CN104398935A - Hemorrhoid eliminating tablet and preparation method thereof - Google Patents
Hemorrhoid eliminating tablet and preparation method thereof Download PDFInfo
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- CN104398935A CN104398935A CN201410760593.1A CN201410760593A CN104398935A CN 104398935 A CN104398935 A CN 104398935A CN 201410760593 A CN201410760593 A CN 201410760593A CN 104398935 A CN104398935 A CN 104398935A
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- 208000014617 hemorrhoid Diseases 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000001035 drying Methods 0.000 claims abstract description 16
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 15
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 15
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 241000628997 Flos Species 0.000 claims description 10
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 9
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 8
- 229930091371 Fructose Natural products 0.000 claims description 8
- 239000005715 Fructose Substances 0.000 claims description 8
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 8
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
- 229960003943 hypromellose Drugs 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000000741 silica gel Substances 0.000 claims description 8
- 229910002027 silica gel Inorganic materials 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 208000007536 Thrombosis Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 201000007772 internal hemorrhoid Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 6
- 235000013399 edible fruits Nutrition 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 3
- 240000005528 Arctium lappa Species 0.000 abstract description 2
- 235000003130 Arctium lappa Nutrition 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 2
- 235000008078 Arctium minus Nutrition 0.000 abstract 1
- 235000000404 Poncirus trifoliata Nutrition 0.000 abstract 1
- 244000202052 Poncirus trifoliata Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
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- 241000607292 Maguireothamnus speciosus Species 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8994—Coix (Job's tears)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
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- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a hemorrhoid eliminating tablet and a preparation method thereof. The hemorrhoid eliminating tablet is characterized by being prepared from 10 g of burdock, 50 g of semen coicis, 200 g of sophora flower bud, 250 g of radix rubiae, 250 g of fruit of trifoliate orange, and 250 g of rhizoma sparganii, and prepared by the following steps: using a carbon dioxide supercritical extraction method to extract the raw materials, drying under reduced pressure, using a high-powered nano-scale impact mill to crush the dried materials to form nanometer dry paste, and adding functional auxiliary materials to the dry paste, so as to prepare the hemorrhoid eliminating tablet. The disintegration time of the hemorrhoid eliminating tablet is remarkably shortened; the curative effect is obviously better than that of the hemorrhoid eliminating tablet sold in the market, so that the hemorrhoid eliminating tablet can achieve a positive effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of pile eliminating tablet and preparation method thereof.
Background technology
Pile eliminating tablet heat clearing away, removing heat from blood, hemostasis, circulation of qi promoting dissipating blood stasis.For internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, mixed hemorrhoids thrombosis.Commercially available pile eliminating tablet is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides pile eliminating tablet that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Fructus Arctii 10g, Semen Coicis 50g, Flos Sophorae Immaturus 200g, Radix Rubiae 250g, Fructus Aurantii 250g, Rhizoma Sparganii 250g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 15 ~ 25Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add fructose 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional leucine 7 ~ 9g, granulate, be pressed into 1000, obtained pile eliminating tablet.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Fructus Arctii: China's coastal port one ministerial standard.This product is the dry mature fruit of feverfew Fructus Arctii Arctium laPPa L..To gather during fruit maturation in autumn infructescence, dry, lay fruit, removing impurity dries again.
Semen Coicis: China's coastal port one ministerial standard.This product is grass Semen Coicis Coix lacryma-jobi L.var.ma-yuen(ROman.) dry mature kernal of Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, except decapsidate, yellowish-brown seed coat and impurity, collect kernel.
The Flos Sophorae Immaturus: China's coastal port one ministerial standard.This product is the dry flower and alabastrum of leguminous plant Chinese scholartree Sophora japonica L..Summer, the flowers are in blossom put or alabastrum is formed time gather, dry in time, except debranching, stalk and impurity.The former practises title " Flos Sophorae ", and the latter practises title " Flos Sophorae Immaturus ".
Radix Rubiae: China's coastal port one ministerial standard.This product is the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..Spring, Qiu Erji excavate, removing silt, dry.
Fructus Aurantii: China's coastal port one ministerial standard.This product is the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.July gathers when peel is still green, is two halves from middle part crosscut, dries or cold drying.
Rhizoma Sparganii: China's coastal port one ministerial standard.This product is the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganium stoloniferumBuch-Ham..Spring winter to next year excavates, and clean, crust of pruning, dries.
Fructose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Hypromellose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Micropowder silica gel: Chinese Pharmacopoeia version two ministerial standard in 2010.
