CN104127828A - Guangmaining tablet and preparation method thereof - Google Patents
Guangmaining tablet and preparation method thereof Download PDFInfo
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- CN104127828A CN104127828A CN201410405689.6A CN201410405689A CN104127828A CN 104127828 A CN104127828 A CN 104127828A CN 201410405689 A CN201410405689 A CN 201410405689A CN 104127828 A CN104127828 A CN 104127828A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 15
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 15
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 8
- 235000021419 vinegar Nutrition 0.000 claims abstract description 8
- 239000000052 vinegar Substances 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000009286 sanguis draxonis Substances 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- 229920001353 Dextrin Polymers 0.000 claims description 8
- 239000004375 Dextrin Substances 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000009670 cang er zi wan Substances 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 235000019425 dextrin Nutrition 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 206010002383 Angina Pectoris Diseases 0.000 claims description 6
- 206010052895 Coronary artery insufficiency Diseases 0.000 claims description 5
- 208000029078 coronary artery disease Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 244000144730 Amygdalus persica Species 0.000 abstract description 2
- 241000382455 Angelica sinensis Species 0.000 abstract description 2
- 241000737253 Lygodium japonicum Species 0.000 abstract description 2
- 241001289529 Fallopia multiflora Species 0.000 abstract 1
- 235000006040 Prunus persica var persica Nutrition 0.000 abstract 1
- 244000067505 Xanthium strumarium Species 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- 230000010354 integration Effects 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 241000345998 Calamus manan Species 0.000 description 3
- 235000012950 rattan cane Nutrition 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000004345 fruit ripening Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000005070 ripening Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 235000011446 Amygdalus persica Nutrition 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
- 240000005629 Curcuma phaeocaulis Species 0.000 description 1
- 235000003391 Curcuma phaeocaulis Nutrition 0.000 description 1
- 241000963390 Curcuma wenyujin Species 0.000 description 1
- 235000003394 Curcuma wenyujin Nutrition 0.000 description 1
- 240000009138 Curcuma zedoaria Species 0.000 description 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 description 1
- 241000005043 Lygodiaceae Species 0.000 description 1
- 244000021150 Orbignya martiana Species 0.000 description 1
- 235000014643 Orbignya martiana Nutrition 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 240000002381 Prunus davidiana Species 0.000 description 1
- 241000304195 Salvia miltiorrhiza Species 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- 241000800405 Spatholobus suberectus Species 0.000 description 1
- 241001251949 Xanthium sibiricum Species 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 244000186071 dragons blood palm Species 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000019509 white turmeric Nutrition 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Guangmaining tablet and a preparation method thereof. The Guangmaining tablet is characterized by being prepared from 100g of lygodium japonicum, 100g of cocklebur fruits, 112.5g of salviae miltiorrhizae, 112.5g of caulis spatholobi, 25.5g of resina draconis, 45g of corydalis tubers (processed with vinegar), 45g of angelica sinensis, 45g of radix curcumae, 75g of polygonum multiflorum and 30g of peach kernels (fried). The preparation method comprises the following steps: extracting by adopting a carbon dioxide supercritical fluid extraction method; drying under reduced pressure; smashing into a nanometer dried paste by using a high-energy nanometer impact grinder; and adding functional auxiliary materials to prepare the Guangmaining tablet. The disintegration time of the Guangmaining tablet is remarkably shortened, the curative effect of the Guangmaining tablet is remarkably superior to that of the commercially available Guangmaining tablets, and a positive effect is obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to peaceful sheet of a kind of arteria coronaria and preparation method thereof.
Background technology
The peaceful sheet blood circulation promoting and blood stasis dispelling of arteria coronaria, promoting the circulation of QI to relieve pain.This product be mainly used in taking stabbing pain over the chest, fixing do not move, enter Night Watch very, palpitation and uneasiness, purplish tongue, deep and stringy pulse be as coronary heart diseases and angina pectoris, the coronary insufficiency of primary symptom.The peaceful sheet of commercially available arteria coronaria is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, has the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides peaceful sheet of arteria coronaria that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Rhizoma Corydalis (vinegar system) 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30～40Mpa, 30～40 DEG C of extraction temperature, separator pressure 10～20Mpa, 50～60 DEG C of separator temperatures, disengaging time 2～4 hours, carbon dioxide flow 40～50L per hour, obtains extracting solution; Get 60 DEG C～80 DEG C drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add mannitol 150～200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, dextrin 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, mix homogeneously, with 50～70% ethanol wet granulations, 60 DEG C～80 DEG C are dry, additional carboxymethyl starch sodium 7～9g, granulate, is pressed into 1500, makes the peaceful sheet of arteria coronaria.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Spora Lygodii: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is Lygodiaceae plant Spora Lygodii Lygodium japonicum(Thunb.) the drying and ripening spore of Sw..When autumn, spore did not come off, tap rattan leaf, dry, crumple or lay spore, remove rattan leaf.
