CN104225046A - Hyperostosis-resistant tablet and preparation method thereof - Google Patents
Hyperostosis-resistant tablet and preparation method thereof Download PDFInfo
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- CN104225046A CN104225046A CN201410402612.3A CN201410402612A CN104225046A CN 104225046 A CN104225046 A CN 104225046A CN 201410402612 A CN201410402612 A CN 201410402612A CN 104225046 A CN104225046 A CN 104225046A
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Abstract
The invention discloses a hyperostosis-resistant tablet and a preparation method thereof. The hyperostosis-resistant tablet is characterized by being prepared from the following components: 240g of prepared rehmannia root, 136g of buckeye, 136g of pyrola, 136g of rhizoma drynariae, and 136g of caulis spatholobi. The preparation method comprises the following steps of: extracting by using a supercritical carbon dioxide extraction method, drying at reduced pressure, crushing into nano dry paste by using a high-energy nano impact mill, and adding functional auxiliaries, thus obtaining the hyperostosis-resistant tablet. The hyperostosis-resistant tablet provided by the invention has the advantages that the disintegration time is obviously shortened; the curative effect is obviously prior to that of the commercial hyperostosis-resistant tablet; and active effects are obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Kanggu-Zengsheng tablet and preparation method thereof.
Background technology
Kanggu-Zengsheng tablet the kidney invigorating, invigorates blood circulation, pain relieving.For hypertrophic spondylitis, cervical vertebra pain, calcanean spur, proliferative arthritis, Kaschin-Beck disease.Existing Kanggu-Zengsheng tablet is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides Kanggu-Zengsheng tablet that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Radix Rehmanniae Preparata 240g, Semen Aesculi 136g, Herba Pyrolae 136g, Rhizoma Drynariae 136g, Caulis Spatholobi 136g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, granulate, be pressed into 1500, obtained Kanggu-Zengsheng tablet.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Radix Rehmanniae Preparata: China's coastal port one ministerial standard.This product is the Preparation process product of Radix Rehmanniae.
Semen Aesculi: China's coastal port one ministerial standard.This product is the dry mature seed of Hippocastanaceae plant Aesculus chinensis Bunge Aesculus chinensis Bge., Radix Aesculi Aesculus chinensis Bge. var. chekiangensis (Hu et Fang) Fang or Aesculus Aesculus wilsonii Rehd..Gather during fruit maturation in autumn, removing peel, dries or cold drying.
Herba Pyrolae: China's coastal port one ministerial standard.This product is the dry herb of Pyrolaceae plant Herba pyrolae japonicae Pyrola callianthaH.Andres or traditional embankment Pyrola decorata H.Andres.The whole year all can excavate, and removing impurity, when shining softer to blade.Bank up to blade purpling brown, dry.
Rhizoma Drynariae: China's coastal port one ministerial standard.This product is Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortunei(Kunze) dry rhizome of J.Sm..The whole year all can excavate, removing silt, dry. or burn remove floss (scale) again.
Caulis Spatholobi: China's coastal port one ministerial standard.This product is the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Autumn, season in winter two gather, and removing branch and leaf, section, dries.
Calcium sulfate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Hypromellose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Micropowder silica gel: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethylstach sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above Kanggu-Zengsheng tablet all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Radix Rehmanniae Preparata 240g, Semen Aesculi 136g, Herba Pyrolae 136g, Rhizoma Drynariae 136g, Caulis Spatholobi 136g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 20Mpa, extraction temperature 20 DEG C, separator pressure 10Mpa, separator temperature 40 DEG C, disengaging time 2 hours, carbon dioxide flow 20L per hour, obtains extracting solution; Get extracting solution 60 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 80g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35g, crospolyvinylpyrrolidone 35g, cross-linking sodium carboxymethyl cellulose 35g, hypromellose 25g, micropowder silica gel 15g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, granulate, be pressed into 1500, obtained Kanggu-Zengsheng tablet.
Specific embodiments of the invention 2
Get Radix Rehmanniae Preparata 240g, Semen Aesculi 136g, Herba Pyrolae 136g, Rhizoma Drynariae 136g, Caulis Spatholobi 136g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 20Mpa, separator temperature 60 DEG C, disengaging time 4 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 45g, hypromellose 35g, micropowder silica gel 25g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, granulate, be pressed into 1500, obtained Kanggu-Zengsheng tablet.
