CN105362578A - Tablets for regulating menstruation and preparation method thereof - Google Patents
Tablets for regulating menstruation and preparation method thereof Download PDFInfo
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- CN105362578A CN105362578A CN201510913377.0A CN201510913377A CN105362578A CN 105362578 A CN105362578 A CN 105362578A CN 201510913377 A CN201510913377 A CN 201510913377A CN 105362578 A CN105362578 A CN 105362578A
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- tablets
- carbon dioxide
- rhizoma
- radix
- radix angelicae
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- 230000005906 menstruation Effects 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 230000001105 regulatory effect Effects 0.000 title abstract description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000001035 drying Methods 0.000 claims abstract description 18
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 15
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 8
- 239000005913 Maltodextrin Substances 0.000 claims description 8
- 229920002774 Maltodextrin Polymers 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 8
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 8
- 239000004327 boric acid Substances 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 8
- 229950005770 hyprolose Drugs 0.000 claims description 8
- 229940035034 maltodextrin Drugs 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 208000004998 Abdominal Pain Diseases 0.000 claims description 5
- 208000019255 Menstrual disease Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 241000382455 Angelica sinensis Species 0.000 abstract description 2
- 241001466453 Laminaria Species 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 4
- 230000010354 integration Effects 0.000 description 3
- 241000213006 Angelica dahurica Species 0.000 description 2
- 241000125183 Crithmum maritimum Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241001290610 Abildgaardia Species 0.000 description 1
- 241000199899 Alariaceae Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241001466452 Laminariaceae Species 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 241000124464 Paeonia veitchii Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000758706 Piperaceae Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
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Abstract
The invention discloses tablets for regulating menstruation and a preparation method thereof. The preparation method is characterized by including, taking 44g of radix angelicae dahuricae, 15.4g of laminaria, 77g of fructus piperis longi, 144g of angelica sinensis, 15.4g of rhizoma chuanxiong, 388g of rhizoma cyperi, 23.1g of rhizoma atractylodis macrocephalae, 15.4g of radix paeoniae rubra and 46.2g of radix rehmanniae praeparata, extracting with a carbon dioxide supercritical extraction method, drying under reduced pressure, using a high-energy nano impact grinder to grind into nano dry paste, and adding functional auxiliary materials to prepare the tablets for regulating the menstruation. The tablets for regulating the menstruation has the advantages that disintegrating time is shortened evidently, the curative effect of the tablets is evidently better than that of existing tablets for regulating the menstruation on the market, and a positive effect is achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Fuke Tiaojing tablets and preparation method thereof.
Background technology
Fuke Tiaojing tablets nourishes blood, regulating menstruation, pain relieving.For menoxenia, abdominal pain in menstruation.Commercially available Fuke Tiaojing tablets is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides Fuke Tiaojing tablets that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Radix Angelicae Dahuricae 44g, Thallus Laminariae (Thallus Eckloniae) 15.4g, Fructus Piperis Longi 77g, Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 15.4g, Rhizoma Cyperi 388g, Rhizoma Atractylodis Macrocephalae 23.1g, Radix Paeoniae Rubra 15.4g, Radix Rehmanniae Preparata 46.2g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 23 ~ 36Mpa, extraction temperature 23 ~ 44 DEG C, separator pressure 10 ~ 19Mpa, separator temperature 41 ~ 56 DEG C, disengaging time 1.7 ~ 3.8 hours, carbon dioxide flow 24 ~ 37L per hour, obtains extracting solution; Get extracting solution 61 ~ 77 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional sodium alginate 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained Fuke Tiaojing tablets 1000.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
The Radix Angelicae Dahuricae: China's coastal port one ministerial standard.This product is samphire Radix Angelicae Dahuricae Angelicadahurica(Fisch.exHOffm.) Benth.etHook.f. or Radix angelicae dahuricae Angelicadahurica(Fisch.exHoffm.) Benth.etHook.f.var.formosana(Boiss.) dry root of ShanetYuan.Excavate when between summer, autumn, leaf is yellow, removing must be reported and silt, dries or cold drying.
Thallus Laminariae (Thallus Eckloniae): China's coastal port one ministerial standard.This product is the dry thallus of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) LaminariaJaponicaAresch. or Alariaceae plant Thallus Laminariae (Thallus Eckloniae) EckloniakuromeOkam..Summer, Qiu Erji drag for, and dry.
