CN105343730A - Capsule for treating ulcers and preparation method thereof - Google Patents

Abstract

The invention discloses a capsule for treating ulcers and a preparation method thereof. The capsule for treating ulcers is prepared from 180 g of resurrection lily rhizomes, 35 g of inula flowers, 20 g of pseudo-ginseng, 20 g of catechu, 135 g of cuttlefish bone, 55 g of rhizoma corydalis processed in vinegar, 180 g of astragalus and 25 g of bletilla. A carbon dioxide supercritical extraction method is adopted for extraction and pressure-reducing drying, the raw materials are smashed into nanometer dry paste through a high-energy nanometer impacting mill, functional auxiliaries are added, the capsule for treating ulcers is prepared, the disintegration time is remarkably shortened, the curative effect of the capsule for treating ulcers is remarkably inferior to that of capsules, sold in the market, for treating ulcers, and a positive effect is achieved.

Description

A kind of KUIYANGLING JIAONANG and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of KUIYANGLING JIAONANG and preparation method thereof.

Background technology

KUIYANGLING JIAONANG QI invigorating, blood stasis dispelling, pain relieving.For gastric and duodenal ulcers.Commercially available KUIYANGLING JIAONANG is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.

Summary of the invention

The present invention, for overcoming above-mentioned deficiency, provides KUIYANGLING JIAONANG that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.

Invention embodiment is as follows:

Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17 ~ 37Mpa, extraction temperature 23 ~ 36 DEG C, separator pressure 11 ~ 18Mpa, separator temperature 39 ~ 51 DEG C, disengaging time 1.8 ~ 3.9 hours, carbon dioxide flow 27 ~ 40L per hour, obtains extracting solution; Get extracting solution 65 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.

The raw material standards that above-mentioned embodiment is mentioned is as follows:

Rhizoma Kaempferiae: Chinese Pharmacopoeia version one ministerial standard in 2010.This product has another name called that three a kind of apples, mountain are peppery, Sha Jiang.For the rhizome of zingiberaceous plant Rhizoma Kaempferiae KaempferiagalangaL..Originate in TaiWan, China, Guangdong, Guangxi, Yunnan.Winter excavates, and cleans, and removing fibrous root, section, dries.

Flos Inulae: China's coastal port one ministerial standard.This product is the dry capitulum of feverfew Flos Inulae InulajaponicaThunb. or Eurasian trip Flos Inulae InulabritannicaL..Summer, season in autumn two, the flowers are in blossom gathers when putting, and removing impurity, dries in the shade or dry.

Radix Notoginseng: China's coastal port one ministerial standard.This product is the dry root and rhizome of panax araliaceae plant Punaxnotoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".

Catechu: Chinese Pharmacopoeia version one ministerial standard in 2015.This product is the peeling branch of leguminous plant catechu Aazckcatechu (L.L) Willd, descendants are decocted in dry drying.Gather winter branch, dry, removing crust, is chopped to bulk, decocts with water, concentrated, dry.

Endoconcha Sepiae: Chinese Pharmacopoeia version one ministerial standard in 2010.This product is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune SepiMamaindronideRochebruneo ￡ ^-SiMSepiaescuLentaHoyle.Collect the bone-shaped inner shell of sepiellae seu sepiae fish, cleaning, drying.

Rhizoma Corydalis (vinegar system): China's coastal port one ministerial standard.This product is the dry tuber of papaveraceae plant corydalis CorydalisyanhusnoW.T.Wang.Excavate when early summer stem and leaf is withered, removing fibrous root, cleans, and puts in boiling water and boils to during just without the white heart, take out, dry.

The Radix Astragali: China's coastal port one ministerial standard.This product is leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) Bge, dry root.Spring, autumn two, Lee excavated, and removing fibrous root and root head, dry.

