CN105343730A - Capsule for treating ulcers and preparation method thereof - Google Patents
Capsule for treating ulcers and preparation method thereof Download PDFInfo
- Publication number
- CN105343730A CN105343730A CN201510862207.4A CN201510862207A CN105343730A CN 105343730 A CN105343730 A CN 105343730A CN 201510862207 A CN201510862207 A CN 201510862207A CN 105343730 A CN105343730 A CN 105343730A
- Authority
- CN
- China
- Prior art keywords
- carbon dioxide
- rhizoma
- ground
- pressure
- extracting solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 208000025865 Ulcer Diseases 0.000 title abstract 6
- 239000002775 capsule Substances 0.000 title abstract 6
- 231100000397 ulcer Toxicity 0.000 title abstract 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000001035 drying Methods 0.000 claims abstract description 18
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 15
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 15
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 10
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 10
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 9
- 235000021419 vinegar Nutrition 0.000 claims abstract description 9
- 239000000052 vinegar Substances 0.000 claims abstract description 9
- 238000000605 extraction Methods 0.000 claims abstract description 8
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 8
- 244000080767 Areca catechu Species 0.000 claims abstract 4
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 241000628997 Flos Species 0.000 claims description 10
- 239000009636 Huang Qi Substances 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 241000180649 Panax notoginseng Species 0.000 claims description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 208000000718 duodenal ulcer Diseases 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 7
- 235000006533 astragalus Nutrition 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 241000238371 Sepiidae Species 0.000 abstract description 2
- 241001061264 Astragalus Species 0.000 abstract 1
- 241001313855 Bletilla Species 0.000 abstract 1
- 241000132446 Inula Species 0.000 abstract 1
- 244000062250 Kaempferia rotunda Species 0.000 abstract 1
- 235000013422 Kaempferia rotunda Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000003116 impacting effect Effects 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 244000235603 Acacia catechu Species 0.000 description 6
- 208000011580 syndromic disease Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000045403 Astragalus propinquus Species 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000131317 Capitulum Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000784222 Inula japonica Species 0.000 description 1
- 244000062241 Kaempferia galanga Species 0.000 description 1
- 244000141359 Malus pumila Species 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 241000218180 Papaveraceae Species 0.000 description 1
- 241001663378 Sepiella maindroni Species 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a capsule for treating ulcers and a preparation method thereof. The capsule for treating ulcers is prepared from 180 g of resurrection lily rhizomes, 35 g of inula flowers, 20 g of pseudo-ginseng, 20 g of catechu, 135 g of cuttlefish bone, 55 g of rhizoma corydalis processed in vinegar, 180 g of astragalus and 25 g of bletilla. A carbon dioxide supercritical extraction method is adopted for extraction and pressure-reducing drying, the raw materials are smashed into nanometer dry paste through a high-energy nanometer impacting mill, functional auxiliaries are added, the capsule for treating ulcers is prepared, the disintegration time is remarkably shortened, the curative effect of the capsule for treating ulcers is remarkably inferior to that of capsules, sold in the market, for treating ulcers, and a positive effect is achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of KUIYANGLING JIAONANG and preparation method thereof.
Background technology
KUIYANGLING JIAONANG QI invigorating, blood stasis dispelling, pain relieving.For gastric and duodenal ulcers.Commercially available KUIYANGLING JIAONANG is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides KUIYANGLING JIAONANG that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17 ~ 37Mpa, extraction temperature 23 ~ 36 DEG C, separator pressure 11 ~ 18Mpa, separator temperature 39 ~ 51 DEG C, disengaging time 1.8 ~ 3.9 hours, carbon dioxide flow 27 ~ 40L per hour, obtains extracting solution; Get extracting solution 65 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Rhizoma Kaempferiae: Chinese Pharmacopoeia version one ministerial standard in 2010.This product has another name called that three a kind of apples, mountain are peppery, Sha Jiang.For the rhizome of zingiberaceous plant Rhizoma Kaempferiae KaempferiagalangaL..Originate in TaiWan, China, Guangdong, Guangxi, Yunnan.Winter excavates, and cleans, and removing fibrous root, section, dries.