Fructus Piperis Longi: Chinese Pharmacopoeia version one ministerial standard in 2010.This product is the nearly ripe or mature fruit cluster of the drying of Piperaceae plant Fructus Piperis Longi PiperlongumL..Fruit ear is gathered by during green blackening, and removing impurity, dries.
Radix Angelicae Sinensis: China's coastal port one ministerial standard.This product is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Rhizoma Chuanxiong: China's coastal port one ministerial standard.This product is the dry rhizome of samphire Rhizoma Chuanxiong LigusticumchuanriongHort..The joint dish that summer works as on stem is significantly outstanding, and excavates during purplish, and removing silt, shines post-drying, then remove fibrous root.
Rhizoma Cyperi: China's coastal port one ministerial standard.This product is the dry rhizome of sedge dried tuber CyperusrotundusL..Autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry. or burn and directly to dry afterwards.
The Rhizoma Atractylodis Macrocephalae: China's coastal port one ministerial standard.This product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoldz..Excavate when withered and yellow, the upper leaf of inferior leads in winter becomes fragile, removing silt, dries or dries, then remove fibrous root.
Radix Paeoniae Rubra: China's coastal port one ministerial standard.This product is the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall. or river Radix Paeoniae Rubra PaeoniaveitchiiLynch.Spring, Qiu Erji excavate, and removing rhizome, fibrous root and silt, dry.
Radix Rehmanniae Preparata: China's coastal port one ministerial standard.This product is the Preparation process product of Radix Rehmanniae.
Citric acid: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Hyprolose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Aluminium-magnesium silicate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Sodium chloride: Chinese Pharmacopoeia version two ministerial standard in 2010.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Maltodextrin: Chinese Pharmacopoeia version two ministerial standard in 2010.
Sodium alginate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Boric acid: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above Fuke Tiaojing tablets all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Radix Angelicae Dahuricae 44g, Thallus Laminariae (Thallus Eckloniae) 15.4g, Fructus Piperis Longi 77g, Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 15.4g, Rhizoma Cyperi 388g, Rhizoma Atractylodis Macrocephalae 23.1g, Radix Paeoniae Rubra 15.4g, Radix Rehmanniae Preparata 46.2g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 23Mpa, extraction temperature 23 DEG C, separator pressure 10Mpa, separator temperature 41 DEG C, disengaging time 1.7 hours, carbon dioxide flow 24L per hour, obtains extracting solution; Get extracting solution 61 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35g, hyprolose 35g, cross-linking sodium carboxymethyl cellulose 35g, aluminium-magnesium silicate 15g, sodium chloride 5g, mannitol 4g, maltodextrin 4g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional sodium alginate 7g, boric acid 1g, granulate, tabletting, obtained Fuke Tiaojing tablets 1000.
Specific embodiments of the invention 2
Get Radix Angelicae Dahuricae 44g, Thallus Laminariae (Thallus Eckloniae) 15.4g, Fructus Piperis Longi 77g, Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 15.4g, Rhizoma Cyperi 388g, Rhizoma Atractylodis Macrocephalae 23.1g, Radix Paeoniae Rubra 15.4g, Radix Rehmanniae Preparata 46.2g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 36Mpa, extraction temperature 44 DEG C, separator pressure 19Mpa, separator temperature 56 DEG C, disengaging time 3.8 hours, carbon dioxide flow 37L per hour, obtains extracting solution; Get extracting solution 77 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, hyprolose 45g, cross-linking sodium carboxymethyl cellulose 45g, aluminium-magnesium silicate 25g, sodium chloride 15g, mannitol 6g, maltodextrin 6g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional sodium alginate 9g, boric acid 3g, granulate, tabletting, obtained Fuke Tiaojing tablets 1000.
Specific embodiments of the invention 3
Get Radix Angelicae Dahuricae 44g, Thallus Laminariae (Thallus Eckloniae) 15.4g, Fructus Piperis Longi 77g, Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 15.4g, Rhizoma Cyperi 388g, Rhizoma Atractylodis Macrocephalae 23.1g, Radix Paeoniae Rubra 15.4g, Radix Rehmanniae Preparata 46.2g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 34 DEG C, separator pressure 15Mpa, separator temperature 49 DEG C, disengaging time 2.8 hours, carbon dioxide flow 31L per hour, obtains extracting solution; Get extracting solution 69 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, hyprolose 40g, cross-linking sodium carboxymethyl cellulose 40g, aluminium-magnesium silicate 20g, sodium chloride 10g, mannitol 5g, maltodextrin 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional sodium alginate 8g, boric acid 2g, granulate, tabletting, obtained Fuke Tiaojing tablets 1000.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Fuke Tiaojing tablets.