Fructus Xanthii: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii Xanthium sibiricum Patr..Gather when fruit maturation autumn, dry, except impurity such as destemming, leaves.
Radix Salviae Miltiorrhizae: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Spring, Qiu Erji excavate, and remove silt, dry.
Caulis Spatholobi: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Autumn, two seasons of winter gather, and remove branch and leaf, and section, dries.
Sanguis Draxonis: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is that the resin that oozes out of babassu Sanguis Draxonis Daemonorops draco Bl. fruit is through being processed into.
Rhizoma Corydalis: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is the dry tuber of papaveraceae plant corydalis Corydalis yanhusno W.T.Wang.When early summer stem and leaf is withered, excavate, remove fibrous root, clean, put in boiling water, to boil to proper and during without the white heart, take out, dry.
Radix Angelicae Sinensis: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is umbelliferae angelica Angelica sinensis(Oliv.) dry root of Diels.Autumn end excavates, and removes fibrous root and silt, after moisture slightly evaporates, is bundled into wisp, and upper canopy, with slowly smoke-dried beancurd of pyrotechnics.
Radix Curcumae: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.Chenet C.Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcumakwaugsienis S. G.Lee et C.F.Liang or Rhizoma Curcumae Curcuma pha-eocaulis Val..The above two practise respectively title " RADIX CURCUMAE " and " yellow silk Radix Curcumae ", and all the other claim " osmanthus Radix Curcumae " or " green filament Radix Curcumae " by different habit of character.Winter, stem and leaf was excavated after withering, and removed silt and radicula, steamed or boiled to the saturating heart, dry.
Radix Polygoni Multiflori Preparata: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is the Preparation process product of Radix Polygoni Multiflori.
Semen Persicae: Chinese Pharmacopoeia version one ministerial standard in 2005.This product is rosaceous plant Fructus Persicae Prunus persica(L.) Batsch or Prunus davidiana Prunus davidiana(Cars.) dry mature seed of Franch..After fruit maturation, gather, remove sarcocarp and nucleocapsid, take out seed, dry.
Mannitol: Chinese Pharmacopoeia version two ministerial standards in 2010.
Dextrin: Chinese Pharmacopoeia version two ministerial standards in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standards in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standards in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standards in 2010.
The peaceful sheet of above arteria coronaria raw material used all can be bought and obtain from pharmaceuticals, all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and the pharmacy specification of being correlated with.
The g of unit in the present invention can be also other weight portion, does not affect the present invention program's enforcement.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Rhizoma Corydalis (vinegar system) 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, 30 DEG C of extraction temperature, separator pressure 10Mpa, 50 DEG C of separator temperatures, disengaging time 2 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get 60 DEG C of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add mannitol 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, dextrin 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C are dry, additional carboxymethyl starch sodium 7g, granulate, is pressed into 1500, makes the peaceful sheet of arteria coronaria.
Specific embodiments of the invention 2
Get Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Rhizoma Corydalis (vinegar system) 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, 40 DEG C of extraction temperature, separator pressure 20Mpa, 60 DEG C of separator temperatures, disengaging time 4 hours, carbon dioxide flow 50L per hour, obtains extracting solution; Get 80 DEG C of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add mannitol 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, dextrin 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C are dry, additional carboxymethyl starch sodium 9g, granulate, is pressed into 1500, makes the peaceful sheet of arteria coronaria.
Specific embodiments of the invention 3
Get Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Rhizoma Corydalis (vinegar system) 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 35Mpa, 35 DEG C of extraction temperature, separator pressure 15Mpa, 55 DEG C of separator temperatures, disengaging time 3 hours, carbon dioxide flow 45L per hour, obtains extracting solution; Get 70 DEG C of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, dextrin 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C are dry, additional carboxymethyl starch sodium 8g, granulate, is pressed into 1500, makes the peaceful sheet of arteria coronaria.
Above embodiment explanation, adopts extreme condition and the optimal conditions of embodiment of the present invention all can make the peaceful sheet of arteria coronaria.The peaceful sheet of arteria coronaria making with embodiment 3 is below investigated actual effect of the present invention:
(1) the embodiment peaceful sheet of 3 arteria coronaria and contrast disintegration of the peaceful sheet of commercially available arteria coronaria
1 disintegration time mensuration method
Pressing Chinese Pharmacopoeia version annex XII A in 2010 measures.