Specific embodiments of the invention 3
Get Radix Rehmanniae Preparata 240g, Semen Aesculi 136g, Herba Pyrolae 136g, Rhizoma Drynariae 136g, Caulis Spatholobi 136g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 15Mpa, separator temperature 50 DEG C, disengaging time 3 hours, carbon dioxide flow 30L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, crospolyvinylpyrrolidone 40g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, granulate, be pressed into 1500, obtained Kanggu-Zengsheng tablet.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Kanggu-Zengsheng tablet.Actual effect of the present invention is investigated below with the Kanggu-Zengsheng tablet that embodiment 3 is obtained:
(1) embodiment 3 Kanggu-Zengsheng tablet and commercially available Kanggu-Zengsheng tablet contrast disintegration
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 Kanggu-Zengsheng tablet and commercially available Kanggu-Zengsheng tablet contrast table disintegration
The above results shows, Kanggu-Zengsheng tablet prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available Kanggu-Zengsheng tablet.
(2) embodiment 3 Kanggu-Zengsheng tablet and commercially available Kanggu-Zengsheng tablet treat hypertrophic spondylitis, cervical vertebra pain, calcanean spur, proliferative arthritis, Kaschin-Beck disease clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe hypertrophic spondylitis, cervical vertebra pain, calcanean spur, proliferative arthritis, Kaschin-Beck disease case 110 example, 55 years old mean age altogether.Patient is divided into two groups, test group takes embodiment 3 Kanggu-Zengsheng tablet, and matched group takes commercially available Kanggu-Zengsheng tablet.
2 efficacy assessment standards
According to new Chinese medicine treatment rheumatoid arthritis guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 Kanggu-Zengsheng tablet and commercially available Kanggu-Zengsheng tablet clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, Kanggu-Zengsheng tablet prepared by the present invention is when treating hypertrophic spondylitis, cervical vertebra pain, calcanean spur, proliferative arthritis, Kaschin-Beck disease, evident in efficacy higher than commercially available Kanggu-Zengsheng tablet, p < 0.05.
Claims (3)
1. treat the Chinese medicine of hypertrophic spondylitis, cervical vertebra pain, calcanean spur, proliferative arthritis, Kaschin-Beck disease for one kind, it is characterized in that getting Radix Rehmanniae Preparata 240g, Semen Aesculi 136g, Herba Pyrolae 136g, Rhizoma Drynariae 136g, Caulis Spatholobi 136g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, granulate, obtained Kanggu-Zengsheng tablet.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Rehmanniae Preparata 240g, Semen Aesculi 136g, Herba Pyrolae 136g, Rhizoma Drynariae 136g, Caulis Spatholobi 136g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, granulate, obtained Kanggu-Zengsheng tablet.
3. the preparation method of Chinese medicine according to claim 1, gets Radix Rehmanniae Preparata 240g, Semen Aesculi 136g, Herba Pyrolae 136g, Rhizoma Drynariae 136g, Caulis Spatholobi 136g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 15Mpa, separator temperature 50 DEG C, disengaging time 3 hours, carbon dioxide flow 30L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, crospolyvinylpyrrolidone 40g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, granulate, obtained Kanggu-Zengsheng tablet.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334883A (en) * | 2017-08-02 | 2017-11-10 | 朱明星 | A kind of Chinese medicine for treating protrusion of lumber intervertebral disc and cervical vertebrae hyperosteogeny and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600234A (en) * | 2012-04-13 | 2012-07-25 | 孙长海 | Swertia mileensis dispersible tablet and preparation method thereof |
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- 2014-08-16 CN CN201410402612.3A patent/CN104225046A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600234A (en) * | 2012-04-13 | 2012-07-25 | 孙长海 | Swertia mileensis dispersible tablet and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 苏振武等: "《医院常用药物手册》", 30 June 2011, 军事医学科学院 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334883A (en) * | 2017-08-02 | 2017-11-10 | 朱明星 | A kind of Chinese medicine for treating protrusion of lumber intervertebral disc and cervical vertebrae hyperosteogeny and preparation method thereof |
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