Actual effect of the present invention is investigated below with the Fuke Tiaojing tablets that embodiment 3 is obtained:
(1) embodiment 3 Fuke Tiaojing tablets and contrast disintegration of commercially available Fuke Tiaojing tablets
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 Fuke Tiaojing tablets and commercially available Fuke Tiaojing tablets contrast table disintegration
The above results shows, Fuke Tiaojing tablets prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available Fuke Tiaojing tablets.
(2) embodiment 3 Fuke Tiaojing tablets and commercially available Fuke Tiaojing tablets treatment menoxenia, abdominal pain in menstruation clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe menoxenia altogether, abdominal pain in menstruation case 145 example, 37 years old mean age.Patient is divided into two groups, test group takes embodiment 3 Fuke Tiaojing tablets, and matched group takes commercially available Fuke Tiaojing tablets.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 Fuke Tiaojing tablets and commercially available Fuke Tiaojing tablets clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, Fuke Tiaojing tablets prepared by the present invention is in treatment menoxenia, during abdominal pain in menstruation, evident in efficacy higher than commercially available Fuke Tiaojing tablets, p < 0.05.
Claims (3)
1. a treatment menoxenia, the Chinese medicine of abdominal pain in menstruation, is characterized in that getting Radix Angelicae Dahuricae 44g, Thallus Laminariae (Thallus Eckloniae) 15.4g, Fructus Piperis Longi 77g, Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 15.4g, Rhizoma Cyperi 388g, Rhizoma Atractylodis Macrocephalae 23.1g, Radix Paeoniae Rubra 15.4g, Radix Rehmanniae Preparata 46.2g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 23 ~ 36Mpa, extraction temperature 23 ~ 44 DEG C, separator pressure 10 ~ 19Mpa, separator temperature 41 ~ 56 DEG C, disengaging time 1.7 ~ 3.8 hours, carbon dioxide flow 24 ~ 37L per hour, obtains extracting solution; Get extracting solution 61 ~ 77 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional sodium alginate 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained Fuke Tiaojing tablets.
2. the preparation method of Chinese medicine according to claim 1, it is characterized in that getting Radix Angelicae Dahuricae 44g, Thallus Laminariae (Thallus Eckloniae) 15.4g, Fructus Piperis Longi 77g, Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 15.4g, Rhizoma Cyperi 388g, Rhizoma Atractylodis Macrocephalae 23.1g, Radix Paeoniae Rubra 15.4g, Radix Rehmanniae Preparata 46.2g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 23 ~ 36Mpa, extraction temperature 23 ~ 44 DEG C, separator pressure 10 ~ 19Mpa, separator temperature 41 ~ 56 DEG C, disengaging time 1.7 ~ 3.8 hours, carbon dioxide flow 24 ~ 37L per hour, obtains extracting solution; Get extracting solution 61 ~ 77 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional sodium alginate 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained Fuke Tiaojing tablets.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Angelicae Dahuricae 44g, Thallus Laminariae (Thallus Eckloniae) 15.4g, Fructus Piperis Longi 77g, Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 15.4g, Rhizoma Cyperi 388g, Rhizoma Atractylodis Macrocephalae 23.1g, Radix Paeoniae Rubra 15.4g, Radix Rehmanniae Preparata 46.2g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 34 DEG C, separator pressure 15Mpa, separator temperature 49 DEG C, disengaging time 2.8 hours, carbon dioxide flow 31L per hour, obtains extracting solution; Get extracting solution 69 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, hyprolose 40g, cross-linking sodium carboxymethyl cellulose 40g, aluminium-magnesium silicate 20g, sodium chloride 10g, mannitol 5g, maltodextrin 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional sodium alginate 8g, boric acid 2g, granulate, tabletting, obtained Fuke Tiaojing tablets.
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| CN201510913377.0A CN105362578A (en) | 2015-12-12 | 2015-12-12 | Tablets for regulating menstruation and preparation method thereof |
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