Pseudobulbus Bletillae (Rhizoma Bletillae): China's coastal port one ministerial standard.This product is orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletillastriafa(Thunb.) drying of Reichb.f. determines stem.Summer, Qiu Erji dig, and removing fibrous root, cleans, and put in boiling water and boil or steam to without the white heart, shine to half-dried, removing crust, dries.

Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.

Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.

Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.

Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.

Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.

Magnesium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.

Raw material used by above KUIYANGLING JIAONANG all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.

In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.

Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.

Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.

Four detailed description of the invention

Specific embodiments of the invention 1

Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17Mpa, extraction temperature 23 DEG C, separator pressure 11Mpa, separator temperature 39 DEG C, disengaging time 1.8 hours, carbon dioxide flow 27L per hour, obtains extracting solution; Get extracting solution 65 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.

Specific embodiments of the invention 2

Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 37Mpa, extraction temperature 36 DEG C, separator pressure 18Mpa, separator temperature 51 DEG C, disengaging time 3.9 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.

Specific embodiments of the invention 3

Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 27Mpa, extraction temperature 30 DEG C, separator pressure 14Mpa, separator temperature 45 DEG C, disengaging time 3 hours, carbon dioxide flow 34L per hour, obtains extracting solution; Get extracting solution 72 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.

Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make KUIYANGLING JIAONANG.Actual effect of the present invention is investigated below with the KUIYANGLING JIAONANG that embodiment 3 is obtained:

(1) embodiment 3 KUIYANGLING JIAONANG and contrast disintegration of commercially available KUIYANGLING JIAONANG

1 disintegration time mensuration method

Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.

Contrast 2 disintegrations

Table 1 embodiment 3 KUIYANGLING JIAONANG and commercially available KUIYANGLING JIAONANG contrast table disintegration

The above results shows, KUIYANGLING JIAONANG prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available KUIYANGLING JIAONANG.

(2) embodiment 3 KUIYANGLING JIAONANG and commercially available KUIYANGLING JIAONANG treatment gastric and duodenal ulcers Disease Clinical observation of curative effect

1 case scenario

Statistics outpatient service and inpatient, observe gastric and duodenal ulcers case 134 example, 29 years old mean age altogether.Patient is divided into two groups, test group takes embodiment 3 KUIYANGLING JIAONANG, and matched group takes commercially available KUIYANGLING JIAONANG.

2 efficacy assessment standards

According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:

Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.

Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.

Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.

Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.

Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.

3 clinical observation result

Table 2 embodiment 3 KUIYANGLING JIAONANG and commercially available KUIYANGLING JIAONANG clinical efficacy contrast table

Above-mentioned clinical observation on the therapeutic effect result shows, KUIYANGLING JIAONANG prepared by the present invention is when treating gastric and duodenal ulcers disease, evident in efficacy higher than commercially available KUIYANGLING JIAONANG, p < 0.05.

Claims (3)

1. treat the Chinese medicine of gastric and duodenal ulcers disease for one kind, it is characterized in that getting Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17 ~ 37Mpa, extraction temperature 23 ~ 36 DEG C, separator pressure 11 ~ 18Mpa, separator temperature 39 ~ 51 DEG C, disengaging time 1.8 ~ 3.9 hours, carbon dioxide flow 27 ~ 40L per hour, obtains extracting solution; Get extracting solution 65 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG.

2. the preparation method of Chinese medicine according to claim 1, it is characterized in that getting Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17 ~ 37Mpa, extraction temperature 23 ~ 36 DEG C, separator pressure 11 ~ 18Mpa, separator temperature 39 ~ 51 DEG C, disengaging time 1.8 ~ 3.9 hours, carbon dioxide flow 27 ~ 40L per hour, obtains extracting solution; Get extracting solution 65 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG.

3. the preparation method of Chinese medicine according to claim 1, gets Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 27Mpa, extraction temperature 30 DEG C, separator pressure 14Mpa, separator temperature 45 DEG C, disengaging time 3 hours, carbon dioxide flow 34L per hour, obtains extracting solution; Get extracting solution 72 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained KUIYANGLING JIAONANG.