CN105362344A - Hongyao tablet and preparation method thereof - Google Patents
Hongyao tablet and preparation method thereof Download PDFInfo
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- CN105362344A CN105362344A CN201510905076.3A CN201510905076A CN105362344A CN 105362344 A CN105362344 A CN 105362344A CN 201510905076 A CN201510905076 A CN 201510905076A CN 105362344 A CN105362344 A CN 105362344A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a Hongyao tablet and a preparation method thereof. The preparation method is characterized by comprising the following steps: taking 195 g of dayflower, 136.5 g of fructus schizandrae, 682.5 g of pseudo-ginseng, 195 g of Ligusticum wallichii, 195 g of Angelica sinensis and 175 g of flos carthami; extracting by using a carbon dioxide supercritical extraction method; drying under reduced pressure; pulverizing into nano dried cream by using a high-energy nano impact mill; adding functional adjuvant; and preparing into the Hongyao tablet. The disintegration time is shortened remarkably, the curative effect of the Hongyao tablet is remarkably higher than that of Hongyao tablets in markets, and the positive effect is achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of mercurochrome tablet and preparation method thereof.
Background technology
Mercurochrome tablet promoting blood circulation and stopping pain, eliminating blood stasis to promote regeneration of blood.For traumatic injury, swelling and pain due to blood stasis, rheumatic numbness.Commercially available mercurochrome tablet is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides mercurochrome tablet that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Herba Commelinae 195g, Fructus Schisandrae Chinensis 136.5g, Radix Notoginseng 682.5g, Rhizoma Chuanxiong 195g, Radix Angelicae Sinensis 195g, Flos Carthami 175g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 42Mpa, extraction temperature 18 ~ 42 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 38 ~ 58 DEG C, disengaging time 2.0 ~ 3.4 hours, carbon dioxide flow 25 ~ 36L per hour, obtains extracting solution; Get extracting solution 61 ~ 75 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional methylcellulose 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained mercurochrome tablet 1500.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Herba Commelinae: China's coastal port one ministerial standard.This product is the dry aerial parts of Commelianaceae plant duck grass CommelinacommunisL..Summer, Qiu Erji gather, and dry.
Fructus Schisandrae Chinensis: China's coastal port one ministerial standard.This product is magnoliaceae schisandra Schisandrachfnensis(Turcz.) dry mature fruit of Baill., practise and claim " Radix Schisandrae Bicoloris ".Pluck during fruit maturation in autumn, dry or dry after steaming, removing carpopodium and impurity.
Radix Notoginseng: China's coastal port one ministerial standard.This product is the dry root and rhizome of panax araliaceae plant Punaxnotoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".
Rhizoma Chuanxiong: China's coastal port one ministerial standard.This product is the dry rhizome of samphire Rhizoma Chuanxiong LigusticumchuanriongHort..The joint dish that summer works as on stem is significantly outstanding, and excavates during purplish, and removing silt, shines post-drying, then remove fibrous root.
Radix Angelicae Sinensis: China's coastal port one ministerial standard.This product is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Flos Carthami: China's coastal port one ministerial standard.This product is the dried floral of feverfew Flos Carthami CarthamustinctoriusL..Pluck when summer, flower was red by xanthochromia, dry in the shade or dry.
Citric acid: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Hyprolose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Aluminium-magnesium silicate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Sodium chloride: Chinese Pharmacopoeia version two ministerial standard in 2010.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Maltodextrin: Chinese Pharmacopoeia version two ministerial standard in 2010.
Methylcellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Boric acid: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above mercurochrome tablet all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Herba Commelinae 195g, Fructus Schisandrae Chinensis 136.5g, Radix Notoginseng 682.5g, Rhizoma Chuanxiong 195g, Radix Angelicae Sinensis 195g, Flos Carthami 175g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20Mpa, extraction temperature 18 DEG C, separator pressure 13Mpa, separator temperature 38 DEG C, disengaging time 2.0 hours, carbon dioxide flow 25L per hour, obtains extracting solution; Get extracting solution 61 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35g, hyprolose 35g, cross-linking sodium carboxymethyl cellulose 35g, aluminium-magnesium silicate 15g, sodium chloride 5g, mannitol 4g, maltodextrin 4g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional methylcellulose 7g, boric acid 1g, granulate, tabletting, obtained mercurochrome tablet 1500.