Flos Inulae: China's coastal port one ministerial standard.This product is the dry capitulum of feverfew Flos Inulae InulajaponicaThunb. or Eurasian trip Flos Inulae InulabritannicaL..Summer, season in autumn two, the flowers are in blossom gathers when putting, and removing impurity, dries in the shade or dry.
Radix Notoginseng: China's coastal port one ministerial standard.This product is the dry root and rhizome of panax araliaceae plant Punaxnotoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".
Catechu: Chinese Pharmacopoeia version one ministerial standard in 2015.This product is the peeling branch of leguminous plant catechu Aazckcatechu (L.L) Willd, descendants are decocted in dry drying.Gather winter branch, dry, removing crust, is chopped to bulk, decocts with water, concentrated, dry.
Endoconcha Sepiae: Chinese Pharmacopoeia version one ministerial standard in 2010.This product is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune SepiMamaindronideRochebruneo ￡ ^-SiMSepiaescuLentaHoyle.Collect the bone-shaped inner shell of sepiellae seu sepiae fish, cleaning, drying.
Rhizoma Corydalis (vinegar system): China's coastal port one ministerial standard.This product is the dry tuber of papaveraceae plant corydalis CorydalisyanhusnoW.T.Wang.Excavate when early summer stem and leaf is withered, removing fibrous root, cleans, and puts in boiling water and boils to during just without the white heart, take out, dry.
The Radix Astragali: China's coastal port one ministerial standard.This product is leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) Bge, dry root.Spring, autumn two, Lee excavated, and removing fibrous root and root head, dry.
Pseudobulbus Bletillae (Rhizoma Bletillae): China's coastal port one ministerial standard.This product is orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletillastriafa(Thunb.) drying of Reichb.f. determines stem.Summer, Qiu Erji dig, and removing fibrous root, cleans, and put in boiling water and boil or steam to without the white heart, shine to half-dried, removing crust, dries.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Magnesium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above KUIYANGLING JIAONANG all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17Mpa, extraction temperature 23 DEG C, separator pressure 11Mpa, separator temperature 39 DEG C, disengaging time 1.8 hours, carbon dioxide flow 27L per hour, obtains extracting solution; Get extracting solution 65 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.
Specific embodiments of the invention 2
Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 37Mpa, extraction temperature 36 DEG C, separator pressure 18Mpa, separator temperature 51 DEG C, disengaging time 3.9 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.
Specific embodiments of the invention 3
Get Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 27Mpa, extraction temperature 30 DEG C, separator pressure 14Mpa, separator temperature 45 DEG C, disengaging time 3 hours, carbon dioxide flow 34L per hour, obtains extracting solution; Get extracting solution 72 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained KUIYANGLING JIAONANG 1000.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make KUIYANGLING JIAONANG.Actual effect of the present invention is investigated below with the KUIYANGLING JIAONANG that embodiment 3 is obtained:
(1) embodiment 3 KUIYANGLING JIAONANG and contrast disintegration of commercially available KUIYANGLING JIAONANG
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 KUIYANGLING JIAONANG and commercially available KUIYANGLING JIAONANG contrast table disintegration
The above results shows, KUIYANGLING JIAONANG prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available KUIYANGLING JIAONANG.
(2) embodiment 3 KUIYANGLING JIAONANG and commercially available KUIYANGLING JIAONANG treatment gastric and duodenal ulcers Disease Clinical observation of curative effect
1 case scenario
Statistics outpatient service and inpatient, observe gastric and duodenal ulcers case 134 example, 29 years old mean age altogether.Patient is divided into two groups, test group takes embodiment 3 KUIYANGLING JIAONANG, and matched group takes commercially available KUIYANGLING JIAONANG.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 KUIYANGLING JIAONANG and commercially available KUIYANGLING JIAONANG clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, KUIYANGLING JIAONANG prepared by the present invention is when treating gastric and duodenal ulcers disease, evident in efficacy higher than commercially available KUIYANGLING JIAONANG, p < 0.05.
