours, carbon dioxide flow 21 ~ 32L per hour, obtains extracting solution; Get extracting solution 62 ~ 76 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained XIAOSHUAN TONGLUO JIAONANG.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Herba Pogostemonis 15.6g, Pericarpium Granati 78g, Semen Coicis 104g, Fructus Piperis Longi 156g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Astragali 412g, Rhizoma Alismatis 128g, Radix Notoginseng 144g, Flos Sophorae 78g, Ramulus Cinnamomi 156g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 19 ~ 44Mpa, extraction temperature 24 ~ 37 DEG C, separator pressure 11 ~ 20Mpa, separator temperature 41 ~ 51 DEG C, disengaging time 2.6 ~ 3.9 hours, carbon dioxide flow 21 ~ 32L per hour, obtains extracting solution; Get extracting solution 62 ~ 76 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained XIAOSHUAN TONGLUO JIAONANG.
3. the preparation method of Chinese medicine according to claim 1, gets Herba Pogostemonis 15.6g, Pericarpium Granati 78g, Semen Coicis 104g, Fructus Piperis Longi 156g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Astragali 412g, Rhizoma Alismatis 128g, Radix Notoginseng 144g, Flos Sophorae 78g, Ramulus Cinnamomi 156g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 32Mpa, extraction temperature 31 DEG C, separator pressure 16Mpa, separator temperature 46 DEG C, disengaging time 3.3 hours, carbon dioxide flow 27L per hour, obtains extracting solution; Get extracting solution 69 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained XIAOSHUAN TONGLUO JIAONANG.
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