Specific embodiments of the invention 2
Get Herba Commelinae 195g, Fructus Schisandrae Chinensis 136.5g, Radix Notoginseng 682.5g, Rhizoma Chuanxiong 195g, Radix Angelicae Sinensis 195g, Flos Carthami 175g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 42Mpa, extraction temperature 42 DEG C, separator pressure 19Mpa, separator temperature 58 DEG C, disengaging time 3.4 hours, carbon dioxide flow 36L per hour, obtains extracting solution; Get extracting solution 75 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, hyprolose 45g, cross-linking sodium carboxymethyl cellulose 45g, aluminium-magnesium silicate 25g, sodium chloride 15g, mannitol 6g, maltodextrin 6g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional methylcellulose 9g, boric acid 3g, granulate, tabletting, obtained mercurochrome tablet 1500.
Specific embodiments of the invention 3
Get Herba Commelinae 195g, Fructus Schisandrae Chinensis 136.5g, Radix Notoginseng 682.5g, Rhizoma Chuanxiong 195g, Radix Angelicae Sinensis 195g, Flos Carthami 175g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 31Mpa, extraction temperature 30 DEG C, separator pressure 15Mpa, separator temperature 48 DEG C, disengaging time 2.7 hours, carbon dioxide flow 31L per hour, obtains extracting solution; Get extracting solution 68 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, hyprolose 40g, cross-linking sodium carboxymethyl cellulose 40g, aluminium-magnesium silicate 20g, sodium chloride 10g, mannitol 5g, maltodextrin 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional methylcellulose 8g, boric acid 2g, granulate, tabletting, obtained mercurochrome tablet 1500.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make mercurochrome tablet.
Actual effect of the present invention is investigated below with the mercurochrome tablet that embodiment 3 is obtained:
(1) embodiment 3 mercurochrome tablet and contrast disintegration of commercially available mercurochrome tablet
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 mercurochrome tablet and commercially available mercurochrome tablet contrast table disintegration
The above results shows, mercurochrome tablet prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available mercurochrome tablet.
(2) embodiment 3 mercurochrome tablet and commercially available mercurochrome tablet treatment traumatic injury, swelling and pain due to blood stasis, rheumatic numbness clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe traumatic injury, swelling and pain due to blood stasis altogether, rheumatic numbness case 153 example, 55 years old mean age.Patient is divided into two groups, test group takes embodiment 3 mercurochrome tablet, and matched group takes commercially available mercurochrome tablet.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 mercurochrome tablet and commercially available mercurochrome tablet clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, mercurochrome tablet prepared by the present invention is treating traumatic injury, swelling and pain due to blood stasis, during rheumatic numbness, evident in efficacy higher than commercially available mercurochrome tablet, p < 0.05.
Claims (3)
1. treat a traumatic injury, swelling and pain due to blood stasis, the Chinese medicine of rheumatic numbness, it is characterized in that getting Herba Commelinae 195g, Fructus Schisandrae Chinensis 136.5g, Radix Notoginseng 682.5g, Rhizoma Chuanxiong 195g, Radix Angelicae Sinensis 195g, Flos Carthami 175g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 42Mpa, extraction temperature 18 ~ 42 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 38 ~ 58 DEG C, disengaging time 2.0 ~ 3.4 hours, carbon dioxide flow 25 ~ 36L per hour, obtains extracting solution; Get extracting solution 61 ~ 75 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional methylcellulose 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained mercurochrome tablet.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Herba Commelinae 195g, Fructus Schisandrae Chinensis 136.5g, Radix Notoginseng 682.5g, Rhizoma Chuanxiong 195g, Radix Angelicae Sinensis 195g, Flos Carthami 175g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 42Mpa, extraction temperature 18 ~ 42 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 38 ~ 58 DEG C, disengaging time 2.0 ~ 3.4 hours, carbon dioxide flow 25 ~ 36L per hour, obtains extracting solution; Get extracting solution 61 ~ 75 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional methylcellulose 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained mercurochrome tablet.
3. the preparation method of Chinese medicine according to claim 1, gets Herba Commelinae 195g, Fructus Schisandrae Chinensis 136.5g, Radix Notoginseng 682.5g, Rhizoma Chuanxiong 195g, Radix Angelicae Sinensis 195g, Flos Carthami 175g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 31Mpa, extraction temperature 30 DEG C, separator pressure 15Mpa, separator temperature 48 DEG C, disengaging time 2.7 hours, carbon dioxide flow 31L per hour, obtains extracting solution; Get extracting solution 68 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, hyprolose 40g, cross-linking sodium carboxymethyl cellulose 40g, aluminium-magnesium silicate 20g, sodium chloride 10g, mannitol 5g, maltodextrin 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional methylcellulose 8g, boric acid 2g, granulate, tabletting, obtained mercurochrome tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510905076.3A CN105362344A (en) | 2015-12-10 | 2015-12-10 | Hongyao tablet and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510905076.3A CN105362344A (en) | 2015-12-10 | 2015-12-10 | Hongyao tablet and preparation method thereof |
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| CN105362344A true CN105362344A (en) | 2016-03-02 |
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