Claims (3)
1. treat the Chinese medicine of gastric and duodenal ulcers disease for one kind, it is characterized in that getting Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17 ~ 37Mpa, extraction temperature 23 ~ 36 DEG C, separator pressure 11 ~ 18Mpa, separator temperature 39 ~ 51 DEG C, disengaging time 1.8 ~ 3.9 hours, carbon dioxide flow 27 ~ 40L per hour, obtains extracting solution; Get extracting solution 65 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG.
2. the preparation method of Chinese medicine according to claim 1, it is characterized in that getting Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 17 ~ 37Mpa, extraction temperature 23 ~ 36 DEG C, separator pressure 11 ~ 18Mpa, separator temperature 39 ~ 51 DEG C, disengaging time 1.8 ~ 3.9 hours, carbon dioxide flow 27 ~ 40L per hour, obtains extracting solution; Get extracting solution 65 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained KUIYANGLING JIAONANG.
3. the preparation method of Chinese medicine according to claim 1, gets Rhizoma Kaempferiae 180g, Flos Inulae 35g, Radix Notoginseng 20g, catechu 20g, Endoconcha Sepiae 135g, Rhizoma Corydalis (vinegar system) 55g, Radix Astragali 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 27Mpa, extraction temperature 30 DEG C, separator pressure 14Mpa, separator temperature 45 DEG C, disengaging time 3 hours, carbon dioxide flow 34L per hour, obtains extracting solution; Get extracting solution 72 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained KUIYANGLING JIAONANG.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510862207.4A CN105343730A (en) | 2015-12-01 | 2015-12-01 | Capsule for treating ulcers and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510862207.4A CN105343730A (en) | 2015-12-01 | 2015-12-01 | Capsule for treating ulcers and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105343730A true CN105343730A (en) | 2016-02-24 |
Family
ID=55319889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510862207.4A Pending CN105343730A (en) | 2015-12-01 | 2015-12-01 | Capsule for treating ulcers and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105343730A (en) |
-
2015
- 2015-12-01 CN CN201510862207.4A patent/CN105343730A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105343730A (en) | Capsule for treating ulcers and preparation method thereof | |
| CN105456763A (en) | Shenkangning capsules and preparation method thereof | |
| CN104491302A (en) | Bone-reunion capsules and preparation method thereof | |
| CN105434977A (en) | Huoxiang Zhengqi capsule and preparation method thereof | |
| CN105343210A (en) | Spur pill and preparation method thereof | |
| CN105343336A (en) | Xiaotangling capsules and preparing method thereof | |
| CN104398935A (en) | Hemorrhoid eliminating tablet and preparation method thereof | |
| CN105343681A (en) | Cough-relieving exocarpium citri grandis capsules and preparation method thereof | |
| CN105456700A (en) | Kidney-tonifying bone-supplementing capsule and preparation method thereof | |
| CN105343263A (en) | Dabaidu capsule and preparation method thereof | |
| CN105412598A (en) | Stomach-recovering capsule and preparation method thereof | |
| CN105395514A (en) | Zhonghua ganling capsule and preparation method thereof | |
| CN104474384A (en) | Fuganning tablet and preparation method thereof | |
| CN104383251A (en) | Koji capsule and preparation method thereof | |
| CN105343677A (en) | Embolism eliminating and collateral dredging capsules and preparing method thereof | |
| CN104225359A (en) | Jiangtangjia tablet and preparation method thereof | |
| CN104127828A (en) | Guangmaining tablet and preparation method thereof | |
| CN105412457A (en) | Capsule for treating hemialgia and preparation method thereof | |
| CN105343527A (en) | Naolingsu capsules and preparation method thereof | |
| CN105343574A (en) | Coronal relaxing capsule and preparation method thereof | |
| CN105343679A (en) | Capsule for regulating menstruation and invigorating blood circulation and preparation method thereof | |
| CN105770584A (en) | Heart calming tablet and preparation method thereof | |
| CN105412753A (en) | Stone removing capsule and preparation method thereof | |
| CN104224956A (en) | Mind-calming tablet and preparation method thereof | |
| CN104224934A (en) | Rhizoma corydalis pain-relieving capsule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160224 |
|
| WD01 | Invention patent application deemed withdrawn after publication |