Leucine: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above pile eliminating tablet all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Fructus Arctii 10g, Semen Coicis 50g, Flos Sophorae Immaturus 200g, Radix Rubiae 250g, Fructus Aurantii 250g, Rhizoma Sparganii 250g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20Mpa, extraction temperature 20 DEG C, separator pressure 15Mpa, separator temperature 40 DEG C, disengaging time 2 hours, carbon dioxide flow 20L per hour, obtains extracting solution; Get extracting solution 60 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add fructose 80g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35g, crospolyvinylpyrrolidone 35g, cross-linking sodium carboxymethyl cellulose 35g, hypromellose 25g, micropowder silica gel 15g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional leucine 7g, granulate, is pressed into 1000, obtained pile eliminating tablet.
Specific embodiments of the invention 2
Get Fructus Arctii 10g, Semen Coicis 50g, Flos Sophorae Immaturus 200g, Radix Rubiae 250g, Fructus Aurantii 250g, Rhizoma Sparganii 250g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 25Mpa, separator temperature 60 DEG C, disengaging time 4 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add fructose 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 45g, hypromellose 35g, micropowder silica gel 25g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional leucine 9g, granulate, is pressed into 1000, obtained pile eliminating tablet.
Specific embodiments of the invention 3
Get Fructus Arctii 10g, Semen Coicis 50g, Flos Sophorae Immaturus 200g, Radix Rubiae 250g, Fructus Aurantii 250g, Rhizoma Sparganii 250g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 20Mpa, separator temperature 50 DEG C, disengaging time 3 hours, carbon dioxide flow 30L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add fructose 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, crospolyvinylpyrrolidone 40g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional leucine 8g, granulate, is pressed into 1000, obtained pile eliminating tablet.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make pile eliminating tablet.Actual effect of the present invention is investigated below with the pile eliminating tablet that embodiment 3 is obtained:
(1) embodiment 3 pile eliminating tablet and commercially available pile eliminating tablet contrast disintegration
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 pile eliminating tablet and commercially available pile eliminating tablet contrast table disintegration
The above results shows, pile eliminating tablet prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available pile eliminating tablet.
(2) embodiment 3 pile eliminating tablet and commercially available pile eliminating tablet treat internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, mixed hemorrhoids thrombus disease clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe internal hemorrhoid, external hemorrhoid, mixed hemorrhoid altogether, mixed hemorrhoids thrombus disease case 120 example, 39 years old mean age.Patient is divided into two groups, test group takes embodiment 3 pile eliminating tablet, and matched group takes commercially available pile eliminating tablet.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 pile eliminating tablet and commercially available pile eliminating tablet clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, pile eliminating tablet prepared by the present invention is treating internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, evident in efficacy higher than commercially available pile eliminating tablet during mixed hemorrhoids thrombus disease, p < 0.05.
Claims (3)
1. treat an internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, the Chinese medicine of mixed hemorrhoids thrombus disease, it is characterized in that getting Fructus Arctii 10g, Semen Coicis 50g, Flos Sophorae Immaturus 200g, Radix Rubiae 250g, Fructus Aurantii 250g, Rhizoma Sparganii 250g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 15 ~ 25Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add fructose 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional leucine 7 ~ 9g, granulate, tabletting, obtained pile eliminating tablet.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Fructus Arctii 10g, Semen Coicis 50g, Flos Sophorae Immaturus 200g, Radix Rubiae 250g, Fructus Aurantii 250g, Rhizoma Sparganii 250g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 15 ~ 25Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add fructose 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional leucine 7 ~ 9g, granulate, tabletting, obtained pile eliminating tablet.
3. the preparation method of Chinese medicine according to claim 1, gets Fructus Arctii 10g, Semen Coicis 50g, Flos Sophorae Immaturus 200g, Radix Rubiae 250g, Fructus Aurantii 250g, Rhizoma Sparganii 250g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 20Mpa, separator temperature 50 DEG C, disengaging time 3 hours, carbon dioxide flow 30L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add fructose 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, crospolyvinylpyrrolidone 40g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional leucine 8g, granulate, tabletting, obtained pile eliminating tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410760593.1A CN104398935A (en) | 2014-12-13 | 2014-12-13 | Hemorrhoid eliminating tablet and preparation method thereof |
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| CN201410760593.1A CN104398935A (en) | 2014-12-13 | 2014-12-13 | Hemorrhoid eliminating tablet and preparation method thereof |
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| CN104398935A true CN104398935A (en) | 2015-03-11 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3145287A1 (en) | 2023-01-31 | 2024-08-02 | Le Rouge Français | Particular process for preparing an extract of at least one plant belonging to the Rubiaceae family. |
-
2014
- 2014-12-13 CN CN201410760593.1A patent/CN104398935A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3145287A1 (en) | 2023-01-31 | 2024-08-02 | Le Rouge Français | Particular process for preparing an extract of at least one plant belonging to the Rubiaceae family. |
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Application publication date: 20150311 |