Contrast 2 disintegrations
The table 1 embodiment peaceful sheet of 3 arteria coronaria and the peaceful sheet of commercially available arteria coronaria contrast table disintegration
The above results shows, the peaceful sheet of arteria coronaria prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high with respect to the peaceful sheet of commercially available arteria coronaria.
(2) the peaceful sheet treatment of the embodiment peaceful sheet of 3 arteria coronaria and commercially available arteria coronaria coronary heart diseases and angina pectoris, coronary insufficiency clinical observation on the therapeutic effect
1 case situation
Statistics outpatient service and inpatient, observe coronary heart diseases and angina pectoris, coronary insufficiency case 110 examples, 54 years old mean age altogether.Patient is divided into two groups, and test group is taken the peaceful sheet of embodiment 3 arteria coronaria, and matched group is taken the peaceful sheet of commercially available arteria coronaria.
2 efficacy assessment standards
Treat angina pectoris guideline of clinical investigations tcm syndrome curative effect determinate standard according to new Chinese medicine:
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integration reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integration reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integration reduces < 30%.
Increase the weight of: tcm clinical practice symptom, sign all have and increase the weight of, syndrome integration reduces < 0.
Computing formula: [integration before (the rear integration of integration-treatment before treatment) ÷ treatment] × 100%.
3 clinical observation result
The table 2 embodiment peaceful sheet of 3 arteria coronaria and the peaceful sheet clinical efficacy of commercially available arteria coronaria contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, the peaceful sheet of arteria coronaria prepared by the present invention is in the time for the treatment of coronary heart diseases and angina pectoris, coronary insufficiency, evident in efficacy higher than the peaceful sheet of commercially available arteria coronaria, p < 0.05.
Claims (3)
1. a treatment coronary heart disease, angina pectoris, the Chinese medicine of coronary insufficiency, it is characterized in that getting Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Rhizoma Corydalis (vinegar system) 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30～40Mpa, 30～40 DEG C of extraction temperature, separator pressure 10～20Mpa, 50～60 DEG C of separator temperatures, disengaging time 2～4 hours, carbon dioxide flow 40～50L per hour, obtain extracting solution, get 60 DEG C～80 DEG C drying under reduced pressure of extracting solution, get dry extract, get dry cream and add mannitol 150～200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm, get mixing dried cream powder, dextrin 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, mix homogeneously, with 50～70% ethanol wet granulations, 60 DEG C～80 DEG C are dry, additional carboxymethyl starch sodium 7～9g, granulate, suppresses to obtain the peaceful sheet of arteria coronaria.
2. the preparation method of Chinese medicine according to claim 1, it is characterized in that getting Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Rhizoma Corydalis (vinegar system) 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30～40Mpa, 30～40 DEG C of extraction temperature, separator pressure 10～20Mpa, 50～60 DEG C of separator temperatures, disengaging time 2～4 hours, carbon dioxide flow 40～50L per hour, obtain extracting solution, get 60 DEG C～80 DEG C drying under reduced pressure of extracting solution, get dry extract, get dry cream and add mannitol 150～200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm, get mixing dried cream powder, dextrin 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, mix homogeneously, with 50～70% ethanol wet granulations, 60 DEG C～80 DEG C are dry, additional carboxymethyl starch sodium 7～9g, granulate, suppresses to obtain the peaceful sheet of arteria coronaria.
3. the preparation method of Chinese medicine according to claim 1, get Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Rhizoma Corydalis (vinegar system) 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, is ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 35Mpa, 35 DEG C of extraction temperature, separator pressure 15Mpa, 55 DEG C of separator temperatures, disengaging time 3 hours, carbon dioxide flow 45L per hour, obtains extracting solution; Get 70 DEG C of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, dextrin 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C are dry, additional carboxymethyl starch sodium 8g, granulate, suppresses to obtain the peaceful sheet of arteria coronaria.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940802A (en) * | 2015-05-26 | 2015-09-30 | 陈宝书 | Traditional Chinese medicine for treating heart disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600234A (en) * | 2012-04-13 | 2012-07-25 | 孙长海 | Swertia mileensis dispersible tablet and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600234A (en) * | 2012-04-13 | 2012-07-25 | 孙长海 | Swertia mileensis dispersible tablet and preparation method thereof |
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| Title |
|---|
| 邹冬良等: "冠脉宁片的制备工艺研究", 《中国药房》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940802A (en) * | 2015-05-26 | 2015-09-30 | 陈宝书 | Traditional Chinese medicine for treating heart disease |
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Application publication date: 20141105 |